The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3-D SYS CORP DEL COM NEW 88554D205 141 16,000 SH   DFND 3 0 16,000 0
3M CO COM 88579Y101 386 2,250 SH   DFND 3 0 2,250 0
ABBOTT LABS COM 002824100 2,002 23,925 SH   DFND 3 0 23,925 0
ABBVIE INC COM 00287Y109 6,720 96,000 SH   DFND 3 0 96,000 0
ABEONA THERAPEUTICS INC COM 00289Y107 471 98,900 SH   DFND 3 0 98,900 0
ACER THERAPEUTICS INC COM 00444P108 54 15,700 SH   DFND 3 0 15,700 0
ACTINIUM PHARMACEUTICALS INC COM 00507W107 147 596,752 SH   DFND 3 0 596,752 0
ACTINIUM PHARMACEUTICALS INC COM 00507W107 42 168,851 SH Call DFND 3 0 168,851 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 1,328 223,959 SH   DFND 3 0 223,959 0
ADOBE INC COM 00724F101 1,144 3,900 SH   DFND 3 0 3,900 0
ADVANCED MICRO DEVICES INC COM 007903107 984 32,000 SH   DFND 3 0 32,000 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 1,309 204,148 SH   DFND 3 0 204,148 0
AGILE THERAPEUTICS INC COM 00847L100 580 411,503 SH   DFND 3 0 411,503 0
AGILENT TECHNOLOGIES INC COM 00846U101 744 10,160 SH   DFND 3 0 10,160 0
AGIOS PHARMACEUTICALS INC COM 00847X104 3,062 61,652 SH   DFND 3 0 61,652 0
AGNICO EAGLE MINES LTD COM 008474108 1,129 22,200 SH   DFND 3 0 22,200 0
AKAMAI TECHNOLOGIES INC COM 00971T101 627 7,900 SH   DFND 3 0 7,900 0
ALBEMARLE CORP COM 012653101 607 8,730 SH   DFND 3 0 8,730 0
ALBIREO PHARMA INC COM 01345P106 6,259 197,005 SH   DFND 3 0 197,005 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 2,643 233,858 SH   DFND 3 0 233,858 0
ALEXION PHARMACEUTICALS INC COM 015351109 566 4,490 SH   DFND 3 0 4,490 0
ALGONQUIN PWR UTILS CORP COM 015857105 1,321 63,540 SH   DFND 3 0 63,540 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 627 3,700 SH   DFND   0 3,700 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 2,736 16,010 SH   DFND 3 0 16,010 0
ALLENA PHARMACEUTICALS INC COM 018119107 124 29,877 SH   DFND 3 0 29,877 0
ALLERGAN PLC SHS G0177J108 581 3,500 SH   DFND 3 0 3,500 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 3,860 54,300 SH   DFND 3 0 54,300 0
ALPHABET INC CAP STK CL A 02079K305 4,651 4,320 SH   DFND 3 0 4,320 0
ALPHABET INC CAP STK CL C 02079K107 2,594 2,411 SH   DFND 3 0 2,411 0
ALTRIA GROUP INC COM 02209S103 2,768 57,780 SH   DFND 3 0 57,780 0
AMAZON COM INC COM 023135106 4,892 2,569 SH   DFND 3 0 2,569 0
AMERICAN EXPRESS CO COM 025816109 1,717 13,855 SH   DFND 3 0 13,855 0
AMERICAN RLTY CAP PPTYS INC NOTE 3.750% 12/1 02917TAB0 28,592 28,319,000 SH   DFND 1 0 28,319,000 0
AMERICAN RLTY CAP PPTYS INC NOTE 3.750% 12/1 02917TAB0 10,601 10,500,000 SH   DFND   0 10,500,000 0
AMERICAN TOWER CORP NEW COM 03027X100 286 1,387 SH   DFND 3 0 1,387 0
AMGEN INC COM 031162100 613 3,330 SH   DFND 3 0 3,330 0
AMICUS THERAPEUTICS INC COM 03152W109 8,904 741,969 SH   DFND 3 0 741,969 0
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 117,863 16,438,356 SH   DFND   0 16,438,356 0
