The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 24,165 900,000 SH   SOLE   900,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 14,018 150,000 SH   SOLE   150,000 0 0
ANAPTYSBIO INC COM 032724106 8,401 115,000 SH   SOLE   115,000 0 0
ARVINAS INC COM 04335A105 2,583 175,000 SH   SOLE   175,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 45,315 385,000 SH   SOLE   385,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 9,250 185,000 SH Put SOLE   185,000 0 0
AXSOME THERAPEUTICS INC COM 05464T104 4,411 310,000 SH   SOLE   310,000 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 4,070 500,000 SH   SOLE   500,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 7,875 175,000 SH Call SOLE   175,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 6,829 175,000 SH   SOLE   175,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 19,212 240,000 SH   SOLE   240,000 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 9,960 750,000 SH   SOLE   750,000 0 0
CATALYST BIOSCIENCES INC COM NEW 14888D208 811 100,000 SH   SOLE   100,000 0 0
CHIASMA INC COM 16706W102 3,640 700,000 SH   SOLE   700,000 0 0
COHERUS BIOSCIENCES INC COM 19249H103 6,138 450,000 SH   SOLE   450,000 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 6,554 850,000 SH   SOLE   850,000 0 0
EPIZYME INC COM 29428V104 6,195 500,000 SH   SOLE   500,000 0 0
FIBROGEN INC COM 31572Q808 625 11,500 SH   SOLE   11,500 0 0
AMICUS THERAPEUTICS INC COM 03152W109 17,680 1,300,000 SH   SOLE   1,300,000 0 0
INVESCO CURNCYSHS SWISS FRAN SWISS FRANC 46138R108 8,574 91,800 SH   SOLE   91,800 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 15,879 300,000 SH   SOLE   300,000 0 0
GENOCEA BIOSCIENCES INC COM 372427104 1,180 2,000,000 SH   SOLE   2,000,000 0 0
IMMUNOMEDICS INC COM 452907108 15,368 800,000 SH   SOLE   800,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 10,937 1,150,000 SH   SOLE   1,150,000 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 11,448 400,000 SH   SOLE   400,000 0 0
KADMON HLDGS INC COM 48283N106 5,544 2,100,000 SH   SOLE   2,100,000 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 7,265 500,000 SH   SOLE   500,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 10,995 150,000 SH   SOLE   150,000 0 0
OBSEVA SA COM H5861P103 2,558 200,000 SH   SOLE   200,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 5,364 300,000 SH   SOLE   300,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 8,799 700,000 SH   SOLE   700,000 0 0
RA PHARMACEUTICALS INC COM 74933V108 6,720 300,000 SH   SOLE   300,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 10,524 600,000 SH   SOLE   600,000 0 0
RETROPHIN INC COM 761299106 11,315 500,000 SH   SOLE   500,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 11,929 75,000 SH   SOLE   75,000 0 0
SOLID BIOSCIENCES INC COM 83422E105 920 100,000 SH   SOLE   100,000 0 0
TRICIDA INC COM 89610F101 5,793 150,000 SH   SOLE   150,000 0 0
VIEWRAY INC COM 92672L107 5,543 750,000 SH   SOLE   750,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 14,716 80,000 SH   SOLE   80,000 0 0