The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCURAY INC COM 004397105 48 10,037 SH   DFND   0 10,037 0
ACORDA THERAPEUTICS INC NOTE 1.750% 6/1 00484MAA4 1,107 1,247,000 PRN   DFND   0 1,247,000 0
AGILENT TECHNOLOGIES INC COM 00846U101 452 5,623 SH   DFND   0 5,623 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 235 17,247 SH   DFND   0 17,247 0
ALDER BIOPHARMACEUTICALS INC NOTE 2.500% 2/0 014339AA3 131 137,000 PRN   DFND   0 137,000 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 1,007 5,520 SH   DFND   0 5,520 0
ALIGN TECHNOLOGY INC COM 016255101 954 3,354 SH   DFND   0 3,354 0
ALLENA PHARMACEUTICALS INC COM 018119107 2,085 296,961 SH   DFND   0 296,961 0
ALLERGAN PLC SHS G0177J108 1,684 11,505 SH   DFND   0 11,505 0
ALPHABET INC CAP STK CL A 02079K305 779 662 SH   DFND   0 662 0
AMAZON COM INC COM 023135106 1,086 610 SH   DFND   0 610 0
ANTHEM INC COM 036752103 1,988 6,928 SH   DFND   0 6,928 0
APTINYX INC COM 03836N103 55 13,614 SH   DFND   0 13,614 0
APTIV PLC SHS G6095L109 984 12,375 SH   DFND   0 12,375 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 1,820 40,605 SH   DFND   0 40,605 0
AUDENTES THERAPEUTICS INC COM 05070R104 656 16,823 SH   DFND   0 16,823 0
BLUEPRINT MEDICINES CORP COM 09627Y109 782 9,766 SH   DFND   0 9,766 0
CARDIOVASCULAR SYS INC DEL COM 141619106 173 4,470 SH   DFND   0 4,470 0
CLOVIS ONCOLOGY INC NOTE 1.250% 5/0 189464AC4 87 111,000 PRN   DFND   0 111,000 0
COHERUS BIOSCIENCES INC COM 19249H103 111 8,114 SH   DFND   0 8,114 0
COUPA SOFTWARE INC COM 22266L106 492 5,411 SH   DFND   0 5,411 0
CTRIP COM INTL LTD SPONSORED ADS 22943F100 524 11,999 SH   DFND   0 11,999 0
DERMIRA INC COM 24983L104 207 15,257 SH   DFND   0 15,257 0
DERMIRA INC NOTE 3.000% 5/1 24983LAB0 72 81,000 PRN   DFND   0 81,000 0
DROPBOX INC CL A 26210C104 801 36,742 SH   DFND   0 36,742 0
EDWARDS LIFESCIENCES CORP COM 28176E908 574 3,000 SH Call DFND   0 3,000 0
EDWARDS LIFESCIENCES CORP COM 28176E108 1,285 6,717 SH   DFND   0 6,717 0
ENDOLOGIX INC NOTE 3.250%11/0 29266SAB2 300 413,000 PRN   DFND   0 413,000 0
EQUILLIUM INC COM 29446K106 55 6,926 SH   DFND   0 6,926 0
ESPERION THERAPEUTICS INC NE COM 29664W105 757 18,847 SH   DFND   0 18,847 0
EXACT SCIENCES CORP COM 30063P105 616 7,115 SH   DFND   0 7,115 0
FAIR ISAAC CORP COM 303250104 741 2,728 SH   DFND   0 2,728 0
FATE THERAPEUTICS INC COM 31189P102 138 7,872 SH   DFND   0 7,872 0
FLUIDIGM CORP DEL COM 34385P108 194 14,624 SH   DFND   0 14,624 0
GODADDY INC CL A 380237107 2,447 32,538 SH   DFND   0 32,538 0
GRITSTONE ONCOLOGY INC COM 39868T105 116 8,749 SH   DFND   0 8,749 0
HCA HEALTHCARE INC COM 40412C101 748 5,736 SH   DFND   0 5,736 0
HUMANA INC COM 444859902 2,181 8,200 SH Call DFND   0 8,200 0
HUMANA INC COM 444859102 1,938 7,287 SH   DFND   0 7,287 0
ICU MED INC COM 44930G107 1,316 5,499 SH   DFND   0 5,499 0
INTUIT COM 461202103 2,000 7,651 SH   DFND   0 7,651 0
INVESCO QQQ TR UNIT SER 1 46090E953 4,366 24,300 SH Put DFND   0 24,300 0
IQVIA HLDGS INC COM 46266C105 626 4,349 SH   DFND   0 4,349 0
IRHYTHM TECHNOLOGIES INC COM 450056106 417 5,565 SH   DFND   0 5,565 0