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 22,325 3,113,645 SH   DFND 2 0 3,113,645 0
AMPHENOL CORP NEW CL A 032095101 1,048 10,960 SH   DFND 3 0 10,960 0
ANAPTYSBIO INC COM 032724106 801 14,696 SH   DFND 3 0 14,696 0
ANGLOGOLD ASHANTI LTD SPONSORED ADR 035128206 1,608 90,000 SH   DFND 3 0 90,000 0
ANTARES PHARMA INC COM 036642106 2,574 809,378 SH   DFND 3 0 809,378 0
APACHE CORP COM 037411105 802 28,000 SH   DFND 3 0 28,000 0
APELLIS PHARMACEUTICALS INC COM 03753U106 6,424 262,728 SH   DFND 3 0 262,728 0
APPLE INC COM 037833100 2,351 11,770 SH   DFND 3 0 11,770 0
APPLIED MATLS INC COM 038222105 425 9,500 SH   DFND 3 0 9,500 0
ARES CAP CORP NOTE 3.750% 2/0 04010LAT0 1,017 1,000,000 SH   DFND   0 1,000,000 0
ARES CAP CORP NOTE 3.750% 2/0 04010LAT0 30,501 30,000,000 SH   DFND 1 0 30,000,000 0
ARES CAP CORP COM 04010L103 3,168 178,707 SH   DFND 3 0 178,707 0
ARGENX SE SPONSORED ADR 04016X101 8,467 61,483 SH   DFND 3 0 61,483 0
ARQULE INC COM 04269E107 2,397 221,297 SH   DFND 3 0 221,297 0
ARRAY BIOPHARMA INC COM 04269X105 23,051 498,733 SH   DFND 3 0 498,733 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 8,097 74,689 SH   DFND 3 0 74,689 0
ASSEMBLY BIOSCIENCES INC COM 045396108 471 33,993 SH   DFND 3 0 33,993 0
AT&T INC COM 00206R102 973 29,500 SH   DFND 3 0 29,500 0
ATRICURE INC COM 04963C209 5,910 200,559 SH   DFND 3 0 200,559 0
AVNET INC COM 053807103 672 15,000 SH   DFND 3 0 15,000 0
AXALTA COATING SYS LTD COM G0750C108 299 10,000 SH   DFND 3 0 10,000 0
BANK AMER CORP COM 060505104 226 8,000 SH   DFND 3 0 8,000 0
BARRICK GOLD CORPORATION COM 067901108 1,727 110,000 SH   DFND 3 0 110,000 0
BERKSHIRE HATHAWAY INC DEL CL A 084670108 1,273 4 SH   DFND 3 0 4 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 3,074 14,500 SH   DFND 3 0 14,500 0
BEST INC SPONSORED ADS 08653C106 36,553 6,634,021 SH   DFND   0 6,634,021 0
BEST INC SPONSORED ADS 08653C106 1,471 266,898 SH   DFND 1 0 266,898 0
BEYONDSPRING INC SHS G10830100 5,688 240,000 SH   DFND 2 0 240,000 0
BIOLINERX LTD SPONSORED ADS 09071M106 263 730,228 SH   DFND 3 0 730,228 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 8,206 97,650 SH   DFND 3 0 97,650 0
BLACKROCK INC COM 09247X101 1,701 3,662 SH   DFND 3 0 3,662 0
BLACKSTONE GROUP L P COM UNIT LTD 09253U108 2,168 48,920 SH   DFND 3 0 48,920 0
BOOKING HLDGS INC COM 09857L108 4,631 2,510 SH   DFND 3 0 2,510 0
BOSTON BEER INC CL A 100557107 439 1,200 SH   DFND 3 0 1,200 0
BOSTON SCIENTIFIC CORP COM 101137107 328 7,825 SH   DFND 3 0 7,825 0
BRISTOL MYERS SQUIBB CO COM 110122108 3,743 83,000 SH   DFND 3 0 83,000 0
BROOKDALE SR LIVING INC COM 112463104 7,736 1,073,000 SH   DFND 1 0 1,073,000 0
BROOKDALE SR LIVING INC COM 112463104 1,803 250,000 SH   DFND   0 250,000 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 6,054 127,000 SH   DFND 3 0 127,000 0
BROOKFIELD BUSINESS PARTNERS UNIT LTD LP G16234109 4,715 85,530 SH   DFND 3 0 85,530 0
