The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Acer Therapeutics Inc Common 00444P108 14,071 579,051 SH   SOLE   579,051 0 0
Aclaris Therapeutics, Inc. Common 00461U105 9,867 1,647,214 SH   SOLE   1,647,214 0 0
Agile Therapeutics, Inc. Common 00847L100 2,286 1,513,975 SH   SOLE   1,513,975 0 0
Akari Therapeutics Plc ADR 00972G108 1,238 345,850 SH   SOLE   345,850 0 0
Amyris, Inc Common 03236M200 11,653 5,575,785 SH   SOLE   5,575,785 0 0
Apellis Pharmaceuticals, Inc. Common 03753U106 7,479 383,538 SH   SOLE   383,538 0 0
Arrowhead Pharmaceuticals Inc Common 04280A100 42,728 2,328,475 SH   SOLE   2,328,475 0 0
Ascendis Pharma A/S ADR 04351P101 240,912 2,046,832 SH   SOLE   2,046,832 0 0
Aurinia Pharmaceuticals Inc. Common 05156V102 7,886 1,213,290 SH   SOLE   1,213,290 0 0
Biohaven Pharmaceutical Holding Company Ltd Common G11196105 25,991 504,980 SH   SOLE   504,980 0 0
BioPharmX Corporation Common 09072X101 1,419 16,128,515 SH   SOLE   16,128,515 0 0
Codexis, Inc Common 192005106 53,767 2,618,951 SH   SOLE   2,618,951 0 0
Crinetics Pharmaceuticals Inc Common 22663K107 76,819 3,375,169 SH   SOLE   3,375,169 0 0
Cymabay Therapeutics Inc Common 23257D103 27,304 2,056,000 SH   SOLE   2,056,000 0 0
DBV Technologies S.A. ADR 23306J101 2,082 269,995 SH   SOLE   269,995 0 0
Dermira Inc Common 24983L104 9,485 700,000 SH   SOLE   700,000 0 0
Eiger BioPharmaceuticals Inc Common 28249U105 25,042 1,791,257 SH   SOLE   1,791,257 0 0
Galmed Pharmaceuticals Ltd SHS M47238106 7,936 971,337 SH   SOLE   971,337 0 0
Genocea Biosciences Inc Common 372427104 4,609 7,811,206 SH   SOLE   7,811,206 0 0
Homology Medicines, Inc. Common 438083107 32,160 1,159,742 SH   SOLE   1,159,742 0 0
Insmed Inc Common Par 457669307 34,020 1,170,290 SH   SOLE   1,170,290 0 0
Iovance Biotherapeutics, Inc. Common 462260100 15,216 1,600,000 SH   SOLE   1,600,000 0 0
Kadmon Holdings Inc Common 48283N106 33,281 12,606,605 SH   SOLE   12,606,605 0 0
Kala Pharmaceuticals, Inc. Common 483119103 8,626 1,043,020 SH   SOLE   1,043,020 0 0
KalVista Pharmaceuticals Inc. Common 483497103 38,899 1,359,149 SH   SOLE   1,359,149 0 0
Kiniksa Pharmaceuticals Common G5269C101 15,233 843,478 SH   SOLE   843,478 0 0
Matinas Biopharma Hldgs Inc Common 576810105 7,432 6,818,181 SH   SOLE   6,818,181 0 0
MEI Pharma Inc Common 55279B202 17,739 5,778,106 SH   SOLE   5,778,106 0 0
Menlo Therapeutics Inc. Common 586858102 31,488 4,011,236 SH   SOLE   4,011,236 0 0
Mirati Therapeutics Inc. Common 60468T105 18,406 251,107 SH   SOLE   251,107 0 0
Nabriva Therapeutics AG SHS G63637105 10,745 4,403,687 SH   SOLE   4,403,687 0 0
Obseva SA Common H5861P103 11,986 937,147 SH   SOLE   937,147 0 0
Orchard Therapeutics plc ADS 68570P101 8,611 481,609 SH   SOLE   481,609 0 0
Precision Biosciences Inc Common 74019P108 5,035 280,511 SH   SOLE   280,511 0 0
Selecta Biosciences Inc Common 816212104 1,289 546,054 SH   SOLE   546,054 0 0
Sierra Oncology, Inc Common 82640U107 4,169 2,438,270 SH   SOLE   2,438,270 0 0
Sinovac Biotech Ltd. SHS P8696W104 38,173 5,900,000 SH   SOLE   5,900,000 0 0
Soleno Therapeutics, Inc. Common 834203200 8,981 4,359,683 SH   SOLE   4,359,683 0 0
Soleno Therapeutics, Inc. - Warrant Warrant 834203135 28 188,772 SH   SOLE   188,772 0 0
Strongbridge Biopharma plc SHS USD G85347105 4,552 914,062 SH   SOLE   914,062 0 0
Sunesis Pharmaceuticals, Inc. Common Par 867328700 121 99,441 SH   SOLE   99,441 0 0
Trevena, Inc. Common 89532E109 1,925 1,233,677 SH   SOLE   1,233,677 0 0
Tricida, Inc. Common 89610F101 29,529 781,185 SH   SOLE   781,185 0 0
Uniqure NV Common N90064101 10,757 180,336 SH   SOLE   180,336 0 0
Verona Pharma PLC ADS 925050106 9,704 1,492,951 SH   SOLE   1,492,951 0 0
Xenon Pharmaceuticals Inc Common 98420N105 14,280 1,405,476 SH   SOLE   1,405,476 0 0
Zai Lab Limited ADR 98887Q104 2,113 71,595 SH   SOLE   71,595 0 0
Zogenix Inc Common 98978L204 5,776 105,000 SH   SOLE   105,000 0 0
Zymeworks Inc Common 98985W102 10,034 620,134 SH   SOLE   620,134 0 0