The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COM 00289Y107 2,944 400,000 SH   DFND 1 400,000 0 0
ACCELERON PHARMA INC COM 00434H108 1,863 40,000 SH   DFND 1 40,000 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 2,519 420,555 SH   DFND 1 420,555 0 0
ALLAKOS INC COM 01671P100 30,375 750,000 SH   DFND 1 750,000 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 12,456 600,000 SH   DFND 1 600,000 0 0
ANAPTYSBIO INC COM 032724106 67,206 920,000 SH   DFND 1 920,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 70,200 3,600,000 SH   DFND 1 3,600,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 11,207 250,000 SH   DFND 1 250,000 0 0
ARGENX SE SPONSORED ADR 04016X101 34,331 275,000 SH   DFND 1 275,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 12,190 500,000 SH   DFND 1 500,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 70,620 600,000 SH   DFND 1 600,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 21,863 550,000 SH   DFND 1 550,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 3,902 100,000 SH   DFND 1 100,000 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 26,750 850,000 SH   DFND 1 850,000 0 0
AVROBIO INC COM 05455M100 6,615 300,000 SH   DFND 1 300,000 0 0
AXONICS MODULATION TECH INC COM 05465P101 30,477 1,272,495 SH   DFND 1 1,272,495 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 56,617 1,100,000 SH   DFND 1 1,100,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 36,023 450,000 SH   DFND 1 450,000 0 0
CELLECTAR BIOSCIENCES-CW19 *W EXP 08/20/201 15117F120 5 52,999 SH   DFND 1 52,999 0 0
CHEMOCENTRYX INC COM 16383L106 35,085 2,525,900 SH   DFND 1 2,525,900 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 3,028 200,000 SH   DFND 1 200,000 0 0
CONSTELLATION PHARMACEUTICALS I COM 210373106 17,231 1,271,687 SH   DFND 1 1,271,687 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 32,148 900,000 SH   DFND 1 900,000 0 0
EIDOS THERAPEUTICS INC COM 28249H104 11,902 507,564 SH   DFND 1 507,564 0 0
GALAPAGOS NV SPON ADR 36315X101 34,965 300,000 SH   DFND 1 300,000 0 0
GENFIT S A ADS 372279109 8,400 350,000 SH   DFND 1 350,000 0 0
GOSSAMER BIO INC COM 38341P102 14,153 653,129 SH   DFND 1 653,129 0 0
HARPOON THERAPEUTICS INC COM 41358P106 6,382 673,891 SH   DFND 1 673,891 0 0
HERON THERAPEUTICS INC COM 427746102 3,666 150,000 SH   DFND 1 150,000 0 0
INCYTE CORP COM 45337C102 2,580 30,000 SH   DFND 1 30,000 0 0
INFLARX NV COM N44821101 97,876 2,590,000 SH   DFND 1 2,590,000 0 0
INSPIRE MED SYS INC COM 457730109 14,195 250,000 SH   DFND 1 250,000 0 0
ITERUM THERAPEUTICS PLC SHS G6333L101 3,198 398,300 SH   DFND 1 398,300 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 23,062 1,300,000 SH   DFND 1 1,300,000 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 4,876 270,000 SH   DFND 1 270,000 0 0
KURA ONCOLOGY INC COM 50127T109 23,226 1,400,000 SH   DFND 1 1,400,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 4,778 607,903 SH   DFND 1 607,903 0 0
MIRATI THERAPEUTICS INC COM 60468T105 78,798 1,075,000 SH   DFND 1 1,075,000 0 0
MYOKARDIA INC COM 62857M105 31,194 600,000 SH   DFND 1 600,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 15,516 650,000 SH   DFND 1 650,000 0 0
NEKTAR THERAPEUTICS COM 640268108 16,800 500,000 SH   DFND 1 500,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 7,929 90,000 SH   DFND 1 90,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 11,628 650,143 SH   DFND 1 650,143 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 150 416,666 SH   DFND 1 416,666 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 7,985 839,642 SH   DFND 1 839,642 0 0
PRECISION BIOSCIENCES INC COM 74019P108 14,001 780,018 SH   DFND 1 780,018 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 48,005 1,411,898 SH   DFND 1 1,411,898 0 0
QUOTIENT LTD SHS G73268107 41,446 4,600,000 SH   DFND 1 4,600,000 0 0
RA PHARMACEUTICALS INC COM 74933V108 8,960 400,000 SH   DFND 1 400,000 0 0
REATA PHARMACEUTICALS INC-A CL A 75615P103 52,564 615,000 SH   DFND 1 615,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 29,818 1,700,000 SH   DFND 1 1,700,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 11,765 650,000 SH   DFND 1 650,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 20,677 130,000 SH   DFND 1 130,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 35,757 300,000 SH   DFND 1 300,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 3,361 178,891 SH   DFND 1 178,891 0 0
SOLID BIOSCIENCES INC COM 83422E105 2,300 250,000 SH   DFND 1 250,000 0 0
TRANSLATE BIO INC COM 89374L104 4,632 454,549 SH   DFND 1 454,549 0 0
TRICIDA INC COM 89610F101 38,990 1,009,586 SH   DFND 1 1,009,586 0 0
TWIST BIOSCIENCE CORP COM 90184D100 16,367 706,064 SH   DFND 1 706,064 0 0
X4 PHARMACEUTICALS INC COM 98420X103 4,400 252,749 SH   DFND 1 252,749 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 83,750 925,000 SH Put DFND 1 925,000 0 0
Y-MABS THERAPEUTICS INC COM 984241109 18,753 715,482 SH   DFND 1 715,482 0 0
ZAI LAB LTD ADR 98887Q104 10,328 350,000 SH   DFND 1 350,000 0 0
ZOGENIX INC COM NEW 98978L204 24,755 450,000 SH   DFND 1 450,000 0 0