BROOKFIELD RENEWABLE PARTNER PARTNERSHIP UNIT G16258108 7,114 120,000 SH   DFND 3 0 120,000 0
CELGENE CORP COM 151020104 2,032 22,000 SH   DFND 3 0 22,000 0
CERUS CORP COM 157085101 3,306 669,245 SH   DFND 3 0 669,245 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 216 553 SH   DFND 3 0 553 0
CHECK CAP LTD SHS M2361E203 270 127,559 SH   DFND 2 0 127,559 0
CHECK CAP LTD *W EXP 02/28/202 M2361E120 13 333,333 SH   DFND 2 0 333,333 0
CHECK POINT SOFTWARE TECH LT ORD M22465104 207 1,800 SH   DFND 3 0 1,800 0
CHEMOCENTRYX INC COM 16383L106 1,150 128,637 SH   DFND 3 0 128,637 0
CHENIERE ENERGY INC COM NEW 16411R208 225 3,295 SH   DFND 3 0 3,295 0
CHIASMA INC COM 16706W102 923 123,954 SH   DFND 3 0 123,954 0
CHINA INDEX HLDGS LTD SPNSRD ADS A 16954W101 9,770 2,752,119 SH   DFND 1 0 2,752,119 0
CHINA INDEX HLDGS LTD SPNSRD ADS A 16954W101 1,542 434,380 SH   DFND   0 434,380 0
CHUBB LIMITED COM H1467J104 1,888 12,831 SH   DFND 3 0 12,831 0
CIDARA THERAPEUTICS INC COM 171757107 481 306,686 SH   DFND 3 0 306,686 0
CINTAS CORP COM 172908105 1,414 6,000 SH   DFND 3 0 6,000 0
CISCO SYS INC COM 17275R102 412 7,400 SH   DFND 3 0 7,400 0
CITIGROUP INC COM NEW 172967424 818 12,000 SH   DFND 3 0 12,000 0
CLEVELAND CLIFFS INC COM 185899101 521 50,000 SH   DFND 3 0 50,000 0
COEUR MNG INC COM NEW 192108504 687 162,500 SH   DFND 3 0 162,500 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 2,828 44,850 SH   DFND 3 0 44,850 0
COHERUS BIOSCIENCES INC COM 19249H103 5,120 238,248 SH   DFND 3 0 238,248 0
COLGATE PALMOLIVE CO COM 194162103 1,807 25,050 SH   DFND 3 0 25,050 0
COLONY CAP INC NOTE 5.000% 4/1 19624RAA4 19,209 20,000,000 SH   DFND 1 0 20,000,000 0
COLONY CAP INC NOTE 3.875% 1/1 19624RAB2 38,992 40,000,000 SH   DFND 1 0 40,000,000 0
COLONY CAP INC NEW CL A COM 19626G108 14,730 2,946,017 SH   DFND 1 0 2,946,017 0
COLONY CAP INC NEW CL A COM 19626G108 19,116 3,823,280 SH   DFND   0 3,823,280 0
COMPUTER TASK GROUP INC COM 205477102 94 22,844 SH   DFND 3 0 22,844 0
CONSTELLATION BRANDS INC CL A 21036P108 369 1,960 SH   DFND 3 0 1,960 0
CONTRAFECT CORP COM 212326102 3,801 7,453,857 SH   DFND 2 0 7,453,857 0
CORVUS PHARMACEUTICALS INC COM 221015100 624 184,116 SH   DFND 3 0 184,116 0
COSTCO WHSL CORP NEW COM 22160K105 266 1,000 SH   DFND 3 0 1,000 0
CTI BIOPHARMA CORP COM 12648L601 390 459,274 SH   DFND 3 0 459,274 0
CTRIP COM INTL LTD NOTE 1.990% 7/0 22943FAH3 4,918 4,500,000 SH   DFND 1 0 4,500,000 0
CTRIP COM INTL LTD NOTE 1.250% 9/1 22943FAM2 29,885 30,000,000 SH   DFND 1 0 30,000,000 0
CTRIP COM INTL LTD NOTE 1.000% 7/0 22943FAF7 99 100,000 SH   DFND 3 0 100,000 0
CUMMINS INC COM 231021106 673 4,000 SH   DFND 3 0 4,000 0
CURIS INC COM NEW 231269200 1,065 581,834 SH   DFND 3 0 581,834 0
CVS HEALTH CORP COM 126650100 417 7,612 SH   DFND 3 0 7,612 0
CYMABAY THERAPEUTICS INC COM 23257D103 2,407 336,205 SH   DFND 1 0 336,205 0
CYMABAY THERAPEUTICS INC COM 23257D103 1,887 263,529 SH   DFND   0 263,529 0
