The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2U INC COM USD0.001 COM 90214J101 37,230 989,096 SH   DFND   0 0 989,096
ABIOMED INC COM USD0.01 COM 003654100 44,045 169,084 SH   DFND   0 0 169,084
ACACIA COMMUNICATIONS INC COM COM 00401C108 819 17,377 SH   DFND   0 0 17,377
ACTIVISION BLIZZARD INC COM USD0.000001 COM 00507V109 3,475 73,623 SH   DFND   0 0 73,623
ADAPTIVE BIOTECHNOLOGIES CORP COM COM 00650F109 28,581 591,749 SH   DFND   0 0 591,749
ADESTO TECHNOLOGIES CORP COM COM 00687D101 12,608 1,547,003 SH   DFND   0 0 1,547,003
ADOBE INC COM COM 00724F101 49,153 166,817 SH   DFND   0 0 166,817
ADYEN NV 144A COM N3501V104 83,091 107,521 SH   DFND   0 0 107,521
AEROJET ROCKETDYNE HLDGS INC COM COM 007800105 30,871 689,542 SH   DFND   0 0 689,542
AFTERPAY TOUCH GROUP LTD ISIN #AU000000APT1 SEDOL #BF5L8B9 COM Q3583G105 3,295 187,284 SH   DFND   0 0 187,284
ALASKA COMM SYS GRP INC COM 01167P101 3,055 1,786,765 SH   DFND   0 0 1,786,765
ALDEYRA THERAPEUTICS USD0.001 COM 01438T106 1,308 218,042 SH   DFND   0 0 218,042
ALIBABA GROUP HOLDING LTD SPON ADS EACH REP ONE ORD SHS COM 01609W102 68,759 405,776 SH   DFND   0 0 405,776
ALLAKOS INC COM COM 01671P100 1,401 32,335 SH   DFND   0 0 32,335
ALLEGIANT TRAVEL COMPANY COM USD0.001 COM 01748X102 13,401 93,390 SH   DFND   0 0 93,390
ALLOGENE THERAPEUTICS INC COM COM 019770106 59 2,182 SH   DFND   0 0 2,182
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 70,951 977,819 SH   DFND   0 0 977,819
ALPHABET INC CAP STK CL A COM 02079K305 48,933 45,191 SH   DFND   0 0 45,191
ALPHABET INC CAP STK CL C COM 02079K107 55,235 51,100 SH   DFND   0 0 51,100
ALTIUS MINERALS CORP COM ISIN #CA0209361009 SEDOL #2122355 COM 020936100 7,103 729,672 SH   DFND   0 0 729,672
ALTUS MIDSTREAM CO CL A COM 02215L100 7,823 2,103,019 SH   DFND   0 0 2,103,019
AMAZON.COM INC COM 023135106 418,959 221,247 SH   DFND   0 0 221,247
AMERICAN EAGLE OUTFITTERS INC COM COM 02553E106 53,602 3,171,727 SH   DFND   0 0 3,171,727
AMERICAN TOWER CORP COM USD0.01 COM 03027X100 16,875 82,537 SH   DFND   0 0 82,537
AMICUS THERAPEUTICS INC COM 03152W109 187 15,000 SH   DFND   0 0 15,000
AMYRIS INC COM NEW COM 03236M200 194 54,586 SH   DFND   0 0 54,586
ANAPLAN INC COM COM 03272L108 11,718 232,182 SH   DFND   0 0 232,182
APACHE CORP COM USD0.625 COM 037411105 5,972 206,159 SH   DFND   0 0 206,159
APPFOLIO INC COM CL A COM 03783C100 23,600 230,766 SH   DFND   0 0 230,766
APPIAN CORP CL A COM 03782L101 2,357 65,352 SH   DFND   0 0 65,352
APPLIED OPTOELECTRONICS INC COM COM 03823U102 78 7,560 SH   DFND   0 0 7,560
AQUANTIA CORP COM COM 03842Q108 7,955 610,546 SH   DFND   0 0 610,546
ARCO PLATFORM LTD COM USD0.00005 CL A COM G04553106 17,618 402,427 SH   DFND   0 0 402,427
ARCUS BIOSCIENCES INC COM COM 03969F109 163 20,443 SH   DFND   0 0 20,443
