The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 2,502 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
AC IMMUNE SA SHS H00263105 5,550 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 10,296 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
ACCELERON PHARMA INC COM 00434H108 61,620 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 9,660 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
ADURO BIOTECH INC COM 00739L101 1,540 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 1,157 168,954 SH   DFND 1,2,3,4,5,6 168,954 0 0
AGENUS INC COM NEW 00847G705 7,500 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 24,940 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 4,988 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 2,057 425,000 SH   DFND 1,2,3,4,5,6 425,000 0 0
ALBIREO PHARMA INC COM 01345P106 14,508 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 10,005 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
ALECTOR INC COM 014442107 4,275 225,000 SH   DFND 1,2,3,4,5,6 225,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 76,253 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 33,890 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 5,370 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 29,024 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 10,884 150,000 SH Call DFND 1,2,3,4,5,6 150,000 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 16,305 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 31,200 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
ARAVIVE INC COM 03890D108 1,845 307,466 SH   DFND 1,2,3,4,5,6 307,466 0 0
ARCUS BIOSCIENCES INC COM 03969F109 2,147 270,000 SH   DFND 1,2,3,4,5,6 270,000 0 0
ARGENX SE SPONSORED ADR 04016X101 31,148 220,000 SH   DFND 1,2,3,4,5,6 220,000 0 0
ARQULE INC COM 04269E107 7,707 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 17,273 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 23,127 1,150,000 SH   DFND 1,2,3,4,5,6 1,150,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 13,251 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
AUTOLUS THERAPEUTICS PLC SPONSORED ADS 05280R100 8,050 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
AVANTOR INC COM 05352A100 133,630 7,000,000 SH   DFND 1,2,3,4,5,6 7,000,000 0 0
AVROBIO INC COM 05455M100 1,463 90,000 SH   DFND 1,2,3,4,5,6 90,000 0 0
AXCELLA HEALTH INC COM 05454B105 3,628 389,741 SH   DFND 1,2,3,4,5,6 389,741 0 0
BEIGENE LTD SPONSORED ADR 07725L102 80,568 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
BLUEBIRD BIO INC COM 09609G100 12,720 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 70,748 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 5,394 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 102,038 2,250,000 SH Call DFND 1,2,3,4,5,6 2,250,000 0 0
CHANGE HEALTHCARE INC COM 15912K100 10,950 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 4,710 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 6,829 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 15,590 1,361,584 SH   DFND 1,2,3,4 1,361,584 0 0
DENALI THERAPEUTICS INC COM 24823R105 8,304 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 15,750 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
EPIZYME INC COM 29428V104 20,708 1,650,000 SH   DFND 1,2,3,4,5,6 1,650,000 0 0
FATE THERAPEUTICS INC COM 31189P102 30,450 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
FIBROGEN INC COM 31572Q808 8,132 180,000 SH   DFND 1,2,3,4,5,6 180,000 0 0
FRONTDOOR INC COM 35905A109 4,355 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
GENERAL MTRS CO COM 37045V100 38,530 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
GOSSAMER BIO INC COM 38341P102 8,872 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
GOSSAMER BIO INC COM 38341P102 26,815 1,208,968 SH   DFND 1,2,3,4 1,208,968 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 5,570 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
HOOKIPA PHARMA INC COM 43906K100 3,601 535,000 SH   DFND 1,2,3,4,5,6 535,000 0 0
HOOKIPA PHARMA INC COM 43906K100 4,035 599,616 SH   DFND 1,2,3,4 599,616 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 12,688 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
INCYTE CORP COM 45337C102 21,240 250,000 SH Call DFND 1,2,3,4,5,6 250,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 17,164 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,209 110,532 SH   DFND 1,2,3,4 110,532 0 0
