The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3-D SYS CORP DEL COM NEW 88554D205 171 16,000 SH   DFND 3 0 16,000 0
3M CO COM 88579Y101 334 1,600 SH   DFND 3 0 1,600 0
ABBOTT LABS COM 002824100 2,374 29,885 SH   DFND 3 0 29,885 0
ABEONA THERAPEUTICS INC COM 00289Y107 719 98,900 SH   DFND 3 0 98,900 0
ACADIA PHARMACEUTICALS INC COM 004225108 1,572 59,000 SH   DFND 3 0 59,000 0
ACER THERAPEUTICS INC COM 00444P108 373 15,700 SH   DFND 3 0 15,700 0
ACTINIUM PHARMACEUTICALS INC COM 00507W107 26 56,283 SH   DFND 3 0 56,283 0
ACTINIUM PHARMACEUTICALS INC COM 00507W107 78 168,851 SH Call DFND 3 0 168,851 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 1,610 223,959 SH   DFND 3 0 223,959 0
ADOBE INC COM 00724F101 237 900 SH   DFND 3 0 900 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 1,400 176,148 SH   DFND 3 0 176,148 0
AGILE THERAPEUTICS INC COM 00847L100 630 411,503 SH   DFND 3 0 411,503 0
AGILENT TECHNOLOGIES INC COM 00846U101 810 10,160 SH   DFND 3 0 10,160 0
AKAMAI TECHNOLOGIES INC COM 00971T101 562 7,900 SH   DFND 3 0 7,900 0
ALBEMARLE CORP COM 012653101 942 11,600 SH   DFND 3 0 11,600 0
ALBIREO PHARMA INC COM 01345P106 6,269 197,005 SH   DFND 3 0 197,005 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 3,113 233,858 SH   DFND 3 0 233,858 0
ALGONQUIN PWR UTILS CORP COM 015857105 670 33,300 SH   DFND 3 0 33,300 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 675 3,700 SH   DFND   0 3,700 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 3,391 19,080 SH   DFND 3 0 19,080 0
ALLENA PHARMACEUTICALS INC COM 018119107 209 29,877 SH   DFND 3 0 29,877 0
ALLERGAN PLC SHS G0177J108 587 4,000 SH   DFND 3 0 4,000 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 4,376 48,300 SH   DFND 3 0 48,300 0
ALPHABET INC CAP STK CL A 02079K305 5,551 4,735 SH   DFND 3 0 4,735 0
ALPHABET INC CAP STK CL C 02079K107 2,829 2,421 SH   DFND 3 0 2,421 0
ALTRIA GROUP INC COM 02209S103 301 5,247 SH   DFND   0 5,247 0
ALTRIA GROUP INC COM 02209S103 2,330 41,100 SH   DFND 3 0 41,100 0
AMAZON COM INC COM 023135106 4,911 2,769 SH   DFND 3 0 2,769 0
AMERICAN EXPRESS CO COM 025816109 1,567 14,355 SH   DFND 3 0 14,355 0
AMERICAN RLTY CAP PPTYS INC NOTE 3.750% 12/1 02917TAB0 28,285 28,319,000 SH   DFND 1 0 28,319,000 0
AMERICAN RLTY CAP PPTYS INC NOTE 3.750% 12/1 02917TAB0 10,488 10,500,000 SH   DFND   0 10,500,000 0
AMERICAN TOWER CORP NEW COM 03027X100 270 1,387 SH   DFND 3 0 1,387 0
AMGEN INC COM 031162100 726 3,870 SH   DFND 3 0 3,870 0
AMICUS THERAPEUTICS INC COM 03152W109 7,816 581,969 SH   DFND 3 0 581,969 0
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 232,932 16,438,356 SH   DFND   0 16,438,356 0
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 44,120 3,113,645 SH   DFND 2 0 3,113,645 0
AMPHENOL CORP NEW CL A 032095101 1,030 10,960 SH   DFND 3 0 10,960 0
ANAPTYSBIO INC COM 032724106 2,121 30,696 SH   DFND 3 0 30,696 0
ANGLOGOLD ASHANTI LTD SPONSORED ADR 035128206 387 30,000 SH   DFND 3 0 30,000 0
