The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 81,561 1,337,288 SH   DFND   0 1,337,288 0
ACCURAY INC COM 004397105 20,707 5,050,570 SH   DFND   0 5,050,570 0
ACORDA THERAPEUTICS INC COM 00484M106 62,011 2,160,664 SH   DFND   0 2,160,664 0
ACORDA THERAPEUTICS INC NOTE 1.750% 6/1 00484MAA4 38,486 39,619,000 PRN   DFND   0 39,619,000 0
ACTIVISION BLIZZARD INC COM 00507V109 42,179 552,659 SH   DFND   0 552,659 0
AERIE PHARMACEUTICALS INC COM 00771V108 183,751 2,720,218 SH   DFND   0 2,720,218 0
AGILENT TECHNOLOGIES INC COM 00846U101 68,832 1,113,069 SH   DFND   0 1,113,069 0
AGIOS PHARMACEUTICALS INC COM 00847X104 51,760 614,506 SH   DFND   0 614,506 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 34,853 2,205,913 SH   DFND   0 2,205,913 0
ALDER BIOPHARMACEUTICALS INC NOTE 2.500% 2/0 014339AA3 33,750 32,411,000 PRN   DFND   0 32,411,000 0
ALIBABA GROUP HLDG LTD COM 01609W102 28,943 156,000 SH Call DFND   0 156,000 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 73,801 397,786 SH   DFND   0 397,786 0
ALLENA PHARMACEUTICALS INC COM 018119107 22,670 1,739,805 SH   DFND   0 1,739,805 0
ALPHABET INC CAP STK CL A 02079K305 101,372 89,774 SH   DFND   0 89,774 0
AMAZON COM INC COM 023135106 51,091 30,057 SH   DFND   0 30,057 0
ANAPTYSBIO INC COM 032724106 9,828 138,338 SH   DFND   0 138,338 0
ANTHEM INC COM 036752103 168,345 707,244 SH   DFND   0 707,244 0
APPLE INC COM 037833100 21,292 115,026 SH   DFND   0 115,026 0
APTINYX INC COM 03836N103 6,717 330,885 SH   DFND   0 330,885 0
APTINYX INC COM 03836N103 25,355 1,049,031 SH   DFND   0 1,049,031 0
ARCUS BIOSCIENCES INC COM 03969F109 9,404 768,279 SH   DFND   0 768,279 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 52,184 1,196,891 SH   DFND   0 1,196,891 0
AUDENTES THERAPEUTICS INC COM 05070R104 16,254 425,382 SH   DFND   0 425,382 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 5,301 197,874 SH   DFND   0 197,874 0
BAIDU INC SPON ADR REP A 056752108 89,216 367,146 SH   DFND   0 367,146 0
BAXTER INTL INC COM 071813109 63,881 865,121 SH   DFND   0 865,121 0
BLUEPRINT MEDICINES CORP COM 09627Y109 53,582 844,081 SH   DFND   0 844,081 0
BOSTON SCIENTIFIC CORP COM 101137107 43,070 1,317,120 SH   DFND   0 1,317,120 0
BOX INC CL A 10316T104 1,258 50,359 SH   DFND   0 50,359 0
CARBON BLACK INC COM 14081R103 6,093 234,327 SH   DFND   0 234,327 0
CARDIOVASCULAR SYS INC DEL COM 141619106 39,808 1,230,921 SH   DFND   0 1,230,921 0
CENTENE CORP DEL COM 15135B101 80,237 651,218 SH   DFND   0 651,218 0
CIRRUS LOGIC INC COM 172755100 28,998 756,546 SH   DFND   0 756,546 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 4,247 322,732 SH   DFND   0 322,732 0
CLOVIS ONCOLOGY INC COM 189464100 35,680 784,700 SH Call DFND   0 784,700 0
CLOVIS ONCOLOGY INC COM 189464100 106,274 2,337,225 SH   DFND   0 2,337,225 0
CLOVIS ONCOLOGY INC NOTE 1.250% 5/0 189464AC4 44,169 47,801,000 PRN   DFND   0 47,801,000 0
CME GROUP INC COM CL A 12572Q105 20,483 124,955 SH   DFND   0 124,955 0
COUPA SOFTWARE INC COM 22266L106 33,354 535,892 SH   DFND   0 535,892 0
CTRIP COM INTL LTD AMERICAN DEP SHS 22943F100 39,353 826,224 SH   DFND   0 826,224 0
