The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AMAG PHARMACEUTICALS INC COM 00163U106 10,097 664,681 SH   DFND 1,2 664,681 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 44,504 2,752,256 SH   DFND 1,2 2,752,256 0 0
ACCELERON PHARMA INC COM 00434H108 45,143 1,036,575 SH   DFND 1,2 1,036,575 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 2,931 40,197 SH   DFND 1,2 40,197 0 0
ARGENX SE SPONSORED ADR 04016X101 1,777 18,500 SH   DFND 1,2 18,500 0 0
ARRAY BIOPHARMA INC COM 04269X105 26,363 1,850,000 SH   DFND 1,2 1,850,000 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 61,512 7,622,256 SH   DFND 1,2 7,622,256 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 11,164 1,418,489 SH   DFND 1,2 1,418,489 0 0
CYTOKINETICS INC COM 23282W605 20,055 3,173,288 SH   DFND 1,2 3,173,288 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 10,163 143,481 SH   DFND 1,2 143,481 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 22,305 2,398,409 SH   DFND 1,2 2,398,409 0 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U108 48,439 1,180,000 SH   DFND 1,2 1,180,000 0 0
INTERCEPT PHARMACEUTICALS INC COM 45845P108 20,158 200,000 SH Put DFND 1,2 200,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 2,278 200,000 SH Put DFND 1,2 200,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 2,278 200,000 SH Put DFND 1,2 200,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 49,271 5,567,348 SH   DFND 1,2 5,567,348 0 0
KRYSTAL BIOTECH INC COM 501147102 10,226 492,100 SH   DFND 1,2 492,100 0 0
KURA ONCOLOGY INC COM 50127T109 38,884 2,769,527 SH   DFND 1,2 2,769,527 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 3,100 27,500 SH   DFND 1,2 27,500 0 0
MENLO THERAPEUTICS INC COM 586858102 9,082 2,204,407 SH   DFND 1,2 2,204,407 0 0
MILLENDO THERAPEUTICS INC COM 60040X103 10,240 1,288,093 SH   DFND 1,2 1,288,093 0 0
NOVAVAX INC COM 670002104 4,600 2,500,000 SH Call DFND 1,2 2,500,000 0 0
NOVAVAX INC COM 670002104 3,680 2,000,000 SH Call DFND 1,2 2,000,000 0 0
PTC THERAPEUTICS INC COM 69366J200 42,042 1,225,000 SH   DFND 1,2 1,225,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 6,431 955,618 SH   DFND 1,2 955,618 0 0
PROTEOSTASIS THERAPEUTICS INC COM 74373B109 9,867 3,045,423 SH   DFND 1,2 3,045,423 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 28,077 1,379,700 SH   DFND 1,2 1,379,700 0 0
SAGE THERAPEUTICS INC COM 78667J108 2,491 26,000 SH Put DFND 1,2 26,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 2,491 26,000 SH Call DFND 1,2 26,000 0 0
SAVARA INC CMN COM 805111101 13,771 1,819,195 SH   DFND 1,2 1,819,195 0 0
SPARK THERAPEUTICS INC COM 84652J103 24,682 630,600 SH   DFND 1,2 630,600 0 0
STREAMLINE HEALTH SOLUTIONS COM 86323X106 105 130,137 SH   DFND 1,2 130,137 0 0
SUNESIS PHARMACEUTICALS INC COM 867328700 132 317,962 SH   DFND 1,2 317,962 0 0
TG THERAPEUTICS INC COM 88322Q108 12,300 3,000,000 SH   DFND 1,2 3,000,000 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 38,202 350,800 SH   DFND 1,2 350,800 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 33,142 200,000 SH Put DFND 1,2 200,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 3,432 365,132 SH   DFND 1,2 365,132 0 0
ZAFGEN INC COM 98885E103 17,812 3,598,392 SH   DFND 1,2 3,598,392 0 0
ZOGENIX INC COM 98978L204 36,460 1,000,000 SH   DFND 1,2 1,000,000 0 0
OSMOTICA PHARMACEUTICALS PLC SHS G6S41R101 11,625 1,500,000 SH   DFND 1,2 1,500,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 14,531 4,047,561 SH   DFND 1,2 4,047,561 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 35,346 1,657,873 SH   DFND 1,2 1,657,873 0 0