The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris Therapeutics Common Shares 00461U105 22,353 1,539,480 SH   SOLE   1,539,480 0 0
Amarin Ordinary Shares 023111206 0 1 SH   SOLE   1 0 0
Amarin Common Shares - ADR 023111206 84,739 5,208,305 SH   SOLE   5,208,305 0 0
Apellis Pharmaceuticals, Inc Common Shares 03753U106 9,772 549,580 SH   SOLE   549,580 0 0
Ascendis Pharma A/S Ordinary Shares 04351P101 104,942 1,480,976 SH   SOLE   1,480,976 0 0
Ascendis Pharma A/S Common Shares - ADR 04351P101 70,756 998,538 SH   SOLE   998,538 0 0
Audentes Therapeutics Common Shares 05070R104 36,963 933,640 SH   SOLE   933,640 0 0
Auris Medical Holding AG Warrant(s) H0381L104 0 140,000 SH   SOLE   140,000 0 0
Chiasma Common Shares 16706W102 5,869 1,630,221 SH   SOLE   1,630,221 0 0
Chiasma Warrant(s) 16706W102 0 136,881 SH   SOLE   136,881 0 0
Coherus BioSciences Common Shares 19249H103 47,326 2,868,221 SH   SOLE   2,868,221 0 0
Edge Therapeutics Common Shares 279870109 2,339 2,852,711 SH   SOLE   2,852,711 0 0
Entasis Therapeutics Holdings Inc. Common Shares 293614103 12,840 1,180,178 SH   SOLE   1,180,178 0 0
Histogenics Common Shares 43358V109 1,132 2,077,040 SH   SOLE   2,077,040 0 0
Iterum Therapeutics Common Shares G6333L101 11,438 1,726,514 SH   SOLE   1,726,514 0 0
Kiniksa Pharmaceuticals, Ltd Common Shares - Class A G5269C101 23,529 922,700 SH   SOLE   922,700 0 0
Merus N.V. Common Shares N5749R100 38,711 1,961,039 SH   SOLE   1,961,039 0 0
Natera Common Shares 632307104 74,227 3,100,560 SH   SOLE   3,100,560 0 0
Nucana Biomed Ordinary Shares GB00BYWYV 99,680 4,000,000 SH   SOLE   4,000,000 0 0
Nucana Biomed Common Shares - ADR 67022C106 16,613 666,666 SH   SOLE   666,666 0 0
ObsEva SA Common Shares H5861P103 85,636 4,749,623 SH   SOLE   4,749,623 0 0
Principia Biopharma Common Shares 74257L108 59,556 2,038,208 SH   SOLE   2,038,208 0 0
Principia Biopharma Warrant(s) 74257L108 0 20,938 SH   SOLE   20,938 0 0
Spark Therapeutics Common Shares 84652J103 26,253 481,270 SH   SOLE   481,270 0 0
Synlogic Inc. (fmrly Mirna) Common Shares 87166L100 8,170 574,972 SH   SOLE   574,972 0 0
Y-mAbs Therapeutics, Inc Common Shares 984241109 55,890 2,104,278 SH   SOLE   2,104,278 0 0
Adamas Pharmaceuticals Inc COMM 00548A106 976 48,743 SH   SOLE   48,743 0 0
Adaptimmune Therapeutics PLC ADR 00653A107 172 12,678 SH   SOLE   12,678 0 0
Aduro Biotech Inc COMM 00739L101 196 26,712 SH   SOLE   26,712 0 0
Aimmune Therapeutics Inc COMM 00900T107 853 31,263 SH   SOLE   31,263 0 0
Alexion Pharmaceuticals Inc COMM 015351109 1,278 9,196 SH   SOLE   9,196 0 0
Allergan plc COMM G0177J108 2,577 13,529 SH   SOLE   13,529 0 0
Amicus Therapeutics Inc COMM 03152W109 760 62,834 SH   SOLE   62,834 0 0
