The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACHAOGEN INC | COM | 004449104 | 20,808 | 5,215,128 | SH | DFND | 5,215,128 | 0 | 0 | ||
| ADAPTIMMUNE THERAPEUTICS PLC | ADR | 00653A107 | 214,690 | 15,832,611 | SH | DFND | 15,832,611 | 0 | 0 | ||
| AFFIMED NV | COM | N01045108 | 22,354 | 5,138,888 | SH | DFND | 5,138,888 | 0 | 0 | ||
| AKARI THERAPEUTICS PLC | ADR | 00972G108 | 1,158 | 452,167 | SH | DFND | 452,167 | 0 | 0 | ||
| ALLAKOS INC | COM | 01671P100 | 102,046 | 2,268,188 | SH | DFND | 2,268,188 | 0 | 0 | ||
| ARDELYX INC | COM | 039697107 | 66,707 | 15,335,047 | SH | DFND | 15,335,047 | 0 | 0 | ||
| ARQULE INC | COM | 04269E107 | 14,265 | 2,520,316 | SH | DFND | 2,520,316 | 0 | 0 | ||
| ARSANIS INC | COM | 042873109 | 3,240 | 2,000,000 | SH | DFND | 2,000,000 | 0 | 0 | ||
| AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 31,928 | 4,808,483 | SH | DFND | 4,808,483 | 0 | 0 | ||
| AVEO PHARMACEUTICALS INC | COM | 053588109 | 61,891 | 18,698,038 | SH | DFND | 18,698,038 | 0 | 0 | ||
| AYTU BIOSCIENCE INC | COM PAR | 054754700 | 6 | 2,246 | SH | DFND | 2,246 | 0 | 0 | ||
| BLOOM ENERGY CORP | COM CL A | 093712107 | 45,440 | 1,333,333 | SH | DFND | 1,333,333 | 0 | 0 | ||
| CHAMPIONS ONCOLOGY INC | COM NEW | 15870P307 | 27,297 | 1,562,500 | SH | DFND | 1,562,500 | 0 | 0 | ||
| CLEMENTIA PHARMACEUTICALS INC | COM | 185575107 | 23,880 | 2,141,697 | SH | DFND | 2,141,697 | 0 | 0 | ||
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 92,722 | 2,090,678 | SH | DFND | 2,090,678 | 0 | 0 | ||
| CTI BIOPHARMA CORP | COM NEW | 12648L601 | 8,100 | 3,750,000 | SH | DFND | 3,750,000 | 0 | 0 | ||
| DASAN ZHONE SOLUTIONS INC | COM NEW | 23305L206 | 13,569 | 956,255 | SH | DFND | 956,255 | 0 | 0 | ||
| DERMIRA INC | COM | 24983L104 | 38,222 | 3,506,649 | SH | DFND | 3,506,649 | 0 | 0 | ||
| ENDOLOGIX INC | COM | 29266S106 | 4,756 | 2,490,204 | SH | DFND | 2,490,204 | 0 | 0 | ||
| EPIZYME INC | COM | 29428V104 | 68,485 | 6,460,851 | SH | DFND | 6,460,851 | 0 | 0 | ||
| ERYTECH PHARMA SA | ADR | 29604W108 | 5,356 | 625,000 | SH | DFND | 625,000 | 0 | 0 | ||
| GENOCEA BIOSCIENCES INC | COM | 372427104 | 19,500 | 25,000,000 | SH | DFND | 25,000,000 | 0 | 0 | ||
| GLYCOMIMETICS INC | COM | 38000Q102 | 130,882 | 9,089,041 | SH | DFND | 9,089,041 | 0 | 0 | ||
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 25,419 | 2,382,286 | SH | DFND | 2,382,286 | 0 | 0 | ||
| LIQUIDIA TECHNOLOGIES INC | COM | 53635D202 | 68,193 | 2,486,062 | SH | DFND | 2,486,062 | 0 | 0 | ||
| MEI PHARMA INC | COM NEW | 55279B202 | 24,656 | 5,720,572 | SH | DFND | 5,720,572 | 0 | 0 | ||
| MERSANA THERAPEUTICS INC | COM | 59045L106 | 81,443 | 8,144,267 | SH | DFND | 8,144,267 | 0 | 0 | ||
| NIGHTSTAR THERAPEUTICS PLC | ADR | 65413A101 | 14,593 | 714,285 | SH | DFND | 714,285 | 0 | 0 | ||
| OBSEVA SA | COM | H5861P103 | 82,696 | 4,586,563 | SH | DFND | 4,586,563 | 0 | 0 | ||
| PROTEOSTASIS THERAPEUTICS INC | COM | 74373B109 | 13,392 | 5,556,778 | SH | DFND | 5,556,778 | 0 | 0 | ||
| RA PHARMACEUTICALS INC | COM | 74933V108 | 99,380 | 5,493,636 | SH | DFND | 5,493,636 | 0 | 0 | ||
| REGULUS THERAPEUTICS INC | COM | 75915K101 | 26,044 | 10,989,010 | SH | DFND | 10,989,010 | 0 | 0 | ||
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 143,292 | 4,912,306 | SH | DFND | 4,912,306 | 0 | 0 | ||
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 10,411 | 3,243,150 | SH | DFND | 3,243,150 | 0 | 0 | ||
| SENSEONICS HOLDINGS INC | COM | 81727U105 | 147,337 | 30,888,266 | SH | DFND | 30,888,266 | 0 | 0 | ||
| STRONGBRIDGE BIOPHARMA PLC | SHS USD | G85347105 | 20,085 | 4,141,308 | SH | DFND | 4,141,308 | 0 | 0 | ||
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 2,597 | 1,298,274 | SH | DFND | 1,298,274 | 0 | 0 | ||
| SURFACE ONCOLOGY INC | COM | 86877M209 | 36,268 | 3,315,149 | SH | DFND | 3,315,149 | 0 | 0 | ||
| SYNLOGIC INC | COM | 87166L100 | 60,100 | 4,229,410 | SH | DFND | 4,229,410 | 0 | 0 | ||
| TESARO INC | COM | 881569107 | 406,506 | 10,420,555 | SH | DFND | 10,420,555 | 0 | 0 | ||
| TRACON PHARMACEUTICALS INC | COM | 89237H100 | 7,108 | 3,467,181 | SH | DFND | 3,467,181 | 0 | 0 | ||
| TREVENA INC | COM | 89532E109 | 8,081 | 3,811,691 | SH | DFND | 3,811,691 | 0 | 0 | ||
| TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 7,250 | 1,250,000 | SH | DFND | 1,250,000 | 0 | 0 | ||
| VERONA PHARMA PLC | ADS | 925050106 | 15,258 | 1,219,674 | SH | DFND | 1,219,674 | 0 | 0 | ||