The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 90,017 1,227,060 SH   DFND   0 1,227,060 0
ACCURAY INC COM 004397105 17,666 3,925,756 SH   DFND   0 3,925,756 0
ACORDA THERAPEUTICS INC COM 00484M106 33,387 1,699,100 SH Call DFND   0 1,699,100 0
ACORDA THERAPEUTICS INC COM 00484M106 24,512 1,247,434 SH   DFND   0 1,247,434 0
ACORDA THERAPEUTICS INC NOTE 1.750% 6/1 00484MAA4 81,023 95,433,000 PRN   DFND   0 95,433,000 0
ACTIVISION BLIZZARD INC COM 00507V109 32,472 390,334 SH   DFND   0 390,334 0
ACXIOM HOLDINGS INC COM 005125109 30,425 615,767 SH   DFND   0 615,767 0
AERIE PHARMACEUTICALS INC COM 00771V108 139,007 2,258,443 SH   DFND   0 2,258,443 0
AGILENT TECHNOLOGIES INC COM 00846U101 88,027 1,247,899 SH   DFND   0 1,247,899 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 31,912 1,916,664 SH   DFND   0 1,916,664 0
ALDER BIOPHARMACEUTICALS INC NOTE 2.500% 2/0 014339AA3 38,109 35,536,000 PRN   DFND   0 35,536,000 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 32,339 196,280 SH   DFND   0 196,280 0
ALLAKOS INC COM 01671P100 25,158 624,735 SH   DFND   0 624,735 0
ALLENA PHARMACEUTICALS INC COM 018119107 18,994 1,768,568 SH   DFND   0 1,768,568 0
ALLERGAN PLC SHS G0177J108 131,421 689,949 SH   DFND   0 689,949 0
ALPHABET INC CAP STK CL A 02079K305 106,731 88,421 SH   DFND   0 88,421 0
AMAZON COM INC COM 023135106 64,783 32,343 SH   DFND   0 32,343 0
AMN HEALTHCARE SERVICES INC COM 001744101 53,994 987,100 SH Put DFND   0 987,100 0
ANAPTYSBIO INC COM 032724106 105,194 1,054,361 SH   DFND   0 1,054,361 0
ANTHEM INC COM 036752103 145,710 531,690 SH   DFND   0 531,690 0
APPLE INC COM 037833100 63,575 281,628 SH   DFND   0 281,628 0
APTINYX INC COM 03836N103 49,520 1,754,679 SH   DFND   0 1,754,679 0
ARCUS BIOSCIENCES INC COM 03969F109 10,090 723,834 SH   DFND   0 723,834 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 125,614 2,729,555 SH   DFND   0 2,729,555 0
AUDENTES THERAPEUTICS INC COM 05070R104 61,528 1,554,139 SH   DFND   0 1,554,139 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 6,736 219,628 SH   DFND   0 219,628 0
AVROBIO INC COM 05455M100 7,726 148,949 SH   DFND   0 148,949 0
BLUEPRINT MEDICINES CORP COM 09627Y109 112,409 1,440,038 SH   DFND   0 1,440,038 0
BOSTON SCIENTIFIC CORP COM 101137107 73,443 1,907,622 SH   DFND   0 1,907,622 0
CARBON BLACK INC COM 14081R103 4,899 231,286 SH   DFND   0 231,286 0
CARDIOVASCULAR SYS INC DEL COM 141619106 39,841 1,017,917 SH   DFND   0 1,017,917 0
CIGNA CORPORATION COM 125509109 294,091 1,412,200 SH Call DFND   0 1,412,200 0
CIGNA CORPORATION COM 125509109 18,191 87,351 SH   DFND   0 87,351 0
CIRRUS LOGIC INC COM 172755100 43,438 1,125,349 SH   DFND   0 1,125,349 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 3,598 322,732 SH   DFND   0 322,732 0
CLOVIS ONCOLOGY INC COM 189464100 22,033 750,200 SH Call DFND   0 750,200 0
CLOVIS ONCOLOGY INC COM 189464100 56,623 1,927,928 SH   DFND   0 1,927,928 0
CLOVIS ONCOLOGY INC NOTE 1.250% 5/0 189464AC4 44,730 57,632,000 PRN   DFND   0 57,632,000 0