AnaptysBio Inc COMM 032724106 979 9,808 SH   SOLE   9,808 0 0
ArQule Inc COMM 04269E107 304 53,734 SH   SOLE   53,734 0 0
AstraZeneca PLC ADR 046353108 1,344 33,965 SH   SOLE   33,965 0 0
AstraZeneca PLC COMM 046353108 1,080 27,300 SH Call SOLE   27,300 0 0
Biohaven Pharmaceutical Holding Company Ltd COMM G11196105 705 18,784 SH   SOLE   18,784 0 0
Blueprint Medicines Corp COMM 09627Y109 565 7,240 SH   SOLE   7,240 0 0
Catalyst Pharmaceuticals Inc COMM 14888U101 675 178,518 SH   SOLE   178,518 0 0
Clearside Biomedical Inc COMM 185063104 526 85,510 SH   SOLE   85,510 0 0
Conatus Pharmaceuticals Inc COMM 20600T108 441 76,034 SH   SOLE   76,034 0 0
Dermira Inc COMM 24983L104 761 69,798 SH   SOLE   69,798 0 0
Epizyme Inc COMM 29428V104 435 41,084 SH   SOLE   41,084 0 0
Esperion Therapeutics Inc COMM 29664W105 229 5,165 SH   SOLE   5,165 0 0
Exelixis Inc COMM 30161Q104 1,009 56,960 SH   SOLE   56,960 0 0
Fate Therapeutics Inc COMM 31189P102 241 14,800 SH   SOLE   14,800 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 540 94,204 SH   SOLE   94,204 0 0
Heron Therapeutics Inc COMM 427746102 1,318 41,646 SH   SOLE   41,646 0 0
Kadmon Holdings Inc COMM 48283N106 639 191,168 SH   SOLE   191,168 0 0
Kadmon Holdings Inc Warrant 48283N106 0 59,909 SH   SOLE   59,909 0 0
Kala Pharmaceuticals Inc COMM 483119103 133 13,472 SH   SOLE   13,472 0 0
Kura Oncology Inc COMM 50127T109 605 34,568 SH   SOLE   34,568 0 0
Molecular Partners AG COMM H55351102 652 29,092 SH   SOLE   29,092 0 0
MorphoSys AG COMM D55040105 452 4,227 SH   SOLE   4,227 0 0
OncoMed Pharmaceuticals Inc COMM 68234X102 146 68,899 SH   SOLE   68,899 0 0
Otonomy Inc COMM 68906L105 296 107,674 SH   SOLE   107,674 0 0
Puma Biotechnology Inc COMM 74587V107 2,176 47,458 SH   SOLE   47,458 0 0
Rhythm Pharmaceuticals Inc COMM 76243J105 646 22,162 SH   SOLE   22,162 0 0
Rigel Pharmaceuticals Inc COMM 766559603 1,475 459,442 SH   SOLE   459,442 0 0
Sanofi SA ADR 80105N105 2,598 58,153 SH   SOLE   58,153 0 0
Sarepta Therapeutics Inc COMM 803607100 682 4,221 SH   SOLE   4,221 0 0
Savara Inc COMM 805111101 1,084 97,138 SH   SOLE   97,138 0 0
Spring Bank Pharmaceuticals Inc COMM 849431101 325 26,954 SH   SOLE   26,954 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 197 24,405 SH   SOLE   24,405 0 0
TESARO Inc COMM 881569107 1,230 31,533 SH   SOLE   31,533 0 0
Adamas Pharmaceuticals Inc COMM 00548A106 3,888 194,205 SH   OTR 2 194,205 0 0
Adaptimmune Therapeutics PLC ADR 00653A107 685 50,488 SH   OTR 2 50,488 0 0
Aduro Biotech Inc COMM 00739L101 783 106,483 SH   OTR 2 106,483 0 0
Aimmune Therapeutics Inc COMM 00900T107 3,425 125,554 SH   OTR 2 125,554 0 0
