The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 1,600 22,118 SH   DFND   0 22,118 0
ACCURAY INC COM 004397105 76 22,424 SH   DFND   0 22,424 0
ACORDA THERAPEUTICS INC COM 00484M906 326 20,900 SH Call DFND   0 20,900 0
ACORDA THERAPEUTICS INC COM 00484M106 204 13,101 SH   DFND   0 13,101 0
ACORDA THERAPEUTICS INC NOTE 1.750% 6/1 00484MAA4 922 1,108,000 PRN   DFND   0 1,108,000 0
AERIE PHARMACEUTICALS INC COM 00771V108 814 22,559 SH   DFND   0 22,559 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 625 4,557 SH   DFND   0 4,557 0
ALIGN TECHNOLOGY INC COM 016255101 773 3,689 SH   DFND   0 3,689 0
ALLAKOS INC COM 01671P100 4,304 88,079 SH   DFND   0 88,079 0
ALLENA PHARMACEUTICALS INC COM 018119107 1,645 301,889 SH   DFND   0 301,889 0
ALLOGENE THERAPEUTICS INC COM 019770106 135 5,007 SH   DFND   0 5,007 0
ALPHABET INC CAP STK CL A 02079K305 1,730 1,656 SH   DFND   0 1,656 0
AMAZON COM INC COM 023135106 2,103 1,400 SH   DFND   0 1,400 0
ANAPLAN INC COM 03272L108 24 889 SH   DFND   0 889 0
ANAPTYSBIO INC COM 032724106 429 6,731 SH   DFND   0 6,731 0
ANTHEM INC COM 036752103 2,291 8,722 SH   DFND   0 8,722 0
APTINYX INC COM 03836N103 973 58,840 SH   DFND   0 58,840 0
ARCUS BIOSCIENCES INC COM 03969F109 17 1,575 SH   DFND   0 1,575 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 1,535 39,408 SH   DFND   0 39,408 0
ARGENX SE SPONSORED ADR 04016X101 110 1,148 SH   DFND   0 1,148 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 17 271 SH   DFND   0 271 0
AUDENTES THERAPEUTICS INC COM 05070R104 495 23,226 SH   DFND   0 23,226 0
AVROBIO INC COM 05455M100 27 1,643 SH   DFND   0 1,643 0
BLACKROCK INC COM 09247X101 1,712 4,358 SH   DFND   0 4,358 0
BLUEPRINT MEDICINES CORP COM 09627Y109 859 15,932 SH   DFND   0 15,932 0
CARBON BLACK INC COM 14081R103 83 6,163 SH   DFND   0 6,163 0
CARDIOVASCULAR SYS INC DEL COM 141619106 415 14,574 SH   DFND   0 14,574 0
CIGNA CORP NEW COM 125523900 2,032 10,700 SH Call DFND   0 10,700 0
CIGNA CORP NEW COM 125523100 744 3,918 SH   DFND   0 3,918 0
CLOVIS ONCOLOGY INC NOTE 2.500% 9/1 189464AB6 548 652,000 PRN   DFND   0 652,000 0
CME GROUP INC COM CL A 12572Q105 1,078 5,728 SH   DFND   0 5,728 0
COUPA SOFTWARE INC COM 22266L106 476 7,575 SH   DFND   0 7,575 0
DAVITA INC COM 23918K108 627 12,180 SH   DFND   0 12,180 0
DOCUSIGN INC COM 256163106 21 518 SH   DFND   0 518 0
DROPBOX INC CL A 26210C104 795 38,899 SH   DFND   0 38,899 0
EDWARDS LIFESCIENCES CORP COM 28176E108 1,601 10,450 SH   DFND   0 10,450 0
ELASTIC N V ORD SHS N14506104 137 1,911 SH   DFND   0 1,911 0
ENDOLOGIX INC NOTE 3.250%11/0 29266SAB2 295 413,000 PRN   DFND   0 413,000 0
EQUILLIUM INC COM 29446K106 64 7,879 SH   DFND   0 7,879 0
ESPERION THERAPEUTICS INC NE COM 29664W105 1,166 25,341 SH   DFND   0 25,341 0
FATE THERAPEUTICS INC COM 31189P102 158 12,287 SH   DFND   0 12,287 0
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 19 20,600 PRN   DFND   0 20,600 0
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAD0 325 282,000 PRN   DFND   0 282,000 0