ARENA PHARMACEUTICALS INC COM NEW COM 040047607 643 10,971 SH   DFND   0 0 10,971
ARISTA NETWORKS INC COM USD0.0001 COM 040413106 110,067 423,955 SH   DFND   0 0 423,955
ASV HLDGS INC COM COM 00215L104 4,754 694,070 SH   DFND   0 0 694,070
ATLASSIAN CORPORATION PLC COM USD0.1 CL A COM G06242104 24,988 190,978 SH   DFND   0 0 190,978
AUDENTES THERAPEUTICS INC COM COM 05070R104 66,632 1,759,958 SH   DFND   0 0 1,759,958
AUTO TRADER GROUP PLC ORD GBP0.01 ISIN #GB00BVYVFW23 SEDOL #BVYV COM G06708104 5,955 854,080 SH   DFND   0 0 854,080
AUTODESK INC COM COM 052769106 143,073 878,286 SH   DFND   0 0 878,286
AVEDRO INC COM COM 05355N109 335 17,035 SH   DFND   0 0 17,035
AXIS BANK GDR EACH REPR 1 INR10 REG S ISIN #US05462W1099 SEDOL # COM 05462W109 878 15,085 SH   DFND   0 0 15,085
AXOGEN INC COM COM 05463X106 11,174 564,342 SH   DFND   0 0 564,342
AZUL SA SPON ADR EACH REP 3 PFD SHS COM 05501U106 117,629 3,517,620 SH   DFND   0 0 3,517,620
AZURRX BIOPHARMA INC COM COM 05502L105 926 544,606 SH   DFND   0 0 544,606
BANDWIDTH INC COM CL A COM 05988J103 40,460 539,328 SH   DFND   0 0 539,328
BARCLAYS BANK PLC IPATH B SHRT TERM COM 06746P621 5,926 227,938 SH   DFND   0 0 227,938
BERKLEY W R CORP COM COM 084423102 5,880 89,189 SH   DFND   0 0 89,189
BERKSHIRE HATHAWAY INC COM USD0.0033 CLASS B COM 084670702 288 1,351 SH   DFND   0 0 1,351
BEYOND MEAT INC COM COM 08862E109 7,929 49,345 SH   DFND   0 0 49,345
BIOSCRIP INC COM 09069N108 40,910 15,734,496 SH   DFND   0 0 15,734,496
BLACK KNIGHT INC COM COM 09215C105 5,448 90,576 SH   DFND   0 0 90,576
BLUEBIRD BIO INC COM COM 09609G100 5,024 39,500 SH   DFND   0 0 39,500
BOSTON SCIENTIFIC CORP COM 101137107 1,810 42,120 SH   DFND   0 0 42,120
BRIGHTCOVE INC COM USD0.001 COM 10921T101 308 29,834 SH   DFND   0 0 29,834
CALIX INC COM COM 13100M509 854 130,177 SH   DFND   0 0 130,177
CALYXT INC COM COM 13173L107 122 9,783 SH   DFND   0 0 9,783
CAREDX INC COM COM 14167L103 2,991 83,112 SH   DFND   0 0 83,112
CARL ZEISS MEDITEC AG NPV ISIN #DE0005313704 SEDOL #5922961 COM D14895102 1,739 17,569 SH   DFND   0 0 17,569
CARVANA CO CL A COM 146869102 18,044 288,296 SH   DFND   0 0 288,296
CATAPULT GROUP INTERNATIONAL ISIN #AU000000CAT9 SEDOL #BTL0Y76 COM Q2159P101 160 208,773 SH   DFND   0 0 208,773
CHARLOTTES WEB HOLDINGS INC COM NPV COM 16106R109 1,088 74,331 SH   DFND   0 0 74,331
CHART INDUSTRIES INC COM USD0.01 COM 16115Q308 9,403 122,302 SH   DFND   0 0 122,302
CHEGG INC COM USD0.001 COM 163092109 178,153 4,616,555 SH   DFND   0 0 4,616,555
CHEWY INC CL A COM 16679L109 419 11,963 SH   DFND   0 0 11,963
CHIPOTLE MEXICAN GRILL INC COM COM 169656105 23 32 SH   DFND   0 0 32
CODEXIS INC COM USD0.0001 COM 192005106 46,221 2,507,900 SH   DFND   0 0 2,507,900
CONSTRUCTION PARTNERS INC COM CL A COM 21044C107 110 7,306 SH   DFND   0 0 7,306
