The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
58 COM INC SPON ADR REP A 31680Q104 64,730 933,520 SH   SOLE 933,520 0 0
ACCELERON PHARMA INC COM 00434H108 2,838 58,500 SH   SOLE 58,500 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 2,540 37,600 SH   SOLE 37,600 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 2,544 30,200 SH   SOLE 30,200 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 394,484 2,126,255 SH   SOLE 1,972,955 0 153,300
ALLY FINL INC COM 02005N100 104,478 3,977,100 SH   SOLE 3,517,800 0 459,300
ALPHABET INC CAP STK CL A 02079K305 208,225 184,402 SH   SOLE 170,112 0 14,290
ALPHABET INC CAP STK CL C 02079K107 202,863 181,834 SH   SOLE 166,748 0 15,086
ANALOG DEVICES INC COM 032654105 623 6,500 SH   SOLE 6,500 0 0
APPLE INC COM 037833100 2,351 12,700 SH   SOLE 12,700 0 0
ARCUS BIOSCIENCES INC COM 03969F109 647 52,841 SH   SOLE 52,841 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 2,532 284,495 SH   SOLE 284,495 0 0
BAIDU INC SPON ADR REP A 056752108 73,290 301,604 SH   SOLE 301,604 0 0
BARRICK GOLD CORP COM 067901108 7,702 586,595 SH   SOLE 586,595 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 1,302 13,820 SH   SOLE 13,820 0 0
BITAUTO HLDGS LTD SPONSORED ADS 091727107 104,024 4,374,448 SH   SOLE 4,212,348 0 162,100
CALLAWAY GOLF CO COM 131193104 21,172 1,116,100 SH   SOLE 1,116,100 0 0
CARNIVAL CORP UNIT 99/99/9999 143658300 1,677 29,260 SH   SOLE 29,260 0 0
CENTURYLINK INC COM 156700106 7,682 412,151 SH   SOLE 412,151 0 0
CF INDS HLDGS INC COM 125269100 118,629 2,671,833 SH   SOLE 2,277,433 0 394,400
CISCO SYS INC COM 17275R102 1,536 35,700 SH   SOLE 35,700 0 0
COHERUS BIOSCIENCES INC COM 19249H103 1,918 137,000 SH   SOLE 137,000 0 0
DERMIRA INC COM 24983L104 579 62,900 SH   SOLE 62,900 0 0
EBAY INC COM 278642103 1,113 30,700 SH   SOLE 30,700 0 0
EQUIFAX INC COM 294429105 87,290 697,703 SH   SOLE 622,703 0 75,000
FACEBOOK INC CL A 30303M102 346,461 1,782,940 SH   SOLE 1,606,540 0 176,400
FIVE PRIME THERAPEUTICS INC COM 33830X104 1,489 94,200 SH   SOLE 94,200 0 0
FOUNDATION MEDICINE INC COM 350465100 2,966 21,700 SH   SOLE 21,700 0 0
GILEAD SCIENCES INC COM 375558103 215,703 3,044,930 SH   SOLE 2,672,830 0 372,100
GOLDEN OCEAN GROUP LTD SHS NEW G39637205 140,400 2,000,000 SH   SOLE 2,000,000 0 0
HANESBRANDS INC COM 410345102 23,986 1,089,300 SH   SOLE 1,089,300 0 0
ICON PLC SHS G4705A100 2,584 19,500 SH   SOLE 19,500 0 0
IHS MARKIT LTD SHS G47567105 26,079 505,500 SH   SOLE 505,500 0 0
INCYTE CORP COM 45337C102 1,405 20,964 SH   SOLE 20,964 0 0
INFINERA CORPORATION COM 45667G103 580 58,400 SH   SOLE 58,400 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 2,159 1,130,432 SH   SOLE 1,130,432 0 0
INTEL CORP COM 458140100 265,110 5,333,131 SH   SOLE 5,042,731 0 290,400
INTELLIA THERAPEUTICS INC COM 45826J105 1,505 55,000 SH   SOLE 55,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,543 80,700 SH   SOLE 80,700 0 0
JD COM INC SPON ADR CL A 47215P106 39,435 1,012,442 SH   SOLE 1,012,442 0 0
JOHNSON & JOHNSON COM 478160104 3,980 32,800 SH   SOLE 32,800 0 0
LAM RESEARCH CORP COM 512807108 1,158 6,700 SH   SOLE 6,700 0 0
LIBERTY GLOBAL PLC SHS CL A G5480U104 408 14,800 SH   SOLE 14,800 0 0
LIVANOVA PLC SHS G5509L101 2,464 24,682 SH   SOLE 24,682 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 675 50,000 SH   SOLE 50,000 0 0
