The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AFFIMED N V | COM | N01045108 | 7,830 | 1,800,000 | SH | DFND | 1,800,000 | 0 | 0 | ||
| APTINYX INC | COM | 03836N103 | 95,281 | 3,290,079 | SH | DFND | 3,290,079 | 0 | 0 | ||
| ARVINAS INC | COM | 04335A105 | 38,515 | 2,283,048 | SH | DFND | 2,283,048 | 0 | 0 | ||
| AVEO PHARMACEUTICALS INC | COM | 053588109 | 1,331 | 402,118 | SH | DFND | 402,118 | 0 | 0 | ||
| AVROBIO INC | COM | 05455M100 | 8,940 | 172,350 | SH | DFND | 172,350 | 0 | 0 | ||
| CHIMERIX INC | COM | 16934W106 | 3,890 | 1,000,000 | SH | DFND | 1,000,000 | 0 | 0 | ||
| CRINETICS PHARMACEUTICALS INC | COM | 22663K107 | 4,805 | 167,700 | SH | DFND | 167,700 | 0 | 0 | ||
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 19,723 | 444,708 | SH | DFND | 444,708 | 0 | 0 | ||
| DECIPHERA PHARMACEUTICALS INC | COM | 24344T101 | 158,912 | 4,104,140 | SH | DFND | 4,104,140 | 0 | 0 | ||
| EDGE THERAPEUTICS INC | COM | 279870109 | 1,923 | 2,344,868 | SH | DFND | 2,344,868 | 0 | 0 | ||
| ITERUM THERAPEUTICS PLC | SHS | G6333L101 | 9,648 | 1,456,303 | SH | DFND | 1,456,303 | 0 | 0 | ||
| MINERVA NEUROSCIENCES INC | COM | 603380106 | 1,632 | 130,000 | SH | DFND | 130,000 | 0 | 0 | ||
| NEURONETICS INC | COM | 64131A105 | 49,472 | 1,543,115 | SH | DFND | 1,543,115 | 0 | 0 | ||
| OBSEVA SA | COM | H5861P103 | 16,236 | 900,501 | SH | DFND | 900,501 | 0 | 0 | ||
| PRINCIPIA BIOPHARMA INC | COM | 74257L108 | 76,723 | 2,625,713 | SH | DFND | 2,625,713 | 0 | 0 | ||
| PROTEON THERAPEUTICS INC | COM | 74371L109 | 2,925 | 1,500,000 | SH | DFND | 1,500,000 | 0 | 0 | ||
| SIERRA ONCOLOGY INC | COM | 82640U107 | 8,535 | 5,020,446 | SH | DFND | 5,020,446 | 0 | 0 | ||
| UNUM THERAPEUTICS INC | COM | 903214104 | 18,494 | 1,795,545 | SH | DFND | 1,795,545 | 0 | 0 | ||
| VERSARTIS INC | COM | 92529L102 | 3,470 | 2,478,400 | SH | DFND | 2,478,400 | 0 | 0 | ||
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 21,271 | 425,429 | SH | DFND | 425,429 | 0 | 0 | ||