The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ALPHABET INC CAP STK CL A 02079K305 34,772 29,546 SH   DFND 1,2,3,4 29,546 0 0
ALPS ETF TR ALERIAN MLP 00162Q866 8,160 813,561 SH   DFND 1,2,3,4 813,561 0 0
AMAZON COM INC COM 023135106 23,992 13,473 SH   DFND 1,2,3,4 13,473 0 0
ARGENX SE SPONSORED ADR 04016X101 33,775 270,548 SH   DFND 1,2,3,4 270,548 0 0
ASHLAND GLOBAL HLDGS INC COM 044186104 8,831 113,025 SH   DFND 1,2,3,4 113,025 0 0
ATHENEX INC COM 04685N103 6,594 538,291 SH   DFND 1,2,3,4 538,291 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 4,215 108,031 SH   DFND 1,2,3,4 108,031 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 5,147 100,000 SH Call DFND 1,2,3,4 100,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 43,454 844,266 SH   DFND 1,2,3,4 844,266 0 0
BOSTON SCIENTIFIC CORP COM 101137107 21,594 562,641 SH   DFND 1,2,3,4 562,641 0 0
CAMECO CORP COM 13321L108 9,699 822,683 SH   DFND 1,2,3,4 822,683 0 0
CANADIAN PAC RY LTD COM 13645T100 21,740 105,521 SH   DFND 1,2,3,4 105,521 0 0
CELGENE CORP COM 151020104 23,985 254,244 SH   DFND 1,2,3,4 254,244 0 0
CONSTELLIUM NV CL A N22035104 16,503 2,068,005 SH   DFND 1,2,3,4 2,068,005 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 4,294 184,994 SH   DFND 1,2,3,4 184,994 0 0
DELL TECHNOLOGIES INC CL C 24703L202 414 7,050 SH   DFND 1,2,3,4 7,050 0 0
DESTINATION MATERNITY CORP COM 25065D100 381 174,816 SH   DFND 1,2,3,4 174,816 0 0
DOCUSIGN INC COM 256163106 4,399 84,864 SH   DFND 1,2,3,4 84,864 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 9,567 50,000 SH Put DFND 1,2,3,4 50,000 0 0
ELDORADO RESORTS INC COM 28470R102 27,928 598,167 SH   DFND 1,2,3,4 598,167 0 0
FIBROGEN INC COM 31572Q808 5,435 100,000 SH Put DFND 1,2,3,4 100,000 0 0
FLEXION THERAPEUTICS INC COM 33938J106 11,033 884,018 SH   DFND 1,2,3,4 884,018 0 0
GREAT ELM CAP GROUP INC COM NEW 39036P209 5,385 1,267,030 SH   DFND 1,2,3,4 1,267,030 0 0
GTY TECHNOLOGY HOLDINGS INC *W EXP 02/19/202 362409112 241 400,000 SH   DFND 1,2,3,4 400,000 0 0
HERON THERAPEUTICS INC COM 427746102 3,666 150,000 SH Call DFND 1,2,3,4 150,000 0 0
HERON THERAPEUTICS INC COM 427746102 26,595 1,088,166 SH   DFND 1,2,3,4 1,088,166 0 0
IMMUNOGEN INC COM 45253H101 542 200,000 SH Call DFND 1,2,3,4 200,000 0 0
INFLARX NV COM N44821101 6,629 175,414 SH   DFND 1,2,3,4 175,414 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 11,186 100,000 SH Put DFND 1,2,3,4 100,000 0 0
IONIS PHARMACEUTICALS INC COM 462222100 8,117 100,000 SH Put DFND 1,2,3,4 100,000 0 0
IQVIA HLDGS INC COM 46266C105 14,927 103,768 SH   DFND 1,2,3,4 103,768 0 0
KEMPHARM INC NOTE 5.500% 2/0 488445AB3 1,496 3,000,000 PRN   DFND 1,2,3,4 3,000,000 0 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 20,212 231,794 SH   DFND 1,2,3,4 231,794 0 0
LAMB WESTON HLDGS INC COM 513272104 14,708 196,260 SH   DFND 1,2,3,4 196,260 0 0
LATTICE SEMICONDUCTOR CORP COM 518415104 7,975 668,468 SH   DFND 1,2,3,4 668,468 0 0
LIONS GATE ENTMNT CORP CL A VTG 535919401 15,662 1,001,427 SH   DFND 1,2,3,4 1,001,427 0 0
LYFT INC CL A COM 55087P104 431 5,500 SH   DFND 1,2,3,4 5,500 0 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 12,391 622,979 SH   DFND 1,2,3,4 622,979 0 0
MICROSOFT CORP COM 594918104 31,852 270,067 SH   DFND 1,2,3,4 270,067 0 0
MIDDLEBY CORP COM 596278101 34,130 262,481 SH   DFND 1,2,3,4 262,481 0 0
MOLECULAR TEMPLATES INC COM 608550109 2,988 514,225 SH   DFND 1,2,3,4 514,225 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 11,295 552,317 SH   DFND 1,2,3,4 552,317 0 0
NORFOLK SOUTHERN CORP COM 655844108 28,404 151,980 SH   DFND 1,2,3,4 151,980 0 0
ONESPAWORLD HOLDINGS LIMITED COM P73684113 1,417 103,756 SH   DFND 1,2,3,4 103,756 0 0
RAMACO RES INC COM 75134P303 1,602 276,246 SH   DFND 1,2,3,4 276,246 0 0
RAPID7 INC COM 753422104 5,061 100,000 SH   DFND 1,2,3,4 100,000 0 0
RH COM 74967X103 16,398 159,285 SH   DFND 1,2,3,4 159,285 0 0
ROYAL CARIBBEAN CRUISES LTD COM V7780T103 25,605 223,393 SH   DFND 1,2,3,4 223,393 0 0
SALESFORCE COM INC COM 79466L302 12,273 77,494 SH   DFND 1,2,3,4 77,494 0 0
SELECT SECTOR SPDR TR SBI CONS STPLS 81369Y308 550 9,800 SH   DFND 1,2,3,4 9,800 0 0
SESEN BIO INC COM 817763105 5,397 5,239,557 SH   DFND 1,2,3,4 5,239,557 0 0
SOL GEL TECHNOLOGIES SHS M8694L103 1,624 239,949 SH   DFND 1,2,3,4 239,949 0 0
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS 85789A105 2,284 178,453 SH   DFND 1,2,3,4 178,453 0 0
TECK RESOURCES LTD CL B 878742204 12,730 549,191 SH   DFND 1,2,3,4 549,191 0 0
TEMPUR SEALY INTL INC COM 88023U101 20,433 354,309 SH   DFND 1,2,3,4 354,309 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 15,767 57,603 SH   DFND 1,2,3,4 57,603 0 0
TRILOGY METALS INC NEW COM 89621C105 2,470 1,004,135 SH   DFND 1,2,3,4 1,004,135 0 0
TRONOX HOLDINGS PLC SHS G9087Q102 6,512 495,195 SH   DFND 1,2,3,4 495,195 0 0
TYSON FOODS INC CL A 902494103 15,777 227,230 SH   DFND 1,2,3,4 227,230 0 0
WILLSCOT CORP COM 971375126 8,944 806,476 SH   DFND 1,2,3,4 806,476 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 8,399 65,775 SH   DFND 1,2,3,4 65,775 0 0