The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 82,796 1,144,699 SH   DFND   0 1,144,699 0
ACCURAY INC COM 004397105 9,366 2,746,636 SH   DFND   0 2,746,636 0
ACORDA THERAPEUTICS INC COM 00484M906 27,093 1,739,000 SH Call DFND   0 1,739,000 0
ACORDA THERAPEUTICS INC COM 00484M106 17,273 1,108,659 SH   DFND   0 1,108,659 0
ACORDA THERAPEUTICS INC NOTE 1.750% 6/1 00484MAA4 75,652 90,886,000 PRN   DFND   0 90,886,000 0
ACTIVISION BLIZZARD INC COM 00507V109 197 4,226 SH   DFND   0 4,226 0
ADOBE INC COM 00724F101 242 1,071 SH   DFND   0 1,071 0
AERIE PHARMACEUTICALS INC COM 00771V108 68,371 1,893,935 SH   DFND   0 1,893,935 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 23,889 174,284 SH   DFND   0 174,284 0
ALIGN TECHNOLOGY INC COM 016255101 49,687 237,248 SH   DFND   0 237,248 0
ALLAKOS INC COM 01671P100 30,215 618,284 SH   DFND   0 618,284 0
ALLENA PHARMACEUTICALS INC COM 018119107 9,636 1,768,104 SH   DFND   0 1,768,104 0
ALLOGENE THERAPEUTICS INC COM 019770106 16,621 617,193 SH   DFND   0 617,193 0
ALPHABET INC CAP STK CL A 02079K305 69,062 66,091 SH   DFND   0 66,091 0
AMAZON COM INC COM 023135106 82,200 54,728 SH   DFND   0 54,728 0
ANAPLAN INC COM 03272L108 891 33,587 SH   DFND   0 33,587 0
ANAPTYSBIO INC COM 032724106 38,615 605,345 SH   DFND   0 605,345 0
ANTHEM INC COM 036752103 118,557 451,421 SH   DFND   0 451,421 0
APTINYX INC COM 03836N103 30,634 1,852,132 SH   DFND   0 1,852,132 0
ARCUS BIOSCIENCES INC COM 03969F109 2,380 220,976 SH   DFND   0 220,976 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 117,421 3,014,672 SH   DFND   0 3,014,672 0
ARGENX SE SPONSORED ADR 04016X101 11,320 117,834 SH   DFND   0 117,834 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 1,724 27,519 SH   DFND   0 27,519 0
AUDENTES THERAPEUTICS INC COM 05070R104 64,413 3,021,259 SH   DFND   0 3,021,259 0
AVROBIO INC COM 05455M100 4,020 241,413 SH   DFND   0 241,413 0
BLACKROCK INC COM 09247X101 65,513 166,775 SH   DFND   0 166,775 0
BLUEPRINT MEDICINES CORP COM 09627Y109 79,271 1,470,436 SH   DFND   0 1,470,436 0
CARBON BLACK INC COM 14081R103 3,104 231,286 SH   DFND   0 231,286 0
CARDIOVASCULAR SYS INC DEL COM 141619106 45,580 1,599,867 SH   DFND   0 1,599,867 0
CIGNA CORP NEW COM 125523900 105,273 554,300 SH Call DFND   0 554,300 0
CIGNA CORP NEW COM 125523100 38,440 202,399 SH   DFND   0 202,399 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 9,995 849,904 SH   DFND   0 849,904 0
CLOVIS ONCOLOGY INC NOTE 2.500% 9/1 189464AB6 54,481 64,864,000 PRN   DFND   0 64,864,000 0
CME GROUP INC COM CL A 12572Q105 41,237 219,204 SH   DFND   0 219,204 0
COUPA SOFTWARE INC COM 22266L106 18,834 299,615 SH   DFND   0 299,615 0
DAVITA INC COM 23918K108 49,517 962,234 SH   DFND   0 962,234 0
DOCUSIGN INC COM 256163106 769 19,199 SH   DFND   0 19,199 0
DROPBOX INC CL A 26210C104 31,098 1,522,197 SH   DFND   0 1,522,197 0
EDWARDS LIFESCIENCES CORP COM 28176E108 82,838 540,827 SH   DFND   0 540,827 0
ELASTIC N V ORD SHS N14506104 5,157 72,151 SH   DFND   0 72,151 0
ENDOLOGIX INC NOTE 3.250%11/0 29266SAB2 33,876 47,379,000 PRN   DFND   0 47,379,000 0
EQUILLIUM INC COM 29446K106 11,049 1,353,987 SH   DFND   0 1,353,987 0
ESPERION THERAPEUTICS INC NE COM 29664W105 86,434 1,879,003 SH   DFND   0 1,879,003 0
FATE THERAPEUTICS INC COM 31189P102 18,873 1,471,000 SH   DFND   0 1,471,000 0
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 1,768 1,911,400 PRN   DFND   0 1,911,400 0
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAD0 34,036 29,532,000 PRN   DFND   0 29,532,000 0
