The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3-D SYS CORP DEL COM NEW 88554D205 160 16,000 SH   DFND 3 0 16,000 0
3M CO COM 88579Y101 2,212 11,600 SH   DFND 3 0 11,600 0
ABBOTT LABS COM 002824100 2,111 29,885 SH   DFND 3 0 29,885 0
ABEONA THERAPEUTICS INC COM 00289Y107 477 71,900 SH   DFND 3 0 71,900 0
ACADIA PHARMACEUTICALS INC COM 004225108 2,704 175,000 SH   DFND 3 0 175,000 0
ACELRX PHARMACEUTICALS INC COM 00444T100 709 301,708 SH   DFND 3 0 301,708 0
ACER THERAPEUTICS INC COM 00444P108 291 15,700 SH   DFND 3 0 15,700 0
ACHAOGEN INC COM 004449104 360 263,120 SH   DFND 3 0 263,120 0
ACTINIUM PHARMACEUTICALS INC COM 00507W107 87 225,134 SH Call DFND 3 0 225,134 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 1,664 196,959 SH   DFND 3 0 196,959 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 778 97,148 SH   DFND 3 0 97,148 0
AGILE THERAPEUTICS INC COM 00847L100 286 466,302 SH   DFND 3 0 466,302 0
AGILENT TECHNOLOGIES INC COM 00846U101 675 10,160 SH   DFND 3 0 10,160 0
ALBEMARLE CORP COM 012653101 857 11,100 SH   DFND 3 0 11,100 0
ALBIREO PHARMA INC COM 01345P106 4,492 197,005 SH   DFND 3 0 197,005 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 1,892 184,813 SH   DFND 3 0 184,813 0
ALEXION PHARMACEUTICALS INC COM 015351109 3,235 33,224 SH   DFND 1 0 33,224 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 1,832 13,235 SH   DFND 3 0 13,235 0
ALLENA PHARMACEUTICALS INC COM 018119107 154 29,877 SH   DFND 3 0 29,877 0
ALLIANCE DATA SYSTEMS CORP COM 018581108 465 3,100 SH   DFND   0 3,100 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 3,313 48,300 SH   DFND 3 0 48,300 0
ALPHABET INC CAP STK CL A 02079K305 6,808 6,515 SH   DFND   0 6,515 0
ALPHABET INC CAP STK CL A 02079K305 6,038 5,735 SH   DFND 3 0 5,735 0
ALPHABET INC CAP STK CL C 02079K107 2,005 1,921 SH   DFND 3 0 1,921 0
ALTRIA GROUP INC COM 02209S103 612 12,400 SH   DFND   0 12,400 0
ALTRIA GROUP INC COM 02209S103 896 18,400 SH   DFND 3 0 18,400 0
AMAZON COM INC COM 023135106 2,751 1,882 SH   DFND 3 0 1,882 0
AMERICAN EXPRESS CO COM 025816109 498 5,255 SH   DFND 3 0 5,255 0
AMERICAN RLTY CAP PPTYS INC NOTE 3.750% 12/1 02917TAB0 27,932 28,319,000 SH   DFND 1 0 28,319,000 0
AMERICAN RLTY CAP PPTYS INC NOTE 3.750% 12/1 02917TAB0 6,816 7,000,000 SH   DFND   0 7,000,000 0
AMERICAN TOWER CORP NEW COM 03027X100 220 1,387 SH   DFND 3 0 1,387 0
AMGEN INC COM 031162100 634 3,330 SH   DFND 3 0 3,330 0
AMICUS THERAPEUTICS INC COM 03152W109 4,955 533,969 SH   DFND 3 0 533,969 0
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 222,411 16,438,356 SH   DFND   0 16,438,356 0
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 42,128 3,113,645 SH   DFND 2 0 3,113,645 0
AMPHENOL CORP NEW CL A 032095101 881 10,960 SH   DFND 3 0 10,960 0
ANAPTYSBIO INC COM 032724106 1,334 21,596 SH   DFND 3 0 21,596 0
ANGLOGOLD ASHANTI LTD SPONSORED ADR 035128206 626 50,000 SH   DFND 3 0 50,000 0
ANTARES PHARMA INC COM 036642106 1,414 539,600 SH   DFND 3 0 539,600 0