CYMABAY THERAPEUTICS INC COM 23257D103 1,641 234,362 SH   DFND 3 0 234,362 0
CYTOKINETICS INC COM NEW 23282W605 1,642 148,353 SH   DFND 3 0 148,353 0
CYTOMX THERAPEUTICS INC COM 23284F105 1,035 97,457 SH   DFND 3 0 97,457 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 2,887 128,037 SH   DFND 1 0 128,037 0
DECKERS OUTDOOR CORP COM 243537107 731 4,170 SH   DFND 3 0 4,170 0
DERMIRA INC COM 24983L104 3,822 425,626 SH   DFND 3 0 425,626 0
DEUTSCHE BANK AG NAMEN AKT D18190898 6,428 861,000 SH   DFND 3 0 861,000 0
DICERNA PHARMACEUTICALS INC COM 253031108 2,972 188,673 SH   DFND 3 0 188,673 0
DISNEY WALT CO COM DISNEY 254687106 1,742 12,508 SH   DFND 3 0 12,508 0
ECOLAB INC COM 278865100 388 2,021 SH   DFND 3 0 2,021 0
EDAP TMS S A SPONSORED ADR 268311107 1,145 397,568 SH   DFND 3 0 397,568 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,554 145,188 SH   DFND 3 0 145,188 0
ELECTRONIC ARTS INC COM 285512109 562 5,667 SH   DFND 3 0 5,667 0
EMERSON ELEC CO COM 291011104 229 3,470 SH   DFND 3 0 3,470 0
ENCOMPASS HEALTH CORP COM 29261A100 241 3,885 SH   DFND 3 0 3,885 0
EXXON MOBIL CORP COM 30231G102 1,224 16,150 SH   DFND 3 0 16,150 0
EZCORP INC CL A NON VTG 302301106 115 12,000 SH   DFND 3 0 12,000 0
FACEBOOK INC CL A 30303M102 4,557 24,048 SH   DFND 3 0 24,048 0
FANG HLDGS LTD ADR 30711Y102 8,629 13,886,734 SH   DFND 1 0 13,886,734 0
FANG HLDGS LTD ADR 30711Y102 1,426 2,294,114 SH   DFND   0 2,294,114 0
FIAT CHRYSLER AUTOMOBILES N SHS N31738102 417 30,000 SH   DFND 3 0 30,000 0
FIRST MAJESTIC SILVER CORP COM 32076V103 777 100,000 SH   DFND 3 0 100,000 0
FIRST SOLAR INC COM 336433107 1,205 18,400 SH   DFND 3 0 18,400 0
FOOT LOCKER INC COM 344849104 403 9,790 SH   DFND 3 0 9,790 0
FORTIS INC COM 349553107 1,323 19,560 SH   DFND 3 0 19,560 0
GARMIN LTD SHS H2906T109 2,007 25,000 SH   DFND 3 0 25,000 0
GENERAL ELECTRIC CO COM 369604103 1,092 105,000 SH   DFND 3 0 105,000 0
GILEAD SCIENCES INC COM 375558103 5,958 88,186 SH   DFND   0 88,186 0
GILEAD SCIENCES INC COM 375558103 12,307 182,157 SH   DFND 1 0 182,157 0
GILEAD SCIENCES INC COM 375558103 9,031 134,630 SH   DFND 3 0 134,630 0
GOLD FIELDS LTD NEW SPONSORED ADR 38059T106 1,626 300,000 SH   DFND 3 0 300,000 0
GOLDMAN SACHS GROUP INC COM 38141G104 797 4,000 SH   DFND 3 0 4,000 0
GRAND CANYON ED INC COM 38526M106 444 3,800 SH   DFND 3 0 3,800 0
HARPOON THERAPEUTICS INC COM 41358P106 2,590 199,200 SH   DFND 1 0 199,200 0
HARPOON THERAPEUTICS INC COM 41358P106 1,615 124,200 SH   DFND   0 124,200 0
HDFC BANK LTD SPONSORED ADS 40415F101 2,534 19,680 SH   DFND 3 0 19,680 0
HERON THERAPEUTICS INC COM 427746102 3,162 171,557 SH   DFND 3 0 171,557 0
HOME DEPOT INC COM 437076102 559 2,700 SH   DFND 3 0 2,700 0
HONEYWELL INTL INC COM 438516106 421 2,424 SH   DFND 3 0 2,424 0
HUAMI CORP SPONSORED ADS 44331K103 258 25,837 SH   DFND   0 25,837 0