COUPA SOFTWARE INC COM COM 22266L106 34,145 269,690 SH   DFND   0 0 269,690
COVANTA HLDG CORP COM COM 22282E102 8,483 473,660 SH   DFND   0 0 473,660
CRIMSON WINE GROUP COM USD0.01 COM 22662X100 662 82,773 SH   DFND   0 0 82,773
CROWDSTRIKE HLDGS INC CL A WHEN DISTRIBUTED COM 22788C105 6,761 99,006 SH   DFND   0 0 99,006
DEERE & COMPANY COM 244199105 17 100 SH   DFND   0 0 100
DEXCOM INC COM 252131107 113,320 756,275 SH   DFND   0 0 756,275
DIGI INTL INC COM COM 253798102 820 64,640 SH   DFND   0 0 64,640
DISNEY WALT CO COM 254687106 13,753 98,490 SH   DFND   0 0 98,490
DOCUSIGN INC COM COM 256163106 1,496 30,088 SH   DFND   0 0 30,088
EHEALTH INC COM COM 28238P109 47,329 549,700 SH   DFND   0 0 549,700
ELASTIC N V COM EUR0.01 COM N14506104 8,786 117,676 SH   DFND   0 0 117,676
ELECTRONIC ARTS COM 285512109 196 1,931 SH   DFND   0 0 1,931
ENPHASE ENERGY INC COM USD0.00001 COM 29355A107 71,568 3,925,840 SH   DFND   0 0 3,925,840
ENTERCOM COMMUNICATIONS CORP CL A COM 293639100 5,884 1,014,407 SH   DFND   0 0 1,014,407
EPAM SYS INC COM USD0.001 COM 29414B104 98,016 566,242 SH   DFND   0 0 566,242
EROS INTERNATIONAL COM GBP0.30 COM G3788M114 1,154 855,016 SH   DFND   0 0 855,016
ESPERION THERAPEUTICS INC COM USD0.001 COM 29664W105 53 1,132 SH   DFND   0 0 1,132
ETSY INC COM COM 29786A106 219,625 3,578,703 SH   DFND   0 0 3,578,703
EVERBRIDGE INC COM COM 29978A104 16,470 184,184 SH   DFND   0 0 184,184
EXACT SCIENCES CORP COM 30063P105 222,893 1,888,287 SH   DFND   0 0 1,888,287
EXTRACTION OIL AND GAS INC COM COM 30227M105 504 116,355 SH   DFND   0 0 116,355
FACEBOOK INC-CLASS A COM 30303M102 73,212 379,339 SH   DFND   0 0 379,339
FARFETCH LTD COM USD0.04 CLASS A COM 30744W107 28,608 1,375,363 SH   DFND   0 0 1,375,363
FASTLY INC CL A COM 31188V100 6,068 299,197 SH   DFND   0 0 299,197
FIVE BELOW INC COM COM 33829M101 83,173 692,996 SH   DFND   0 0 692,996
FLEX LNG LTD (BM) USD0.10 ISIN #BMG359472021 SEDOL #BJJMGB2 COM ZZCKKNHC2 5,647 478,588 SH   DFND   0 0 478,588
FLEXION THERAPEUTICS INC COM COM 33938J106 10,340 840,650 SH   DFND   0 0 840,650
FLIR SYS INC COM 302445101 18,014 332,983 SH   DFND   0 0 332,983
FLOOR &DECOR HLDGS INC CL A COM 339750101 17,062 407,204 SH   DFND   0 0 407,204
FORESCOUT TECHNOLOGIES INC COM COM 34553D101 14,415 425,733 SH   DFND   0 0 425,733
FORTESCUE METALS GROUP LTD NPV ISIN #AU000000FMG4 SEDOL #6086253 COM Q39360104 4,916 776,659 SH   DFND   0 0 776,659
FRANCO NEVADA CORP COM ISIN #CA3518581051 SEDOL #B29NF31 COM 351858105 6,538 77,030 SH   DFND   0 0 77,030
FRESHPET INC COM COM 358039105 115,940 2,547,572 SH   DFND   0 0 2,547,572
FUNKO INC COM CL A COM 361008105 3,184 131,460 SH   DFND   0 0 131,460
GALAPAGOS NV NPV ISIN #BE0003818359 SEDOL #B07Q2V5 COM B44170106 97,789 756,902 SH   DFND   0 0 756,902
