The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 94,875 | 4,312,498 | SH | DFND | 1 | 4,312,498 | 0 | 0 | |
| ABEONA THERAPEUTICS INC | COM | 00289Y107 | 8,790 | 549,404 | SH | DFND | 1 | 549,404 | 0 | 0 | |
| ACCELERON PHARMA INC | COM | 00434H108 | 3,477 | 71,667 | SH | DFND | 1 | 71,667 | 0 | 0 | |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 10,495 | 525,538 | SH | DFND | 1 | 525,538 | 0 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 87,622 | 1,233,422 | SH | DFND | 1 | 1,233,422 | 0 | 0 | |
| ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 19,620 | 450,000 | SH | DFND | 1 | 450,000 | 0 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 23,079 | 278,536 | SH | DFND | 1 | 278,536 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 11,222 | 668,743 | SH | DFND | 1 | 668,743 | 0 | 0 | |
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 24,728 | 371,739 | SH | DFND | 1 | 371,739 | 0 | 0 | |
| AUDENTES THERAPEUTICS INC | COM | 05070R104 | 12,340 | 322,945 | SH | DFND | 1 | 322,945 | 0 | 0 | |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 40,870 | 1,525,587 | SH | DFND | 1 | 1,525,587 | 0 | 0 | |
| AVROBIO INC | COM | 05455M100 | 43,062 | 1,507,783 | SH | DFND | 1 | 1,507,783 | 0 | 0 | |
| BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 11,253 | 284,735 | SH | DFND | 1 | 284,735 | 0 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 34,914 | 550,000 | SH | DFND | 1 | 550,000 | 0 | 0 | |
| CELLECTAR BIOSCIENCES INC | *W EXP 08/20/201 | 15117F120 | 10 | 52,999 | SH | DFND | 1 | 52,999 | 0 | 0 | |
| CLEARSIDE BIOMEDICAL INC | COM | 185063104 | 12,828 | 1,200,000 | SH | DFND | 1 | 1,200,000 | 0 | 0 | |
| COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 | 6,837 | 286,668 | SH | DFND | 1 | 286,668 | 0 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 7,497 | 3,392,234 | SH | DFND | 1 | 3,392,234 | 0 | 0 | |
| DICERNA PHARMACEUTICALS INC | COM | 253031108 | 44,112 | 3,600,954 | SH | DFND | 1 | 3,600,954 | 0 | 0 | |
| EIDOS THERAPEUTICS INC | COM | 28249H104 | 7,455 | 385,846 | SH | DFND | 1 | 385,846 | 0 | 0 | |
| G1 THERAPEUTICS INC | COM | 3621LQ109 | 31,291 | 719,985 | SH | DFND | 1 | 719,985 | 0 | 0 | |
| GEMPHIRE THERAPEUTICS INC | COM | 36870A108 | 10,614 | 1,041,635 | SH | DFND | 1 | 1,041,635 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 7,425 | 191,108 | SH | DFND | 1 | 191,108 | 0 | 0 | |
| INCYTE CORP | COM | 45337C102 | 13,400 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| INFLARX NV | COM | N44821101 | 47,964 | 1,487,265 | SH | DFND | 1 | 1,487,265 | 0 | 0 | |
| INSPIRE MED SYS INC | COM | 457730109 | 11,590 | 325,000 | SH | DFND | 1 | 325,000 | 0 | 0 | |
| INTEC PHARMA LTD JERUSALEM | SHS | M53644106 | 3,405 | 773,816 | SH | DFND | 1 | 773,816 | 0 | 0 | |
| ITERUM THERAPEUTICS PLC | SHS | G6333L101 | 5,445 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| KEZAR LIFE SCIENCES INC | COM | 49372L100 | 27,211 | 1,572,910 | SH | DFND | 1 | 1,572,910 | 0 | 0 | |
