The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 24,831 | 1,196,098 | SH | DFND | 1,2 | 1,196,098 | 0 | 0 | |
| ACCELERON PHARMA INC | COM | 00434H108 | 52,524 | 917,767 | SH | DFND | 1,2 | 917,767 | 0 | 0 | |
| ACER THERAPEUTICS INC | COM | 00444P108 | 1,803 | 58,461 | SH | DFND | 1,2 | 58,461 | 0 | 0 | |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 26,256 | 300,000 | SH | DFND | 1,2 | 300,000 | 0 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 9,788 | 129,060 | SH | DFND | 1,2 | 129,060 | 0 | 0 | |
| BIOCRYST PHARMACEUTICALS | COM | 09058V103 | 60,874 | 7,978,275 | SH | DFND | 1,2 | 7,978,275 | 0 | 0 | |
| CTI BIOPHARMA CORP | COM | 12648L601 | 46 | 21,441 | SH | DFND | 1,2 | 21,441 | 0 | 0 | |
| CYTOKINETICS INC | COM | 23282W605 | 21,470 | 2,179,688 | SH | DFND | 1,2 | 2,179,688 | 0 | 0 | |
| ENANTA PHARMACEUTICALS INC | COM | 29251M106 | 17,981 | 210,400 | SH | DFND | 1,2 | 210,400 | 0 | 0 | |
| ENDOCYTE INC | COM | 29269A102 | 28,524 | 1,606,100 | SH | DFND | 1,2 | 1,606,100 | 0 | 0 | |
| EXELIXIS INC | COM | 30161Q104 | 36,769 | 2,075,000 | SH | DFND | 1,2 | 2,075,000 | 0 | 0 | |
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 22,937 | 1,647,753 | SH | DFND | 1,2 | 1,647,753 | 0 | 0 | |
| INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 4,340 | 200,000 | SH | Put | DFND | 1,2 | 200,000 | 0 | 0 |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 39,334 | 3,496,340 | SH | DFND | 1,2 | 3,496,340 | 0 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 37,084 | 2,119,106 | SH | DFND | 1,2 | 2,119,106 | 0 | 0 | |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 8,651 | 40,400 | SH | DFND | 1,2 | 40,400 | 0 | 0 | |
| MENLO THERAPEUTICS INC | COM | 586858102 | 12,848 | 1,304,407 | SH | DFND | 1,2 | 1,304,407 | 0 | 0 | |
| PTC THERAPEUTICS INC | COM | 69366J200 | 33,721 | 717,458 | SH | DFND | 1,2 | 717,458 | 0 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 10,109 | 982,449 | SH | DFND | 1,2 | 982,449 | 0 | 0 | |
| SAVARA INC | COM | 805111101 | 25,033 | 2,243,084 | SH | DFND | 1,2 | 2,243,084 | 0 | 0 | |
| SIERRA ONCOLOGY INC | COM | 82640U107 | 834 | 490,843 | SH | DFND | 1,2 | 490,843 | 0 | 0 | |
| SPARK THERAPEUTICS INC | COM | 84652J103 | 21,446 | 393,147 | SH | DFND | 1,2 | 393,147 | 0 | 0 | |
| STREAMLINE HEALTH SOLUTIONS | COM | 86323X106 | 153 | 130,137 | SH | DFND | 1,2 | 130,137 | 0 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM | 867328700 | 2,000 | 1,000,000 | SH | DFND | 1,2 | 1,000,000 | 0 | 0 | |
| TG THERAPEUTICS INC | COM | 88322Q108 | 10,920 | 1,950,000 | SH | DFND | 1,2 | 1,950,000 | 0 | 0 | |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 | 38,364 | 300,000 | SH | DFND | 1,2 | 300,000 | 0 | 0 | |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | 26,488 | 1,400,000 | SH | DFND | 1,2 | 1,400,000 | 0 | 0 | |
| ZAFGEN INC | COM | 98885E103 | 39,645 | 3,391,385 | SH | DFND | 1,2 | 3,391,385 | 0 | 0 | |
| ZYMEWORKS INC | COM | 98985W102 | 3,799 | 241,970 | SH | DFND | 1,2 | 241,970 | 0 | 0 | |
| FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 23,094 | 4,030,268 | SH | DFND | 1,2 | 4,030,268 | 0 | 0 | |