GASLOG LTD COM USD0.01 COM G37585109 2,571 178,563 SH   DFND   0 0 178,563
GEOPARK LIMITED COM USD0.001 COM G38327105 4,101 221,194 SH   DFND   0 0 221,194
GLAUKOS CORP COM COM 377322102 108,724 1,441,959 SH   DFND   0 0 1,441,959
GLOBANT SA USD1.20 COM L44385109 77,960 771,497 SH   DFND   0 0 771,497
GOGO INC COM COM 38046C109 280 70,448 SH   DFND   0 0 70,448
GOL LINHAS AEREAS INTELIGENTES SA PFD COM 38045R206 6,993 414,267 SH   DFND   0 0 414,267
GOLAR LNG LIMITED COM STK USD1.00 COM G9456A100 3,241 175,394 SH   DFND   0 0 175,394
GOLDMAN SACHS GROUP INC COM USD0.01 COM 38141G104 88,764 433,841 SH   DFND   0 0 433,841
GOOSEHEAD INS INC COM CL A COM 38267D109 26,502 554,428 SH   DFND   0 0 554,428
GRACE(W.R.)&CO COM USD0.01 COM 38388F108 15,303 201,068 SH   DFND   0 0 201,068
GROCERY OUTLET HLDG CORP COM COM 39874R101 658 20,000 SH   DFND   0 0 20,000
GRUPO FINANCIERO GALICIA SA SPON ADR EACH REP 10 CL B SHS COM 399909100 2,147 60,479 SH   DFND   0 0 60,479
GTT COMMUNICATIONS INC COM USD0.0001 COM 362393100 25,583 1,453,563 SH   DFND   0 0 1,453,563
GUARDANT HEALTH INC COM COM 40131M109 59 685 SH   DFND   0 0 685
GUIDEWIRE SOFTWARE INC COM USD0.0001 COM 40171V100 509 5,021 SH   DFND   0 0 5,021
GW PHARMACEUTICALS PLC ADS COM 36197T103 494 2,864 SH   DFND   0 0 2,864
HDFC BANK LTD SPON ADS EACH REP 3 ORD SHS COM 40415F101 54,844 421,745 SH   DFND   0 0 421,745
HEALTH INS INNOVATIONS INC COM CL A COM 42225K106 361 13,940 SH   DFND   0 0 13,940
HEALTHEQUITY INC COM COM 42226A107 4,449 68,034 SH   DFND   0 0 68,034
HEICO CORP COM 422806109 177 1,322 SH   DFND   0 0 1,322
HEICO CORP COM USD0.01 COM 422806208 6,957 67,298 SH   DFND   0 0 67,298
HOWARD HUGHES CORP COM COM 44267D107 276 2,229 SH   DFND   0 0 2,229
HUBSPOT INC COM COM 443573100 131,983 774,003 SH   DFND   0 0 774,003
ICICI BANK LIMITED SPON ADR EACH REPR 2 ORD SHS COM 45104G104 5,954 472,935 SH   DFND   0 0 472,935
ILLUMINA INC COM USD0.01 COM 452327109 38,661 105,014 SH   DFND   0 0 105,014
IMPINJ INC COM COM 453204109 1,346 47,036 SH   DFND   0 0 47,036
INSPIRE MED SYS INC COM COM 457730109 16,906 278,755 SH   DFND   0 0 278,755
INSULET CORP COM COM 45784P101 2,729 22,857 SH   DFND   0 0 22,857
INTUITIVE SURGICAL INC COM NEW COM 46120E602 105,315 200,772 SH   DFND   0 0 200,772
INVITAE CORP COM COM 46185L103 122,516 5,213,466 SH   DFND   0 0 5,213,466
IOVANCE BIOTHERAPEUTICS INC COM COM 462260100 3,410 139,080 SH   DFND   0 0 139,080
IQIYI INC SPON EACH ADS REP 7 ORD SHS CLASS A COM 46267X108 7,827 379,054 SH   DFND   0 0 379,054
IRHYTHM TECHNOLOGIES INC COM COM 450056106 8,795 111,222 SH   DFND   0 0 111,222
IROBOT CORP COM COM 462726100 77,166 842,056 SH   DFND   0 0 842,056
JPMORGAN CHASE &CO. COM USD1.00 COM 46625H100 8,351 74,692 SH   DFND   0 0 74,692
