The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris Therapeutics COMM 00461U105 14,127 1,911,573 SH   SOLE   1,911,573 0 0
Amarin ADR 023111206 70,885 5,208,305 SH   SOLE   5,208,305 0 0
Apellis Pharmaceuticals, Inc COMM 03753U106 654 49,580 SH   SOLE   49,580 0 0
Ascendis Pharma A/S ADR 04351P101 93,883 1,498,538 SH   SOLE   1,498,538 0 0
Audentes Therapeutics COMM 05070R104 19,905 933,640 SH   SOLE   933,640 0 0
Chiasma COMM 16706W102 5,070 1,630,221 SH   SOLE   1,630,221 0 0
Coherus BioSciences COMM 19249H103 25,957 2,868,221 SH   SOLE   2,868,221 0 0
Edge Therapeutics COMM 279870109 916 2,852,711 SH   SOLE   2,852,711 0 0
Entasis Therapeutics Holdings Inc. COMM 293614103 4,803 1,180,178 SH   SOLE   1,180,178 0 0
Iterum Therapeutics COMM G6333L101 8,650 1,726,514 SH   SOLE   1,726,514 0 0
Kiniksa Pharmaceuticals, Ltd COMM CL A G5269C101 25,919 922,700 SH   SOLE   922,700 0 0
Merus N.V. COMM N5749R100 27,455 1,961,039 SH   SOLE   1,961,039 0 0
Natera COMM 632307104 43,284 3,100,560 SH   SOLE   3,100,560 0 0
Nucana Biomed Ltd ADR 67022C106 32,867 2,266,666 SH   SOLE   2,266,666 0 0
Nucana Biomed Ltd Ordinary Sh GB00BYWYV 34,800 2,400,000 SH   SOLE   2,400,000 0 0
ObsEva SA COMM H5861P103 60,130 4,749,623 SH   SOLE   4,749,623 0 0
Principia Biopharma COMM 74257L108 55,827 2,038,208 SH   SOLE   2,038,208 0 0
Spark Therapeutics COMM 84652J103 18,837 481,270 SH   SOLE   481,270 0 0
Synlogic Inc. (fmrly Mirna) COMM 87166L100 4,031 574,972 SH   SOLE   574,972 0 0
Y-mAbs Therapeutics, Inc COMM 984241109 42,801 2,104,278 SH   SOLE   2,104,278 0 0
Aimmune Therapeutics Inc COMM 00900T107 633 26,467 SH   SOLE   26,467 0 0
Amicus Therapeutics Inc COMM 03152W109 972 101,505 SH   SOLE   101,505 0 0
AnaptysBio Inc COMM 032724106 240 3,769 SH   SOLE   3,769 0 0
AstraZeneca PLC ADR 046353108 1,811 47,681 SH   SOLE   47,681 0 0
Biohaven Pharmaceutical Holding Company Ltd COMM G11196105 543 14,673 SH   SOLE   14,673 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 1,804 21,184 SH   SOLE   21,184 0 0
Clovis Oncology Inc COMM 189464100 778 43,342 SH   SOLE   43,342 0 0
Conatus Pharmaceuticals Inc COMM 20600T108 166 96,139 SH   SOLE   96,139 0 0
Deciphera Pharmaceuticals Inc COMM 24344T101 839 39,992 SH   SOLE   39,992 0 0
Dermira Inc COMM 24983L104 587 81,685 SH   SOLE   81,685 0 0
Epizyme Inc COMM 29428V104 519 84,246 SH   SOLE   84,246 0 0
Fate Therapeutics Inc COMM 31189P102 444 34,621 SH   SOLE   34,621 0 0
FibroGen Inc COMM 31572Q808 558 12,051 SH   SOLE   12,051 0 0
Five Prime Therapeutics Inc COMM 33830X104 442 47,504 SH   SOLE   47,504 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 450 125,378 SH   SOLE   125,378 0 0
GW Pharmaceuticals PLC ADR 36197T103 440 4,519 SH   SOLE   4,519 0 0
Gilead Sciences Inc COMM 375558103 2,011 32,156 SH   SOLE   32,156 0 0
Heron Therapeutics Inc COMM 427746102 1,406 54,197 SH   SOLE   54,197 0 0
ImmunoGen Inc COMM 45253H101 323 67,348 SH   SOLE   67,348 0 0
Incyte Corp COMM 45337C102 1,806 28,396 SH   SOLE   28,396 0 0
Intercept Pharmaceuticals Inc COMM 45845P108 827 8,201 SH   SOLE   8,201 0 0
Kadmon Holdings Inc COMM 48283N106 510 244,958 SH   SOLE   244,958 0 0
Kala Pharmaceuticals Inc COMM 483119103 320 65,517 SH   SOLE   65,517 0 0
MacroGenics Inc COMM 556099109 637 50,152 SH   SOLE   50,152 0 0