ANTHEM INC COM 036752103 916 3,510 SH   DFND 3 0 3,510 0
APACHE CORP COM 037411105 749 28,000 SH   DFND 3 0 28,000 0
APELLIS PHARMACEUTICALS INC COM 03753U106 3,908 294,728 SH   DFND 3 0 294,728 0
APPLE INC COM 037833100 1,454 9,350 SH   DFND 3 0 9,350 0
APPLE INC COM 037833100 457 2,900 SH   DFND   0 2,900 0
APPLIED MATLS INC COM 038222105 252 8,000 SH   DFND 3 0 8,000 0
ARCHER DANIELS MIDLAND CO COM 039483102 267 6,520 SH   DFND 3 0 6,520 0
ARES CAP CORP COM 04010L103 1,985 128,707 SH   DFND 3 0 128,707 0
ARES CAP CORP NOTE 3.750% 2/0 04010LAT0 30,074 30,000,000 SH   DFND 1 0 30,000,000 0
ARGENX SE SPONSORED ADR 04016X101 3,109 32,405 SH   DFND 3 0 32,405 0
ARRAY BIOPHARMA INC COM 04269X105 6,643 460,055 SH   DFND 3 0 460,055 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 551 46,000 SH   DFND 3 0 46,000 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 3,245 53,326 SH   DFND 3 0 53,326 0
ASSEMBLY BIOSCIENCES INC COM 045396108 737 33,993 SH   DFND 3 0 33,993 0
ASSURANT INC COM 04621X108 765 8,700 SH   DFND 3 0 8,700 0
AT&T INC COM 00206R102 830 29,500 SH   DFND 3 0 29,500 0
ATRICURE INC COM 04963C209 5,734 197,459 SH   DFND 3 0 197,459 0
AUDENTES THERAPEUTICS INC COM 05070R104 546 26,000 SH   DFND 3 0 26,000 0
AURORA MOBILE LTD ADS 051857100 1,506 214,483 SH   DFND 1 0 214,483 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 826 337,043 SH   DFND 3 0 337,043 0
AVEO PHARMACEUTICALS INC COM 053588109 335 206,491 SH   DFND 3 0 206,491 0
BANK AMER CORP COM 060505104 1,005 40,783 SH   DFND   0 40,783 0
BARRICK GOLD CORP COM 067901108 548 40,000 SH   DFND 3 0 40,000 0
BECTON DICKINSON & CO COM 075887109 851 3,830 SH   DFND 3 0 3,830 0
BERKSHIRE HATHAWAY INC DEL CL A 084670108 1,791 6 SH   DFND 3 0 6 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 3,342 16,700 SH   DFND 3 0 16,700 0
BEST INC SPONSORED ADS 08653C106 27,266 6,634,021 SH   DFND   0 6,634,021 0
BEYONDSPRING INC SHS G10830100 4,500 240,000 SH   DFND 2 0 240,000 0
BIODELIVERY SCIENCES INTL IN COM 09060J106 834 286,645 SH   DFND 3 0 286,645 0
BIOGEN INC COM 09062X103 589 2,000 SH   DFND 3 0 2,000 0
BIOLINERX LTD SPONSORED ADS 09071M106 611 1,357,415 SH   DFND 3 0 1,357,415 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 7,556 89,950 SH   DFND 3 0 89,950 0
BLACKROCK INC COM 09247X101 252 650 SH   DFND 3 0 650 0
BOEING CO COM 097023105 967 3,050 SH   DFND 3 0 3,050 0
BOOKING HLDGS INC COM 09857L108 754 438 SH   DFND   0 438 0
BOOKING HLDGS INC COM 09857L108 3,350 1,950 SH   DFND 3 0 1,950 0
BOSTON BEER INC CL A 100557107 296 1,200 SH   DFND 3 0 1,200 0
BOSTON SCIENTIFIC CORP COM 101137107 266 7,715 SH   DFND 3 0 7,715 0
BROOKDALE SR LIVING INC COM 112463104 7,189 1,073,000 SH   DFND 1 0 1,073,000 0
BROOKDALE SR LIVING INC COM 112463104 49,114 7,330,384 SH   DFND   0 7,330,384 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 4,901 128,500 SH   DFND 3 0 128,500 0
BROOKFIELD RENEWABLE PARTNER PARTNERSHIP UNIT G16258108 4,504 100,000 SH   DFND 3 0 100,000 0