KB HOME COM COM 48666K109 203 7,908 SH   DFND   0 0 7,908
KIRKLAND LAKE GOLD COM NPV ISIN #CA49741E1007 SEDOL #BD4G349 COM 49741E100 17,352 404,297 SH   DFND   0 0 404,297
KORNIT DIGITAL LTD ORD ILS0.01 COM M6372Q113 33,541 1,059,419 SH   DFND   0 0 1,059,419
LENDINGTREE INC NEW COM COM 52603B107 400 953 SH   DFND   0 0 953
LGI HOMES INC COM COM 50187T106 100,320 1,404,450 SH   DFND   0 0 1,404,450
LHC GROUP INC COM COM 50187A107 7,036 58,841 SH   DFND   0 0 58,841
LIBERTY MEDIA CORP DELAWARE COM A BRAVES GRP COM 531229706 4,491 161,556 SH   DFND   0 0 161,556
LIBERTY MEDIA CORP DELAWARE COM C BRAVES GRP COM 531229888 16,992 607,493 SH   DFND   0 0 607,493
LIBERTY MEDIA CORP DELAWARE COM SER C FRMLA COM 531229854 4,569 122,121 SH   DFND   0 0 122,121
LIVEPERSON INC COM USD0.001 COM 538146101 85,332 3,043,221 SH   DFND   0 0 3,043,221
LONZA GROUP AG-REG ISIN #CH0013841017 SEDOL #7333378 COM H50524133 37,206 110,128 SH   DFND   0 0 110,128
LOVESAC COMPANY COM COM 54738L109 9,064 291,731 SH   DFND   0 0 291,731
LULULEMON ATHLETICA INC COM USD0.005 COM 550021109 6,895 38,263 SH   DFND   0 0 38,263
LUMENTUM HLDGS INC COM COM 55024U109 1,043 19,525 SH   DFND   0 0 19,525
LYFT INC CL A COM COM 55087P104 57,690 877,954 SH   DFND   0 0 877,954
MADISON SQUARE GARDEN CO NEW CL A COM 55825T103 6,930 24,757 SH   DFND   0 0 24,757
MAG SILVER CORP COM NPV ISIN #CA55903Q1046 SEDOL #2581332 COM 55903Q104 16,720 1,586,357 SH   DFND   0 0 1,586,357
MAGENTA THERAPEUTICS INC COM COM 55910K108 61,552 4,172,988 SH   DFND   0 0 4,172,988
MAGNOLIA OIL &GAS CORP CL A COM 559663109 7,247 625,835 SH   DFND   0 0 625,835
MAKEMYTRIP LTD USD0.0005 COM V5633W109 2,448 98,698 SH   DFND   0 0 98,698
MARTIN MARIETTA MATERIALS INC COM USD0.01 COM 573284106 108,984 473,617 SH   DFND   0 0 473,617
MASTERCARD INC CL A COM 57636Q104 24,864 93,994 SH   DFND   0 0 93,994
MATCH GROUP INC COM COM 57665R106 72,893 1,083,594 SH   DFND   0 0 1,083,594
MAYVILLE ENGINEERING CO INC COM COM 578605107 7,774 563,332 SH   DFND   0 0 563,332
MERCADOLIBRE INC COM USD0.001 COM 58733R102 97,610 159,553 SH   DFND   0 0 159,553
MERCURY SYS INC COM COM 589378108 247 3,518 SH   DFND   0 0 3,518
MESA AIR GROUP INC COM NEW COM 590479135 6,897 754,620 SH   DFND   0 0 754,620
MICROSOFT CORP COM 594918104 77,386 577,676 SH   DFND   0 0 577,676
MIMECAST LIMITED COM USD0.012 COM G14838109 1,329 28,461 SH   DFND   0 0 28,461
MISONIX INC COM 604871103 4,788 188,352 SH   DFND   0 0 188,352
MOLECULAR TEMPLATES INC COM COM 608550109 8,174 978,916 SH   DFND   0 0 978,916
MONGODB INC CL A COM 60937P106 193,571 1,272,738 SH   DFND   0 0 1,272,738
MONOLITHIC PWR SYS INC COM COM 609839105 13,558 99,854 SH   DFND   0 0 99,854
NEOPHOTONICS CORP COM COM 64051T100 568 135,814 SH   DFND   0 0 135,814
NETFLIX COM INC COM COM 64110L106 522,246 1,421,773 SH   DFND   0 0 1,421,773