GODADDY INC CL A 380237107 3,710 56,532 SH   DFND   0 56,532 0
GREEN DOT CORP CL A 39304D102 265 3,335 SH   DFND   0 3,335 0
GRITSTONE ONCOLOGY INC COM 39868T105 171 12,951 SH   DFND   0 12,951 0
HCA HEALTHCARE INC COM 40412C101 944 7,588 SH   DFND   0 7,588 0
HUMANA INC COM 444859102 2,264 7,902 SH   DFND   0 7,902 0
ICU MED INC COM 44930G107 527 2,297 SH   DFND   0 2,297 0
INTUIT COM 461202103 1,256 6,380 SH   DFND   0 6,380 0
IRHYTHM TECHNOLOGIES INC COM 450056106 325 4,681 SH   DFND   0 4,681 0
ISHARES TR EMERGING MARKETS 464287904 2,660 68,100 SH Call DFND   0 68,100 0
KURA ONCOLOGY INC COM 50127T109 141 10,072 SH   DFND   0 10,072 0
LIVE NATION ENTERTAINMENT IN COM 538034109 101 2,053 SH   DFND   0 2,053 0
LIVERAMP HLDGS INC COM 53815P108 223 5,763 SH   DFND   0 5,763 0
MADISON SQUARE GARDEN CO NEW CL A 55825T103 980 3,659 SH   DFND   0 3,659 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 9 3,137 SH   DFND   0 3,137 0
MEDICINES CO NOTE 2.750% 7/1 584688AG0 816 1,075,000 PRN   DFND   0 1,075,000 0
MERIT MED SYS INC COM 589889104 533 9,549 SH   DFND   0 9,549 0
MICROCHIP TECHNOLOGY INC COM 595017104 1,940 26,975 SH   DFND   0 26,975 0
MICROSOFT CORP COM 594918104 1,803 17,754 SH   DFND   0 17,754 0
MOLINA HEALTHCARE INC COM 60855R100 643 5,529 SH   DFND   0 5,529 0
MYOKARDIA INC COM 62857M105 812 16,623 SH   DFND   0 16,623 0
NEON THERAPEUTICS INC COM 64050Y100 4,187 832,358 SH   DFND   0 832,358 0
NEVRO CORP COM 64157F103 267 6,854 SH   DFND   0 6,854 0
NEW YORK TIMES CO CL A 650111107 465 20,877 SH   DFND   0 20,877 0
PACIRA PHARMACEUTICALS INC COM 695127100 265 6,151 SH   DFND   0 6,151 0
PAYPAL HLDGS INC COM 70450Y103 2,051 24,389 SH   DFND   0 24,389 0
PENUMBRA INC COM 70975L107 1,386 11,346 SH   DFND   0 11,346 0
PFIZER INC COM 717081103 753 17,254 SH   DFND   0 17,254 0
PIVOTAL SOFTWARE INC COM CL A 72582H107 524 32,019 SH   DFND   0 32,019 0
SAGE THERAPEUTICS INC COM 78667J108 592 6,184 SH   DFND   0 6,184 0
SALESFORCE COM INC COM 79466L302 2,096 15,301 SH   DFND   0 15,301 0
SERVICENOW INC COM 81762P102 251 1,411 SH   DFND   0 1,411 0
SIENNA BIOPHARMACEUTICALS IN COM 82622H108 35 15,283 SH   DFND   0 15,283 0
SOLID BIOSCIENCES INC COM 83422E105 328 12,250 SH   DFND   0 12,250 0
SPARK THERAPEUTICS INC COM 84652J103 1,036 26,477 SH   DFND   0 26,477 0
SQUARE INC CL A 852234103 748 13,336 SH   DFND   0 13,336 0
STONECO LTD COM CL A G85158106 42 2,289 SH   DFND   0 2,289 0
TABLEAU SOFTWARE INC CL A 87336U105 971 8,090 SH   DFND   0 8,090 0
THERMO FISHER SCIENTIFIC INC COM 883556102 1,136 5,076 SH   DFND   0 5,076 0
TWILIO INC CL A 90138F102 343 3,842 SH   DFND   0 3,842 0
UNITEDHEALTH GROUP INC COM 91324P102 1,159 4,654 SH   DFND   0 4,654 0
UNITY BIOTECHNOLOGY INC COM 91381U101 5,020 308,730 SH   DFND   0 308,730 0
VIEWRAY INC COM 92672L107 131 21,604 SH   DFND   0 21,604 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 459 16,853 SH   DFND   0 16,853 0
ZIMMER BIOMET HLDGS INC COM 98956P102 1,312 12,649 SH   DFND   0 12,649 0
ZSCALER INC COM 98980G102 49 1,258 SH   DFND   0 1,258 0