Alexion Pharmaceuticals Inc COMM 015351109 5,104 36,718 SH   OTR 2 36,718 0 0
Allergan plc COMM G0177J108 10,273 53,932 SH   OTR 2 53,932 0 0
Amicus Therapeutics Inc COMM 03152W109 3,028 250,487 SH   OTR 2 250,487 0 0
AnaptysBio Inc COMM 032724106 3,901 39,101 SH   OTR 2 39,101 0 0
ArQule Inc COMM 04269E107 1,240 218,997 SH   OTR 2 218,997 0 0
AstraZeneca PLC ADR 046353108 5,348 135,164 SH   OTR 2 135,164 0 0
AstraZeneca PLC COMM 046353108 4,297 108,600 SH Call OTR 2 108,600 0 0
Biohaven Pharmaceutical Holding Company Ltd COMM G11196105 2,807 74,751 SH   OTR 2 74,751 0 0
Blueprint Medicines Corp COMM 09627Y109 2,251 28,831 SH   OTR 2 28,831 0 0
Catalyst Pharmaceuticals Inc COMM 14888U101 3,337 882,791 SH   OTR 2 882,791 0 0
Clearside Biomedical Inc COMM 185063104 2,096 340,885 SH   OTR 2 340,885 0 0
Conatus Pharmaceuticals Inc COMM 20600T108 1,756 302,678 SH   OTR 2 302,678 0 0
Dermira Inc COMM 24983L104 3,032 278,167 SH   OTR 2 278,167 0 0
Epizyme Inc COMM 29428V104 1,734 163,615 SH   OTR 2 163,615 0 0
Esperion Therapeutics Inc COMM 29664W105 912 20,547 SH   OTR 2 20,547 0 0
Exelixis Inc COMM 30161Q104 4,017 226,685 SH   OTR 2 226,685 0 0
Fate Therapeutics Inc COMM 31189P102 960 58,907 SH   OTR 2 58,907 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 2,152 375,543 SH   OTR 2 375,543 0 0
Heron Therapeutics Inc COMM 427746102 5,255 166,024 SH   OTR 2 166,024 0 0
Kadmon Holdings Inc COMM 48283N106 3,199 957,858 SH   OTR 2 957,858 0 0
Kala Pharmaceuticals Inc COMM 483119103 537 54,373 SH   OTR 2 54,373 0 0
Kura Oncology Inc COMM 50127T109 2,446 139,775 SH   OTR 2 139,775 0 0
Molecular Partners AG COMM H55351102 2,596 115,868 SH   OTR 2 115,868 0 0
MorphoSys AG COMM D55040105 1,802 16,850 SH   OTR 2 16,850 0 0
OncoMed Pharmaceuticals Inc COMM 68234X102 251 118,257 SH   OTR 2 118,257 0 0
Otonomy Inc COMM 68906L105 1,602 582,545 SH   OTR 2 582,545 0 0
Puma Biotechnology Inc COMM 74587V107 8,674 189,190 SH   OTR 2 189,190 0 0
Rhythm Pharmaceuticals Inc COMM 76243J105 2,634 90,312 SH   OTR 2 90,312 0 0
Rigel Pharmaceuticals Inc COMM 766559603 5,879 1,831,567 SH   OTR 2 1,831,567 0 0
Sanofi SA ADR 80105N105 10,356 231,827 SH   OTR 2 231,827 0 0
Sarepta Therapeutics Inc COMM 803607100 2,714 16,801 SH   OTR 2 16,801 0 0
Savara Inc COMM 805111101 4,418 395,834 SH   OTR 2 395,834 0 0
Spring Bank Pharmaceuticals Inc COMM 849431101 1,294 107,422 SH   OTR 2 107,422 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 785 97,183 SH   OTR 2 97,183 0 0
TESARO Inc COMM 881569107 4,901 125,637 SH   OTR 2 125,637 0 0
Adamas Pharmaceuticals Inc COMM 00548A106 2,058 102,808 SH   OTR 1 102,808 0 0
Adaptimmune Therapeutics PLC ADR 00653A107 363 26,753 SH   OTR 1 26,753 0 0