MorphoSys AG COMM D55040105 1,237 12,126 SH   SOLE   12,126 0 0
Neurocrine Biosciences Inc COMM 64125C109 662 9,264 SH   SOLE   9,264 0 0
Orchard Therapeutics PLC ADR 68570P101 505 32,081 SH   SOLE   32,081 0 0
Osmotica Pharmaceuticals PLC COMM G6S41R101 286 36,901 SH   SOLE   36,901 0 0
Otonomy Inc COMM 68906L105 285 154,237 SH   SOLE   154,237 0 0
Pacira Pharmaceuticals Inc COMM 695127100 110 2,562 SH   SOLE   2,562 0 0
Puma Biotechnology Inc COMM 74587V107 584 28,693 SH   SOLE   28,693 0 0
Reata Pharmaceuticals Inc COMM 75615P103 1,336 23,813 SH   SOLE   23,813 0 0
Rigel Pharmaceuticals Inc COMM 766559603 1,168 508,013 SH   SOLE   508,013 0 0
Sanofi SA ADR 80105N105 2,141 49,315 SH   SOLE   49,315 0 0
Sarepta Therapeutics Inc COMM 803607100 804 7,363 SH   SOLE   7,363 0 0
Savara Inc COMM 805111101 852 112,569 SH   SOLE   112,569 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 235 52,741 SH   SOLE   52,741 0 0
TESARO Inc COMM 881569107 1,491 20,083 SH   SOLE   20,083 0 0
Xencor Inc COMM 98401F105 1,088 30,080 SH   SOLE   30,080 0 0
Aimmune Therapeutics Inc COMM 00900T107 2,406 100,567 SH   OTR 2 100,567 0 0
Amicus Therapeutics Inc COMM 03152W109 3,701 386,359 SH   OTR 2 386,359 0 0
AnaptysBio Inc COMM 032724106 913 14,315 SH   OTR 2 14,315 0 0
AstraZeneca PLC ADR 046353108 6,873 180,956 SH   OTR 2 180,956 0 0
Biohaven Pharmaceutical Holding Company Ltd COMM G11196105 2,061 55,733 SH   OTR 2 55,733 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 6,846 80,397 SH   OTR 2 80,397 0 0
Clovis Oncology Inc COMM 189464100 2,958 164,681 SH   OTR 2 164,681 0 0
Conatus Pharmaceuticals Inc COMM 20600T108 632 365,126 SH   OTR 2 365,126 0 0
Deciphera Pharmaceuticals Inc COMM 24344T101 3,188 151,881 SH   OTR 2 151,881 0 0
Dermira Inc COMM 24983L104 2,231 310,232 SH   OTR 2 310,232 0 0
Epizyme Inc COMM 29428V104 1,984 322,104 SH   OTR 2 322,104 0 0
Fate Therapeutics Inc COMM 31189P102 1,687 131,478 SH   OTR 2 131,478 0 0
FibroGen Inc COMM 31572Q808 2,118 45,769 SH   OTR 2 45,769 0 0
Five Prime Therapeutics Inc COMM 33830X104 1,678 180,415 SH   OTR 2 180,415 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 1,709 476,173 SH   OTR 2 476,173 0 0
GW Pharmaceuticals PLC ADR 36197T103 1,672 17,164 SH   OTR 2 17,164 0 0
Gilead Sciences Inc COMM 375558103 7,633 122,036 SH   OTR 2 122,036 0 0
Heron Therapeutics Inc COMM 427746102 5,338 205,779 SH   OTR 2 205,779 0 0
ImmunoGen Inc COMM 45253H101 1,228 255,781 SH   OTR 2 255,781 0 0
Incyte Corp COMM 45337C102 6,858 107,841 SH   OTR 2 107,841 0 0
Intercept Pharmaceuticals Inc COMM 45845P108 3,139 31,145 SH   OTR 2 31,145 0 0
Kadmon Holdings Inc COMM 48283N106 1,992 957,858 SH   OTR 2 957,858 0 0
Kala Pharmaceuticals Inc COMM 483119103 1,232 252,044 SH   OTR 2 252,044 0 0
MacroGenics Inc COMM 556099109 2,419 190,468 SH   OTR 2 190,468 0 0
MorphoSys AG COMM D55040105 4,700 46,066 SH   OTR 2 46,066 0 0
Neurocrine Biosciences Inc COMM 64125C109 2,513 35,185 SH   OTR 2 35,185 0 0
Orchard Therapeutics PLC ADR 68570P101 1,944 123,580 SH   OTR 2 123,580 0 0
Osmotica Pharmaceuticals PLC COMM G6S41R101 1,094 141,191 SH   OTR 2 141,191 0 0
Otonomy Inc COMM 68906L105 1,084 585,775 SH   OTR 2 585,775 0 0
Pacira Pharmaceuticals Inc COMM 695127100 418 9,721 SH   OTR 2 9,721 0 0
Puma Biotechnology Inc COMM 74587V107 2,219 109,058 SH   OTR 2 109,058 0 0
