The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 322 11,981 SH   SOLE   11,981 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 324 4,806 SH   SOLE   4,806 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 1,342 9,927 SH   SOLE   9,927 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 1,248 13,351 SH   SOLE   13,351 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 345 16,641 SH   SOLE   16,641 0 0
AMGEN INC COM 031162100 236 1,242 SH   SOLE   1,242 0 0
AMICUS THERAPEUTICS INC COM 03152W109 500 36,731 SH   SOLE   36,731 0 0
ANAPTYSBIO INC COM 032724106 447 6,116 SH   SOLE   6,116 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 438 9,770 SH   SOLE   9,770 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 729 6,190 SH   SOLE   6,190 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 677 17,339 SH   SOLE   17,339 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 808 9,099 SH   SOLE   9,099 0 0
BIO TECHNE CORP COM 09073M104 308 1,551 SH   SOLE   1,551 0 0
BLUEBIRD BIO INC COM 09609G100 919 5,840 SH   SOLE   5,840 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 543 6,780 SH   SOLE   6,780 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 1,574 33,000 SH   SOLE   33,000 0 0
CELGENE CORP COM 151020104 803 8,510 SH   SOLE   8,510 0 0
CELLECTIS S A SPONSORED ADS 15117K103 409 22,309 SH   SOLE   22,309 0 0
CHARLES RIV LABS INTL INC COM 159864107 307 2,112 SH   SOLE   2,112 0 0
CHECKPOINT THERAPEUTICS INC COM 162828107 322 112,760 SH   SOLE   112,760 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 272 25,284 SH   SOLE   25,284 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 432 18,631 SH   SOLE   18,631 0 0
DIREXION SHS ETF TR SP BIOTCH BL NEW 25490K323 5,869 98,011 SH   SOLE   98,011 0 0
EPIZYME INC COM 29428V104 624 50,378 SH   SOLE   50,378 0 0
EXACT SCIENCES CORP COM 30063P105 528 6,093 SH   SOLE   6,093 0 0
EXELIXIS INC COM 30161Q104 272 11,440 SH   SOLE   11,440 0 0
FIBROGEN INC COM 31572Q808 262 4,827 SH   SOLE   4,827 0 0
FORTRESS BIOTECH INC COM 34960Q109 417 234,030 SH   SOLE   234,030 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 619 3,674 SH   SOLE   3,674 0 0
G1 THERAPEUTICS INC COM 3621LQ109 346 20,844 SH   SOLE   20,844 0 0
GILEAD SCIENCES INC COM 375558103 238 3,667 SH   SOLE   3,667 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 502 9,479 SH   SOLE   9,479 0 0
GRIFOLS S A SP ADR REP B NVT 398438408 263 13,082 SH   SOLE   13,082 0 0
ILLUMINA INC COM 452327109 1,452 4,675 SH   SOLE   4,675 0 0
IMMUNOMEDICS INC COM 452907108 1,202 62,575 SH   SOLE   62,575 0 0
INCYTE CORP COM 45337C102 913 10,613 SH   SOLE   10,613 0 0
INSMED INC COM PAR $.01 457669307 783 26,936 SH   SOLE   26,936 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 487 28,490 SH   SOLE   28,490 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 644 5,756 SH   SOLE   5,756 0 0
INTREXON CORP COM 46122T102 170 32,284 SH   SOLE   32,284 0 0
IONIS PHARMACEUTICALS INC COM 462222100 1,633 20,124 SH   SOLE   20,124 0 0
IQVIA HLDGS INC COM 46266C105 286 1,985 SH   SOLE   1,985 0 0
ISHARES TR NASDAQ BIOTECH 464287556 13,975 125,000 SH   SOLE   125,000 0 0
ISHARES TR NASDAQ BIOTECH 464287556 9,503 85,000 SH Call SOLE   85,000 0 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 219 1,745 SH   SOLE   1,745 0 0
MACROGENICS INC COM 556099109 541 30,075 SH   SOLE   30,075 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 447 3,570 SH   SOLE   3,570 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 2,339 3,235 SH   SOLE   3,235 0 0
NEKTAR THERAPEUTICS COM 640268108 346 10,305 SH   SOLE   10,305 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 247 2,807 SH   SOLE   2,807 0 0
PACIRA PHARMACEUTICALS INC COM 695127100 428 11,250 SH   SOLE   11,250 0 0
RECRO PHARMA INC COM 75629F109 67 11,353 SH   SOLE   11,353 0 0
REGENERON PHARMACEUTICALS COM 75886F107 904 2,201 SH   SOLE   2,201 0 0
REGENXBIO INC COM 75901B107 506 8,832 SH   SOLE   8,832 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 391 21,610 SH   SOLE   21,610 0 0
SANGAMO THERAPEUTICS INC COM 800677106 320 33,529 SH   SOLE   33,529 0 0
SAREPTA THERAPEUTICS INC COM 803607100 388 3,252 SH   SOLE   3,252 0 0
SEATTLE GENETICS INC COM 812578102 1,306 17,832 SH   SOLE   17,832 0 0
SPARK THERAPEUTICS INC COM 84652J103 1,105 9,699 SH   SOLE   9,699 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 408 11,648 SH   SOLE   11,648 0 0
SURFACE ONCOLOGY INC COM 86877M209 253 53,063 SH   SOLE   53,063 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 351 5,064 SH   SOLE   5,064 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 258 2,199 SH   SOLE   2,199 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 1,485 8,074 SH   SOLE   8,074 0 0
VIKING THERAPEUTICS INC COM 92686J106 482 48,485 SH   SOLE   48,485 0 0
XENCOR INC COM 98401F105 340 10,935 SH   SOLE   10,935 0 0
ZOGENIX INC COM NEW 98978L204 535 9,725 SH   SOLE   9,725 0 0
ALKERMES PLC SHS G01767105 282 7,722 SH   SOLE   7,722 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 559 10,852 SH   SOLE   10,852 0 0
AC IMMUNE SA SHS H00263105 201 39,801 SH   SOLE   39,801 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 472 13,214 SH   SOLE   13,214 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 1,920 138,461 SH   SOLE   138,461 0 0
QIAGEN NV SHS NEW N72482123 1,174 28,858 SH   SOLE   28,858 0 0
UNIQURE NV SHS N90064101 848 14,215 SH   SOLE   14,215 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 377 9,716 SH   SOLE   9,716 0 0