The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCURAY INC COM 004397105 7,715 1,617,297 SH   DFND   0 1,617,297 0
ACORDA THERAPEUTICS INC NOTE 1.750% 6/1 00484MAA4 83,582 94,177,000 PRN   DFND   0 94,177,000 0
AGILENT TECHNOLOGIES INC COM 00846U101 22,592 281,069 SH   DFND   0 281,069 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 31,482 2,306,367 SH   DFND   0 2,306,367 0
ALDER BIOPHARMACEUTICALS INC NOTE 2.500% 2/0 014339AA3 16,517 17,213,000 PRN   DFND   0 17,213,000 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 33,245 182,212 SH   DFND   0 182,212 0
ALIGN TECHNOLOGY INC COM 016255101 60,531 212,889 SH   DFND   0 212,889 0
ALLENA PHARMACEUTICALS INC COM 018119107 10,272 1,463,208 SH   DFND   0 1,463,208 0
ALLERGAN PLC SHS G0177J108 84,162 574,837 SH   DFND   0 574,837 0
ALPHABET INC CAP STK CL A 02079K305 25,949 22,049 SH   DFND   0 22,049 0
AMAZON COM INC COM 023135106 35,829 20,120 SH   DFND   0 20,120 0
ANTHEM INC COM 036752103 99,409 346,397 SH   DFND   0 346,397 0
APTINYX INC COM 03836N103 7,270 1,795,149 SH   DFND   0 1,795,149 0
APTIV PLC SHS G6095L109 31,114 391,418 SH   DFND   0 391,418 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 145,932 3,255,230 SH   DFND   0 3,255,230 0
AUDENTES THERAPEUTICS INC COM 05070R104 79,229 2,030,481 SH   DFND   0 2,030,481 0
BLUEPRINT MEDICINES CORP COM 09627Y109 77,174 964,075 SH   DFND   0 964,075 0
CARDIOVASCULAR SYS INC DEL COM 141619106 17,278 446,921 SH   DFND   0 446,921 0
CLOVIS ONCOLOGY INC NOTE 1.250% 5/0 189464AC4 10,091 12,889,000 PRN   DFND   0 12,889,000 0
COHERUS BIOSCIENCES INC COM 19249H103 12,918 947,061 SH   DFND   0 947,061 0
COUPA SOFTWARE INC COM 22266L106 16,460 180,922 SH   DFND   0 180,922 0
CTRIP COM INTL LTD SPONSORED ADS 22943F100 16,581 379,510 SH   DFND   0 379,510 0
DERMIRA INC COM 24983L104 34,973 2,581,033 SH   DFND   0 2,581,033 0
DERMIRA INC NOTE 3.000% 5/1 24983LAB0 13,244 14,919,000 PRN   DFND   0 14,919,000 0
DROPBOX INC CL A 26210C104 25,347 1,162,707 SH   DFND   0 1,162,707 0
EDWARDS LIFESCIENCES CORP COM 28176E908 29,943 156,500 SH Call DFND   0 156,500 0
EDWARDS LIFESCIENCES CORP COM 28176E108 68,938 360,307 SH   DFND   0 360,307 0
ENDOLOGIX INC NOTE 3.250%11/0 29266SAB2 34,452 47,379,000 PRN   DFND   0 47,379,000 0
EQUILLIUM INC COM 29446K106 11,576 1,446,972 SH   DFND   0 1,446,972 0
ESPERION THERAPEUTICS INC NE COM 29664W105 65,327 1,627,079 SH   DFND   0 1,627,079 0
EXACT SCIENCES CORP COM 30063P105 49,058 566,359 SH   DFND   0 566,359 0
FAIR ISAAC CORP COM 303250104 23,430 86,256 SH   DFND   0 86,256 0
FATE THERAPEUTICS INC COM 31189P102 22,517 1,281,536 SH   DFND   0 1,281,536 0
FLUIDIGM CORP DEL COM 34385P108 19,156 1,441,363 SH   DFND   0 1,441,363 0
GODADDY INC CL A 380237107 80,785 1,074,417 SH   DFND   0 1,074,417 0
GRITSTONE ONCOLOGY INC COM 39868T105 4,983 374,656 SH   DFND   0 374,656 0
HCA HEALTHCARE INC COM 40412C101 37,413 286,951 SH   DFND   0 286,951 0
HUMANA INC COM 444859902 104,565 393,100 SH Call DFND   0 393,100 0
HUMANA INC COM 444859102 96,950 364,473 SH   DFND   0 364,473 0
ICU MED INC COM 44930G107 89,715 374,860 SH   DFND   0 374,860 0
INTUIT COM 461202103 66,016 252,539 SH   DFND   0 252,539 0
INVESCO QQQ TR UNIT SER 1 46090E953 365,734 2,035,700 SH Put DFND   0 2,035,700 0
IQVIA HLDGS INC COM 46266C105 39,819 276,809 SH   DFND   0 276,809 0
IRHYTHM TECHNOLOGIES INC COM 450056106 40,631 542,033 SH   DFND   0 542,033 0