MELCO RESORT ENTERTAINMENT L ADR 585464100 76,657 2,737,767 SH   SOLE 2,737,767 0 0
MERCK & CO INC COM 58933Y105 1,141 18,800 SH   SOLE 18,800 0 0
MERUS N V COM N5749R100 2,327 102,219 SH   SOLE 102,219 0 0
MICROCHIP TECHNOLOGY INC COM 595017104 70,032 770,000 SH   SOLE 770,000 0 0
MICRON TECHNOLOGY INC COM 595112103 1,059 20,200 SH   SOLE 20,200 0 0
MICROSOFT CORP COM 594918104 2,288 23,200 SH   SOLE 23,200 0 0
MYOVANT SCIENCES LTD COM G637AM102 1,240 54,200 SH   SOLE 54,200 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 3,181 232,500 SH   SOLE 232,500 0 0
NETGEAR INC COM 64111Q104 444 7,100 SH   SOLE 7,100 0 0
NEWMONT MINING CORP COM 651639106 3,809 101,000 SH   SOLE 101,000 0 0
NIELSEN HLDGS PLC SHS EUR G6518L108 7,679 248,258 SH   SOLE 248,258 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 16,532 861,500 SH   SOLE 861,500 0 0
ORACLE CORP COM 68389X105 2,225 50,500 SH   SOLE 50,500 0 0
PAYPAL HLDGS INC COM 70450Y103 100,603 1,208,151 SH   SOLE 1,208,151 0 0
PEABODY ENERGY CORP NEW COM 704551100 154,395 3,394,799 SH   SOLE 2,954,799 0 440,000
PERKINELMER INC COM 714046109 2,827 38,600 SH   SOLE 38,600 0 0
PERRIGO CO PLC SHS G97822103 780 10,700 SH   SOLE 10,700 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 630 124,200 SH   SOLE 124,200 0 0
PROTHENA CORP PLC SHS G72800108 1,971 135,200 SH   SOLE 135,200 0 0
QIAGEN NV SHS NEW N72482123 21,839 603,941 SH   SOLE 603,941 0 0
QIWI PLC SPON ADR REP B 74735M108 40,262 2,556,346 SH   SOLE 2,255,116 0 301,230
QUANTERIX CORP COM 74766Q101 2,513 175,000 SH   SOLE 175,000 0 0
SANGAMO THERAPEUTICS INC COM 800677106 751 52,900 SH   SOLE 52,900 0 0
SCHLUMBERGER LTD COM 806857108 121,948 1,819,300 SH   SOLE 1,459,900 0 359,400
SEATTLE GENETICS INC COM 812578102 2,689 40,500 SH   SOLE 40,500 0 0
SINA CORP ORD G81477104 303,623 3,585,106 SH   SOLE 3,458,619 0 126,487
SKYWORKS SOLUTIONS INC COM 83088M102 108,128 1,118,760 SH   SOLE 994,460 0 124,300
SOHU COM LTD SPONSORED ADS 83410S108 31,196 878,761 SH   SOLE 878,761 0 0
STAMPS COM INC COM NEW 852857200 658 2,600 SH   SOLE 2,600 0 0
SUNCOR ENERGY INC NEW COM 867224107 422 10,360 SH   SOLE 10,360 0 0
TECHNIPFMC PLC COM G87110105 265,096 8,352,100 SH   SOLE 7,198,800 0 1,153,300
TESARO INC COM 881569107 765 17,200 SH   SOLE 17,200 0 0
TRANSOCEAN LTD REG SHS H8817H100 117,123 8,714,500 SH   SOLE 7,831,900 0 882,600
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 1,054 175,339 SH   SOLE 175,339 0 0
TWILIO INC CL A 90138F102 437 7,800 SH   SOLE 7,800 0 0
UNITED TECHNOLOGIES CORP COM 913017109 1,000 8,000 SH   SOLE 8,000 0 0
UNUM THERAPEUTICS INC COM 903214104 3,229 225,000 SH   SOLE 225,000 0 0
VERISIGN INC COM 92343E102 770 5,600 SH   SOLE 5,600 0 0
WARRIOR MET COAL INC COM 93627C101 1,348 48,900 SH   SOLE 48,900 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 1,232 32,200 SH   SOLE 32,200 0 0
WEIBO CORP SPONSORED ADR 948596101 6,914 77,900 SH   SOLE 77,900 0 0
XILINX INC COM 983919101 731 11,200 SH   SOLE 11,200 0 0
YY INC ADS REPCOM CLA 98426T106 53,436 531,860 SH   SOLE 531,860 0 0
ZAI LAB LTD ADR 98887Q104 465 20,000 SH   SOLE 20,000 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 197,792 9,889,624 SH   SOLE 8,929,459 0 960,165