NEW PACIFIC METALS CORP COM NPV ISIN #CA6478241012 SEDOL #BF4CP8 COM 647824101 2,295 1,249,546 SH   DFND   0 0 1,249,546
NEW RELIC INC COM COM 64829B100 8,972 103,708 SH   DFND   0 0 103,708
NEW YORK TIMES CO CL A COM 650111107 169,091 5,183,649 SH   DFND   0 0 5,183,649
NINTENDO CO LTD ADR(8 CNV INTO 1 ORD)NPV COM 654445303 2,855 62,309 SH   DFND   0 0 62,309
NOBLE MIDSTREAM PARTNERS LP COM UNIT REPST COM 65506L105 34 1,014 SH   DFND   0 0 1,014
NUVECTRA CORP COM COM 67075N108 2,668 796,325 SH   DFND   0 0 796,325
NV5 GLOBAL INC COM COM 62945V109 7,753 95,240 SH   DFND   0 0 95,240
NVIDIA CORP COM 67066G104 30,047 182,959 SH   DFND   0 0 182,959
OCADO GROUP PLC ORD GBP0.02 ISIN #GB00B3MBS747 SEDOL #B3MBS74 COM G6718L106 189,221 12,740,079 SH   DFND   0 0 12,740,079
OKTA INC CL A COM 679295105 257,531 2,085,099 SH   DFND   0 0 2,085,099
PAGERDUTY INC COM COM 69553P100 6,983 148,427 SH   DFND   0 0 148,427
PALO ALTO NETWORKS INC COM USD0.0001 COM 697435105 17,492 85,845 SH   DFND   0 0 85,845
PALOMAR HLDGS INC COM COM 69753M105 2,389 99,366 SH   DFND   0 0 99,366
PARAMOUNT RESOURCES LIMITED COM NPV CLASS A ISIN #CA6993202069 S COM 699320206 824 164,918 SH   DFND   0 0 164,918
PAYPAL HLDGS INC COM COM 70450Y103 24,910 217,631 SH   DFND   0 0 217,631
PDF SOLUTIONS INC COM 693282105 728 55,477 SH   DFND   0 0 55,477
PDVWIRELESS INC COM COM 69290R104 360 7,663 SH   DFND   0 0 7,663
PENSKE AUTOMOTIVE GROUP INC COM 70959W103 3,373 71,313 SH   DFND   0 0 71,313
PENUMBRA INC COM COM 70975L107 780 4,876 SH   DFND   0 0 4,876
PINDUODUO INC SPON ADS EACH REP 4 ORD SHS COM 722304102 219 10,600 SH   DFND   0 0 10,600
PINTEREST INC CL A COM 72352L106 35,616 1,308,459 SH   DFND   0 0 1,308,459
PIVOTAL SOFTWARE INC COM CL A COM 72582H107 3,118 295,247 SH   DFND   0 0 295,247
PLANET FITNESS INC CL A COM 72703H101 3,272 45,168 SH   DFND   0 0 45,168
PLURALSIGHT INC COM CL A COM 72941B106 4,479 147,737 SH   DFND   0 0 147,737
POOL CORP COM COM 73278L105 74,114 388,030 SH   DFND   0 0 388,030
PREVAIL THERAPEUTICS INC COM COM 74140Y101 389 29,480 SH   DFND   0 0 29,480
PROOFPOINT INC COM USD0.0001 COM 743424103 5,918 49,217 SH   DFND   0 0 49,217
Q2 HLDGS INC COM COM 74736L109 84,945 1,112,431 SH   DFND   0 0 1,112,431
QUANTERIX CORP COM COM 74766Q101 103,673 3,068,168 SH   DFND   0 0 3,068,168
QUOTIENT LTD COM NPV COM G73268107 4,183 447,361 SH   DFND   0 0 447,361
R1 RCM INC COM COM 749397105 6,865 545,696 SH   DFND   0 0 545,696
REECE LIMITED NPV ISIN #AU000000REH4 SEDOL #6728801 COM Q80528138 5,239 764,850 SH   DFND   0 0 764,850
RELIANCE INDUSTRIES SPON GDR EACH REP 2 ORD SHS 144A ISIN #US759 COM ZZC27DZQ8 263 7,287 SH   DFND   0 0 7,287
REVOLVE GROUP INC CL A COM 76156B107 698 20,229 SH   DFND   0 0 20,229
