The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
21VIANET GROUP INC SPONSORED ADR 90138A103 93,122 10,778,004 SH   DFND 8,23 10,778,004 0 0
AC IMMUNE SA SHS H00263105 24,703 2,614,095 SH   DFND 12,22,27 2,614,095 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 60,035 616,630 SH   DFND 4,12,16 616,630 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 3,751,493 27,369,175 SH   DFND 2,6,19,20,21 27,369,175 0 0
ALTERYX INC COM CL A 02156B103 651 10,939 SH   DFND 11,13 10,939 0 0
AMAZON COM INC COM 023135106 52,799 35,153 SH   DFND 2,19,21 35,153 0 0
AMYRIS INC NOTE 6.500% 5/1 03236MAC5 9,937 10,000,000 PRN   DFND 4,12,16 10,000,000 0 0
ANTERO RES CORP COM 03674X106 51,880 5,525,014 SH   DFND 9,21 5,525,014 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 5,121 1,422,475 SH   DFND 12,22,27 1,422,475 0 0
BEIGENE LTD SPONSORED ADR 07725L102 318,404 2,270,100 SH   DFND 12,22,27 2,270,100 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 202,036 2,372,712 SH   DFND 4,12,16,22,27 2,372,712 0 0
BOEING CO COM 097023105 169,518 525,636 SH   DFND 9,21 525,636 0 0
BP PLC SPONSORED ADR 055622104 34,145 900,457 SH   DFND 9,21 900,457 0 0
CENTURYLINK INC COM 156700106 1,866,498 123,201,207 SH   DFND 2,3,7,10,19,21,23 123,201,207 0 0
CHINA BIOLOGIC PRODS HLDGS I COM G21515104 75,151 990,000 SH   DFND 12,22,27 990,000 0 0
COGNEX CORP COM 192422103 5,383 139,192 SH   DFND 2,19,21 139,192 0 0
COHERUS BIOSCIENCES INC COM 19249H103 59,333 6,556,116 SH   DFND 12,22,27 6,556,116 0 0
COUPA SOFTWARE INC COM 22266L106 3,181 50,597 SH   DFND 11,13 50,597 0 0
CTRIP COM INTL LTD AMERICAN DEP SHS 22943F100 196,372 7,256,928 SH   DFND 2,6,9,19,21 7,256,928 0 0
DELL TECHNOLOGIES INC CL C 24703L202 888,545 18,181,818 SH   DFND 17,23,26 18,181,818 0 0
DENALI THERAPEUTICS INC COM 24823R105 91,120 4,410,457 SH   DFND 12,22,25,27 4,410,457 0 0
DOWDUPONT INC COM 26078J100 300,562 5,620,090 SH   DFND 9,21 5,620,090 0 0
EROS INTL PLC SHS NEW G3788M114 22,842 2,755,310 SH   DFND 6,19,21 2,755,310 0 0
EVOQUA WATER TECHNOLOGIES CO COM 30057T105 57,962 6,037,705 SH   DFND 11,13 6,037,705 0 0
FARFETCH LTD ORD SH CL A 30744W107 79,171 4,470,415 SH   DFND 18,19,21 4,470,415 0 0
FTS INTERNATIONAL INC COM 30283W104 295,898 41,617,144 SH   DFND 11,15 41,617,144 0 0
GILEAD SCIENCES INC COM 375558103 695,920 11,125,816 SH   DFND 2,12,19,21,22,27 11,125,816 0 0
GLOBAL PMTS INC COM 37940X102 90,360 876,176 SH   DFND 12,14 876,176 0 0
GRACE W R & CO DEL NEW COM 38388F108 141,991 2,187,501 SH   DFND 9,21 2,187,501 0 0
GUARDANT HEALTH INC COM 40131M109 60,633 1,613,007 SH   DFND 12,22,25 1,613,007 0 0
HDFC BANK LTD ADR REPS 3 SHS 40415F101 104,757 1,011,265 SH   DFND 9,21 1,011,265 0 0
HOMOLOGY MEDICINES INC COM 438083107 72,006 3,220,293 SH   DFND 12,22,25,27 3,220,293 0 0
ICICI BK LTD ADR 45104G104 88,904 8,639,819 SH   DFND 4,9,12,21 8,639,819 0 0
IHS MARKIT LTD SHS G47567105 643,553 13,415,742 SH   DFND 8,23 13,415,742 0 0
ILLUMINA INC COM 452327109 16,632 55,452 SH   DFND 2,19,21 55,452 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 10,791 790,527 SH   DFND 9,12,21,22,25 790,527 0 0
KKR REAL ESTATE FIN TR INC COM 48251K100 46,707 2,439,024 SH   DFND 2,19,21 2,439,024 0 0
MASTERCARD INCORPORATED CL A 57636Q104 271,791 1,440,714 SH   DFND 2,12,14,19,21 1,440,714 0 0
NEWFIELD EXPL CO COM 651290108 60,291 4,112,635 SH   DFND 2,19,21 4,112,635 0 0
NIO INC SPON ADS 62914V106 264,017 41,446,985 SH   DFND 1,23,24 41,446,985 0 0
OKTA INC CL A 679295105 450 7,046 SH   DFND 11,13 7,046 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 15,730 1,000,000 SH   DFND 12,22,27 1,000,000 0 0
PAYPAL HLDGS INC COM 70450Y103 528,634 6,286,524 SH   DFND 6,12,14,19,21 6,286,524 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 101,000 5,174,168 SH   DFND 2,4,12,16,19,21,22,27 5,174,168 0 0
PPG INDS INC COM 693506107 176,617 1,727,645 SH   DFND 2,19,21 1,727,645 0 0
REGENERON PHARMACEUTICALS COM 75886F107 47,192 126,351 SH   DFND 12,22,27 126,351 0 0
ROCKWELL AUTOMATION INC COM 773903109 6,683 44,409 SH   DFND 2,19,21 44,409 0 0
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 217,884 3,635,028 SH   DFND 9,21 3,635,028 0 0
TENCENT MUSIC ENTMT GROUP SPON ADS 88034P109 32,753 2,477,516 SH   DFND 8,23 2,477,516 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 336,376 1,503,087 SH   DFND 4,12,16 1,503,087 0 0
TOTAL S A SPONSORED ADR 89151E109 24,049 460,885 SH   DFND 9,21 460,885 0 0
TUNIU CORP SPONSORED ADS CL 89977P106 39,825 8,194,444 SH   DFND 8,23 8,194,444 0 0
TURQUOISE HILL RES LTD COM 900435108 84,086 50,960,943 SH   DFND 5,23,24 50,960,943 0 0
UNIVAR INC COM 91336L107 249,744 14,078,012 SH   DFND 5,23,24 14,078,012 0 0
VIRTU FINL INC CL A 928254101 434,842 16,880,503 SH   DFND 2,11,13,19,21 16,880,503 0 0
VISA INC COM CL A 92826C839 567,473 4,300,992 SH   DFND 2,12,14,19,21 4,300,992 0 0
WORLDPAY INC CL A 981558109 185,433 2,426,186 SH   DFND 2,12,14,19,21 2,426,186 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 192,758 12,176,750 SH   DFND 2,19,21 12,176,750 0 0