The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACHILLION PHARMACEUTICALS COM 00448Q201 3,119 847,636 SH   SOLE 847,636 0 0
ADVAXIS INC COM NEW 007624208 1,567 1,666,666 SH   SOLE 1,666,666 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 8,172 132,770 SH   SOLE 132,770 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 5,525 625,738 SH   SOLE 625,738 0 0
ALDER BIOPHARMACEUTICALS INC NOTE 2.500% 2/0 014339AA3 269 250,000 PRN   SOLE 250,000 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 6,594 396,013 SH   SOLE 396,013 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 2,627 359,860 SH   SOLE 359,860 0 0
APTINYX INC COM 03836N103 420 14,500 SH   SOLE 14,500 0 0
ARDELYX INC COM 039697107 2,057 472,859 SH   SOLE 472,859 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 4,535 98,547 SH   SOLE 98,547 0 0
ARGENX SE SPONSORED ADR 04016X101 4,877 64,300 SH   SOLE 64,300 0 0
ARQULE INC COM 04269E107 2,534 447,664 SH   SOLE 447,664 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 5,473 77,242 SH   SOLE 77,242 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 396 10,673 SH   SOLE 10,673 0 0
ATRICURE INC COM 04963C209 10,289 293,729 SH   SOLE 293,729 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 185 30,000 SH   SOLE 30,000 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 4,975 652,086 SH   SOLE 652,086 0 0
BIOHAVEN PHARMACEUTICALS HOLD COM G11196105 1,127 30,000 SH   SOLE 30,000 0 0
BIOTELEMETRY INC COM 090672106 3,016 46,800 SH   SOLE 46,800 0 0
BIOTIME INC COM 09066L105 235 100,000 SH   SOLE 100,000 0 0
BLUEBIRD BIO INC COM 09609G100 2,993 20,500 SH   SOLE 20,500 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 7,235 92,691 SH   SOLE 92,691 0 0
CARA THERAPEUTICS INC COM 140755109 2,702 112,811 SH   SOLE 112,811 0 0
CARDIOVASCULAR SYSTEMS INC COM 141619106 2,200 56,200 SH   SOLE 56,200 0 0
CIDARA THERAPEUTICS INC COM 171757107 936 212,766 SH   SOLE 212,766 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 3,263 294,511 SH   SOLE 294,511 0 0
CYTOKINETICS INC COM NEW 23282W605 617 62,690 SH   SOLE 62,690 0 0
DERMIRA INC COM 24983L104 55 5,000 SH   SOLE 5,000 0 0
DEXCOM INC COM 252131107 5,292 37,000 SH   SOLE 37,000 0 0
DEXCOM INC NOTE 0.750% 5/1 252131AF4 383 250,000 PRN   SOLE 250,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 1,808 118,500 SH   SOLE 118,500 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 4,630 808,000 SH   SOLE 808,000 0 0
GALAPAGOS NV SPON ADR 36315X101 4,453 39,609 SH   SOLE 39,609 0 0
IMMUNE DESIGN CORP COM 45252L103 1,133 328,500 SH   SOLE 328,500 0 0
IMMUNOMEDICS INC COM 452907108 3,708 178,000 SH   SOLE 178,000 0 0
INCYTE CORP COM 45337C102 1,485 21,500 SH   SOLE 21,500 0 0
INSULET CORP NOTE 1.375% 45784PAG6 1,909 1,500,000 PRN   SOLE 1,500,000 0 0
INTEC PHARMA LTD JERUSALEM SHS M53644106 3,034 537,000 SH   SOLE 537,000 0 0
ISHARES TR NASDAQ BIOTECH ETF 464287556 3,183 26,100 SH   SOLE 26,100 0 0
JOHNSON AND JOHNSON COM 478160104 1,299 9,400 SH   SOLE 9,400 0 0
KADMON HOLDINGS INC COM 48283N106 210 63,000 SH   SOLE 63,000 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 392 17,725 SH   SOLE 17,725 0 0
KURA ONCOLOGY INC COM 50127T109 4,209 240,500 SH   SOLE 240,500 0 0
LEAP THERPEUTICS INC COM 52187K101 1,096 140,643 SH   SOLE 140,643 0 0
LOXO ONCOLOGY INC COM 548862101 28,986 169,675 SH   SOLE 169,675 0 0
LUMINEX CORP COM 55027E102 4,195 138,391 SH   SOLE 138,391 0 0
MACROGENICS INC COM 556099109 1,679 78,305 SH   SOLE 78,305 0 0
MASIMO CORPORATION COM 574795100 374 3,000 SH   SOLE 3,000 0 0
MENLO THERAPEUTICS INC COM 586858102 3,073 312,000 SH   SOLE 312,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 338 26,907 SH   SOLE 26,907 0 0
NATUS MEDICAL INC COM 639050103 1,351 37,900 SH   SOLE 37,900 0 0
NEON THERAPEUICS INC COM 64050Y100 427 50,000 SH   SOLE 50,000 0 0
NEOS THERAPEUTICS INC COM 64052L106 133 27,500 SH   SOLE 27,500 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 5,042 41,008 SH   SOLE 41,008 0 0
NOVAVAX INC COM 670002104 1,316 700,000 SH   SOLE 700,000 0 0
NXSTAGE MEDICAL INC COM 67072V103 8,538 306,119 SH   SOLE 306,119 0 0
OBSEVA SA COM H5861P103 781 43,338 SH   SOLE 43,338 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109 5,038 260,336 SH   SOLE 260,336 0 0
RADIUS HEALTH INC COM NEW 750469207 365 20,500 SH   SOLE 20,500 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 3,080 4,000,000 PRN   SOLE 4,000,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 442 137,600 SH   SOLE 137,600 0 0
SAGE THERAPEUTICS INC COM 78667J108 14,027 99,306 SH   SOLE 99,306 0 0
SCYNEXIS INC COM 811292101 1,528 1,272,927 SH   SOLE 1,272,927 0 0
SOL GEL TECHNOLOGIES LTD SHS M8694L103 263 35,000 SH   SOLE 35,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 736 70,000 SH   SOLE 70,000 0 0
STEREOTAXIS INC COM 85916J409 16,553 13,680,554 SH   SOLE 13,680,554 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 747 373,702 SH   SOLE 373,702 0 0
SUTRO BIOPHARMA INC COM 869367102 412 27,494 SH   SOLE 27,494 0 0
TRANSLATE BIO INC COM 89374L104 1,517 151,739 SH   SOLE 151,739 0 0
UROGEN PHARMA LTD COM M96088105 708 15,000 SH   SOLE 15,000 0 0
VBI VACCINES INC COM NEW 91822J103 2,262 934,691 SH   SOLE 934,691 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 2,395 47,900 SH   SOLE 47,900 0 0
XENON PHARMACEUTICALS INC COM 98420N105 3,137 237,683 SH   SOLE 237,683 0 0
ZAFGEN INC COM 98885E103 1,003 85,842 SH   SOLE 85,842 0 0
ZOGENIX INC COM NEW 98978L204 6,858 138,264 SH   SOLE 138,264 0 0