IAC INTERACTIVECORP COM 44919P508 1,156 5,300 SH   DFND 3 0 5,300 0
IAMGOLD CORP COM 450913108 501 150,000 SH   DFND 3 0 150,000 0
IMMUNOMEDICS INC COM 452907108 3,468 250,433 SH   DFND 3 0 250,433 0
INCYTE CORP COM 45337C102 10,108 119,310 SH   DFND 3 0 119,310 0
INFINITY PHARMACEUTICALS INC COM 45665G303 728 418,296 SH   DFND 3 0 418,296 0
INFOSYS LTD SPONSORED ADR 456788108 1,736 163,510 SH   DFND 3 0 163,510 0
INTEL CORP COM 458140100 332 7,000 SH   DFND 3 0 7,000 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 1,211 14,165 SH   DFND 3 0 14,165 0
INTERNATIONAL BUSINESS MACHS COM 459200101 819 5,915 SH   DFND 3 0 5,915 0
INTUIT COM 461202103 1,262 4,891 SH   DFND 3 0 4,891 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 9,333 413,154 SH   DFND 3 0 413,154 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 4,755 439,853 SH   DFND 3 0 439,853 0
JOHNSON & JOHNSON COM 478160104 2,018 14,345 SH   DFND 3 0 14,345 0
JPMORGAN CHASE & CO COM 46625H100 1,881 17,280 SH   DFND 3 0 17,280 0
KADMON HLDGS INC COM 48283N106 317 161,877 SH   DFND 3 0 161,877 0
KALA PHARMACEUTICALS INC COM 483119103 1,447 246,024 SH   DFND 3 0 246,024 0
KINROSS GOLD CORP COM 496902404 386 100,000 SH   DFND 3 0 100,000 0
KURA ONCOLOGY INC COM 50127T109 7,341 370,958 SH   DFND 3 0 370,958 0
L BRANDS INC COM 501797104 1,883 72,150 SH   DFND   0 72,150 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 3,742 416,260 SH   DFND 3 0 416,260 0
LAS VEGAS SANDS CORP COM 517834107 1,317 22,400 SH   DFND 3 0 22,400 0
LAUDER ESTEE COS INC CL A 518439104 364 2,000 SH   DFND 3 0 2,000 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 1,104 181,000 SH   DFND 3 0 181,000 0
LIBERTY GLOBAL PLC SHS CL A G5480U104 803 30,000 SH   DFND 3 0 30,000 0
LIBERTY MEDIA CORP DELAWARE NOTE 1.375%10/1 531229AB8 111 100,000 SH   DFND 3 0 100,000 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 342 3,000 SH   DFND 3 0 3,000 0
LILLY ELI & CO COM 532457108 1,365 12,245 SH   DFND 3 0 12,245 0
LINDE PLC SHS G5494J103 2,490 12,520 SH   DFND 3 0 12,520 0
LIVE NATION ENTERTAINMENT IN NOTE 2.500% 3/1 538034AQ2 120 100,000 SH   DFND 3 0 100,000 0
LKQ CORP COM 501889208 1,129 43,000 SH   DFND 3 0 43,000 0
LOGITECH INTL S A SHS H50430232 653 17,560 SH   DFND 3 0 17,560 0
LULULEMON ATHLETICA INC COM 550021109 270 1,500 SH   DFND 3 0 1,500 0
MACQUARIE INFRASTRUCTURE COR NOTE 2.875% 7/1 55608BAA3 100 100,000 SH   DFND 3 0 100,000 0
MACROGENICS INC COM 556099109 2,191 131,573 SH   DFND 3 0 131,573 0
MADDEN STEVEN LTD COM 556269108 275 8,250 SH   DFND 3 0 8,250 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 5,192 209,385 SH   DFND   0 209,385 0
MANHATTAN ASSOCS INC COM 562750109 271 4,000 SH   DFND 3 0 4,000 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 1,117 284,860 SH   DFND 3 0 284,860 0
MARSH & MCLENNAN COS INC COM 571748102 270 2,720 SH   DFND 3 0 2,720 0
MARTIN MARIETTA MATLS INC COM 573284106 241 1,063 SH   DFND 3 0 1,063 0