CARDINAL HEALTH INC COM 14149Y108 2,056 46,081 SH   DFND   0 46,081 0
CERUS CORP COM 157085101 2,438 498,538 SH   DFND 3 0 498,538 0
CF INDS HLDGS INC COM 125269100 521 11,973 SH   DFND   0 11,973 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 228 802 SH   DFND 3 0 802 0
CHECK CAP LTD SHS M2361E203 274 127,559 SH   DFND 2 0 127,559 0
CHECK CAP LTD *W EXP 02/28/202 M2361E120 40 333,333 SH   DFND 2 0 333,333 0
CHEMOCENTRYX INC COM 16383L106 1,059 100,976 SH   DFND 3 0 100,976 0
CHINA LODGING GROUP LTD NOTE 0.375% 11/0 16949NAC3 1,945 2,000,000 SH   DFND 1 0 2,000,000 0
CHUBB LIMITED COM H1467J104 1,408 10,981 SH   DFND 3 0 10,981 0
CIDARA THERAPEUTICS INC COM 171757107 659 306,686 SH   DFND 3 0 306,686 0
CIENA CORP COM NEW 171779309 859 26,500 SH   DFND 3 0 26,500 0
CINTAS CORP COM 172908105 686 4,100 SH   DFND 3 0 4,100 0
CISCO SYS INC COM 17275R102 1,146 26,700 SH   DFND 3 0 26,700 0
CITIGROUP INC COM NEW 172967424 621 12,000 SH   DFND 3 0 12,000 0
CITRIX SYS INC COM 177376100 827 8,100 SH   DFND 3 0 8,100 0
CLEARSIDE BIOMEDICAL INC COM 185063104 178 164,781 SH   DFND 3 0 164,781 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 2,627 234,526 SH   DFND 3 0 234,526 0
CLEVELAND CLIFFS INC COM 185899101 931 120,000 SH   DFND 3 0 120,000 0
CME GROUP INC COM CL A 12572Q105 848 4,600 SH   DFND 3 0 4,600 0
COCA COLA CO COM 191216100 1,854 39,000 SH   DFND 3 0 39,000 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 2,917 46,250 SH   DFND 3 0 46,250 0
COHERUS BIOSCIENCES INC COM 19249H103 576 65,500 SH   DFND 3 0 65,500 0
COLGATE PALMOLIVE CO COM 194162103 346 5,800 SH   DFND 3 0 5,800 0
COLONY CAP INC NOTE 5.000% 4/1 19624RAA4 17,749 20,000,000 SH   DFND 1 0 20,000,000 0
COLONY CAP INC NOTE 3.875% 1/1 19624RAB2 37,336 40,000,000 SH   DFND 1 0 40,000,000 0
COLONY CAP INC NEW CL A COM 19626G108 53,577 11,447,972 SH   DFND 1 0 11,447,972 0
COLONY CAP INC NEW CL A COM 19626G108 24,515 5,238,193 SH   DFND   0 5,238,193 0
COMPASS MINERALS INTL INC COM 20451N101 306 7,400 SH   DFND 3 0 7,400 0
CONTRAFECT CORP COM 212326102 11,408 7,455,957 SH   DFND 2 0 7,455,957 0
CORVUS PHARMACEUTICALS INC COM 221015100 523 158,982 SH   DFND 3 0 158,982 0
COSTCO WHSL CORP NEW COM 22160K105 201 1,000 SH   DFND 3 0 1,000 0
COWEN INC CL A NEW 223622606 6,966 522,161 SH   DFND   0 522,161 0
CRITEO S A SPONS ADS 226718104 7,452 328,011 SH   DFND 1 0 328,011 0
CRITEO S A SPONS ADS 226718104 7,831 344,670 SH   DFND   0 344,670 0
CTI BIOPHARMA CORP COM NEW 12648L601 253 300,428 SH   DFND 3 0 300,428 0
CTRIP COM INTL LTD NOTE 1.990% 7/0 22943FAH3 52,704 54,500,000 SH   DFND 1 0 54,500,000 0
CTRIP COM INTL LTD NOTE 1.250% 9/1 22943FAM2 29,105 30,000,000 SH   DFND 1 0 30,000,000 0
CTRIP COM INTL LTD NOTE 1.000% 7/0 22943FAF7 94 100,000 SH   DFND 3 0 100,000 0
CUMMINS INC COM 231021106 530 4,000 SH   DFND 3 0 4,000 0
CURIS INC COM NEW 231269200 149 201,086 SH   DFND 3 0 201,086 0
CVS HEALTH CORP COM 126650100 402 6,164 SH   DFND 3 0 6,164 0