RIGHTMOVE ORD GBP0.001 ISIN #GB00BGDT3G23 SEDOL #BGDT3G2 COM G7565D106 15,990 2,349,655 SH   DFND   0 0 2,349,655
RINGCENTRAL INC-CLASS A COM 76680R206 207,866 1,808,792 SH   DFND   0 0 1,808,792
ROKU INC COM CL A COM 77543R102 319,298 3,525,035 SH   DFND   0 0 3,525,035
ROYAL GOLD INC COM ISIN #US7802871084 SEDOL #2430553 COM 780287108 20 198 SH   DFND   0 0 198
SAFETY INS GROUP INC COM 78648T100 449 4,720 SH   DFND   0 0 4,720
SALESFORCE.COM INC COM USD0.001 COM 79466L302 94,365 621,928 SH   DFND   0 0 621,928
SAREPTA THERAPEUTICS INC COM COM 803607100 150,735 992,007 SH   DFND   0 0 992,007
SCORPIO TANKERS INC COM USD0.01 (POST REV SPLIT) COM Y7542C130 383 12,961 SH   DFND   0 0 12,961
SEASPINE HLDGS CORP COM COM 81255T108 317 23,940 SH   DFND   0 0 23,940
SEMLER SCIENTIFIC INC COM USD0.001 COM 81684M104 4,150 94,970 SH   DFND   0 0 94,970
SENESTECH INC COM COM 81720R109 2,215 1,230,790 SH   DFND   0 0 1,230,790
SENSEONICS HLDGS INC COM COM 81727U105 34,699 17,009,227 SH   DFND   0 0 17,009,227
SERVICENOW INC COM USD0.001 COM 81762P102 38,553 140,414 SH   DFND   0 0 140,414
SHAKE SHACK INC CL A COM 819047101 168,990 2,340,584 SH   DFND   0 0 2,340,584
SHERWIN WILLIAMS CO COM 824348106 959 2,092 SH   DFND   0 0 2,092
SHOCKWAVE MED INC COM COM 82489T104 82,632 1,447,401 SH   DFND   0 0 1,447,401
SHOPIFY INC COM NPV CL A ISIN #CA82509L1076 SEDOL #BX865C7 COM 82509L107 113,063 376,687 SH   DFND   0 0 376,687
SHOTSPOTTER INC COM COM 82536T107 97,153 2,198,021 SH   DFND   0 0 2,198,021
SI BONE INC COM COM 825704109 8,718 428,633 SH   DFND   0 0 428,633
SILK ROAD MEDICAL INC COM COM 82710M100 2,923 60,320 SH   DFND   0 0 60,320
SILVERCREST METALS INC COM NPV ISIN #CA8283631015 SEDOL #BYVY3D2 COM 828363101 20,558 5,063,551 SH   DFND   0 0 5,063,551
SITEONE LANDSCAPE SUPPLY INC COM COM 82982L103 21,453 309,561 SH   DFND   0 0 309,561
SIX FLAGS ENTMT CORP NEW COM COM 83001A102 3,811 76,721 SH   DFND   0 0 76,721
SLACK TECHNOLOGIES INC COM CL A COM 83088V102 97,048 2,587,944 SH   DFND   0 0 2,587,944
SNAP INC CL A COM 83304A106 9,414 658,321 SH   DFND   0 0 658,321
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SOLARIS OILFIELD INFRSTR INC COM CL A COM 83418M103 8,136 543,126 SH   DFND   0 0 543,126
SPLUNK INC COM USD0.001 COM 848637104 6,121 48,673 SH   DFND   0 0 48,673
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SQUARE INC CL A COM 852234103 122,371 1,687,184 SH   DFND   0 0 1,687,184
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STAAR SURGICAL CO COM NEW PAR $0.01 COM 852312305 2,865 97,513 SH   DFND   0 0 97,513
STAR BULK CARRIERS CORP COM USD0.01(POST REV SPLIT) COM Y8162K204 606 62,773 SH   DFND   0 0 62,773
STARS GROUP INC(THE) COM NPV ISIN #CA85570W1005 SEDOL #BDG1MJ0 COM 85570W100 356 20,854 SH   DFND   0 0 20,854
STITCH FIX INC COM CL A COM 860897107 17,065 533,457 SH   DFND   0 0 533,457