LIVE NATION ENTERTAINMENT IN COM 538034109 1,033 16,256 SH   DFND   0 16,256 0
LYFT INC CL A COM 55087P104 219 2,792 SH   DFND   0 2,792 0
MADISON SQUARE GARDEN CO NEW CL A 55825T103 1,046 3,567 SH   DFND   0 3,567 0
MERIT MED SYS INC COM 589889104 719 11,629 SH   DFND   0 11,629 0
MICROCHIP TECHNOLOGY INC COM 595017104 2,581 31,111 SH   DFND   0 31,111 0
MICROSOFT CORP COM 594918104 1,059 8,978 SH   DFND   0 8,978 0
MIRATI THERAPEUTICS INC COM 60468T105 96 1,309 SH   DFND   0 1,309 0
MOLINA HEALTHCARE INC COM 60855R100 1,041 7,331 SH   DFND   0 7,331 0
MYOKARDIA INC COM 62857M105 799 15,362 SH   DFND   0 15,362 0
NEON THERAPEUTICS INC COM 64050Y100 2,320 359,125 SH   DFND   0 359,125 0
NETFLIX INC COM 64110L106 974 2,731 SH   DFND   0 2,731 0
NEVRO CORP COM 64157F103 575 9,192 SH   DFND   0 9,192 0
NEW YORK TIMES CO CL A 650111107 1,718 52,307 SH   DFND   0 52,307 0
NXP SEMICONDUCTORS N V COM N6596X109 1,008 11,400 SH   DFND   0 11,400 0
PACIRA PHARMACEUTICALS INC COM 695127100 121 3,173 SH   DFND   0 3,173 0
PAYPAL HLDGS INC COM 70450Y103 1,616 15,567 SH   DFND   0 15,567 0
PENUMBRA INC COM 70975L107 1,197 8,144 SH   DFND   0 8,144 0
PERKINELMER INC COM 714046109 667 6,924 SH   DFND   0 6,924 0
PFIZER INC COM 717081103 2,160 50,864 SH   DFND   0 50,864 0
PIVOTAL SOFTWARE INC COM CL A 72582H107 385 18,464 SH   DFND   0 18,464 0
PTC THERAPEUTICS INC COM 69366J200 417 11,083 SH   DFND   0 11,083 0
PUMA BIOTECHNOLOGY INC COM 74587V107 1,066 27,493 SH   DFND   0 27,493 0
QUALCOMM INC COM 747525903 5,720 100,300 SH Call DFND   0 100,300 0
SAGE THERAPEUTICS INC COM 78667J108 340 2,138 SH   DFND   0 2,138 0
SALESFORCE COM INC COM 79466L302 989 6,243 SH   DFND   0 6,243 0
SEA LTD SPONSORED ADS 81141R100 750 31,867 SH   DFND   0 31,867 0
SHOPIFY INC CL A 82509L107 128 620 SH   DFND   0 620 0
SIENNA BIOPHARMACEUTICALS IN COM 82622H108 31 13,247 SH   DFND   0 13,247 0
SPARK THERAPEUTICS INC COM 84652J103 441 3,874 SH   DFND   0 3,874 0
SPDR SERIES TRUST S&P METALS MNG 78464A905 935 31,500 SH Call DFND   0 31,500 0
SPLUNK INC COM 848637104 355 2,848 SH   DFND   0 2,848 0
SQUARE INC CL A 852234103 1,322 17,641 SH   DFND   0 17,641 0
STRYKER CORP COM 863667101 2,293 11,607 SH   DFND   0 11,607 0
TABLEAU SOFTWARE INC CL A 87336U105 489 3,839 SH   DFND   0 3,839 0
THERMO FISHER SCIENTIFIC INC COM 883556102 1,541 5,630 SH   DFND   0 5,630 0
TWILIO INC CL A 90138F102 492 3,810 SH   DFND   0 3,810 0
UNIQURE NV SHS N90064101 203 3,411 SH   DFND   0 3,411 0
UNITEDHEALTH GROUP INC COM 91324P102 2,234 9,035 SH   DFND   0 9,035 0
UNITY BIOTECHNOLOGY INC COM 91381U101 48 5,962 SH   DFND   0 5,962 0
VOYAGER THERAPEUTICS INC COM 92915B106 194 10,136 SH   DFND   0 10,136 0
WAVE LIFE SCIENCES LTD SHS Y95308105 287 7,383 SH   DFND   0 7,383 0
WELLCARE HEALTH PLANS INC COM 94946T906 1,430 5,300 SH Call DFND   0 5,300 0
WELLCARE HEALTH PLANS INC COM 94946T106 1,582 5,866 SH   DFND   0 5,866 0
WRIGHT MED GROUP N V ORD SHS N96617118 348 11,057 SH   DFND   0 11,057 0
ZAI LAB LTD ADR 98887Q104 0 6 SH   DFND   0 6 0
ZIMMER BIOMET HLDGS INC COM 98956P102 2,430 19,030 SH   DFND   0 19,030 0