The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AC IMMUNE SA | SHS | H00263105 | 21,074 | 2,230,027 | SH | DFND | 1 | 0 | 2,230,027 | 0 | |
| ALBIREO PHARMA INC | COM | 01345P106 | 4,918 | 200,500 | SH | DFND | 1 | 0 | 200,500 | 0 | |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 2,366 | 643,059 | SH | DFND | 1 | 0 | 643,059 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 14,051 | 220,265 | SH | DFND | 1 | 0 | 220,265 | 0 | |
| ARCUS BIOSCIENCES INC | COM | 03969F109 | 25,973 | 2,411,623 | SH | DFND | 1 | 0 | 2,411,623 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 7,769 | 80,868 | SH | DFND | 1 | 0 | 80,868 | 0 | |
| ARQULE INC | COM | 04269E107 | 17,258 | 6,230,418 | SH | DFND | 1 | 0 | 6,230,418 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 67,603 | 4,744,062 | SH | DFND | 1 | 0 | 4,744,062 | 0 | |
| BIOLINERX LTD | SPONSORED ADS | 09071M106 | 11,368 | 25,995,575 | SH | DFND | 1 | 0 | 25,995,575 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 30,996 | 574,967 | SH | DFND | 1 | 0 | 574,967 | 0 | |
| CALITHERA BIOSCIENCES INC | COM | 13089P101 | 13,226 | 3,298,282 | SH | DFND | 1 | 0 | 3,298,282 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 72,961 | 6,687,523 | SH | DFND | 1 | 0 | 6,687,523 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 6,826 | 2,904,684 | SH | DFND | 1 | 0 | 2,904,684 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 14,438 | 1,150,445 | SH | DFND | 1 | 0 | 1,150,445 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 2,905 | 1,898,990 | SH | DFND | 1 | 0 | 1,898,990 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 6,938 | 1,890,507 | SH | DFND | 1 | 0 | 1,890,507 | 0 | |
| CTI BIOPHARMA CORP | COM NEW | 12648L601 | 5,084 | 6,929,690 | SH | DFND | 1 | 0 | 6,929,690 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 26,232 | 4,150,639 | SH | DFND | 1 | 0 | 4,150,639 | 0 | |
| DICERNA PHARMACEUTICALS INC | COM | 253031108 | 12,996 | 1,215,727 | SH | DFND | 1 | 0 | 1,215,727 | 0 | |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 6,858 | 675,000 | SH | DFND | 1 | 0 | 675,000 | 0 | |
| ERYTECH PHARMA | SPONSORED ADR | 29604W108 | 4,234 | 625,000 | SH | DFND | 1 | 0 | 625,000 | 0 | |
| ESSA PHARMA INC | COM NEW | 29668H708 | 1,219 | 580,368 | SH | DFND | 1 | 0 | 580,368 | 0 | |
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 25,867 | 2,781,346 | SH | DFND | 1 | 0 | 2,781,346 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 6,614 | 8,480,079 | SH | DFND | 1 | 0 | 8,480,079 | 0 | |
| GALMED PHARMACEUTICALS LTD | SHS | M47238106 | 12,830 | 1,878,508 | SH | DFND | 1 | 0 | 1,878,508 | 0 | |
| GENOCEA BIOSCIENCES INC | COM | 372427104 | 1,467 | 5,114,455 | SH | DFND | 1 | 0 | 5,114,455 | 0 | |
| IMMUNE DESIGN CORP | COM | 45252L103 | 6,741 | 5,185,383 | SH | DFND | 1 | 0 | 5,185,383 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 20,564 | 17,426,968 | SH | DFND | 1 | 0 | 17,426,968 | 0 | |
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 508 | 9,399 | SH | DFND | 1 | 0 | 9,399 | 0 | |
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 | 4,991 | 252,693 | SH | DFND | 1 | 0 | 252,693 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 38,963 | 2,775,156 | SH | DFND | 1 | 0 | 2,775,156 | 0 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 552 | 3,944 | SH | DFND | 1 | 0 | 3,944 | 0 | |
| MEI PHARMA INC | COM NEW | 55279B202 | 7,864 | 2,978,708 | SH | DFND | 1 | 0 | 2,978,708 | 0 | |
| MERRIMACK PHARMACEUTICALS INC | COM NEW | 590328209 | 2,787 | 721,935 | SH | DFND | 1 | 0 | 721,935 | 0 | |
| MERUS N V | COM | N5749R100 | 63,209 | 4,514,913 | SH | DFND | 1 | 0 | 4,514,913 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 29,221 | 688,851 | SH | DFND | 1 | 0 | 688,851 | 0 | |
| MOLECULAR TEMPLATES INC | COM | 608550109 | 13,592 | 3,364,421 | SH | DFND | 1 | 0 | 3,364,421 | 0 | |
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 3,021 | 4,042,989 | SH | DFND | 1 | 0 | 4,042,989 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 19,838 | 7,457,921 | SH | DFND | 1 | 0 | 7,457,921 | 0 | |
| PRINCIPIA BIOPHARMA INC | COM | 74257L108 | 4,007 | 146,300 | SH | DFND | 1 | 0 | 146,300 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 11,034 | 1,639,458 | SH | DFND | 1 | 0 | 1,639,458 | 0 | |
| REALM THERAPEUTICS PLC | SPONSORED ADS | 75606L103 | 668 | 360,866 | SH | DFND | 1 | 0 | 360,866 | 0 | |
| REGULUS THERAPEUTICS INC | COM NEW | 75915K200 | 979 | 1,051,940 | SH | DFND | 1 | 0 | 1,051,940 | 0 | |
| REPLIMUNE GROUP INC | COM | 76029N106 | 8,996 | 899,617 | SH | DFND | 1 | 0 | 899,617 | 0 | |
| SPERO THERAPEUTICS INC | COM | 84833T103 | 5,185 | 843,146 | SH | DFND | 1 | 0 | 843,146 | 0 | |
| SPRING BK PHARMACEUTICALS INC | COM | 849431101 | 9,888 | 951,701 | SH | DFND | 1 | 0 | 951,701 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 951 | 2,287,860 | SH | DFND | 1 | 0 | 2,287,860 | 0 | |
| SURFACE ONCOLOGY INC | COM | 86877M209 | 1,916 | 451,850 | SH | DFND | 1 | 0 | 451,850 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 8,845 | 1,987,669 | SH | DFND | 1 | 0 | 1,987,669 | 0 | |
| VBI VACCINES INC | COM NEW | 91822J103 | 8,347 | 5,216,857 | SH | DFND | 1 | 0 | 5,216,857 | 0 | |
| VERASTEM INC | COM | 92337C104 | 11,807 | 3,513,994 | SH | DFND | 1 | 0 | 3,513,994 | 0 | |
| VICAL INC | COM NEW | 925602203 | 1,517 | 1,285,848 | SH | DFND | 1 | 0 | 1,285,848 | 0 | |
| XENCOR INC | COM | 98401F105 | 21,460 | 593,465 | SH | DFND | 1 | 0 | 593,465 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 11,287 | 1,788,774 | SH | DFND | 1 | 0 | 1,788,774 | 0 | |
| XOMA CORP DEL | COM NEW | 98419J206 | 22,378 | 1,769,029 | SH | DFND | 1 | 0 | 1,769,029 | 0 | |