MASIMO CORP COM 574795100 510 3,500 SH   DFND 3 0 3,500 0
MASTERCARD INC CL A 57636Q104 4,345 16,640 SH   DFND 3 0 16,640 0
MATCH GROUP INC COM 57665R106 375 5,500 SH   DFND 3 0 5,500 0
MCDONALDS CORP COM 580135101 2,640 12,800 SH   DFND 3 0 12,800 0
MCKESSON CORP COM 58155Q103 1,073 7,985 SH   DFND   0 7,985 0
MEDICINES CO COM 584688105 3,291 92,500 SH   DFND 3 0 92,500 0
MEDIDATA SOLUTIONS INC COM 58471A105 687 7,600 SH   DFND 3 0 7,600 0
MEDTRONIC PLC SHS G5960L103 3,040 31,190 SH   DFND 3 0 31,190 0
MEET GROUP INC COM 58513U101 234 70,000 SH   DFND 3 0 70,000 0
MEI PHARMA INC COM NEW 55279B202 995 396,526 SH   DFND 3 0 396,526 0
MERCK & CO INC COM 58933Y105 1,654 19,730 SH   DFND 3 0 19,730 0
MICROCHIP TECHNOLOGY INC NOTE 1.625% 2/1 595017AF1 238 200,000 SH   DFND 3 0 200,000 0
MICROCHIP TECHNOLOGY INC NOTE 1.625% 2/1 595017AD6 53 30,000 SH   DFND 3 0 30,000 0
MICROSOFT CORP COM 594918104 3,519 26,230 SH   DFND 3 0 26,230 0
MOLECULAR TEMPLATES INC COM 608550109 1,125 144,209 SH   DFND 3 0 144,209 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 1,130 91,462 SH   DFND 3 0 91,462 0
MOMO INC NOTE 1.250% 7/0 60879BAB3 61,369 64,583,000 SH   DFND 1 0 64,583,000 0
MSCI INC COM 55354G100 205 875 SH   DFND 3 0 875 0
MYLAN N V SHS EURO N59465109 759 40,000 SH   DFND 3 0 40,000 0
MYLAN N V SHS EURO N59465109 714 37,500 SH   DFND 1 0 37,500 0
MYOKARDIA INC COM 62857M105 3,938 81,528 SH   DFND 3 0 81,528 0
NABRIVA THERAPEUTICS PLC SHS G63637105 1,480 666,589 SH   DFND 3 0 666,589 0
NASDAQ INC COM 631103108 904 9,400 SH   DFND 3 0 9,400 0
NATIONAL OILWELL VARCO INC COM 637071101 707 33,000 SH   DFND 3 0 33,000 0
NATURES SUNSHINE PRODUCTS IN COM 639027101 26,519 2,854,607 SH   DFND 2 0 2,854,607 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 9,750 118,323 SH   DFND 3 0 118,323 0
NEWMONT GOLDCORP CORPORATION COM 651639106 4,659 122,353 SH   DFND 3 0 122,353 0
NEXTCURE INC COM 65343E108 1,498 100,000 SH   DFND 1 0 100,000 0
NEXTCURE INC COM 65343E108 749 50,000 SH   DFND   0 50,000 0
NEXTERA ENERGY INC COM 65339F101 485 2,370 SH   DFND 3 0 2,370 0
NIKE INC CL B 654106103 1,637 19,567 SH   DFND 3 0 19,567 0
NORFOLK SOUTHERN CORP COM 655844108 905 4,680 SH   DFND 3 0 4,680 0
NORTHERN TR CORP COM 665859104 258 2,942 SH   DFND 3 0 2,942 0
NUTRIEN LTD COM 67077M108 439 5,300 SH   DFND 3 0 5,300 0
OBSEVA SA COM H5861P103 2,106 194,991 SH   DFND 3 0 194,991 0
OMNICELL INC COM 68213N109 949 11,000 SH   DFND 3 0 11,000 0
OPKO HEALTH INC COM 68375N103 1,905 858,142 SH   DFND 3 0 858,142 0
ORACLE CORP COM 68389X105 832 14,655 SH   DFND 3 0 14,655 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 3,272 237,783 SH   DFND 2 0 237,783 0
PARATEK PHARMACEUTICALS INC COM 699374302 875 227,383 SH   DFND 3 0 227,383 0
PATTERN ENERGY GROUP INC NOTE 4.000% 7/1 70338PAB6 10,105 10,000,000 SH   DFND 1 0 10,000,000 0
PATTERN ENERGY GROUP INC CL A 70338P100 224 9,815 SH   DFND 3 0 9,815 0