CME GROUP INC COM CL A 12572Q105 21,262 124,918 SH   DFND   0 124,918 0
COUPA SOFTWARE INC COM 22266L106 37,963 479,934 SH   DFND   0 479,934 0
DAVITA INC COM 23918K108 106,859 1,491,826 SH   DFND   0 1,491,826 0
DEXCOM INC COM 252131107 43,671 305,304 SH   DFND   0 305,304 0
DOCUSIGN INC COM 256163106 1,009 19,199 SH   DFND   0 19,199 0
DROPBOX INC CL A 26210C104 76,969 2,868,767 SH   DFND   0 2,868,767 0
EBAY INC COM 278642103 21,002 636,024 SH   DFND   0 636,024 0
EDWARDS LIFESCIENCES CORP COM 28176E108 90,997 522,672 SH   DFND   0 522,672 0
ELANCO ANIMAL HEALTH INC COM 28414H103 28,320 811,700 SH   DFND   0 811,700 0
ELECTRONIC ARTS INC COM 285512109 22,484 186,604 SH   DFND   0 186,604 0
ENDOCYTE INC COM 29269A102 4,163 234,378 SH   DFND   0 234,378 0
ENDOLOGIX INC COM 29266S106 14,150 7,408,585 SH   DFND   0 7,408,585 0
ENDOLOGIX INC NOTE 3.250%11/0 29266SAB2 33,103 47,379,000 PRN   DFND   0 47,379,000 0
ESPERION THERAPEUTICS INC NE COM 29664W105 87,415 1,970,134 SH   DFND   0 1,970,134 0
EVENTBRITE INC COM CL A 29975E109 2,219 58,441 SH   DFND   0 58,441 0
FATE THERAPEUTICS INC COM 31189P102 24,455 1,501,258 SH   DFND   0 1,501,258 0
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 1,660 1,911,400 PRN   DFND   0 1,911,400 0
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAD0 30,829 29,532,000 PRN   DFND   0 29,532,000 0
GODADDY INC CL A 380237107 92,997 1,115,201 SH   DFND   0 1,115,201 0
GREENSKY INC CL A 39572G100 36,687 2,038,160 SH   DFND   0 2,038,160 0
GRITSTONE ONCOLOGY INC COM 39868T105 14,257 1,065,313 SH   DFND   0 1,065,313 0
GRUBHUB INC COM 400110102 15,309 110,436 SH   DFND   0 110,436 0
GUIDEWIRE SOFTWARE INC COM 40171V100 41,250 408,373 SH   DFND   0 408,373 0
HCA HEALTHCARE INC COM 40412C101 72,225 519,159 SH   DFND   0 519,159 0
HUMANA INC COM 444859102 115,439 341,010 SH   DFND   0 341,010 0
ICON PLC SHS G4705A100 45,977 299,037 SH   DFND   0 299,037 0
INOGEN INC COM 45780L104 35,062 143,625 SH   DFND   0 143,625 0
INTUIT COM 461202103 91,777 403,592 SH   DFND   0 403,592 0
INTUITIVE SURGICAL INC COM NEW 46120E602 49,420 86,098 SH   DFND   0 86,098 0
INVUITY INC COM NEW 46187J205 10,066 1,360,334 SH   DFND   0 1,360,334 0
IRHYTHM TECHNOLOGIES INC COM 450056106 22,334 235,941 SH   DFND   0 235,941 0
ISHARES TR RUSSELL 2000 464287655 230,037 1,364,800 SH Put DFND   0 1,364,800 0
ISHARES TR MEDICAL DEVICES 464288810 280,483 1,233,000 SH Put DFND   0 1,233,000 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 161,073 958,025 SH   DFND   0 958,025 0
KURA ONCOLOGY INC COM 50127T109 19,314 1,103,656 SH   DFND   0 1,103,656 0
LKQ CORP COM 501889208 43,719 1,380,466 SH   DFND   0 1,380,466 0
MADISON SQUARE GARDEN CO NEW CL A 55825T103 69,674 220,963 SH   DFND   0 220,963 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 17,741 1,774,094 SH   DFND   0 1,774,094 0
MASTERCARD INCORPORATED CL A 57636Q104 41,523 186,526 SH   DFND   0 186,526 0