CTRIP COM INTL LTD NOTE 1.000% 7/0 22943FAF7 9,965 9,451,000 PRN   DFND   0 9,451,000 0
CUTERA INC COM 232109108 19,640 487,347 SH   DFND   0 487,347 0
DAVITA INC COM 23918K108 29,193 420,400 SH Call DFND   0 420,400 0
DAVITA INC COM 23918K108 89,230 1,285,000 SH   DFND   0 1,285,000 0
DOCUSIGN INC COM 256163106 1,017 19,199 SH   DFND   0 19,199 0
DROPBOX INC CL A 26210C104 49,593 1,529,689 SH   DFND   0 1,529,689 0
EDWARDS LIFESCIENCES CORP COM 28176E108 73,257 503,245 SH   DFND   0 503,245 0
ELECTRONIC ARTS INC COM 285512109 41,051 291,101 SH   DFND   0 291,101 0
ENDOCYTE INC COM 29269A102 56,147 4,068,608 SH   DFND   0 4,068,608 0
ENDOLOGIX INC COM 29266S106 42,689 7,542,158 SH   DFND   0 7,542,158 0
ENDOLOGIX INC NOTE 3.250%11/0 29266SAB2 43,539 47,379,000 PRN   DFND   0 47,379,000 0
ESPERION THERAPEUTICS INC NE COM 29664W105 96,414 2,460,157 SH   DFND   0 2,460,157 0
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 1,550 1,911,400 PRN   DFND   0 1,911,400 0
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAD0 27,174 29,087,000 PRN   DFND   0 29,087,000 0
GODADDY INC CL A 380237107 68,865 975,419 SH   DFND   0 975,419 0
GREENSKY INC CL A 39572G100 17,181 812,328 SH   DFND   0 812,328 0
GUIDEWIRE SOFTWARE INC COM 40171V100 27,012 304,256 SH   DFND   0 304,256 0
HCA HEALTHCARE INC COM 40412C101 53,593 522,345 SH   DFND   0 522,345 0
HERON THERAPEUTICS INC COM 427746102 69,056 1,777,500 SH Put DFND   0 1,777,500 0
HOLOGIC INC COM 436440101 75,235 1,892,703 SH   DFND   0 1,892,703 0
HUMANA INC COM 444859102 91,998 309,101 SH   DFND   0 309,101 0
ICON PLC SHS G4705A100 57,294 432,312 SH   DFND   0 432,312 0
INTUIT COM 461202103 61,003 298,586 SH   DFND   0 298,586 0
INTUITIVE SURGICAL INC COM NEW 46120E602 41,784 87,327 SH   DFND   0 87,327 0
INVESCO QQQ TR UNIT SER 1 46090E103 411,771 2,398,900 SH Put DFND   0 2,398,900 0
INVUITY INC COM NEW 46187J205 5,305 1,360,334 SH   DFND   0 1,360,334 0
IRHYTHM TECHNOLOGIES INC COM 450056106 39,789 490,430 SH   DFND   0 490,430 0
ISHARES TR MSCI EMG MKT 464287234 72,305 1,668,700 SH Put DFND   0 1,668,700 0
ISHARES TR MSCI EMG MKT 464287234 57,932 1,337,000 SH Put DFND   0 1,337,000 0
ISHARES TR RUSSELL 2000 464287655 98,737 602,900 SH Put DFND   0 602,900 0
ISHARES TR RUSSELL 2000 464287655 104,223 636,400 SH Put DFND   0 636,400 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 213,464 1,238,906 SH   DFND   0 1,238,906 0
KURA ONCOLOGY INC COM 50127T109 19,786 1,087,123 SH   DFND   0 1,087,123 0
LANNET INC COM 516012101 21,733 1,598,000 SH Call DFND   0 1,598,000 0
LENDINGTREE INC NEW NOTE 0.625% 6/0 52603BAA5 5,969 4,934,000 PRN   DFND   0 4,934,000 0
MADISON SQUARE GARDEN CO NEW CL A 55825T103 48,929 157,740 SH   DFND   0 157,740 0
MALLINCKRODT PUB LTD CO COM G5785G107 23,495 1,259,100 SH Put DFND   0 1,259,100 0
MASTERCARD INCORPORATED CL A 57636Q104 31,004 157,764 SH   DFND   0 157,764 0
MEDICINES CO COM 584688105 76,666 2,088,997 SH   DFND   0 2,088,997 0
MEDICINES CO NOTE 2.750% 7/1 584688AG0 45,634 45,161,000 PRN   DFND   0 45,161,000 0
