The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 7,802 97,598 SH   SOLE   97,598 0 0
ABEONA THERAPEUTICS COM 00289Y107 93 12,681 SH   SOLE   12,681 0 0
ABIOMED INC COM 003654100 6,405 22,427 SH   SOLE   1,626 0 20,801
ACCELERON PHARMA COM 00434H108 12,546 269,396 SH   SOLE   131,299 0 138,097
ACELRX PHARMACEUTI COM 00444T100 257 73,778 SH   SOLE   73,778 0 0
ADAMAS PHARMACEUTI COM 00548A106 5,751 808,924 SH   SOLE   414,619 0 394,305
AERIE PHARMACEUTIC COM 00771V108 39,898 839,954 SH   SOLE   469,170 0 370,784
AEGLEA BIOTHERAPEU COM 00773J103 104 12,954 SH   SOLE   12,954 0 0
AGIOS PHARMACEUTIC COM 00847X104 4,046 60,000 SH   SOLE   60,000 0 0
ALBIREO PHARMA INC COM 01345P106 7,826 242,978 SH   SOLE   124,789 0 118,189
ALNYLAM PHARMACUETCL COM 02043Q107 36,543 391,041 SH   SOLE   206,841 0 184,200
AMICUS THERAPEUTICS COM 03152W109 46,167 3,394,623 SH   SOLE   1,560,366 0 1,834,257
ANTARES PHARMA INC COM 036642106 143 47,280 SH   SOLE   47,280 0 0
ANTHEM INC COM 036752103 965 3,361 SH   SOLE   3,361 0 0
APELLIS PHARMACEUTIC COM 03753U106 33,693 1,727,829 SH   SOLE   1,357,866 0 369,963
ARRAY BIOPHARMA INC COM 04269X105 22,185 909,968 SH   SOLE   445,610 0 464,358
ASSEMBLY BIOSCIENCES COM 045396108 14,094 715,798 SH   SOLE   501,698 0 214,100
ATRICURE INC COM 04963C209 10,532 393,123 SH   SOLE   111,836 0 281,287
BECTON DICKINSON COM 075887109 753 3,015 SH   SOLE   3,015 0 0
BEIGENE LIMITED SP ADR 07725L102 1,442 10,927 SH   SOLE   10,927 0 0
BIOMARIN PHARMAC INC COM 09061G101 7,135 80,321 SH   SOLE   80,321 0 0
BIOLINERX LTD SP ADR 09071M106 77 178,297 SH   SOLE   178,297 0 0
BLUEPRINT MEDICINES COM 09627Y109 335 4,184 SH   SOLE   4,184 0 0
BOSTON SCIENTIFIC COM 101137107 9,283 241,876 SH   SOLE   241,876 0 0
BRISTOL MYERS SQUIBB COM 110122108 10,434 218,697 SH   SOLE   218,697 0 0
CIGNA CORP COM 125523100 6,563 40,809 SH   SOLE   40,809 0 0
CELGENE CORP COM 151020104 16,953 179,700 SH   SOLE   179,700 0 0
CENTENE CORP DEL COM 15135B101 222 4,180 SH   SOLE   4,180 0 0
CHEMOCENTRYX INC COM 16383L106 247 17,811 SH   SOLE   17,811 0 0
CIDARA THERAPEUTICS COM 171757107 67 25,447 SH   SOLE   25,447 0 0
CLEARSIDE BIOMEDIC COM 185063104 36 25,959 SH   SOLE   25,959 0 0
COLLEGIUM PHARMACEUT COM 19459J104 14,146 934,334 SH   SOLE   542,666 0 391,668
CORVUS PHARMACEUTI COM 221015100 51 12,594 SH   SOLE   12,594 0 0
CYTOKINETICS INC COM 23282W605 126 15,582 SH   SOLE   15,582 0 0
CYTOMX THERAPEUTIC COM 23284F105 108 10,058 SH   SOLE   10,058 0 0