Reata Pharmaceuticals Inc COMM 75615P103 5,069 90,354 SH   OTR 2 90,354 0 0
Rigel Pharmaceuticals Inc COMM 766559603 4,439 1,930,092 SH   OTR 2 1,930,092 0 0
Sanofi SA ADR 80105N105 8,125 187,162 SH   OTR 2 187,162 0 0
Sarepta Therapeutics Inc COMM 803607100 3,053 27,973 SH   OTR 2 27,973 0 0
Savara Inc COMM 805111101 3,241 428,087 SH   OTR 2 428,087 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 891 200,306 SH   OTR 2 200,306 0 0
TESARO Inc COMM 881569107 5,747 77,403 SH   OTR 2 77,403 0 0
Xencor Inc COMM 98401F105 4,131 114,239 SH   OTR 2 114,239 0 0
Aimmune Therapeutics Inc COMM 00900T107 1,166 48,741 SH   OTR 1 48,741 0 0
Amicus Therapeutics Inc COMM 03152W109 1,789 186,772 SH   OTR 1 186,772 0 0
AnaptysBio Inc COMM 032724106 442 6,936 SH   OTR 1 6,936 0 0
AstraZeneca PLC ADR 046353108 3,331 87,691 SH   OTR 1 87,691 0 0
Biohaven Pharmaceutical Holding Company Ltd COMM G11196105 1,000 27,039 SH   OTR 1 27,039 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 3,318 38,961 SH   OTR 1 38,961 0 0
Clovis Oncology Inc COMM 189464100 1,432 79,746 SH   OTR 1 79,746 0 0
Conatus Pharmaceuticals Inc COMM 20600T108 306 176,932 SH   OTR 1 176,932 0 0
Deciphera Pharmaceuticals Inc COMM 24344T101 1,545 73,602 SH   OTR 1 73,602 0 0
Dermira Inc COMM 24983L104 1,081 150,307 SH   OTR 1 150,307 0 0
Epizyme Inc COMM 29428V104 969 157,305 SH   OTR 1 157,305 0 0
Fate Therapeutics Inc COMM 31189P102 817 63,714 SH   OTR 1 63,714 0 0
FibroGen Inc COMM 31572Q808 1,026 22,180 SH   OTR 1 22,180 0 0
Five Prime Therapeutics Inc COMM 33830X104 813 87,425 SH   OTR 1 87,425 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 828 230,742 SH   OTR 1 230,742 0 0
GW Pharmaceuticals PLC ADR 36197T103 810 8,317 SH   OTR 1 8,317 0 0
Gilead Sciences Inc COMM 375558103 3,699 59,139 SH   OTR 1 59,139 0 0
Heron Therapeutics Inc COMM 427746102 2,587 99,737 SH   OTR 1 99,737 0 0
ImmunoGen Inc COMM 45253H101 595 123,946 SH   OTR 1 123,946 0 0
Incyte Corp COMM 45337C102 3,323 52,260 SH   OTR 1 52,260 0 0
Intercept Pharmaceuticals Inc COMM 45845P108 1,525 15,126 SH   OTR 1 15,126 0 0
Kadmon Holdings Inc COMM 48283N106 933 448,356 SH   OTR 1 448,356 0 0
Kala Pharmaceuticals Inc COMM 483119103 626 127,955 SH   OTR 1 127,955 0 0
MacroGenics Inc COMM 556099109 1,172 92,301 SH   OTR 1 92,301 0 0
MorphoSys AG COMM D55040105 2,280 22,344 SH   OTR 1 22,344 0 0
Neurocrine Biosciences Inc COMM 64125C109 1,218 17,051 SH   OTR 1 17,051 0 0
Orchard Therapeutics PLC ADR 68570P101 1,053 66,957 SH   OTR 1 66,957 0 0
Osmotica Pharmaceuticals PLC COMM G6S41R101 581 74,997 SH   OTR 1 74,997 0 0
Otonomy Inc COMM 68906L105 525 283,853 SH   OTR 1 283,853 0 0
Pacira Pharmaceuticals Inc COMM 695127100 203 4,711 SH   OTR 1 4,711 0 0
Puma Biotechnology Inc COMM 74587V107 1,076 52,876 SH   OTR 1 52,876 0 0
Reata Pharmaceuticals Inc COMM 75615P103 2,458 43,817 SH   OTR 1 43,817 0 0
Rigel Pharmaceuticals Inc COMM 766559603 2,171 944,069 SH   OTR 1 944,069 0 0
Sanofi SA ADR 80105N105 3,937 90,698 SH   OTR 1 90,698 0 0
Sarepta Therapeutics Inc COMM 803607100 1,480 13,558 SH   OTR 1 13,558 0 0
Savara Inc COMM 805111101 1,618 213,716 SH   OTR 1 213,716 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 432 97,063 SH   OTR 1 97,063 0 0
TESARO Inc COMM 881569107 2,733 36,811 SH   OTR 1 36,811 0 0
Xencor Inc COMM 98401F105 2,002 55,363 SH   OTR 1 55,363 0 0