CVS HEALTH CORP COM 126650100 432 6,600 SH   DFND   0 6,600 0
CYMABAY THERAPEUTICS INC COM 23257D103 2,646 336,205 SH   DFND 1 0 336,205 0
CYMABAY THERAPEUTICS INC COM 23257D103 2,074 263,529 SH   DFND   0 263,529 0
CYMABAY THERAPEUTICS INC COM 23257D103 1,479 192,362 SH   DFND 3 0 192,362 0
CYTOKINETICS INC COM NEW 23282W605 1,113 177,792 SH   DFND 3 0 177,792 0
CYTOMX THERAPEUTICS INC COM 23284F105 517 35,245 SH   DFND 3 0 35,245 0
DANAHER CORP DEL COM 235851102 538 5,300 SH   DFND 3 0 5,300 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 2,687 128,037 SH   DFND 1 0 128,037 0
DECKERS OUTDOOR CORP COM 243537107 544 4,170 SH   DFND 3 0 4,170 0
DELTA AIR LINES INC DEL COM NEW 247361702 309 6,111 SH   DFND 3 0 6,111 0
DELTA AIR LINES INC DEL COM NEW 247361702 758 15,200 SH   DFND   0 15,200 0
DERMIRA INC COM 24983L104 2,078 313,913 SH   DFND 3 0 313,913 0
DEUTSCHE BANK AG NAMEN AKT D18190898 6,138 793,000 SH   DFND 3 0 793,000 0
DICERNA PHARMACEUTICALS INC COM 253031108 1,154 113,938 SH   DFND 3 0 113,938 0
DISNEY WALT CO COM DISNEY 254687106 905 8,495 SH   DFND 3 0 8,495 0
DOVA PHARMACEUTICALS INC COM 25985T102 1,984 261,780 SH   DFND 2 0 261,780 0
ECOLAB INC COM 278865100 392 2,705 SH   DFND 3 0 2,705 0
EDAP TMS S A SPONSORED ADR 268311107 421 249,143 SH   DFND 3 0 249,143 0
EIDOS THERAPEUTICS INC COM 28249H104 1,308 94,270 SH   DFND 3 0 94,270 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,694 181,813 SH   DFND 3 0 181,813 0
ELECTRONIC ARTS INC COM 285512109 359 4,517 SH   DFND 3 0 4,517 0
EMERSON ELEC CO COM 291011104 226 3,810 SH   DFND 3 0 3,810 0
EXPEDITORS INTL WASH INC COM 302130109 791 11,800 SH   DFND 3 0 11,800 0
EZCORP INC CL A NON VTG 302301106 93 12,000 SH   DFND 3 0 12,000 0
FACEBOOK INC CL A 30303M102 3,283 24,403 SH   DFND 3 0 24,403 0
FACEBOOK INC CL A 30303M102 456 3,480 SH   DFND   0 3,480 0
FANG HLDGS LTD ADR 30711Y102 19,826 13,864,319 SH   DFND 1 0 13,864,319 0
FANG HLDGS LTD ADR 30711Y102 3,009 2,104,200 SH   DFND   0 2,104,200 0
FIRST MAJESTIC SILVER CORP COM 32076V103 596 100,000 SH   DFND 3 0 100,000 0
FIRSTENERGY CORP COM 337932107 889 24,000 SH   DFND 3 0 24,000 0
FIAT CHRYSLER AUTOMOBILES N SHS N31738102 38 2,634 SH   DFND 1 0 2,634 0
FOOT LOCKER INC COM 344849104 508 9,790 SH   DFND 3 0 9,790 0
GALLAGHER ARTHUR J & CO COM 363576109 904 12,500 SH   DFND 3 0 12,500 0
GARMIN LTD SHS H2906T109 2,374 37,700 SH   DFND 3 0 37,700 0
GENERAL DYNAMICS CORP COM 369550108 1,036 6,588 SH   DFND   0 6,588 0
GENERAL ELECTRIC CO COM 369604103 785 108,000 SH   DFND 3 0 108,000 0
GENERAL MTRS CO COM 37045V100 543 16,000 SH   DFND 3 0 16,000 0
GENOCEA BIOSCIENCES INC COM 372427104 119 403,678 SH   DFND 3 0 403,678 0
GILEAD SCIENCES INC COM 375558103 7,440 118,200 SH   DFND 3 0 118,200 0
GILEAD SCIENCES INC COM 375558103 7,537 120,498 SH   DFND   0 120,498 0
GILEAD SCIENCES INC COM 375558103 13,227 211,463 SH   DFND 1 0 211,463 0
GOLD FIELDS LTD NEW SPONSORED ADR 38059T106 344 100,000 SH   DFND 3 0 100,000 0
