The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ASCENDIS PHARMA A S COM 04351P951 22,554 360,000 SH Put SOLE   360,000 0 0
ASCENDIS PHARMA A S COM 04351P901 15,688 250,400 SH Call SOLE   250,400 0 0
CELGENE CORP COM 151020904 12,498 195,000 SH Call SOLE   195,000 0 0
FIBROGEN INC COM 31572Q908 38,912 840,800 SH Call SOLE   840,800 0 0
GILEAD SCIENCES INC COM 375558903 17,833 285,100 SH Call SOLE   285,100 0 0
IRONWOOD PHARMACEUTICALS INC COM 46333X908 909 87,700 SH Call SOLE   87,700 0 0
IRONWOOD PHARMACEUTICALS INC COM 46333X908 11,236 1,084,600 SH Call SOLE   1,084,600 0 0
NEKTAR THERAPEUTICS COM 640268908 10,410 316,700 SH Call SOLE   316,700 0 0
AKCEA THERAPEUTICS INC COM 00972L107 19,282 639,743 SH   SOLE   639,743 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 12,568 3,281,502 SH   SOLE   3,281,502 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 4,535 613,728 SH   SOLE   613,728 0 0
AFFIMED N V COM N01045108 492 158,221 SH   SOLE   158,221 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 4,894 2,265,880 SH   SOLE   2,265,880 0 0
ARRAY BIOPHARMA INC COM 04269X105 9,177 644,002 SH   SOLE   644,002 0 0
ARVINAS INC COM 04335A105 643 50,000 SH   SOLE   50,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 54,398 2,404,853 SH   SOLE   2,404,853 0 0
CHIASMA INC COM 16706W102 1,181 379,753 SH   SOLE   379,753 0 0
CONSTELLATION PHARMACEUTICALS INC COM 210373106 318 79,194 SH   SOLE   79,194 0 0
CURIS INC COM 231269200 2,057 2,982,208 SH   SOLE   2,982,208 0 0
CRISPR THERAPEUTICS AG COM H17182108 5,967 208,850 SH   SOLE   208,850 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 1,084 295,420 SH   SOLE   295,420 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 35,452 3,316,407 SH   SOLE   3,316,407 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 16,212 1,595,643 SH   SOLE   1,595,643 0 0
FIBROGEN INC COM 31572Q808 70,556 1,524,557 SH   SOLE   1,524,557 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 3,039 326,775 SH   SOLE   326,775 0 0
IMMUNE DESIGN CORP COM 45252L103 7,284 5,603,191 SH   SOLE   5,603,191 0 0
IONIS PHARMACEUTICALS INC COM 462222100 39,211 725,326 SH   SOLE   725,326 0 0
IRONWOOD PHARMACEUTICALS INC COM 46333X108 55,750 5,381,282 SH   SOLE   5,381,282 0 0
KURA ONCOLOGY INC COM 50127T109 74,086 5,276,753 SH   SOLE   5,276,753 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 25,016 1,060,018 SH   SOLE   1,060,018 0 0
UNITY BIOTECHNOLOGY INC COM 91381U101 15,725 967,114 SH   SOLE   967,114 0 0
MIRATI THERAPEUTICS INC COM 60468T105 27,453 647,169 SH   SOLE   647,169 0 0
MYOKARDIA INC COM 62857M105 11,452 234,381 SH   SOLE   234,381 0 0
SPARK THERAPEUTICS INC COM 84652J103 44,496 1,136,851 SH   SOLE   1,136,851 0 0
ONCONOVA THERAPEUTICS INC COM 68232V405 893 423,441 SH   SOLE   423,441 0 0
PROQR THERAPEUTICS N V COM N71542109 174 11,022 SH   SOLE   11,022 0 0
PROTHENA CORP PLC COM G72800108 8,634 838,219 SH   SOLE   838,219 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 6,669 450,000 SH   SOLE   450,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109 13,177 1,223,495 SH   SOLE   1,223,495 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 10,775 400,838 SH   SOLE   400,838 0 0
SANGAMO THERAPEUTICS INC COM 800677106 13,613 1,185,831 SH   SOLE   1,185,831 0 0
SOLID BIOSCIENCES INC COM 83422E105 23,242 867,246 SH   SOLE   867,246 0 0
SCHOLAR ROCK HOLDING CORP COM 80706P103 33,863 1,474,228 SH   SOLE   1,474,228 0 0
SURFACE ONCOLOGY INC COM 86877M209 9,588 2,261,328 SH   SOLE   2,261,328 0 0
WAVE LIFE SCIENCES LTD COM Y95308105 9,835 233,933 SH   SOLE   233,933 0 0
XENCOR INC COM 98401F105 35,763 989,018 SH   SOLE   989,018 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 7,863 1,379,487 SH   SOLE   1,379,487 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 4,838 247,858 SH   SOLE   247,858 0 0
DYNAVAX TECHNOLOGIES CORP COM 268158201 1,282 140,118 SH   SOLE   140,118 0 0
CORCEPT THERAPEUTICS INC COM 218352102 2,218 166,005 SH   SOLE   166,005 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 9,521 592,128 SH   SOLE   592,128 0 0
ARGENX SE SPONSORED ADR 04016X101 79,266 825,087 SH   SOLE   825,087 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 42,586 679,746 SH   SOLE   679,746 0 0
ZAI LAB LTD SPONSORED ADR 98887Q104 13,221 569,377 SH   SOLE   569,377 0 0