MEDICINES CO COM 584688105 76,619 2,561,640 SH   DFND   0 2,561,640 0
MEDICINES CO NOTE 2.750% 7/1 584688AG0 83,675 91,758,000 PRN   DFND   0 91,758,000 0
MERIT MED SYS INC COM 589889104 82,771 1,346,963 SH   DFND   0 1,346,963 0
MICROSOFT CORP COM 594918104 39,813 348,110 SH   DFND   0 348,110 0
MOLINA HEALTHCARE INC COM 60855R100 84,993 571,571 SH   DFND   0 571,571 0
MONGODB INC CL A 60937P106 5,083 62,326 SH   DFND   0 62,326 0
MYLAN N V SHS EURO N59465109 171,763 4,692,968 SH   DFND   0 4,692,968 0
MYOKARDIA INC COM 62857M105 122,505 1,878,909 SH   DFND   0 1,878,909 0
NEON THERAPEUTICS INC COM 64050Y100 7,344 978,837 SH   DFND   0 978,837 0
NETFLIX INC COM 64110L106 28,977 77,452 SH   DFND   0 77,452 0
NUCANA PLC SPONSORED ADR 67022C106 9,703 389,358 SH   DFND   0 389,358 0
NVIDIA CORP COM 67066G104 31,967 113,753 SH   DFND   0 113,753 0
PACIRA PHARMACEUTICALS INC COM 695127100 137,501 2,797,574 SH   DFND   0 2,797,574 0
PAYPAL HLDGS INC COM 70450Y103 45,581 518,904 SH   DFND   0 518,904 0
PENUMBRA INC COM 70975L107 108,593 725,401 SH   DFND   0 725,401 0
PERKINELMER INC COM 714046109 67,485 693,791 SH   DFND   0 693,791 0
PIVOTAL SOFTWARE INC COM CL A 72582H107 16,757 855,797 SH   DFND   0 855,797 0
PORTOLA PHARMACEUTICALS INC COM 737010108 122,521 4,600,847 SH   DFND   0 4,600,847 0
PUMA BIOTECHNOLOGY INC COM 74587V107 84,898 1,851,638 SH   DFND   0 1,851,638 0
RED HAT INC COM 756577102 52,932 388,407 SH   DFND   0 388,407 0
SALESFORCE COM INC COM 79466L302 87,099 547,686 SH   DFND   0 547,686 0
SAREPTA THERAPEUTICS INC COM 803607100 19,783 122,490 SH   DFND   0 122,490 0
SIENNA BIOPHARMACEUTICALS IN COM 82622H108 23,361 1,576,311 SH   DFND   0 1,576,311 0
SOLID BIOSCIENCES INC COM 83422E105 37,733 799,777 SH   DFND   0 799,777 0
SPARK THERAPEUTICS INC COM 84652J103 46,885 859,480 SH   DFND   0 859,480 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 62,191 648,700 SH Put DFND   0 648,700 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 73,447 406,165 SH   DFND   0 406,165 0
SQUARE INC CL A 852234103 52,059 525,793 SH   DFND   0 525,793 0
SQUARE INC NOTE 0.375% 3/0 852234AB9 73,880 17,068,000 PRN   DFND   0 17,068,000 0
TABLEAU SOFTWARE INC CL A 87336U105 73,428 657,129 SH   DFND   0 657,129 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 63,469 1,437,247 SH   DFND   0 1,437,247 0
TENABLE HLDGS INC COM 88025T102 5,414 139,242 SH   DFND   0 139,242 0
TENET HEALTHCARE CORP COM NEW 88033G407 96,059 3,375,241 SH   DFND   0 3,375,241 0
UNITEDHEALTH GROUP INC COM 91324P102 60,070 225,793 SH   DFND   0 225,793 0
UNITY BIOTECHNOLOGY INC COM 91381U101 12,572 829,868 SH   DFND   0 829,868 0
VIEWRAY INC COM 92672L107 8,232 879,446 SH   DFND   0 879,446 0
WELLCARE HEALTH PLANS INC COM 94946T106 38,880 121,313 SH   DFND   0 121,313 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 23,338 804,187 SH   DFND   0 804,187 0
ZIMMER BIOMET HLDGS INC COM 98956P102 100,171 761,934 SH   DFND   0 761,934 0
ZSCALER INC COM 98980G102 1,909 46,814 SH   DFND   0 46,814 0