ANTARES PHARMA INC COM 036642106 1,769 591,708 SH   DFND 3 0 591,708 0
APACHE CORP COM 037411105 983 28,000 SH   DFND 3 0 28,000 0
APELLIS PHARMACEUTICALS INC COM 03753U106 5,623 294,728 SH   DFND 3 0 294,728 0
APPLE INC COM 037833100 296 1,557 SH   DFND   0 1,557 0
APPLE INC COM 037833100 1,624 8,600 SH   DFND 3 0 8,600 0
APPLIED MATLS INC COM 038222105 308 8,000 SH   DFND 3 0 8,000 0
ARES CAP CORP NOTE 3.750% 2/0 04010LAT0 998 1,000,000 SH   DFND   0 1,000,000 0
ARES CAP CORP NOTE 3.750% 2/0 04010LAT0 29,932 30,000,000 SH   DFND 1 0 30,000,000 0
ARES CAP CORP COM 04010L103 3,059 178,707 SH   DFND 3 0 178,707 0
ARGENX SE SPONSORED ADR 04016X101 6,688 53,705 SH   DFND 3 0 53,705 0
ARQULE INC COM 04269E107 642 138,000 SH   DFND 3 0 138,000 0
ARRAY BIOPHARMA INC COM 04269X105 9,117 384,055 SH   DFND 3 0 384,055 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 543 30,000 SH   DFND 3 0 30,000 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 7,769 67,426 SH   DFND 3 0 67,426 0
ASSEMBLY BIOSCIENCES INC COM 045396108 686 33,993 SH   DFND 3 0 33,993 0
AT&T INC COM 00206R102 915 29,500 SH   DFND 3 0 29,500 0
ATRICURE INC COM 04963C209 5,291 200,559 SH   DFND 3 0 200,559 0
AUDENTES THERAPEUTICS INC COM 05070R104 687 18,427 SH   DFND 3 0 18,427 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 18 11,997 SH   DFND 3 0 11,997 0
AVNET INC COM 053807103 639 15,000 SH   DFND 3 0 15,000 0
AXALTA COATING SYS LTD COM G0750C108 377 15,000 SH   DFND 3 0 15,000 0
BANK AMER CORP COM 060505104 495 18,100 SH   DFND 3 0 18,100 0
BAOZUN INC SPONSORED ADR 06684L103 20,313 488,992 SH   DFND 1 0 488,992 0
BARRICK GOLD CORPORATION COM 067901108 1,430 103,000 SH   DFND 3 0 103,000 0
BECTON DICKINSON & CO COM 075887109 872 3,530 SH   DFND 3 0 3,530 0
BERKSHIRE HATHAWAY INC DEL CL A 084670108 1,505 5 SH   DFND 3 0 5 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 3,170 15,800 SH   DFND 3 0 15,800 0
BEST INC SPONSORED ADS 08653C106 33,170 6,634,021 SH   DFND   0 6,634,021 0
BEYONDSPRING INC SHS G10830100 3,845 240,000 SH   DFND 2 0 240,000 0
BIOGEN INC COM 09062X103 559 2,400 SH   DFND 3 0 2,400 0
BIOLINERX LTD SPONSORED ADS 09071M106 313 730,228 SH   DFND 3 0 730,228 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 8,575 97,650 SH   DFND 3 0 97,650 0
BLACKROCK INC COM 09247X101 1,823 4,290 SH   DFND 3 0 4,290 0
BLACKSTONE GROUP L P COM UNIT LTD 09253U108 1,497 43,250 SH   DFND 3 0 43,250 0
BOOKING HLDGS INC COM 09857L108 4,132 2,390 SH   DFND 3 0 2,390 0
BOSTON BEER INC CL A 100557107 349 1,200 SH   DFND 3 0 1,200 0
BOSTON SCIENTIFIC CORP COM 101137107 293 7,715 SH   DFND 3 0 7,715 0
BRISTOL MYERS SQUIBB CO COM 110122108 3,971 83,000 SH   DFND 3 0 83,000 0
BROADCOM INC COM 11135F101 247 825 SH   DFND 3 0 825 0
BROOKDALE SR LIVING INC COM 112463104 7,060 1,073,000 SH   DFND 1 0 1,073,000 0
BROOKDALE SR LIVING INC COM 112463104 14,338 2,179,078 SH   DFND   0 2,179,078 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 5,914 127,000 SH   DFND 3 0 127,000 0
