The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 53,700 2,000,000 SH   DFND 1,2 2,000,000 0 0
ACCELERON PHARMA INC COM 00434H108 50,301 1,080,113 SH   DFND 1,2 1,080,113 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 1,077 131,531 SH   DFND 1,2 131,531 0 0
ARRAY BIOPHARMA INC COM 04269X105 43,884 1,800,000 SH   DFND 1,2 1,800,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 4,876 200,000 SH Call DFND 1,2 200,000 0 0
ASCENDIS PHARMA AS SPONSORED ADR 04351P101 48,846 415,000 SH   DFND 1,2 415,000 0 0
ASCENDIS PHARMA AS SPONSORED ADR 04351P101 23,540 200,000 SH Put DFND 1,2 200,000 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 48,480 5,955,762 SH   DFND 1,2 5,955,762 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 13,265 998,841 SH   DFND 1,2 998,841 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 10,310 959,077 SH   DFND 1,2 959,077 0 0
DERMIRA INC COM 24983L104 20,325 1,500,000 SH   DFND 1,2 1,500,000 0 0
DERMIRA INC COM 24983L104 7,524 555,300 SH Put DFND 1,2 555,300 0 0
EPIZYME INC COM 29428V104 26,935 2,173,913 SH   DFND 1,2 2,173,913 0 0
FIBROGEN INC COM 31572Q808 10,870 200,000 SH Put DFND 1,2 200,000 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 32,139 2,398,409 SH   DFND 1,2 2,398,409 0 0
GENFIT SA ADS 372279109 29,528 1,230,314 SH   DFND 1,2 1,230,314 0 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U108 62,457 1,180,000 SH   DFND 1,2 1,180,000 0 0
INTERCEPT PHARMACEUTICALS INC COM 45845P108 44,744 400,000 SH Put DFND 1,2 400,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 52,945 5,567,348 SH   DFND 1,2 5,567,348 0 0
KRYSTAL BIOTECH INC COM 501147102 16,190 492,100 SH   DFND 1,2 492,100 0 0
KURA ONCOLOGY INC COM 50127T109 43,882 2,645,100 SH   DFND 1,2 2,645,100 0 0
MENLO THERAPEUTICS INC COM 586858102 16,148 2,057,027 SH   DFND 1,2 2,057,027 0 0
MILLENDO THERAPEUTICS INC COM 60040X103 19,321 1,288,093 SH   DFND 1,2 1,288,093 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 4,498 309,564 SH   DFND 1,2 309,564 0 0
NOVAVAX INC COM 670002104 1,377 2,500,000 SH Call DFND 1,2 2,500,000 0 0
NOVAVAX INC COM 670002104 1,102 2,000,000 SH Put DFND 1,2 2,000,000 0 0
NOVAVAX INC COM 670002104 1,102 2,000,000 SH Call DFND 1,2 2,000,000 0 0
PTC THERAPEUTICS INC COM 69366J200 68,289 1,814,260 SH   DFND 1,2 1,814,260 0 0
PROTEOSTASIS THERAPEUTICS INC COM 74373B109 4,410 3,500,000 SH   DFND 1,2 3,500,000 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 34,911 900,000 SH   DFND 1,2 900,000 0 0
SAVARA INC COM 805111101 4,867 660,366 SH   DFND 1,2 660,366 0 0
SOLID BIOSCIENCES INC COM 83422E105 1,840 200,000 SH Call DFND 1,2 200,000 0 0
STREAMLINE HEALTH SOLUTIONS COM 86323X106 137 130,137 SH   DFND 1,2 130,137 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 44,581 379,832 SH   DFND 1,2 379,832 0 0
ZAFGEN INC COM 98885E103 8,524 3,110,874 SH   DFND 1,2 3,110,874 0 0
ZOGENIX INC COM 98978L204 65,987 1,199,545 SH   DFND 1,2 1,199,545 0 0
ZYMEWORKS INC COM 98985W102 236 14,610 SH   DFND 1,2 14,610 0 0
BIOHAVEN PHARMACTL HLDG CO COM G11196105 10,294 200,000 SH Put DFND 1,2 200,000 0 0
OSMOTICA PHARMACEUTICALS PLC SHS G6S41R101 5,400 1,500,000 SH   DFND 1,2 1,500,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 10,114 2,697,133 SH   DFND 1,2 2,697,133 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 61,364 1,572,618 SH   DFND 1,2 1,572,618 0 0