STOKE THERAPEUTICS INC COM COM 86150R107 54,304 1,861,623 SH   DFND   0 0 1,861,623
STONECO LTD COM USD0.000079365 CLASS A COM G85158106 43,949 1,485,764 SH   DFND   0 0 1,485,764
SUNRUN INC COM COM 86771W105 1,535 81,813 SH   DFND   0 0 81,813
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T MOBILE US INC COM USD0.00001 COM 872590104 95,516 1,288,324 SH   DFND   0 0 1,288,324
TACTILE SYS TECHNOLOGY INC COM COM 87357P100 4,504 79,131 SH   DFND   0 0 79,131
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TANDEM DIABETES CARE INC COM NEW COM 875372203 40,975 635,079 SH   DFND   0 0 635,079
TELADOC HEALTH INC COM COM 87918A105 88,767 1,336,647 SH   DFND   0 0 1,336,647
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TESLA INC COM COM 88160R101 108,342 484,837 SH   DFND   0 0 484,837
THE A2 MILK COMPANY LTD NPV ISIN #NZATME0002S8 SEDOL #BWSRTS7 COM ZZCXTSUT2 18,365 1,889,515 SH   DFND   0 0 1,889,515
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TRANSDIGM GROUP INC COM COM 893641100 7,750 16,020 SH   DFND   0 0 16,020
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TWILIO INC CL A COM 90138F102 14,472 106,140 SH   DFND   0 0 106,140
TWIST BIOSCIENCE CORP COM COM 90184D100 8,098 279,141 SH   DFND   0 0 279,141
TWITTER INC COM USD0.000005 COM 90184L102 104,859 3,004,564 SH   DFND   0 0 3,004,564
UBER TECHNOLOGIES INC COM COM 90353T100 117,077 2,524,305 SH   DFND   0 0 2,524,305
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UNDER ARMOUR INC COM STK USD0.000333 CLASS A COM 904311107 261 10,308 SH   DFND   0 0 10,308
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VERACYTE INC COM COM 92337F107 110,375 3,871,451 SH   DFND   0 0 3,871,451
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VIEWRAY INC COM COM 92672L107 3,718 422,061 SH   DFND   0 0 422,061
VULCAN MATERIALS CO COM 929160109 5,117 37,264 SH   DFND   0 0 37,264
WHEATON PRECIOUS METALS CORP COM NPV ISIN #CA9628791027 SEDOL #B COM 962879102 1,946 80,478 SH   DFND   0 0 80,478
WILLSCOT CORP COM COM 971375126 875 58,174 SH   DFND   0 0 58,174
WORKDAY INC COM USD0.001 CL A COM 98138H101 43,066 209,484 SH   DFND   0 0 209,484
WORLD WRESTLING ENTERTAINMENT INC CL A COM 98156Q108 72,448 1,003,298 SH   DFND   0 0 1,003,298
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YETI HLDGS INC COM COM 98585X104 2,064 71,302 SH   DFND   0 0 71,302
ZAI LAB LIMITED ADS EACH REP 1 ORD SHS COM 98887Q104 40,585 1,163,886 SH   DFND   0 0 1,163,886
ZENDESK INC COM USD0.01 COM 98936J101 12,462 139,975 SH   DFND   0 0 139,975
ZILLOW GROUP INC CL A COM 98954M101 387 8,455 SH   DFND   0 0 8,455
ZOOM VIDEO COMMUNICATIONS INC CL A COM 98980L101 5,651 63,650 SH   DFND   0 0 63,650
ZUORA INC COM CL A COM 98983V106 3,134 204,565 SH   DFND   0 0 204,565