BROOKFIELD BUSINESS PARTNERS UNIT LTD LP G16234109 3,375 48,530 SH   DFND 3 0 48,530 0
BROOKFIELD RENEWABLE PARTNER PARTNERSHIP UNIT G16258108 5,683 100,000 SH   DFND 3 0 100,000 0
CERUS CORP COM 157085101 3,086 498,538 SH   DFND 3 0 498,538 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 283 802 SH   DFND 3 0 802 0
CHECK CAP LTD SHS M2361E203 344 127,559 SH   DFND 2 0 127,559 0
CHECK CAP LTD *W EXP 02/28/202 M2361E120 43 333,333 SH   DFND 2 0 333,333 0
CHECK POINT SOFTWARE TECH LT ORD M22465104 225 1,800 SH   DFND 3 0 1,800 0
CHEMOCENTRYX INC COM 16383L106 1,222 91,776 SH   DFND 3 0 91,776 0
CHUBB LIMITED COM H1467J104 1,701 12,231 SH   DFND 3 0 12,231 0
CIDARA THERAPEUTICS INC COM 171757107 773 306,686 SH   DFND 3 0 306,686 0
CINTAS CORP COM 172908105 1,204 6,000 SH   DFND 3 0 6,000 0
CISCO SYS INC COM 17275R102 475 8,900 SH   DFND 3 0 8,900 0
CITIGROUP INC COM NEW 172967424 744 12,000 SH   DFND 3 0 12,000 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 6,365 244,826 SH   DFND 3 0 244,826 0
CLEVELAND CLIFFS INC COM 185899101 486 50,000 SH   DFND 3 0 50,000 0
COCA COLA CO COM 191216100 233 5,000 SH   DFND 3 0 5,000 0
COEUR MNG INC COM NEW 192108504 307 72,500 SH   DFND 3 0 72,500 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 3,311 46,250 SH   DFND 3 0 46,250 0
COHERUS BIOSCIENCES INC COM 19249H103 2,641 192,248 SH   DFND 3 0 192,248 0
COLGATE PALMOLIVE CO COM 194162103 1,681 24,950 SH   DFND 3 0 24,950 0
COLONY CAP INC NOTE 5.000% 4/1 19624RAA4 18,909 20,000,000 SH   DFND 1 0 20,000,000 0
COLONY CAP INC NOTE 3.875% 1/1 19624RAB2 38,549 40,000,000 SH   DFND 1 0 40,000,000 0
COLONY CAP INC NEW CL A COM 19626G108 30,955 5,818,564 SH   DFND 1 0 5,818,564 0
COLONY CAP INC NEW CL A COM 19626G108 20,340 3,823,280 SH   DFND   0 3,823,280 0
COMPASS MINERALS INTL INC COM 20451N101 394 7,400 SH   DFND 3 0 7,400 0
COMPUTER TASK GROUP INC COM 205477102 98 22,844 SH   DFND 3 0 22,844 0
CONTRAFECT CORP COM 212326102 2,982 7,453,857 SH   DFND 2 0 7,453,857 0
CORVUS PHARMACEUTICALS INC COM 221015100 669 170,974 SH   DFND 3 0 170,974 0
COSTCO WHSL CORP NEW COM 22160K105 241 1,000 SH   DFND 3 0 1,000 0
COWEN INC CL A NEW 223622606 1,336 92,221 SH   DFND   0 92,221 0
CTI BIOPHARMA CORP COM NEW 12648L601 288 300,428 SH   DFND 3 0 300,428 0
CTRIP COM INTL LTD NOTE 1.990% 7/0 22943FAH3 20,950 18,500,000 SH   DFND 1 0 18,500,000 0
CTRIP COM INTL LTD NOTE 1.250% 9/1 22943FAM2 30,464 30,000,000 SH   DFND 1 0 30,000,000 0
CTRIP COM INTL LTD NOTE 1.000% 7/0 22943FAF7 102 100,000 SH   DFND 3 0 100,000 0
CUMMINS INC COM 231021106 624 4,000 SH   DFND 3 0 4,000 0
CURIS INC COM NEW 231269200 762 396,869 SH   DFND 3 0 396,869 0
CVS HEALTH CORP COM 126650100 420 7,862 SH   DFND 3 0 7,862 0
CYMABAY THERAPEUTICS INC COM 23257D103 4,465 336,205 SH   DFND 1 0 336,205 0
CYMABAY THERAPEUTICS INC COM 23257D103 3,500 263,529 SH   DFND   0 263,529 0
CYMABAY THERAPEUTICS INC COM 23257D103 2,520 192,362 SH   DFND 3 0 192,362 0
CYTOKINETICS INC COM NEW 23282W605 1,981 239,792 SH   DFND 3 0 239,792 0