GOLDCORP INC NEW COM 380956409 228 23,400 SH   DFND 3 0 23,400 0
GOLDMAN SACHS GROUP INC COM 38141G104 662 4,000 SH   DFND 3 0 4,000 0
GOLDMAN SACHS GROUP INC COM 38141G104 487 2,915 SH   DFND   0 2,915 0
GRAND CANYON ED INC COM 38526M106 361 3,800 SH   DFND 3 0 3,800 0
GREEN DOT CORP CL A 39304D102 316 4,100 SH   DFND 3 0 4,100 0
HDFC BANK LTD ADR REPS 3 SHS 40415F101 1,873 18,320 SH   DFND 3 0 18,320 0
HERON THERAPEUTICS INC COM 427746102 1,542 65,557 SH   DFND 3 0 65,557 0
HOME DEPOT INC COM 437076102 273 1,600 SH   DFND 3 0 1,600 0
HOME DEPOT INC COM 437076102 1,321 7,690 SH   DFND   0 7,690 0
HONEYWELL INTL INC COM 438516106 319 2,424 SH   DFND 3 0 2,424 0
IAC INTERACTIVECORP COM 44919P508 1,006 5,500 SH   DFND 3 0 5,500 0
IAMGOLD CORP COM 450913108 545 150,000 SH   DFND 3 0 150,000 0
IKANG HEALTHCARE GROUP INC SPONSORED ADR 45174L108 11,085 543,912 SH   DFND 2 0 543,912 0
IKANG HEALTHCARE GROUP INC SPONSORED ADR 45174L108 48,461 2,377,867 SH   DFND   0 2,377,867 0
IKANG HEALTHCARE GROUP INC SPONSORED ADR 45174L108 34,728 1,704,027 SH   DFND 1 0 1,704,027 0
ILLUMINA INC NOTE 6/1 452327AF6 117 100,000 SH   DFND 3 0 100,000 0
IMMUNOGEN INC COM 45253H101 1,107 248,749 SH   DFND 3 0 248,749 0
IMMUNOMEDICS INC COM 452907108 3,579 235,433 SH   DFND 3 0 235,433 0
INCYTE CORP COM 45337C102 4,776 76,610 SH   DFND 3 0 76,610 0
INFINITY PHARMACEUTICALS INC COM 45665G303 424 378,296 SH   DFND 3 0 378,296 0
INFOSYS LTD SPONSORED ADR 456788108 566 59,930 SH   DFND 3 0 59,930 0
INTEL CORP COM 458140100 204 4,400 SH   DFND 3 0 4,400 0
INTERNATIONAL BUSINESS MACHS COM 459200101 673 5,915 SH   DFND 3 0 5,915 0
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 715 5,400 SH   DFND 3 0 5,400 0
INTUIT COM 461202103 620 3,145 SH   DFND 3 0 3,145 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 3,362 347,701 SH   DFND 3 0 347,701 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 2,520 284,154 SH   DFND 3 0 284,154 0
JOHNSON & JOHNSON COM 478160104 964 7,565 SH   DFND 3 0 7,565 0
JPMORGAN CHASE & CO COM 46625H100 1,468 15,130 SH   DFND 3 0 15,130 0
JPMORGAN CHASE & CO COM 46625H100 964 9,880 SH   DFND   0 9,880 0
KADMON HLDGS INC COM 48283N106 335 161,877 SH   DFND 3 0 161,877 0
KALA PHARMACEUTICALS INC COM 483119103 1,208 246,024 SH   DFND 3 0 246,024 0
KALVISTA PHARMACEUTICALS INC COM 483497103 2,444 137,443 SH   DFND 3 0 137,443 0
KELLOGG CO COM 487836108 853 14,920 SH   DFND 3 0 14,920 0
KINROSS GOLD CORP COM NO PAR 496902404 486 150,000 SH   DFND 3 0 150,000 0
KURA ONCOLOGY INC COM 50127T109 2,643 204,234 SH   DFND 3 0 204,234 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 2,988 308,650 SH   DFND 3 0 308,650 0
LAS VEGAS SANDS CORP COM 517834107 557 10,900 SH   DFND 3 0 10,900 0
LAUDER ESTEE COS INC CL A 518439104 605 4,710 SH   DFND 3 0 4,710 0
L BRANDS INC COM 501797104 12,555 489,098 SH   DFND   0 489,098 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 639 100,621 SH   DFND 3 0 100,621 0
