The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AFFIMED N V | COM | N01045108 | 3,713 | 2,250,000 | SH | DFND | 2,250,000 | 0 | 0 | ||
| APTINYX INC | COM | 03836N103 | 79,521 | 3,290,079 | SH | DFND | 3,290,079 | 0 | 0 | ||
| AVEO PHARMACEUTICALS INC | COM | 053588109 | 909 | 402,118 | SH | DFND | 402,118 | 0 | 0 | ||
| AVROBIO INC | COM | 05455M100 | 4,284 | 150,000 | SH | DFND | 150,000 | 0 | 0 | ||
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 26,131 | 444,708 | SH | DFND | 444,708 | 0 | 0 | ||
| DECIPHERA PHARMACEUTICALS INC | COM | 24344T101 | 161,498 | 4,104,140 | SH | DFND | 4,104,140 | 0 | 0 | ||
| EDGE THERAPEUTICS INC | COM | 279870109 | 2,415 | 2,344,868 | SH | DFND | 2,344,868 | 0 | 0 | ||
| ITERUM THERAPEUTICS PLC | SHS | G6333L101 | 15,539 | 1,456,303 | SH | DFND | 1,456,303 | 0 | 0 | ||
| NEURONETICS INC | COM | 64131A105 | 41,062 | 1,543,115 | SH | DFND | 1,543,115 | 0 | 0 | ||
| OBSEVA SA | COM | H5861P103 | 13,482 | 890,501 | SH | DFND | 890,501 | 0 | 0 | ||
| OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 4,017 | 311,660 | SH | DFND | 311,660 | 0 | 0 | ||
| SIERRA ONCOLOGY INC | COM | 82640U107 | 14,861 | 5,020,446 | SH | DFND | 5,020,446 | 0 | 0 | ||
| UNUM THERAPEUTICS INC | COM | 903214104 | 25,766 | 1,795,545 | SH | DFND | 1,795,545 | 0 | 0 | ||
| VERSARTIS INC | COM | 92529L102 | 4,550 | 2,247,000 | SH | DFND | 2,247,000 | 0 | 0 | ||
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 16,579 | 433,429 | SH | DFND | 433,429 | 0 | 0 | ||