CYTOMX THERAPEUTICS INC COM 23284F105 551 52,445 SH   DFND 3 0 52,445 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 2,972 128,037 SH   DFND 1 0 128,037 0
DECKERS OUTDOOR CORP COM 243537107 613 4,170 SH   DFND 3 0 4,170 0
DERMIRA INC COM 24983L104 4,358 330,626 SH   DFND 3 0 330,626 0
DEUTSCHE BANK AG NAMEN AKT D18190898 6,466 793,000 SH   DFND 3 0 793,000 0
DICERNA PHARMACEUTICALS INC COM 253031108 2,666 188,673 SH   DFND 3 0 188,673 0
DOVA PHARMACEUTICALS INC COM 25985T102 205 23,088 SH   DFND 2 0 23,088 0
ECOLAB INC COM 278865100 492 2,796 SH   DFND 3 0 2,796 0
EDAP TMS S A SPONSORED ADR 268311107 1,072 363,485 SH   DFND 3 0 363,485 0
EIDOS THERAPEUTICS INC COM 28249H104 2,171 94,270 SH   DFND 3 0 94,270 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,970 145,188 SH   DFND 3 0 145,188 0
ELECTRONIC ARTS INC COM 285512109 579 5,667 SH   DFND 3 0 5,667 0
EMERSON ELEC CO COM 291011104 257 3,810 SH   DFND 3 0 3,810 0
EXXON MOBIL CORP COM 30231G102 1,175 14,550 SH   DFND 3 0 14,550 0
EZCORP INC CL A NON VTG 302301106 112 12,000 SH   DFND 3 0 12,000 0
FACEBOOK INC CL A 30303M102 3,954 23,887 SH   DFND 3 0 23,887 0
FANG HLDGS LTD ADR 30711Y102 18,747 13,886,734 SH   DFND 1 0 13,886,734 0
FANG HLDGS LTD ADR 30711Y102 3,097 2,294,114 SH   DFND   0 2,294,114 0
FIAT CHRYSLER AUTOMOBILES N SHS N31738102 532 36,000 SH   DFND 3 0 36,000 0
FIRST MAJESTIC SILVER CORP COM 32076V103 662 100,000 SH   DFND 3 0 100,000 0
FIRSTENERGY CORP COM 337932107 994 24,000 SH   DFND 3 0 24,000 0
FOOT LOCKER INC COM 344849104 591 9,790 SH   DFND 3 0 9,790 0
FORTIS INC COM 349553107 689 10,330 SH   DFND 3 0 10,330 0
GARMIN LTD SHS H2906T109 2,140 25,000 SH   DFND 3 0 25,000 0
GENERAL DYNAMICS CORP COM 369550108 204 1,204 SH   DFND   0 1,204 0
GENERAL ELECTRIC CO COM 369604103 1,127 114,000 SH   DFND 3 0 114,000 0
GENERAL MTRS CO COM 37045V100 445 12,000 SH   DFND 3 0 12,000 0
GENOCEA BIOSCIENCES INC COM 372427104 345 571,028 SH   DFND 3 0 571,028 0
GILEAD SCIENCES INC COM 375558103 5,733 88,186 SH   DFND   0 88,186 0
GILEAD SCIENCES INC COM 375558103 11,842 182,157 SH   DFND 1 0 182,157 0
GILEAD SCIENCES INC COM 375558103 8,031 126,100 SH   DFND 3 0 126,100 0
GOLD FIELDS LTD NEW SPONSORED ADR 38059T106 372 100,000 SH   DFND 3 0 100,000 0
GOLDCORP INC NEW COM 380956409 164 14,400 SH   DFND 3 0 14,400 0
GOLDMAN SACHS GROUP INC COM 38141G104 765 4,000 SH   DFND 3 0 4,000 0
GRAND CANYON ED INC COM 38526M106 429 3,800 SH   DFND 3 0 3,800 0
GREEN DOT CORP CL A 39304D102 217 3,600 SH   DFND 3 0 3,600 0
HARPOON THERAPEUTICS INC COM 41358P106 1,886 199,200 SH   DFND 1 0 199,200 0
HARPOON THERAPEUTICS INC COM 41358P106 1,176 124,200 SH   DFND   0 124,200 0
HDFC BANK LTD SPONSORED ADS 40415F101 2,643 23,260 SH   DFND 3 0 23,260 0
HERON THERAPEUTICS INC COM 427746102 1,544 65,557 SH   DFND 3 0 65,557 0
HOME DEPOT INC COM 437076102 294 1,531 SH   DFND   0 1,531 0
HOME DEPOT INC COM 437076102 304 1,600 SH   DFND 3 0 1,600 0
