The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COM 00289Y107 3,488 488,534 SH   DFND 1 488,534 0 0
ACCELERON PHARMA INC COM 00434H108 2,121 48,695 SH   DFND 1 48,695 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 3,533 478,055 SH   DFND 1 478,055 0 0
ALLAKOS INC COM 01671P100 7,841 150,000 SH   DFND 1 150,000 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 9,527 700,000 SH   DFND 1 700,000 0 0
ANAPTYSBIO INC COM 032724106 70,523 1,105,557 SH   DFND 1 1,105,557 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 59,388 4,502,498 SH   DFND 1 4,502,498 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 11,685 300,000 SH   DFND 1 300,000 0 0
ARGEN SE SPONSORED ADR 04016X101 43,232 450,000 SH   DFND 1 450,000 0 0
ARQULE INC COM 04269E107 809 292,095 SH   DFND 1 292,095 0 0
ARRAY BIOPHARMA INC COM 04269X105 8,276 580,756 SH   DFND 1 580,756 0 0
ARSANIS INC COM 042873109 4,319 1,861,702 SH   DFND 1 1,861,702 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 21,204 338,456 SH   DFND 1 338,456 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 2,597 121,797 SH   DFND 1 121,797 0 0
AVROBIO INC COM 05455M100 22,607 1,357,784 SH   DFND 1 1,357,784 0 0
AXONICS MODULATION TECH INC COM 05465P101 19,429 1,285,828 SH   DFND 1 1,285,828 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 24,037 650,000 SH   DFND 1 650,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 19,480 361,351 SH   DFND 1 361,351 0 0
CELLECTAR BIOSCIENCES INC *W EXP 08/20/201 15117F120 3 52,999 SH   DFND 1 52,999 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 4,213 245,370 SH   DFND 1 245,370 0 0
CONSTELLATION PHARMACEUTICALS I COM 210373106 5,099 1,271,687 SH   DFND 1 1,271,687 0 0
CONTRAFECT CORP COM 212326102 4,446 2,905,638 SH   DFND 1 2,905,638 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 2,857 100,000 SH   DFND 1 100,000 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 4,480 296,712 SH   DFND 1 296,712 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 37,217 3,481,471 SH   DFND 1 3,481,471 0 0
EIDOS THERAPEUTICS INC COM 28249H104 5,309 385,846 SH   DFND 1 385,846 0 0
G1 THERAPEUTICS INC COM 3621LQ109 19,041 994,287 SH   DFND 1 994,287 0 0
HERON THERAPEUTICS INC COM 427746102 4,298 165,682 SH   DFND 1 165,682 0 0
INCYTE CORP COM 45337C102 15,982 251,335 SH   DFND 1 251,335 0 0
INFLARX NV COM N44821101 53,651 1,475,140 SH   DFND 1 1,475,140 0 0
INSPIRE MED SYS INC COM 457730109 12,263 290,239 SH   DFND 1 290,239 0 0
ITERUM THERAPEUTICS PLC SHS G6333L101 2,335 466,002 SH   DFND 1 466,002 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 33,581 1,422,911 SH   DFND 1 1,422,911 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 23,343 831,000 SH   DFND 1 831,000 0 0
KURA ONCOLOGY INC COM 50127T109 7,722 550,000 SH   DFND 1 550,000 0 0
MEIRAGTX HOLDGIN PLC COM G59665102 2,300 238,579 SH   DFND 1 238,579 0 0
MINERVA NEUROSCIENCES INC COM 603380106 4,097 607,903 SH   DFND 1 607,903 0 0
MIRATI THERAPEUTICS INC COM 60468T105 74,307 1,751,699 SH   DFND 1 1,751,699 0 0
MYOKARDIA INC COM 62857M105 33,100 677,451 SH   DFND 1 677,451 0 0
NEKTAR THERAPEUTICS COM 640268108 17,980 547,000 SH   DFND 1 547,000 0 0
NEKTAR THERAPEUTICS COM 640268108 8,218 250,000 SH Call DFND 1 250,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 15,583 218,222 SH   DFND 1 218,222 0 0
OMEROS CORP COM 682143102 2,024 181,700 SH Call DFND 1 181,700 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 5,899 375,000 SH   DFND 1 375,000 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/201 69012T115 64 416,666 SH   DFND 1 416,666 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 3,393 1,097,926 SH   DFND 1 1,097,926 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 40,383 1,474,362 SH   DFND 1 1,474,362 0 0
QUANTERIX CORP COM 74766Q101 1,006 54,945 SH   DFND 1 54,945 0 0
QUOTIENT LTD SHS G73268107 29,148 4,762,772 SH   DFND 1 4,762,772 0 0
RA PHARMACEUTICALS INC COM 74933V108 8,026 441,000 SH   DFND 1 441,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 37,825 674,251 SH   DFND 1 674,251 0 0
REPLIMUNE GROUP INC COM 76029N106 4,678 467,792 SH   DFND 1 467,792 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 28,835 1,945,659 SH   DFND 1 1,945,659 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 5,803 360,910 SH   DFND 1 360,910 0 0
SAGE THERAPEUTICS INC COM 78667J108 17,600 183,732 SH   DFND 1 183,732 0 0
SAGE THERAPEUTICS INC COM 78667J108 17,626 184,000 SH Put DFND 1 184,000 0 0
SANGAMO THERAPEUTICS INC COM 800677106 2,230 194,274 SH   DFND 1 194,274 0 0
SAREPTA THERAPEUTICS INC COM 803607100 9,822 90,000 SH   DFND 1 90,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 4,825 210,078 SH   DFND 1 210,078 0 0
SOLID BIOSCIENCES INC COM 83422E105 17,500 652,987 SH   DFND 1 652,987 0 0
TESARO INC COM 881569107 66,825 900,000 SH   DFND 1 900,000 0 0
TESARO INC COM 881569107 93,057 1,253,300 SH Call DFND 1 1,253,300 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 22,645 884,916 SH   DFND 1 884,916 0 0
TRANSLATE BIO INC COM 89374L104 3,409 454,550 SH   DFND 1 454,550 0 0
TRICIDA INC COM 89610F101 17,252 731,621 SH   DFND 1 731,621 0 0
TWIST BIOSCIENCE CORP COM 90184D100 16,303 706,064 SH   DFND 1 706,064 0 0
Y MABS THERAPEUTICS INC COM 984241109 3,961 194,768 SH   DFND 1 194,768 0 0
ZAI LAB LTD ADR 98887Q104 18,284 787,426 SH   DFND 1 787,426 0 0
ZOGENIX INC COM NEW 98978L204 18,645 511,395 SH   DFND 1 511,395 0 0
ZOGENIX INC COM NEW 98978L204 9,115 250,000 SH Call DFND 1 250,000 0 0