DERMIRA INC COM 24983L104 568 41,902 SH   SOLE   41,902 0 0
DR REDDYS LABS LTD ADR 256135203 798 19,697 SH   SOLE   19,697 0 0
EVELO BIOSCIENCES COM 299734103 5,209 651,077 SH   SOLE   276,029 0 375,048
EVOLENT HEALTH INC COM 30050B101 15,151 1,204,402 SH   SOLE   478,950 0 725,452
EXACT SCIENCES CORP COM 30063P105 3,326 38,400 SH   SOLE   0 0 38,400
FIBROGEN INC COM 31572Q808 4,416 81,260 SH   SOLE   0 0 81,260
FORTY SEVEN INC COM 34983P104 7,539 466,502 SH   SOLE   280,452 0 186,050
GILEAD SCIENCES INC COM 375558103 28,353 436,140 SH   SOLE   436,140 0 0
GLOBAL BLOOD THERA COM 37890U108 14,468 273,341 SH   SOLE   146,588 0 126,753
GLYCOMIMETICS INC COM 38000Q102 6,828 548,007 SH   SOLE   295,900 0 252,107
HCA HEALTHCARE COM 40412C101 693 5,316 SH   SOLE   5,316 0 0
HMS HOLDINGS CORP COM 40425J101 7,537 254,557 SH   SOLE   12,657 0 241,900
HILL-ROM HLDS INC COM 431475102 16,810 158,799 SH   SOLE   15,800 0 142,999
HUMANA INC COM 444859102 490 1,841 SH   SOLE   1,841 0 0
HUTCHISON CHINA ME SP ADR 44842L103 967 31,628 SH   SOLE   31,628 0 0
IRHYTHM TECHNOLOGIES COM 450056106 6,192 82,600 SH   SOLE   0 0 82,600
IMMUNOGEN INC COM 45253H101 157 58,013 SH   SOLE   58,013 0 0
INSPIRE MED SYS INC COM 457730109 4,877 85,900 SH   SOLE   0 0 85,900
INSULET CORP COM 45784P101 8,640 90,860 SH   SOLE   10,951 0 79,909
JOHNSON & JOHNSON COM 478160104 2,488 17,799 SH   SOLE   17,799 0 0
KALVISTA PHARMACEUTI COM 483497103 502 17,551 SH   SOLE   17,551 0 0
KURA ONCOLOGY INC COM 50127T109 196 11,800 SH   SOLE   11,800 0 0
LA JOLLA PHARMACLS COM 503459604 11,311 1,759,171 SH   SOLE   1,084,227 0 674,944
LILLY ELI & CO COM 532457108 14,464 111,465 SH   SOLE   111,465 0 0
MEI PHARMA INC COM 55279B202 137 44,539 SH   SOLE   44,539 0 0
MADRIGAL PHARMACEUTI COM 558868105 5,322 42,487 SH   SOLE   18,800 0 23,687
MARINUS PHARMACUTCLS COM 56854Q101 70 16,800 SH   SOLE   16,800 0 0
MERCK & CO INC COM 58933Y105 13,698 164,700 SH   SOLE   164,700 0 0
MOLECULAR TEMPLATES COM 608550109 2,033 350,000 SH   SOLE   350,000 0 0
MYOKARDIA INC COM 62857M105 211 4,051 SH   SOLE   4,051 0 0
NIGHTSTAR THERAPEU ADR 65413A101 5,929 233,711 SH   SOLE   233,711 0 0
NOVARTIS AG SP ADR 66987V109 19,617 204,046 SH   SOLE   204,046 0 0
PTC THERAPEUTICS I COM 69366J200 17,432 463,137 SH   SOLE   242,280 0 220,857
PFIZER INC COM 717081103 17,800 419,126 SH   SOLE   419,126 0 0
PORTOLA PHARMACEUTIC COM 737010108 21,145 609,357 SH   SOLE   270,215 0 339,142
PROTAGONIST THERAP COM 74366E102 143 11,400 SH   SOLE   11,400 0 0