HONEYWELL INTL INC COM 438516106 384 2,424 SH   DFND 3 0 2,424 0
HORMEL FOODS CORP COM 440452100 888 20,000 SH   DFND 3 0 20,000 0
IAC INTERACTIVECORP COM 44919P508 1,115 5,300 SH   DFND 3 0 5,300 0
IAMGOLD CORP COM 450913108 524 150,000 SH   DFND 3 0 150,000 0
ILLUMINA INC NOTE 6/1 452327AF6 121 100,000 SH   DFND 3 0 100,000 0
IMMUNOMEDICS INC COM 452907108 4,372 235,433 SH   DFND 3 0 235,433 0
INCYTE CORP COM 45337C102 7,272 84,810 SH   DFND 3 0 84,810 0
INFINITY PHARMACEUTICALS INC COM 45665G303 786 418,296 SH   DFND 3 0 418,296 0
INFOSYS LTD SPONSORED ADR 456788108 652 59,930 SH   DFND 3 0 59,930 0
INTEL CORP COM 458140100 343 6,450 SH   DFND 3 0 6,450 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 289 3,865 SH   DFND 3 0 3,865 0
INTERNATIONAL BUSINESS MACHS COM 459200101 828 5,915 SH   DFND 3 0 5,915 0
INTUIT COM 461202103 815 3,145 SH   DFND 3 0 3,145 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 3,917 413,154 SH   DFND 3 0 413,154 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 4,832 379,853 SH   DFND 3 0 379,853 0
JOHNSON & JOHNSON COM 478160104 592 4,265 SH   DFND 3 0 4,265 0
JPMORGAN CHASE & CO COM 46625H100 313 3,094 SH   DFND   0 3,094 0
JPMORGAN CHASE & CO COM 46625H100 1,030 10,230 SH   DFND 3 0 10,230 0
KADMON HLDGS INC COM 48283N106 422 161,877 SH   DFND 3 0 161,877 0
KALA PHARMACEUTICALS INC COM 483119103 1,904 246,024 SH   DFND 3 0 246,024 0
KALVISTA PHARMACEUTICALS INC COM 483497103 2,028 72,606 SH   DFND 3 0 72,606 0
KELLOGG CO COM 487836108 263 4,620 SH   DFND 3 0 4,620 0
KINROSS GOLD CORP COM 496902404 343 100,000 SH   DFND 3 0 100,000 0
KURA ONCOLOGY INC COM 50127T109 4,972 305,958 SH   DFND 3 0 305,958 0
L BRANDS INC COM 501797104 1,990 72,150 SH   DFND   0 72,150 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 2,743 416,260 SH   DFND 3 0 416,260 0
LAS VEGAS SANDS CORP COM 517834107 1,291 21,400 SH   DFND 3 0 21,400 0
LAUDER ESTEE COS INC CL A 518439104 824 5,010 SH   DFND 3 0 5,010 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 952 181,000 SH   DFND 3 0 181,000 0
LIBERTY GLOBAL PLC SHS CL A G5480U104 934 37,000 SH   DFND 3 0 37,000 0
LIBERTY MEDIA CORP DELAWARE NOTE 1.375%10/1 531229AB8 111 100,000 SH   DFND 3 0 100,000 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 371 3,000 SH   DFND 3 0 3,000 0
LILLY ELI & CO COM 532457108 1,476 11,445 SH   DFND 3 0 11,445 0
LINDE PLC COM G5494J103 1,752 10,168 SH   DFND 3 0 10,168 0
LKQ CORP COM 501889208 1,213 43,000 SH   DFND 3 0 43,000 0
LOGITECH INTL S A SHS H50430232 475 12,560 SH   DFND 3 0 12,560 0
LULULEMON ATHLETICA INC COM 550021109 251 1,500 SH   DFND 3 0 1,500 0
MACQUARIE INFRASTRUCTURE COR NOTE 2.875% 7/1 55608BAA3 100 100,000 SH   DFND 3 0 100,000 0
MACROGENICS INC COM 556099109 1,358 77,573 SH   DFND 3 0 77,573 0
MADDEN STEVEN LTD COM 556269108 281 8,250 SH   DFND 3 0 8,250 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 2,231 80,846 SH   DFND 1 0 80,846 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 5,895 213,585 SH   DFND   0 213,585 0
