The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACHILLION PHARMACEUTICALS COM 00448Q201 2,682 947,636 SH   SOLE 947,636 0 0
ADVAXIS INC COM NEW 007624208 1,011 697,000 SH   SOLE 697,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 8,901 131,770 SH   SOLE 131,770 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 6,095 610,738 SH   SOLE 610,738 0 0
ALDER BIOPHARMACEUTICALS INC NOTE 2.500% 2/0 014339AA3 261 250,000 PRN   SOLE 250,000 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 6,257 396,013 SH   SOLE 396,013 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 1,558 421,000 SH   SOLE 421,000 0 0
APTINYX INC COM 03836N103 604 25,000 SH   SOLE 25,000 0 0
ARDELYX INC COM 039697107 1,750 472,859 SH   SOLE 472,859 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 4,153 95,242 SH   SOLE 95,242 0 0
ARGENX SE SPONSORED ADR 04016X101 2,150 25,949 SH   SOLE 25,949 0 0
ARQULE INC COM 04269E107 1,043 188,664 SH   SOLE 188,664 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 4,906 73,745 SH   SOLE 73,745 0 0
ATRICURE INC COM 04963C209 8,530 315,345 SH   SOLE 315,345 0 0
BEIGENE LTD SPONSORED ADR 07725L102 307 2,000 SH   SOLE 2,000 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 221 30,000 SH   SOLE 30,000 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 3,465 604,652 SH   SOLE 604,652 0 0
BIOHAVEN PHARMACEUTICALS HOLD COM G11196105 929 23,500 SH   SOLE 23,500 0 0
BIOTELEMETRY INC COM 090672106 2,453 54,500 SH   SOLE 54,500 0 0
BIOTIME INC COM 09066L105 374 181,600 SH   SOLE 181,600 0 0
BLUEBIRD BIO INC COM 09609G100 628 4,000 SH   SOLE 4,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 5,884 92,691 SH   SOLE 92,691 0 0
CARA THERAPEUTICS INC COM 140755109 1,203 62,811 SH   SOLE 62,811 0 0
CARDIOVASCULAR SYSTEMS INC COM 141619106 1,915 59,200 SH   SOLE 59,200 0 0
CIDARA THERAPEUTICS INC COM 171757107 1,106 212,766 SH   SOLE 212,766 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 3,952 294,511 SH   SOLE 294,511 0 0
CYTOKINETICS INC COM NEW 23282W605 576 69,437 SH   SOLE 69,437 0 0
DERMIRA INC COM 24983L104 212 23,000 SH   SOLE 23,000 0 0
DEXCOM INC COM 252131107 5,224 55,000 SH   SOLE 55,000 0 0
DEXCOM INC DBCV 0.750% 5/1 252131AF4 288 250,000 PRN   SOLE 250,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 1,348 110,000 SH   SOLE 110,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 1,693 338,000 SH   SOLE 338,000 0 0
FORTY SEVEN INC COM 34983P104 160 10,000 SH   SOLE 10,000 0 0
GALAPAGOS NV SPON ADR 36315X101 3,743 40,609 SH   SOLE 40,609 0 0
GALMED PHARMACEUTICALS LTD SHS M47238106 595 50,000 SH   SOLE 50,000 0 0
IMMUNE DESIGN CORP COM 45252L103 1,495 328,500 SH   SOLE 328,500 0 0
IMMUNOMEDICS INC COM 452907108 4,332 183,000 SH   SOLE 183,000 0 0
INCYTE CORP COM 45337C102 1,441 21,500 SH   SOLE 21,500 0 0
INSULET CORP NOTE 1.375% 45784PAG6 1,664 1,500,000 PRN   SOLE 1,500,000 0 0
INTEC PHARMA LTD JERUSALEM SHS M53644106 2,502 568,600 SH   SOLE 568,600 0 0
ISHARES TR NASDAQ BIOTECH ETF 464287556 2,866 26,100 SH   SOLE 26,100 0 0
JOHNSON AND JOHNSON COM 478160104 1,141 9,400 SH   SOLE 9,400 0 0
KADMON HOLDINGS INC COM 48283N106 261 65,500 SH   SOLE 65,500 0 0
KURA ONCOLOGY INC COM 50127T109 4,359 239,500 SH   SOLE 239,500 0 0
LEAP THERPEUTICS INC COM 52187K101 1,365 151,643 SH   SOLE 151,643 0 0
LOXO ONCOLOGY INC COM 548862101 27,527 158,675 SH   SOLE 158,675 0 0
LUMINEX CORP COM 55027E102 5,017 169,891 SH   SOLE 169,891 0 0
MACROGENICS INC COM 556099109 1,617 78,305 SH   SOLE 78,305 0 0
MASIMO CORPORATION COM 574795100 488 5,000 SH   SOLE 5,000 0 0
MENLO THERAPEUTICS INC COM 586858102 2,533 312,000 SH   SOLE 312,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 1,080 130,872 SH   SOLE 130,872 0 0
NATUS MEDICAL INC COM 639050103 1,308 37,900 SH   SOLE 37,900 0 0
NEON THERAPEUICS INC COM 64050Y100 630 50,000 SH   SOLE 50,000 0 0
NEOS THERAPEUTICS INC COM 64052L106 172 27,500 SH   SOLE 27,500 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 4,471 45,508 SH   SOLE 45,508 0 0
NOVAVAX INC COM 670002104 1,005 750,000 SH   SOLE 750,000 0 0
NXSTAGE MEDICAL INC COM 67072V103 8,541 306,119 SH   SOLE 306,119 0 0
OBSEVA SA COM H5861P103 984 64,977 SH   SOLE 64,977 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109 1,251 171,351 SH   SOLE 171,351 0 0
PROTALIX BIOTHERAPEUTICS INC NOTE 4.500% 9/1 74365AAB7 2,375 2,500,000 PRN   SOLE 2,500,000 0 0
RADIUS HEALTH INC COM NEW 750469207 295 10,000 SH   SOLE 10,000 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 3,725 4,000,000 PRN   SOLE 4,000,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 389 137,600 SH   SOLE 137,600 0 0
SAGE THERAPEUTICS INC COM 78667J108 15,027 96,000 SH   SOLE 96,000 0 0
SCYNEXIS INC COM 811292101 2,092 1,275,527 SH   SOLE 1,275,527 0 0
SOL GEL TECHNOLOGIES LTD SHS M8694L103 270 35,000 SH   SOLE 35,000 0 0
STEREOTAXIS INC COM 85916J409 10,534 13,680,554 SH   SOLE 13,680,554 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 792 373,702 SH   SOLE 373,702 0 0
TRANSLATE BIO INC COM 89374L104 253 20,000 SH   SOLE 20,000 0 0
UROGEN PHARMA LTD COM M96088105 498 10,000 SH   SOLE 10,000 0 0
VBI VACCINES INC COM NEW 91822J103 2,570 934,691 SH   SOLE 934,691 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 1,832 47,900 SH   SOLE 47,900 0 0
XENON PHARMACEUTICALS INC COM 98420N105 2,708 294,362 SH   SOLE 294,362 0 0
ZAFGEN INC COM 98885E103 1,671 163,377 SH   SOLE 163,377 0 0
ZOGENIX INC COM NEW 98978L204 4,321 97,764 SH   SOLE 97,764 0 0