GODADDY INC CL A 380237107 145,073 2,210,808 SH   DFND   0 2,210,808 0
GREEN DOT CORP CL A 39304D102 10,145 127,577 SH   DFND   0 127,577 0
GRITSTONE ONCOLOGY INC COM 39868T105 14,280 1,005,613 SH   DFND   0 1,005,613 0
HCA HEALTHCARE INC COM 40412C101 48,760 391,805 SH   DFND   0 391,805 0
HUMANA INC COM 444859102 116,910 408,093 SH   DFND   0 408,093 0
ICU MED INC COM 44930G107 40,359 175,758 SH   DFND   0 175,758 0
INTUIT COM 461202103 49,052 249,183 SH   DFND   0 249,183 0
IRHYTHM TECHNOLOGIES INC COM 450056106 28,891 415,819 SH   DFND   0 415,819 0
ISHARES TR EMERGING MARKETS 464287904 174,634 4,470,900 SH Call DFND   0 4,470,900 0
KURA ONCOLOGY INC COM 50127T109 16,061 1,143,917 SH   DFND   0 1,143,917 0
LIBERTY MEDIA CORP DELAWARE COM SER C FRMLA 531229854 447 14,544 SH   DFND   0 14,544 0
LIVE NATION ENTERTAINMENT IN COM 538034109 4,658 94,574 SH   DFND   0 94,574 0
LIVERAMP HLDGS INC COM 53815P108 9,132 236,405 SH   DFND   0 236,405 0
MADISON SQUARE GARDEN CO NEW CL A 55825T103 38,353 143,267 SH   DFND   0 143,267 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 1,506 524,663 SH   DFND   0 524,663 0
MEDICINES CO NOTE 2.750% 7/1 584688AG0 68,404 90,166,000 PRN   DFND   0 90,166,000 0
MERIT MED SYS INC COM 589889104 39,195 702,293 SH   DFND   0 702,293 0
MICROCHIP TECHNOLOGY INC COM 595017104 74,257 1,032,492 SH   DFND   0 1,032,492 0
MICROSOFT CORP COM 594918104 70,517 694,274 SH   DFND   0 694,274 0
MOLINA HEALTHCARE INC COM 60855R100 40,579 349,159 SH   DFND   0 349,159 0
MYOKARDIA INC COM 62857M105 75,153 1,538,131 SH   DFND   0 1,538,131 0
NEON THERAPEUTICS INC COM 64050Y100 4,924 979,002 SH   DFND   0 979,002 0
NEURONETICS INC COM 64131A105 444 22,937 SH   DFND   0 22,937 0
NEVRO CORP COM 64157F103 21,627 556,095 SH   DFND   0 556,095 0
NEW YORK TIMES CO CL A 650111107 18,048 809,701 SH   DFND   0 809,701 0
NUCANA PLC SPONSORED ADR 67022C106 6,488 447,420 SH   DFND   0 447,420 0
PACIRA PHARMACEUTICALS INC COM 695127100 22,521 523,497 SH   DFND   0 523,497 0
PAYPAL HLDGS INC COM 70450Y103 80,187 953,584 SH   DFND   0 953,584 0
PENUMBRA INC COM 70975L107 110,334 902,898 SH   DFND   0 902,898 0
PFIZER INC COM 717081103 40,747 933,486 SH   DFND   0 933,486 0
PIVOTAL SOFTWARE INC COM CL A 72582H107 20,026 1,224,809 SH   DFND   0 1,224,809 0
SAGE THERAPEUTICS INC COM 78667J108 48,448 505,776 SH   DFND   0 505,776 0
SALESFORCE COM INC COM 79466L302 82,415 601,699 SH   DFND   0 601,699 0
SERVICENOW INC COM 81762P102 9,613 53,991 SH   DFND   0 53,991 0
SIENNA BIOPHARMACEUTICALS IN COM 82622H108 3,658 1,576,619 SH   DFND   0 1,576,619 0
SOLID BIOSCIENCES INC COM 83422E105 35,780 1,335,080 SH   DFND   0 1,335,080 0
SPARK THERAPEUTICS INC COM 84652J103 85,458 2,183,393 SH   DFND   0 2,183,393 0
SQUARE INC CL A 852234103 29,674 529,040 SH   DFND   0 529,040 0
STONECO LTD COM CL A G85158106 1,594 86,453 SH   DFND   0 86,453 0
TABLEAU SOFTWARE INC CL A 87336U105 37,135 309,456 SH   DFND   0 309,456 0
THERMO FISHER SCIENTIFIC INC COM 883556102 58,657 262,107 SH   DFND   0 262,107 0
TWILIO INC CL A 90138F102 13,649 152,841 SH   DFND   0 152,841 0
UNITEDHEALTH GROUP INC COM 91324P102 60,009 240,885 SH   DFND   0 240,885 0
UNITY BIOTECHNOLOGY INC COM 91381U101 13,496 830,015 SH   DFND   0 830,015 0
VIEWRAY INC COM 92672L107 12,834 2,114,316 SH   DFND   0 2,114,316 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 37,678 1,384,206 SH   DFND   0 1,384,206 0
ZIMMER BIOMET HLDGS INC COM 98956P102 70,356 678,328 SH   DFND   0 678,328 0
ZSCALER INC COM 98980G102 1,836 46,814 SH   DFND   0 46,814 0