MANHATTAN ASSOCS INC COM 562750109 218 4,000 SH   DFND 3 0 4,000 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 1,540 390,860 SH   DFND 3 0 390,860 0
MARSH & MCLENNAN COS INC COM 571748102 206 2,220 SH   DFND 3 0 2,220 0
MARTIN MARIETTA MATLS INC COM 573284106 210 1,063 SH   DFND 3 0 1,063 0
MASIMO CORP COM 574795100 478 3,500 SH   DFND 3 0 3,500 0
MASTERCARD INC CL A 57636Q104 5,838 24,858 SH   DFND 3 0 24,858 0
MATCH GROUP INC COM 57665R106 251 4,500 SH   DFND 3 0 4,500 0
MCDONALDS CORP COM 580135101 1,790 9,450 SH   DFND 3 0 9,450 0
MCKESSON CORP COM 58155Q103 935 7,985 SH   DFND   0 7,985 0
MEDICINES CO COM 584688105 1,184 42,500 SH   DFND 3 0 42,500 0
MEDIDATA SOLUTIONS INC COM 58471A105 554 7,600 SH   DFND 3 0 7,600 0
MEDTRONIC PLC SHS G5960L103 2,681 29,800 SH   DFND 3 0 29,800 0
MEET GROUP INC COM 58513U101 256 50,000 SH   DFND 3 0 50,000 0
MEI PHARMA INC COM NEW 55279B202 1,217 396,526 SH   DFND 3 0 396,526 0
MERCADOLIBRE INC COM 58733R102 994 2,000 SH   DFND 3 0 2,000 0
MERCK & CO INC COM 58933Y105 1,837 22,230 SH   DFND 3 0 22,230 0
MICROCHIP TECHNOLOGY INC NOTE 1.625% 2/1 595017AD6 48 30,000 SH   DFND 3 0 30,000 0
MICROCHIP TECHNOLOGY INC NOTE 1.625% 2/1 595017AF1 217 200,000 SH   DFND 3 0 200,000 0
MICROSOFT CORP COM 594918104 3,078 26,325 SH   DFND 3 0 26,325 0
MIDDLEBY CORP COM 596278101 207 1,616 SH   DFND 3 0 1,616 0
MOLECULAR TEMPLATES INC COM 608550109 940 162,991 SH   DFND 3 0 162,991 0
MOMO INC ADR 60879B107 5,808 151,871 SH   DFND 1 0 151,871 0
MOMO INC ADR 60879B107 549 14,352 SH   DFND   0 14,352 0
MONDELEZ INTL INC CL A 609207105 1,120 22,700 SH   DFND 3 0 22,700 0
MORGAN STANLEY COM NEW 617446448 231 5,477 SH   DFND   0 5,477 0
MYLAN N V SHS EURO N59465109 1,063 37,500 SH   DFND 1 0 37,500 0
MYLAN N V SHS EURO N59465109 302 10,660 SH   DFND   0 10,660 0
MYLAN N V SHS EURO N59465109 706 25,000 SH   DFND 3 0 25,000 0
MYOKARDIA INC COM 62857M105 2,696 51,967 SH   DFND 3 0 51,967 0
NABRIVA THERAPEUTICS PLC SHS G63637105 1,593 666,589 SH   DFND 3 0 666,589 0
NATIONAL OILWELL VARCO INC COM 637071101 875 33,000 SH   DFND 3 0 33,000 0
NATURES SUNSHINE PRODUCTS IN COM 639027101 26,519 2,854,607 SH   DFND 2 0 2,854,607 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 8,668 101,323 SH   DFND 3 0 101,323 0
NEWMONT MNG CORP COM 651639106 3,582 100,690 SH   DFND 3 0 100,690 0
NEXTERA ENERGY INC COM 65339F101 455 2,370 SH   DFND 3 0 2,370 0
NIKE INC CL B 654106103 1,644 19,567 SH   DFND 3 0 19,567 0
NORFOLK SOUTHERN CORP COM 655844108 949 5,090 SH   DFND 3 0 5,090 0
NUTRIEN LTD COM 67077M108 559 7,500 SH   DFND 3 0 7,500 0
OBSEVA SA COM H5861P103 2,494 194,991 SH   DFND 3 0 194,991 0
OPKO HEALTH INC COM 68375N103 2,171 858,142 SH   DFND 3 0 858,142 0
ORACLE CORP COM 68389X105 779 14,655 SH   DFND 3 0 14,655 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 4,097 237,783 SH   DFND 2 0 237,783 0
PARATEK PHARMACEUTICALS INC COM 699374302 1,226 227,383 SH   DFND 3 0 227,383 0