| KINIKSA PHARMACEUTICALS LTD | COM CL A | G5269C101 | 13,842 | 831,000 | SH | DFND | 1 | 831,000 | 0 | 0 | |
| MARINUS PHARMACEUTICALS INC | COM | 56854Q101 | 3,380 | 478,111 | SH | DFND | 1 | 478,111 | 0 | 0 | |
| MEIRAGTX HOLDINGS PLC | COM | G59665102 | 2,734 | 238,580 | SH | DFND | 1 | 238,580 | 0 | 0 | |
| MINERVA NEUROSCIENCES INC | COM | 603380106 | 5,015 | 607,903 | SH | DFND | 1 | 607,903 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 94,575 | 1,918,350 | SH | DFND | 1 | 1,918,350 | 0 | 0 | |
| MYOKARDIA INC | COM | 62857M105 | 38,010 | 767,363 | SH | DFND | 1 | 767,363 | 0 | 0 | |
| NEKTAR THERAPEUTICS | COM | 640268108 | 73,245 | 1,500,000 | SH | DFND | 1 | 1,500,000 | 0 | 0 | |
| NEKTAR THERAPEUTICS | COM | 640268108 | 89,281 | 1,828,400 | SH | Call | DFND | 1 | 1,828,400 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 18,775 | 191,112 | SH | DFND | 1 | 191,112 | 0 | 0 | |
| OMEROS CORP | COM | 682143102 | 23,838 | 1,314,118 | SH | DFND | 1 | 1,314,118 | 0 | 0 | |
| OMEROS CORP | COM | 682143902 | 17,578 | 969,000 | SH | Call | DFND | 1 | 969,000 | 0 | 0 |
| ONCOBIOLOGICS INC | *W EXP 02/18/201 | 68235M113 | 20 | 416,666 | SH | DFND | 1 | 416,666 | 0 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 2,568 | 382,139 | SH | DFND | 1 | 382,139 | 0 | 0 | |
| QUANTERIX CORP | COM | 74766Q101 | 12,174 | 847,788 | SH | DFND | 1 | 847,788 | 0 | 0 | |
| QUOTIENT LTD | SHS | G73268107 | 34,456 | 4,290,852 | SH | DFND | 1 | 4,290,852 | 0 | 0 | |
| REATA PHARMACEUTICALS INC | CL A | 75615P103 | 15,737 | 450,000 | SH | DFND | 1 | 450,000 | 0 | 0 | |
| ROCKET PHARMACEUTICALS, INC | COM | 77313F106 | 29,835 | 1,519,890 | SH | DFND | 1 | 1,519,890 | 0 | 0 | |
| SAGE THERAPEUTICS INC | COM | 78667J108 | 37,508 | 239,619 | SH | DFND | 1 | 239,619 | 0 | 0 | |
| SANGAMO THERAPEUTICS INC | COM | 800677106 | 5,427 | 382,192 | SH | DFND | 1 | 382,192 | 0 | 0 | |
| SCHOLAR ROCK HOLDING CORP | COM | 80706P103 | 3,277 | 210,078 | SH | DFND | 1 | 210,078 | 0 | 0 | |
| SOLID BIOSCIENCES INC | COM | 83422E105 | 24,441 | 685,956 | SH | DFND | 1 | 685,956 | 0 | 0 | |
| SPECTRUM PHARMACEUTICALS INC | COM | 84763A108 | 25,152 | 1,200,000 | SH | DFND | 1 | 1,200,000 | 0 | 0 | |
| TESARO INC | COM | 881569107 | 24,459 | 550,000 | SH | DFND | 1 | 550,000 | 0 | 0 | |
| THERAVANCE BIOPHARMA INC | COM | G8807B106 | 29,484 | 1,300,000 | SH | DFND | 1 | 1,300,000 | 0 | 0 | |
| TRANSLATE BIO INC | COM | 89374L104 | 5,750 | 454,550 | SH | DFND | 1 | 454,550 | 0 | 0 | |
| TRICIDA INC | COM | 89610F101 | 27,944 | 934,588 | SH | DFND | 1 | 934,588 | 0 | 0 | |
| TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 3,439 | 573,208 | SH | DFND | 1 | 573,208 | 0 | 0 | |
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 18,246 | 957,821 | SH | DFND | 1 | 957,821 | 0 | 0 | |
| ZAI LAB LTD | ADR | 98887Q104 | 7,746 | 333,166 | SH | DFND | 1 | 333,166 | 0 | 0 | |