LIBERTY MEDIA CORP DELAWARE NOTE 1.375%10/1 531229AB8 107 100,000 SH   DFND 3 0 100,000 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 411 3,000 SH   DFND 3 0 3,000 0
LILLY ELI & CO COM 532457108 1,655 14,660 SH   DFND 3 0 14,660 0
LINDE PLC COM G5494J103 794 5,174 SH   DFND 3 0 5,174 0
LKQ CORP COM 501889208 915 38,000 SH   DFND 3 0 38,000 0
MACQUARIE INFRASTRUCTURE COR NOTE 2.875% 7/1 55608BAA3 101 100,000 SH   DFND 3 0 100,000 0
MACROGENICS INC COM 556099109 837 66,462 SH   DFND 3 0 66,462 0
MADDEN STEVEN LTD COM 556269108 247 8,250 SH   DFND 3 0 8,250 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 6,537 268,681 SH   DFND 1 0 268,681 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 8,505 349,572 SH   DFND   0 349,572 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 1,378 491,997 SH   DFND 3 0 491,997 0
MASIMO CORP COM 574795100 366 3,500 SH   DFND 3 0 3,500 0
MASTERCARD INCORPORATED CL A 57636Q104 4,763 25,240 SH   DFND 3 0 25,240 0
MCDONALDS CORP COM 580135101 799 4,550 SH   DFND 3 0 4,550 0
MCKESSON CORP COM 58155Q103 1,224 11,085 SH   DFND   0 11,085 0
MEDICINES CO COM 584688105 636 34,000 SH   DFND 3 0 34,000 0
MEDIDATA SOLUTIONS INC COM 58471A105 498 7,600 SH   DFND 3 0 7,600 0
MEET GROUP INC COM 58513U101 214 50,000 SH   DFND 3 0 50,000 0
MEI PHARMA INC COM NEW 55279B202 801 396,526 SH   DFND 3 0 396,526 0
MELINTA THERAPEUTICS INC COM 58549G100 449 492,960 SH   DFND 3 0 492,960 0
MERCK & CO INC COM 58933Y105 6,624 87,880 SH   DFND 3 0 87,880 0
MICROCHIP TECHNOLOGY INC NOTE 1.625% 2/1 595017AD6 41 30,000 SH   DFND 3 0 30,000 0
MICROCHIP TECHNOLOGY INC NOTE 1.625% 2/1 595017AF1 193 200,000 SH   DFND 3 0 200,000 0
MICROSOFT CORP COM 594918104 4,953 48,948 SH   DFND 3 0 48,948 0
MOHAWK INDS INC COM 608190104 354 3,000 SH   DFND 3 0 3,000 0
MOLECULAR TEMPLATES INC COM 608550109 427 117,023 SH   DFND 3 0 117,023 0
MONDELEZ INTL INC CL A 609207105 656 16,400 SH   DFND   0 16,400 0
MORGAN STANLEY COM NEW 617446448 596 15,041 SH   DFND   0 15,041 0
MYLAN N V SHS EURO N59465109 2,055 75,000 SH   DFND 1 0 75,000 0
MYLAN N V SHS EURO N59465109 1,008 36,791 SH   DFND   0 36,791 0
MYOKARDIA INC COM 62857M105 1,356 26,513 SH   DFND 3 0 26,513 0
NATIONAL OILWELL VARCO INC COM 637071101 861 33,000 SH   DFND 3 0 33,000 0
NATURES SUNSHINE PRODUCTS IN COM 639027101 23,265 2,854,607 SH   DFND 2 0 2,854,607 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 4,408 62,323 SH   DFND 3 0 62,323 0
NEWMONT MINING CORP COM 651639106 742 21,200 SH   DFND 3 0 21,200 0
NEXTERA ENERGY INC COM 65339F101 408 2,370 SH   DFND 3 0 2,370 0
NIKE INC CL B 654106103 1,571 21,327 SH   DFND 3 0 21,327 0
NORFOLK SOUTHERN CORP COM 655844108 238 1,600 SH   DFND 3 0 1,600 0
NOVARTIS A G SPONSORED ADR 66987V109 532 6,200 SH   DFND   0 6,200 0
NUTRIEN LTD COM 67077M108 451 6,400 SH   DFND 3 0 6,400 0
NVIDIA CORP COM 67066G104 500 3,810 SH   DFND 3 0 3,810 0
OPKO HEALTH INC COM 68375N103 1,943 768,142 SH   DFND 3 0 768,142 0