PROTEOSTASIS THERA COM 74373B109 2,583 2,050,328 SH   SOLE   1,218,305 0 832,023
RA PHARMACEUTICALS COM 74933V108 15,378 686,513 SH   SOLE   366,990 0 319,523
R1 RCM INC COM 749397105 10,512 1,087,098 SH   SOLE   316,298 0 770,800
REVANCE THERAPEUTI COM 761330109 177 11,234 SH   SOLE   11,234 0 0
SAGE THERAPEUTICS COM 78667J108 5,026 31,600 SH   SOLE   31,600 0 0
SAREPTA THERAPEUTICS COM 803607100 15,268 128,098 SH   SOLE   88,800 0 39,298
SAVARA INC COM 805111101 6,605 896,200 SH   SOLE   514,192 0 382,008
SHOCKWAVE MEDICAL COM 82489T104 28,443 849,811 SH   SOLE   849,811 0 0
SIERRA ONCOLOGY INC COM 82640U107 240 140,376 SH   SOLE   140,376 0 0
SPARK THERAPEUTICS COM 84652J103 405 3,554 SH   SOLE   3,554 0 0
SPRING BK PHARMACE COM 849431101 2,902 276,656 SH   SOLE   276,656 0 0
STEMLINE THERAPEUT COM 85858C107 7,659 596,058 SH   SOLE   310,858 0 285,200
TANDEM DIABETES CARE COM 875372203 8,615 135,667 SH   SOLE   23,367 0 112,300
TELADOC HEALTH COM 87918A105 32,886 591,481 SH   SOLE   179,125 0 412,356
TETRAPHASE PHARMAC COM 88165N105 53 39,821 SH   SOLE   39,821 0 0
THERMO FISHER SCI COM 883556102 1,245 4,549 SH   SOLE   4,549 0 0
UNUM THERAPEUTICS COM 903214104 6,969 1,587,437 SH   SOLE   862,009 0 725,428
UNITEDHEALTH GRP INC COM 91324P102 8,528 34,488 SH   SOLE   34,488 0 0
UNIVERSAL HEALTH SVC CL B 913903100 385 2,881 SH   SOLE   2,881 0 0
VERTEX PHARMACEUTICL COM 92532F100 3,729 20,271 SH   SOLE   20,271 0 0
VIEWRAY INC COM 92672L107 8,301 1,123,264 SH   SOLE   338,969 0 784,295
VOCERA COMMUNICATI COM 92857F107 12,069 381,579 SH   SOLE   136,697 0 244,882
WELLCARE HEALTH PLAN COM 94946T106 4,384 16,251 SH   SOLE   16,251 0 0
ZAI LAB LTD ADR 98887Q104 372 12,589 SH   SOLE   12,589 0 0
ZIMMER BIOMET HLDS COM 98956P102 6,091 47,698 SH   SOLE   47,698 0 0
ALLERGAN PLC SHS G0177J108 12,430 84,900 SH   SOLE   84,900 0 0
BIOHAVEN PHARMACTL COM G11196105 201 3,900 SH   SOLE   3,900 0 0
MEDTRONIC PLC SHS G5960L103 9,468 103,951 SH   SOLE   103,951 0 0
MEIRAGTX HLDINGS PLC COM G59665102 5,529 320,896 SH   SOLE   320,896 0 0
NABRIVA THERAPEUTICS SHS G63637105 93 38,255 SH   SOLE   38,255 0 0
QUOTIENT LTD SHS G73268107 159 17,649 SH   SOLE   17,649 0 0
OBSEVA SA COM H5861P103 8,041 628,692 SH   SOLE   628,692 0 0
INTEC PHARMA LTD JER SHS M53644106 5,930 809,000 SH   SOLE   809,000 0 0
UROGEN PHARMA LTD COM M96088105 2,403 65,063 SH   SOLE   65,063 0 0
WRIGHT MED GROUP N V ORD SHS N96617118 15,765 501,272 SH   SOLE   193,600 0 307,672