KALEIDO BIOSCIENCES INC COM 483347100 4,640 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
KALEIDO BIOSCIENCES INC COM 483347100 5,806 500,500 SH   DFND 1,2,3,4 500,500 0 0
KRYSTAL BIOTECH INC COM 501147102 12,081 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 22,117 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 356,798 56,724,650 SH   DFND 1,2,3,4 56,724,650 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 3,668 35,000 SH   DFND 1,2,3,4,5,6 35,000 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 347 23,524 SH   DFND 1,2,3,4,5,6 23,524 0 0
MEDICINES CO COM 584688105 36,470 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MELCO RESORTS AND ENTMT LTD ADR 585464100 21,720 1,000,000 SH Call DFND 1,2,3,4,5,6 1,000,000 0 0
MERUS N V COM N5749R100 5,128 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 15,450 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
MODERNA INC COM 60770K107 7,320 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
MODERNA INC COM 60770K107 67,436 4,606,298 SH   DFND 1,2,3,4 4,606,298 0 0
MORPHIC HLDG INC COM 61775R105 9,910 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
NEKTAR THERAPEUTICS COM 640268108 24,906 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
NEKTAR THERAPEUTICS COM 640268108 3,558 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 16,886 200,000 SH Call DFND 1,2,3,4,5,6 200,000 0 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 1,464 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
NIO INC SPONSORED ADS 62914V106 12,368 4,850,000 SH   DFND 1,2,3,4,5,6 4,850,000 0 0
NIO INC SPONSORED ADS 62914V106 4,463 1,750,000 SH Call DFND 1,2,3,4,5,6 1,750,000 0 0
NVIDIA CORP COM 67066G104 68,977 420,000 SH   DFND 1,2,3,4,5,6 420,000 0 0
NVIDIA CORP COM 67066G104 16,423 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 4,897 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 11,830 1,300,000 SH   DFND 1,2,3,4,5,6 1,300,000 0 0
THE REALREAL INC COM 88339P101 578 20,000 SH   DFND 1,2,3,4,5,6 20,000 0 0
REGENXBIO INC COM 75901B107 7,449 145,000 SH   DFND 1,2,3,4,5,6 145,000 0 0
REPLIMUNE GROUP INC COM 76029N106 8,796 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
RESTORBIO INC COM 76133L103 3,672 360,000 SH   DFND 1,2,3,4,5,6 360,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 5,400 360,000 SH   DFND 1,2,3,4,5,6 360,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 7,079 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 37,497 2,383,791 SH   DFND 1,2,3,4 2,383,791 0 0
SAGE THERAPEUTICS INC COM 78667J108 27,464 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
SANGAMO THERAPEUTICS INC COM 800677106 4,362 405,000 SH   DFND 1,2,3,4,5,6 405,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 6,344 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 30,864 1,946,040 SH   DFND 1,2,3,4 1,946,040 0 0
SELECTA BIOSCIENCES INC COM 816212104 3,759 2,100,000 SH   DFND 1,2,3,4,5,6 2,100,000 0 0
SOLID BIOSCIENCES INC COM 83422E105 6,900 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 6,215 540,000 SH   DFND 1,2,3,4,5,6 540,000 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 5,515 360,000 SH   DFND 1,2,3,4,5,6 360,000 0 0
STONECO LTD COM CL A G85158106 8,874 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
TCR2 THERAPEUTICS INC COM 87808K106 7,012 490,000 SH   DFND 1,2,3,4,5,6 490,000 0 0
TG THERAPEUTICS INC COM 88322Q108 7,785 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
TRANSLATE BIO INC COM 89374L104 9,473 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
TRICIDA INC COM 89610F101 14,206 360,000 SH   DFND 1,2,3,4,5,6 360,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 8,140 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
TWIST BIOSCIENCE CORP COM 90184D100 2,901 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
UBER TECHNOLOGIES INC COM 90353T100 23,190 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 830 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
WEIGHT WATCHERS INTL INC NEW COM 948626106 283,030 14,818,300 SH   DFND 1,2,3,4,7 14,818,300 0 0
XENCOR INC COM 98401F105 11,256 275,000 SH   DFND 1,2,3,4,5,6 275,000 0 0
Y MABS THERAPEUTICS INC COM 984241109 9,148 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 46,390 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0