LIVE NATION ENTERTAINMENT IN COM 538034109 32,685 514,407 SH   DFND   0 514,407 0
LYFT INC CL A COM 55087P104 6,904 88,182 SH   DFND   0 88,182 0
MADISON SQUARE GARDEN CO NEW CL A 55825T103 33,083 112,860 SH   DFND   0 112,860 0
MERIT MED SYS INC COM 589889104 60,427 977,313 SH   DFND   0 977,313 0
MICROCHIP TECHNOLOGY INC COM 595017104 85,185 1,026,821 SH   DFND   0 1,026,821 0
MICROSOFT CORP COM 594918104 34,946 296,300 SH   DFND   0 296,300 0
MIRATI THERAPEUTICS INC COM 60468T105 8,808 120,166 SH   DFND   0 120,166 0
MOLINA HEALTHCARE INC COM 60855R100 71,056 500,538 SH   DFND   0 500,538 0
MYOKARDIA INC COM 62857M105 83,252 1,601,307 SH   DFND   0 1,601,307 0
NEON THERAPEUTICS INC COM 64050Y100 2,729 422,396 SH   DFND   0 422,396 0
NETFLIX INC COM 64110L106 30,814 86,420 SH   DFND   0 86,420 0
NEVRO CORP COM 64157F103 45,084 721,229 SH   DFND   0 721,229 0
NEW YORK TIMES CO CL A 650111107 56,760 1,727,851 SH   DFND   0 1,727,851 0
NXP SEMICONDUCTORS N V COM N6596X109 31,861 360,456 SH   DFND   0 360,456 0
PACIRA PHARMACEUTICALS INC COM 695127100 10,740 282,197 SH   DFND   0 282,197 0
PAYPAL HLDGS INC COM 70450Y103 52,709 507,599 SH   DFND   0 507,599 0
PENUMBRA INC COM 70975L107 106,885 727,057 SH   DFND   0 727,057 0
PERKINELMER INC COM 714046109 45,545 472,656 SH   DFND   0 472,656 0
PFIZER INC COM 717081103 120,322 2,833,096 SH   DFND   0 2,833,096 0
PIVOTAL SOFTWARE INC COM CL A 72582H107 12,177 584,051 SH   DFND   0 584,051 0
PTC THERAPEUTICS INC COM 69366J200 40,906 1,086,776 SH   DFND   0 1,086,776 0
PUMA BIOTECHNOLOGY INC COM 74587V107 101,006 2,603,920 SH   DFND   0 2,603,920 0
QUALCOMM INC COM 747525903 186,979 3,278,600 SH Call DFND   0 3,278,600 0
SAGE THERAPEUTICS INC COM 78667J108 26,987 169,676 SH   DFND   0 169,676 0
SALESFORCE COM INC COM 79466L302 32,529 205,398 SH   DFND   0 205,398 0
SEA LTD SPONSORED ADS 81141R100 23,707 1,007,969 SH   DFND   0 1,007,969 0
SHOPIFY INC CL A 82509L107 4,053 19,616 SH   DFND   0 19,616 0
SIENNA BIOPHARMACEUTICALS IN COM 82622H108 6,228 2,684,678 SH   DFND   0 2,684,678 0
SPARK THERAPEUTICS INC COM 84652J103 24,578 215,821 SH   DFND   0 215,821 0
SPDR SERIES TRUST S&P METALS MNG 78464A905 79,127 2,666,000 SH Call DFND   0 2,666,000 0
SPLUNK INC COM 848637104 11,224 90,080 SH   DFND   0 90,080 0
SQUARE INC CL A 852234103 43,124 575,598 SH   DFND   0 575,598 0
STRYKER CORP COM 863667101 114,452 579,444 SH   DFND   0 579,444 0
TABLEAU SOFTWARE INC CL A 87336U105 15,456 121,435 SH   DFND   0 121,435 0
THERMO FISHER SCIENTIFIC INC COM 883556102 77,035 281,436 SH   DFND   0 281,436 0
TWILIO INC CL A 90138F102 16,245 125,755 SH   DFND   0 125,755 0
UNIQURE NV SHS N90064101 24,866 416,862 SH   DFND   0 416,862 0
UNITEDHEALTH GROUP INC COM 91324P102 111,685 451,689 SH   DFND   0 451,689 0
UNITY BIOTECHNOLOGY INC COM 91381U101 1,096 135,189 SH   DFND   0 135,189 0
VOYAGER THERAPEUTICS INC COM 92915B106 37,343 1,951,061 SH   DFND   0 1,951,061 0
WAVE LIFE SCIENCES LTD SHS Y95308105 35,065 902,578 SH   DFND   0 902,578 0
WELLCARE HEALTH PLANS INC COM 94946T906 84,836 314,500 SH Call DFND   0 314,500 0
WELLCARE HEALTH PLANS INC COM 94946T106 89,782 332,834 SH   DFND   0 332,834 0
WRIGHT MED GROUP N V ORD SHS N96617118 28,625 910,190 SH   DFND   0 910,190 0
ZAI LAB LTD ADR 98887Q104 4,646 157,442 SH   DFND   0 157,442 0
ZIMMER BIOMET HLDGS INC COM 98956P102 121,474 951,246 SH   DFND   0 951,246 0