PAYPAL HLDGS INC COM 70450Y103 2,047 18,010 SH   DFND 3 0 18,010 0
PEPSICO INC COM 713448108 285 2,165 SH   DFND 3 0 2,165 0
PFIZER INC COM 717081103 964 22,200 SH   DFND 3 0 22,200 0
PHILIP MORRIS INTL INC COM 718172109 896 11,500 SH   DFND 3 0 11,500 0
PIERIS PHARMACEUTICALS INC COM 720795103 1,616 364,693 SH   DFND 3 0 364,693 0
PLUG POWER INC COM NEW 72919P202 53 24,000 SH   DFND 3 0 24,000 0
PORTOLA PHARMACEUTICALS INC COM 737010108 1,996 74,800 SH   DFND 3 0 74,800 0
PRICELINE GRP INC NOTE 0.900% 9/1 741503AX4 399 350,000 SH   DFND 3 0 350,000 0
PROGENICS PHARMACEUTICALS IN COM 743187106 2,750 472,580 SH   DFND 3 0 472,580 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 569 47,513 SH   DFND 3 0 47,513 0
PROTALIX BIOTHERAPEUTICS INC COM 74365A101 1,237 2,631,400 SH   DFND 3 0 2,631,400 0
PROTHENA CORP PLC SHS G72800108 1,112 110,179 SH   DFND 3 0 110,179 0
QORVO INC COM 74736K101 292 4,361 SH   DFND 3 0 4,361 0
QUALCOMM INC COM 747525103 1,682 22,300 SH   DFND 3 0 22,300 0
QUOTIENT LTD SHS G73268107 2,589 273,947 SH   DFND 3 0 273,947 0
QUTOUTIAO INC ADS REP SHS A 74915J107 2,896 735,073 SH   DFND 1 0 735,073 0
RA PHARMACEUTICALS INC COM 74933V108 3,100 108,073 SH   DFND 3 0 108,073 0
RETROPHIN INC COM 761299106 1,141 56,837 SH   DFND 3 0 56,837 0
REVANCE THERAPEUTICS INC COM 761330109 6,129 472,532 SH   DFND 1 0 472,532 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 883 40,720 SH   DFND 3 0 40,720 0
ROGERS COMMUNICATIONS INC CL B 775109200 460 5,050 SH   DFND 3 0 5,050 0
SANGAMO THERAPEUTICS INC COM 800677106 663 62,808 SH   DFND 3 0 62,808 0
SCHLUMBERGER LTD COM 806857108 978 25,000 SH   DFND 3 0 25,000 0
SEADRILL LTD COM G7998G106 5,986 1,438,913 SH   DFND 1 0 1,438,913 0
SEATTLE GENETICS INC COM 812578102 8,924 132,605 SH   DFND 3 0 132,605 0
SELECTA BIOSCIENCES INC COM 816212104 824 438,330 SH   DFND 3 0 438,330 0
SERVICENOW INC COM 81762P102 209 750 SH   DFND 3 0 750 0
SINA CORP ORD G81477104 65,657 1,522,312 SH   DFND 1 0 1,522,312 0
SINA CORP ORD G81477104 18,881 437,754 SH   DFND   0 437,754 0
SKYWORKS SOLUTIONS INC COM 83088M102 462 6,000 SH   DFND 3 0 6,000 0
SL GREEN RLTY CORP COM 78440X101 1,592 20,000 SH   DFND 3 0 20,000 0
SOCIEDAD QUIMICA MINERA DE C SPON ADR SER B 833635105 1,956 62,000 SH   DFND 3 0 62,000 0
SOHU COM LTD SPONSORED ADS 83410S108 15,064 1,075,995 SH   DFND 1 0 1,075,995 0
SOLENO THERAPEUTICS INC COM NEW 834203200 514 188,982 SH   DFND 3 0 188,982 0
SOUTHWEST GAS HOLDINGS INC COM 844895102 272 3,070 SH   DFND 3 0 3,070 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108 830 95,246 SH   DFND 3 0 95,246 0
SPERO THERAPEUTICS INC COM 84833T103 962 86,596 SH   DFND 3 0 86,596 0
SPIRIT RLTY CAP INC NEW NOTE 3.750% 5/1 84860WAB8 30,641 30,000,000 SH   DFND 1 0 30,000,000 0
SPIRIT RLTY CAP INC NEW NOTE 3.750% 5/1 84860WAB8 20,419 19,992,000 SH   DFND   0 19,992,000 0