ORACLE CORP COM 68389X105 659 14,655 SH   DFND 3 0 14,655 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 3,039 237,783 SH   DFND 2 0 237,783 0
PARATEK PHARMACEUTICALS INC COM 699374302 1,201 227,383 SH   DFND 3 0 227,383 0
PATTERN ENERGY GROUP INC NOTE 4.000% 7/1 70338PAB6 9,836 10,000,000 SH   DFND 1 0 10,000,000 0
PAYPAL HLDGS INC COM 70450Y103 1,604 19,020 SH   DFND 3 0 19,020 0
PFIZER INC COM 717081103 2,920 68,134 SH   DFND 3 0 68,134 0
PHILIP MORRIS INTL INC COM 718172109 533 8,000 SH   DFND 3 0 8,000 0
PIERIS PHARMACEUTICALS INC COM 720795103 479 187,693 SH   DFND 3 0 187,693 0
PORTOLA PHARMACEUTICALS INC COM 737010108 1,214 74,800 SH   DFND 3 0 74,800 0
PRICELINE GRP INC NOTE 0.900% 9/1 741503AX4 334 300,000 SH   DFND 3 0 300,000 0
PROCTER AND GAMBLE CO COM 742718109 1,399 15,200 SH   DFND 3 0 15,200 0
PROGENICS PHARMACEUTICALS IN COM 743187106 1,773 454,588 SH   DFND 3 0 454,588 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 609 96,513 SH   DFND 3 0 96,513 0
PROTALIX BIOTHERAPEUTICS INC COM 74365A101 795 2,631,400 SH   DFND 3 0 2,631,400 0
QORVO INC COM 74736K101 263 4,361 SH   DFND 3 0 4,361 0
QUALCOMM INC COM 747525103 690 12,300 SH   DFND 3 0 12,300 0
RA PHARMACEUTICALS INC COM 74933V108 1,973 108,073 SH   DFND 3 0 108,073 0
RETROPHIN INC COM 761299106 1,265 56,837 SH   DFND 3 0 56,837 0
REVANCE THERAPEUTICS INC COM 761330109 9,512 472,532 SH   DFND 1 0 472,532 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 779 29,720 SH   DFND 3 0 29,720 0
ROGERS COMMUNICATIONS INC CL B 775109200 502 5,540 SH   DFND 3 0 5,540 0
SCHLUMBERGER LTD COM 806857108 916 25,200 SH   DFND 3 0 25,200 0
SCHWAB CHARLES CORP NEW COM 808513105 780 19,000 SH   DFND 3 0 19,000 0
SEADRILL LTD COM G7998G106 16,642 1,706,914 SH   DFND 1 0 1,706,914 0
SEATTLE GENETICS INC COM 812578102 7,697 136,105 SH   DFND 3 0 136,105 0
SELECTA BIOSCIENCES INC COM 816212104 531 173,000 SH   DFND 3 0 173,000 0
SINA CORP ORD G81477104 81,657 1,522,312 SH   DFND 1 0 1,522,312 0
SINA CORP ORD G81477104 21,963 409,464 SH   DFND   0 409,464 0
SKYWORKS SOLUTIONS INC COM 83088M102 406 6,000 SH   DFND 3 0 6,000 0
SL GREEN RLTY CORP COM 78440X101 1,593 20,000 SH   DFND 3 0 20,000 0
SOCIEDAD QUIMICA MINERA DE C SPON ADR SER B 833635105 2,218 57,000 SH   DFND 3 0 57,000 0
SOHU COM LTD SPONSORED ADS 83410S108 20,232 1,161,450 SH   DFND 1 0 1,161,450 0
SOLENO THERAPEUTICS INC COM NEW 834203200 294 180,413 SH   DFND 3 0 180,413 0
SOUTHWEST GAS HOLDINGS INC COM 844895102 326 4,320 SH   DFND 3 0 4,320 0
SPARK THERAPEUTICS INC COM 84652J103 352 9,500 SH   DFND 3 0 9,500 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108 1,073 121,000 SH   DFND 3 0 121,000 0
SPERO THERAPEUTICS INC COM 84833T103 1,041 162,362 SH   DFND 3 0 162,362 0
SPIRIT AIRLS INC COM 848577102 228 4,000 SH   DFND 3 0 4,000 0
SPIRIT RLTY CAP INC NEW NOTE 2.875% 5/1 84860WAA0 19,959 20,000,000 SH   DFND 1 0 20,000,000 0
SPIRIT RLTY CAP INC NEW NOTE 3.750% 5/1 84860WAB8 29,470 30,000,000 SH   DFND 1 0 30,000,000 0