PATTERN ENERGY GROUP INC NOTE 4.000% 7/1 70338PAB6 10,062 10,000,000 SH   DFND 1 0 10,000,000 0
PAYPAL HLDGS INC COM 70450Y103 2,187 21,058 SH   DFND 3 0 21,058 0
PEPSICO INC COM 713448108 264 2,165 SH   DFND 3 0 2,165 0
PFIZER INC COM 717081103 787 18,600 SH   DFND 3 0 18,600 0
PHILIP MORRIS INTL INC COM 718172109 1,004 11,500 SH   DFND 3 0 11,500 0
PIERIS PHARMACEUTICALS INC COM 720795103 710 222,693 SH   DFND 3 0 222,693 0
PORTOLA PHARMACEUTICALS INC COM 737010108 2,513 74,800 SH   DFND 3 0 74,800 0
PRICELINE GRP INC NOTE 0.900% 9/1 741503AX4 386 350,000 SH   DFND 3 0 350,000 0
PROCTER AND GAMBLE CO COM 742718109 733 7,075 SH   DFND 3 0 7,075 0
PROGENICS PHARMACEUTICALS IN COM 743187106 2,174 472,580 SH   DFND 3 0 472,580 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 585 47,513 SH   DFND 3 0 47,513 0
PROTALIX BIOTHERAPEUTICS INC COM 74365A101 1,129 2,631,400 SH   DFND 3 0 2,631,400 0
QORVO INC COM 74736K101 306 4,361 SH   DFND 3 0 4,361 0
QUALCOMM INC COM 747525103 1,261 22,300 SH   DFND 3 0 22,300 0
QUANTA SVCS INC COM 74762E102 890 23,800 SH   DFND 3 0 23,800 0
QUOTIENT LTD SHS G73268107 2,448 273,247 SH   DFND 3 0 273,247 0
RA PHARMACEUTICALS INC COM 74933V108 2,418 108,073 SH   DFND 3 0 108,073 0
RETROPHIN INC COM 761299106 1,308 56,837 SH   DFND 3 0 56,837 0
REVANCE THERAPEUTICS INC COM 761330109 7,447 472,532 SH   DFND 1 0 472,532 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 887 29,720 SH   DFND 3 0 29,720 0
ROGERS COMMUNICATIONS INC CL B 775109200 536 5,540 SH   DFND 3 0 5,540 0
SCHLUMBERGER LTD COM 806857108 1,230 28,200 SH   DFND 3 0 28,200 0
SEADRILL LTD COM G7998G106 14,184 1,706,914 SH   DFND 1 0 1,706,914 0
SEATTLE GENETICS INC COM 812578102 8,734 121,605 SH   DFND 3 0 121,605 0
SELECTA BIOSCIENCES INC COM 816212104 938 438,330 SH   DFND 3 0 438,330 0
SINA CORP ORD G81477104 90,182 1,522,312 SH   DFND 1 0 1,522,312 0
SINA CORP ORD G81477104 26,378 445,266 SH   DFND   0 445,266 0
SKYWORKS SOLUTIONS INC COM 83088M102 483 6,000 SH   DFND 3 0 6,000 0
SL GREEN RLTY CORP COM 78440X101 1,796 20,000 SH   DFND 3 0 20,000 0
SOCIEDAD QUIMICA MINERA DE C SPON ADR SER B 833635105 2,355 62,000 SH   DFND 3 0 62,000 0
SOHU COM LTD SPONSORED ADS 83410S108 17,840 1,075,995 SH   DFND 1 0 1,075,995 0
SOLENO THERAPEUTICS INC COM NEW 834203200 397 188,982 SH   DFND 3 0 188,982 0
SOUTHWEST GAS HOLDINGS INC COM 844895102 254 3,070 SH   DFND 3 0 3,070 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108 1,017 95,246 SH   DFND 3 0 95,246 0
SPERO THERAPEUTICS INC COM 84833T103 1,248 103,362 SH   DFND 3 0 103,362 0
SPIRIT AIRLS INC COM 848577102 207 4,000 SH   DFND 3 0 4,000 0
SPIRIT RLTY CAP INC NEW NOTE 2.875% 5/1 84860WAA0 19,984 20,000,000 SH   DFND 1 0 20,000,000 0
SPIRIT RLTY CAP INC NEW NOTE 3.750% 5/1 84860WAB8 30,016 30,000,000 SH   DFND 1 0 30,000,000 0
SPIRIT RLTY CAP INC NEW NOTE 3.750% 5/1 84860WAB8 20,003 19,992,000 SH   DFND   0 19,992,000 0
SPRING BK PHARMACEUTICALS IN COM 849431101 328 31,100 SH   DFND 3 0 31,100 0