SPRING BK PHARMACEUTICALS IN COM 849431101 122 31,100 SH   DFND 3 0 31,100 0
STANLEY BLACK & DECKER INC COM 854502101 318 2,220 SH   DFND 3 0 2,220 0
STARBUCKS CORP COM 855244109 1,272 15,225 SH   DFND 3 0 15,225 0
STEMLINE THERAPEUTICS INC COM 85858C107 3,211 212,936 SH   DFND 3 0 212,936 0
SYNLOGIC INC COM 87166L100 342 38,438 SH   DFND 3 0 38,438 0
T MOBILE US INC COM 872590104 953 13,000 SH   DFND 3 0 13,000 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 1,390 35,120 SH   DFND 3 0 35,120 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 771 85,000 SH   DFND 3 0 85,000 0
THE CHARLES SCHWAB CORPORATI COM 808513105 941 23,400 SH   DFND 3 0 23,400 0
THERAVANCE BIOPHARMA INC COM G8807B106 2,967 185,899 SH   DFND 3 0 185,899 0
THOR INDS INC COM 885160101 443 7,610 SH   DFND 3 0 7,610 0
TOTAL S A SPONSORED ADS 89151E109 334 6,000 SH   DFND 3 0 6,000 0
TRANSGLOBE ENERGY CORP COM 893662106 3,377 2,422,923 SH   DFND 1 0 2,422,923 0
TRANSLATE BIO INC COM 89374L104 780 60,683 SH   DFND 3 0 60,683 0
TWITTER INC NOTE 0.250% 9/1 90184LAB8 746 750,000 SH   DFND   0 750,000 0
TWITTER INC NOTE 0.250% 9/1 90184LAB8 73,860 74,300,000 SH   DFND 1 0 74,300,000 0
UBS GROUP AG SHS H42097107 990 87,485 SH   DFND 3 0 87,485 0
ULTA BEAUTY INC COM 90384S303 207 600 SH   DFND 3 0 600 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 3,360 54,144 SH   DFND 3 0 54,144 0
UNITED TECHNOLOGIES CORP COM 913017109 1,187 9,200 SH   DFND 3 0 9,200 0
UNITEDHEALTH GROUP INC COM 91324P102 2,446 9,930 SH   DFND 3 0 9,930 0
VBI VACCINES INC COM NEW 91822J103 1,156 1,051,126 SH   DFND 3 0 1,051,126 0
VEON LTD SPONSORED ADR 91822M106 1,850 660,608 SH   DFND 1 0 660,608 0
VERISIGN INC COM 92343E102 332 1,600 SH   DFND 3 0 1,600 0
VERIZON MUNICATIONS INC COM 92343V104 435 7,605 SH   DFND 3 0 7,605 0
VERRICA PHARMACEUTICALS INC COM 92511W108 3,857 331,933 SH   DFND 1 0 331,933 0
VERRICA PHARMACEUTICALS INC COM 92511W108 5,372 462,346 SH   DFND   0 462,346 0
VICAL INC COM NEW 925602203 265 313,209 SH   DFND 3 0 313,209 0
VIEWRAY INC COM 92672L107 145,112 16,470,258 SH   DFND   0 16,470,258 0
VIKING THERAPEUTICS INC COM 92686J106 579 69,203 SH   DFND 3 0 69,203 0
VISA INC COM CL A 92826C839 3,962 23,140 SH   DFND 3 0 23,140 0
WASTE MGMT INC DEL COM 94106L109 804 6,940 SH   DFND 3 0 6,940 0
WAVE LIFE SCIENCES LTD SHS Y95308105 1,840 70,088 SH   DFND 3 0 70,088 0
WEIBO CORP NOTE 1.250% 11/1 948596AC5 85,711 90,730,000 SH   DFND 1 0 90,730,000 0
WELLS FARGO CO NEW COM 949746101 222 4,795 SH   DFND 3 0 4,795 0
WHEATON PRECIOUS METALS CORP COM 962879102 428 10,400 SH   DFND 3 0 10,400 0
XOMA CORP DEL COM NEW 98419J206 3,939 266,877 SH   DFND 3 0 266,877 0
XYLEM INC COM 98419M100 255 3,120 SH   DFND 3 0 3,120 0
YAMANA GOLD INC COM 98462Y100 42 17,000 SH   DFND 3 0 17,000 0
ZIX CORP COM 98974P100 151 17,000 SH   DFND 3 0 17,000 0
ZOGENIX INC COM NEW 98978L204 2,178 45,700 SH   DFND 3 0 45,700 0