MERIT MED SYS INC COM 589889104 74,528 1,455,616 SH   DFND   0 1,455,616 0
MICROSOFT CORP COM 594918104 901 9,138 SH   DFND   0 9,138 0
MOLINA HEALTHCARE INC COM 60855R100 52,688 537,962 SH   DFND   0 537,962 0
MYLAN N V COM N59465109 45,959 1,271,700 SH Call DFND   0 1,271,700 0
MYLAN N V SHS EURO N59465109 161,933 4,480,720 SH   DFND   0 4,480,720 0
MYOKARDIA INC COM 62857M105 90,329 1,819,315 SH   DFND   0 1,819,315 0
NEON THERAPEUTICS INC COM 64050Y100 5,130 496,797 SH   DFND   0 496,797 0
NEON THERAPEUTICS INC COM 64050Y100 1,735 167,986 SH   DFND   0 167,986 0
NEON THERAPEUTICS INC COM 64050Y100 3,906 309,978 SH   DFND   0 309,978 0
NETFLIX INC COM 64110L106 30,326 77,474 SH   DFND   0 77,474 0
NIGHTSTAR THERAPEUTICS PLC ADR 65413A101 16,272 1,016,980 SH   DFND   0 1,016,980 0
NUCANA PLC SPONSORED ADR 67022C106 7,991 420,567 SH   DFND   0 420,567 0
NVIDIA CORP COM 67066G104 30,715 129,654 SH   DFND   0 129,654 0
PACIRA PHARMACEUTICALS INC COM 695127100 99,682 3,110,213 SH   DFND   0 3,110,213 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 9,360 337,283 SH   DFND   0 337,283 0
PAYPAL HLDGS INC COM 70450Y103 42,614 511,754 SH   DFND   0 511,754 0
PENUMBRA INC COM 70975L107 79,353 574,400 SH   DFND   0 574,400 0
PERKINELMER INC COM 714046109 85,080 1,161,817 SH   DFND   0 1,161,817 0
PIVOTAL SOFTWARE INC COM CL A 72582H107 23,766 979,223 SH   DFND   0 979,223 0
PORTOLA PHARMACEUTICALS INC COM 737010108 191,863 5,079,770 SH   DFND   0 5,079,770 0
PUMA BIOTECHNOLOGY INC COM 74587V107 94,450 1,596,783 SH   DFND   0 1,596,783 0
RED HAT INC COM 756577102 18,494 137,634 SH   DFND   0 137,634 0
S&P GLOBAL INC COM 78409V104 41,005 201,114 SH   DFND   0 201,114 0
SALESFORCE COM INC COM 79466L302 98,785 724,231 SH   DFND   0 724,231 0
SERVICENOW INC COM 81762P102 840 4,868 SH   DFND   0 4,868 0
SIENNA BIOPHARMACEUTICALS IN COM 82622H108 23,564 1,551,293 SH   DFND   0 1,551,293 0
SOLID BIOSCIENCES INC COM 83422E105 16,724 469,367 SH   DFND   0 469,367 0
SPARK THERAPEUTICS INC COM 84652J103 72,562 876,779 SH   DFND   0 876,779 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 58,297 346,510 SH   DFND   0 346,510 0
SQUARE INC CL A 852234103 32,419 525,942 SH   DFND   0 525,942 0
SQUARE INC NOTE 0.375% 3/0 852234AB9 46,123 17,068,000 PRN   DFND   0 17,068,000 0
TABLEAU SOFTWARE INC CL A 87336U105 57,717 590,458 SH   DFND   0 590,458 0
TELEFLEX INC COM 879369106 45,541 169,796 SH   DFND   0 169,796 0
TENET HEALTHCARE CORP COM NEW 88033G407 145,591 4,336,946 SH   DFND   0 4,336,946 0
TWITTER INC COM 90184L102 51,216 1,172,793 SH   DFND   0 1,172,793 0
UNITEDHEALTH GROUP INC COM 91324P102 74,261 302,688 SH   DFND   0 302,688 0
UNITY BIOTECHNOLOGY INC COM 91381U101 2,852 216,182 SH   DFND   0 216,182 0
UNITY BIOTECHNOLOGY INC COM 91381U101 4,121 312,342 SH   DFND   0 312,342 0
UNITY BIOTECHNOLOGY INC COM 91381U101 4,485 297,828 SH   DFND   0 297,828 0
ZILLOW GROUP INC CL C CAP STK 98954M200 21,663 366,797 SH   DFND   0 366,797 0
ZIMMER BIOMET HLDGS INC COM 98956P102 99,696 894,616 SH   DFND   0 894,616 0
ZSCALER INC COM 98980G102 1,674 46,814 SH   DFND   0 46,814 0