SPIRIT RLTY CAP INC NEW NOTE 3.750% 5/1 84860WAB8 18,533 18,992,000 SH   DFND   0 18,992,000 0
SPRING BK PHARMACEUTICALS IN COM 849431101 274 31,100 SH   DFND 3 0 31,100 0
STAMPS COM INC COM NEW 852857200 376 2,400 SH   DFND 3 0 2,400 0
STANLEY BLACK & DECKER INC COM 854502101 219 1,820 SH   DFND 3 0 1,820 0
STARBUCKS CORP COM 855244109 860 13,600 SH   DFND 3 0 13,600 0
STEMLINE THERAPEUTICS INC COM 85858C107 572 58,000 SH   DFND 3 0 58,000 0
SYNLOGIC INC COM 87166L100 286 38,438 SH   DFND 3 0 38,438 0
T MOBILE US INC COM 872590104 814 13,000 SH   DFND 3 0 13,000 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 1,770 48,120 SH   DFND 3 0 48,120 0
TESLA INC COM 88160R101 822 2,600 SH   DFND 3 0 2,600 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 666 43,000 SH   DFND 3 0 43,000 0
THERMO FISHER SCIENTIFIC INC COM 883556102 906 4,100 SH   DFND 3 0 4,100 0
THOR INDS INC COM 885160101 384 7,610 SH   DFND 3 0 7,610 0
TOTAL S A SPONSORED ADR 89151E109 311 6,000 SH   DFND 3 0 6,000 0
TRANSGLOBE ENERGY CORP COM 893662106 4,521 2,422,923 SH   DFND 1 0 2,422,923 0
TRANSLATE BIO INC COM 89374L104 545 74,000 SH   DFND 3 0 74,000 0
TWITTER INC NOTE 0.250% 9/1 90184LAB8 72,190 74,300,000 SH   DFND 1 0 74,300,000 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 1,051 25,000 SH   DFND 3 0 25,000 0
UNDER ARMOUR INC CL A 904311107 716 40,000 SH   DFND 3 0 40,000 0
UNITEDHEALTH GROUP INC COM 91324P102 2,076 8,440 SH   DFND 3 0 8,440 0
UNITEDHEALTH GROUP INC COM 91324P102 710 2,850 SH   DFND   0 2,850 0
VBI VACCINES INC COM NEW 91822J103 935 645,081 SH   DFND 3 0 645,081 0
VEON LTD SPONSORED ADR 91822M106 1,546 660,608 SH   DFND 1 0 660,608 0
VERRICA PHARMACEUTICALS INC COM 92511W108 2,705 331,933 SH   DFND 1 0 331,933 0
VERRICA PHARMACEUTICALS INC COM 92511W108 3,768 462,346 SH   DFND   0 462,346 0
VERTEX PHARMACEUTICALS INC COM 92532F100 812 5,000 SH   DFND 3 0 5,000 0
VIEWRAY INC COM 92672L107 99,981 16,471,258 SH   DFND   0 16,471,258 0
VIKING THERAPEUTICS INC COM 92686J106 505 69,203 SH   DFND 3 0 69,203 0
VIPSHOP HLDGS LTD SPONSORED ADR 92763W103 31,975 5,856,318 SH   DFND 1 0 5,856,318 0
VIPSHOP HLDGS LTD SPONSORED ADR 92763W103 10,146 1,858,164 SH   DFND   0 1,858,164 0
VISA INC COM CL A 92826C839 4,381 33,190 SH   DFND 3 0 33,190 0
WASTE MGMT INC DEL COM 94106L109 1,374 15,600 SH   DFND 3 0 15,600 0
WELLS FARGO CO NEW COM 949746101 218 4,795 SH   DFND 3 0 4,795 0
WORKDAY INC NOTE 0.250%10/0 98138HAF8 121 100,000 SH   DFND 3 0 100,000 0
XOMA CORP DEL COM NEW 98419J206 3,842 316,234 SH   DFND 3 0 316,234 0
XYLEM INC COM 98419M100 223 3,420 SH   DFND 3 0 3,420 0
YAMANA GOLD INC COM 98462Y100 40 17,000 SH   DFND 3 0 17,000 0
YY INC ADS REPCOM CLA 98426T106 3,580 59,800 SH   DFND   0 59,800 0
ZIX CORP COM 98974P100 91 17,000 SH   DFND 3 0 17,000 0
ZOGENIX INC COM NEW 98978L204 1,615 45,700 SH   DFND 3 0 45,700 0
ZYMEWORKS INC COM 98985W102 1,030 88,008 SH   DFND 3 0 88,008 0