Aduro Biotech Inc COMM 00739L101 414 56,384 SH   OTR 1 56,384 0 0
Aimmune Therapeutics Inc COMM 00900T107 1,786 65,478 SH   OTR 1 65,478 0 0
Alexion Pharmaceuticals Inc COMM 015351109 2,703 19,446 SH   OTR 1 19,446 0 0
Allergan plc COMM G0177J108 5,440 28,560 SH   OTR 1 28,560 0 0
Amicus Therapeutics Inc COMM 03152W109 1,604 132,648 SH   OTR 1 132,648 0 0
AnaptysBio Inc COMM 032724106 2,066 20,706 SH   OTR 1 20,706 0 0
ArQule Inc COMM 04269E107 643 113,540 SH   OTR 1 113,540 0 0
AstraZeneca PLC ADR 046353108 2,828 71,479 SH   OTR 1 71,479 0 0
AstraZeneca PLC COMM 046353108 2,275 57,500 SH Call OTR 1 57,500 0 0
Biohaven Pharmaceutical Holding Company Ltd COMM G11196105 1,484 39,531 SH   OTR 1 39,531 0 0
Blueprint Medicines Corp COMM 09627Y109 1,192 15,268 SH   OTR 1 15,268 0 0
Catalyst Pharmaceuticals Inc COMM 14888U101 1,846 488,243 SH   OTR 1 488,243 0 0
Clearside Biomedical Inc COMM 185063104 1,110 180,519 SH   OTR 1 180,519 0 0
Conatus Pharmaceuticals Inc COMM 20600T108 929 160,203 SH   OTR 1 160,203 0 0
Dermira Inc COMM 24983L104 1,606 147,328 SH   OTR 1 147,328 0 0
Epizyme Inc COMM 29428V104 918 86,619 SH   OTR 1 86,619 0 0
Esperion Therapeutics Inc COMM 29664W105 483 10,887 SH   OTR 1 10,887 0 0
Exelixis Inc COMM 30161Q104 2,125 119,949 SH   OTR 1 119,949 0 0
Fate Therapeutics Inc COMM 31189P102 508 31,184 SH   OTR 1 31,184 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 1,140 198,872 SH   OTR 1 198,872 0 0
Heron Therapeutics Inc COMM 427746102 2,783 87,919 SH   OTR 1 87,919 0 0
Kadmon Holdings Inc COMM 48283N106 1,314 393,476 SH   OTR 1 393,476 0 0
Kadmon Holdings Inc Warrant 48283N106 0 240,091 SH   OTR 1 240,091 0 0
Kala Pharmaceuticals Inc COMM 483119103 274 27,810 SH   OTR 1 27,810 0 0
Kura Oncology Inc COMM 50127T109 1,278 73,042 SH   OTR 1 73,042 0 0
MorphoSys AG COMM D55040105 954 8,923 SH   OTR 1 8,923 0 0
OncoMed Pharmaceuticals Inc COMM 68234X102 442 208,588 SH   OTR 1 208,588 0 0
Otonomy Inc COMM 68906L105 818 297,559 SH   OTR 1 297,559 0 0
Puma Biotechnology Inc COMM 74587V107 4,594 100,187 SH   OTR 1 100,187 0 0
Rhythm Pharmaceuticals Inc COMM 76243J105 1,366 46,828 SH   OTR 1 46,828 0 0
Rigel Pharmaceuticals Inc COMM 766559603 3,113 969,922 SH   OTR 1 969,922 0 0
Sanofi SA ADR 80105N105 5,484 122,766 SH   OTR 1 122,766 0 0
Sarepta Therapeutics Inc COMM 803607100 1,436 8,893 SH   OTR 1 8,893 0 0
Savara Inc COMM 805111101 2,291 205,253 SH   OTR 1 205,253 0 0
Spring Bank Pharmaceuticals Inc COMM 849431101 666 55,270 SH   OTR 1 55,270 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 416 51,524 SH   OTR 1 51,524 0 0
TESARO Inc COMM 881569107 2,594 66,505 SH   OTR 1 66,505 0 0