The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COM 00289Y107 6,400 500,000 SH   DFND 1 500,000 0 0
ACCELERON PHARMA INC COM 00434H108 2,862 50,000 SH   DFND 1 50,000 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 7,260 500,000 SH   DFND 1 500,000 0 0
AKCEA THERAPEUTICS INC COM 00972L107 3,502 100,000 SH Put DFND 1 100,000 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 8,135 500,000 SH   DFND 1 500,000 0 0
ANAPTYSBIO INC COM 032724106 113,239 1,135,000 SH   DFND 1 1,135,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 74,187 4,172,498 SH   DFND 1 4,172,498 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 18,868 410,000 SH   DFND 1 410,000 0 0
ARGEN SE SPONSORED ADR 04016X101 14,410 190,000 SH   DFND 1 190,000 0 0
ARQULE INC COM 04269E107 1,698 300,000 SH   DFND 1 300,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 9,120 600,000 SH   DFND 1 600,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 24,801 350,000 SH   DFND 1 350,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 4,949 125,000 SH   DFND 1 125,000 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 40,673 1,326,136 SH   DFND 1 1,326,136 0 0
AVROBIO INC COM 05455M100 77,431 1,492,784 SH   DFND 1 1,492,784 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 9,763 260,000 SH   DFND 1 260,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 29,663 380,000 SH   DFND 1 380,000 0 0
CELLECTAR BIOSCIENCES-CW19 *W EXP 08/20/201 15117F120 4 52,999 SH   DFND 1 52,999 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 2,460 400,000 SH   DFND 1 400,000 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 3,685 250,000 SH   DFND 1 250,000 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 8,558 1,271,687 SH   DFND 1 1,271,687 0 0
CONTRAFECT CORP COM 212326102 6,210 3,000,000 SH   DFND 1 3,000,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 54,275 3,556,669 SH   DFND 1 3,556,669 0 0
EIDOS THERAPEUTICS INC COM 28249H104 3,851 385,846 SH   DFND 1 385,846 0 0
G1 THERAPEUTICS INC COM 3621LQ109 33,491 640,481 SH   DFND 1 640,481 0 0
HERON THERAPEUTICS INC COM 427746102 5,381 170,000 SH   DFND 1 170,000 0 0
INCYTE CORP COM 45337C102 17,961 260,000 SH   DFND 1 260,000 0 0
INFLARX NV COM N44821101 46,042 1,341,540 SH   DFND 1 1,341,540 0 0
INSPIRE MED SYS INC COM 457730109 12,624 300,000 SH   DFND 1 300,000 0 0
ITERUM THERAPEUTICS PLC SHS G6333L101 3,196 476,968 SH   DFND 1 476,968 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 33,248 1,552,911 SH   DFND 1 1,552,911 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 21,191 831,000 SH   DFND 1 831,000 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 3,000 300,000 SH   DFND 1 300,000 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 3,245 238,579 SH   DFND 1 238,579 0 0
MINERVA NEUROSCIENCES INC COM 603380106 7,629 607,903 SH   DFND 1 607,903 0 0
MIRATI THERAPEUTICS INC COM 60468T105 85,251 1,810,000 SH   DFND 1 1,810,000 0 0
MYOKARDIA INC COM 62857M105 45,640 700,000 SH   DFND 1 700,000 0 0
NEKTAR THERAPEUTICS COM 640268108 83,515 1,370,000 SH   DFND 1 1,370,000 0 0
NEKTAR THERAPEUTICS COM 640268108 80,979 1,328,400 SH Call DFND 1 132,840 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 21,516 175,000 SH   DFND 1 175,000 0 0
OMEROS CORP COM 682143102 24,410 1,000,000 SH   DFND 1 1,000,000 0 0
OMEROS CORP COM 682143102 27,752 1,136,900 SH Call DFND 1 1,136,900 0 0
ONCOBIOLOGICS INC - CW17 -A *W EXP 02/18/201 68235M113 9 416,666 SH   DFND 1 416,666 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 43,447 1,486,898 SH   DFND 1 1,486,898 0 0
QUANTERIX CORP COM 74766Q101 1,177 54,945 SH   DFND 1 54,945 0 0
QUOTIENT LTD SHS G73268107 36,618 4,850,000 SH   DFND 1 4,850,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 53,962 660,000 SH   DFND 1 660,000 0 0
REPLIMUNE GROUP INC COM 76029N106 7,531 467,792 SH   DFND 1 467,792 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 36,946 1,500,659 SH   DFND 1 1,500,659 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 8,749 364,559 SH   DFND 1 364,559 0 0
SAGE THERAPEUTICS INC COM 78667J108 26,838 190,000 SH   DFND 1 190,000 0 0
SANGAMO BIOSCIENCES INC COM 800677106 3,390 200,000 SH   DFND 1 200,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 5,410 210,078 SH   DFND 1 210,078 0 0
SOLID BIOSCIENCES INC COM 83422E105 31,635 670,513 SH   DFND 1 670,513 0 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108 8,400 500,000 SH   DFND 1 500,000 0 0
TESARO INC COM 881569107 48,763 1,250,000 SH   DFND 1 1,250,000 0 0
TESARO INC COM 881569107 19,505 500,000 SH Call DFND 1 500,000 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 35,937 1,100,000 SH   DFND 1 1,100,000 0 0
TRANSLATE BIO, INC COM 89374L104 4,546 454,550 SH   DFND 1 454,550 0 0
TRICIDA INC COM 89610F101 22,442 734,588 SH   DFND 1 734,588 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 2,900 500,000 SH   DFND 1 500,000 0 0
Y MABS THERAPEUTICS INC COM 984241109 5,312 200,000 SH   DFND 1 200,000 0 0
ZAI LAB LTD ADR 98887Q104 15,743 808,166 SH   DFND 1 808,166 0 0
ZOGENIX INC COM NEW 98978L204 24,800 500,000 SH   DFND 1 500,000 0 0
ZOGENIX INC COM NEW 98978L204 12,400 250,000 SH Call DFND 1 250,000 0 0