STANLEY BLACK & DECKER INC COM 854502101 245 1,820 SH   DFND 3 0 1,820 0
STARBUCKS CORP COM 855244109 2,102 28,425 SH   DFND 3 0 28,425 0
STEMLINE THERAPEUTICS INC COM 85858C107 3,293 267,936 SH   DFND 3 0 267,936 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 863 725,000 SH   DFND 3 0 725,000 0
SYNLOGIC INC COM 87166L100 299 38,438 SH   DFND 3 0 38,438 0
T MOBILE US INC COM 872590104 899 13,000 SH   DFND 3 0 13,000 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 1,417 35,120 SH   DFND 3 0 35,120 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 746 48,000 SH   DFND 3 0 48,000 0
THE CHARLES SCHWAB CORPORATI COM 808513105 811 19,000 SH   DFND 3 0 19,000 0
THERAVANCE BIOPHARMA INC COM G8807B106 2,386 104,465 SH   DFND 3 0 104,465 0
THERMO FISHER SCIENTIFIC INC COM 883556102 1,189 4,400 SH   DFND 3 0 4,400 0
THOR INDS INC COM 885160101 475 7,610 SH   DFND 3 0 7,610 0
TOTAL S A SPONSORED ADS 89151E109 330 6,000 SH   DFND 3 0 6,000 0
TRANSGLOBE ENERGY CORP COM 893662106 5,719 2,422,923 SH   DFND 1 0 2,422,923 0
TRANSLATE BIO INC COM 89374L104 1,138 115,488 SH   DFND 3 0 115,488 0
TWITTER INC NOTE 0.250% 9/1 90184LAB8 738 750,000 SH   DFND   0 750,000 0
TWITTER INC NOTE 0.250% 9/1 90184LAB8 73,149 74,300,000 SH   DFND 1 0 74,300,000 0
UBS GROUP AG SHS H42097107 2,023 170,925 SH   DFND 3 0 170,925 0
ULTA BEAUTY INC COM 90384S303 207 600 SH   DFND 3 0 600 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 3,153 46,144 SH   DFND 3 0 46,144 0
UNITEDHEALTH GROUP INC COM 91324P102 2,730 11,270 SH   DFND 3 0 11,270 0
VBI VACCINES INC COM NEW 91822J103 1,369 732,081 SH   DFND 3 0 732,081 0
VEON LTD SPONSORED ADR 91822M106 1,381 660,608 SH   DFND 1 0 660,608 0
VERISIGN INC COM 92343E102 272 1,500 SH   DFND 3 0 1,500 0
VERIZON COMMUNICATIONS INC COM 92343V104 350 5,925 SH   DFND 3 0 5,925 0
VERRICA PHARMACEUTICALS INC COM 92511W108 3,588 331,933 SH   DFND 1 0 331,933 0
VERRICA PHARMACEUTICALS INC COM 92511W108 4,998 462,346 SH   DFND   0 462,346 0
VIEWRAY INC COM 92672L107 121,722 16,471,258 SH   DFND   0 16,471,258 0
VIKING THERAPEUTICS INC COM 92686J106 589 69,203 SH   DFND 3 0 69,203 0
VIPSHOP HLDGS LTD SPONSORED ADS A 92763W103 8,372 1,042,588 SH   DFND   0 1,042,588 0
VISA INC COM CL A 92826C839 4,205 27,190 SH   DFND 3 0 27,190 0
WASTE MGMT INC DEL COM 94106L109 1,720 16,630 SH   DFND 3 0 16,630 0
WAVE LIFE SCIENCES LTD SHS Y95308105 2,237 59,088 SH   DFND 3 0 59,088 0
WELLS FARGO CO NEW COM 949746101 235 4,795 SH   DFND 3 0 4,795 0
WORKDAY INC CL A 98138H101 932 4,900 SH   DFND 3 0 4,900 0
WORKDAY INC NOTE 0.250%10/0 98138HAF8 140 100,000 SH   DFND 3 0 100,000 0
XOMA CORP DEL COM NEW 98419J206 3,346 269,877 SH   DFND 3 0 269,877 0
XYLEM INC COM 98419M100 270 3,420 SH   DFND 3 0 3,420 0
YAMANA GOLD INC COM 98462Y100 44 17,000 SH   DFND 3 0 17,000 0
YY INC SPONSORED ADS A 98426T106 307 3,649 SH   DFND   0 3,649 0
ZIX CORP COM 98974P100 113 17,000 SH   DFND 3 0 17,000 0
ZOGENIX INC COM NEW 98978L204 2,492 45,700 SH   DFND 3 0 45,700 0