The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AC IMMUNE SA SHS H00263105 5,592 600,000 SH   DFND 1,2,3,4,5 600,000 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 11,150 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 11,150 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
ACCELERON PHARMA INC COM 00434H108 48,520 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
ACCELERON PHARMA INC COM 00434H108 4,852 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
ADURO BIOTECH INC COM 00739L101 3,850 550,000 SH   DFND 1,2,3,4,5 550,000 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 2,120 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 6,467 1,558,400 SH   DFND 1,2,3,4,5 1,558,400 0 0
AGENUS INC COM NEW 00847G705 6,243 2,750,000 SH   DFND 1,2,3,4,5 2,750,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 29,481 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 4,212 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 4,741 475,000 SH   DFND 1,2,3,4,5 475,000 0 0
ALBIREO PHARMA INC COM 01345P106 17,750 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 64,019 650,000 SH   DFND 1,2,3,4,5 650,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 9,849 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 45,298 2,900,000 SH   DFND 1,2,3,4,5 2,900,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 7,810 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
ANAPTYSBIO INC COM 032724106 14,208 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109 3,672 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
ARGENX SE SPONSORED ADR 04016X101 12,429 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 33,560 2,000,000 SH   DFND 1,2,3,4,5 2,000,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 36,750 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
ATYR PHARMA INC COM 002120103 455 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 9,018 236,000 SH   DFND 1,2,3,4,5 236,000 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 14,065 525,000 SH   DFND 1,2,3,4,5 525,000 0 0
AVROBIO INC COM 05455M100 3,570 125,000 SH   DFND 1,2,3,4,5 125,000 0 0
BANK AMER CORP COM 060505104 179,007 6,350,000 SH Call DFND 1,2,3,4,5 6,350,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 103,768 675,000 SH   DFND 1,2,3,4,5 675,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 18,840 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
BLUEBIRD BIO INC COM 09609G100 26,682 170,000 SH   DFND 1,2,3,4,5 170,000 0 0
BLUEBIRD BIO INC COM 09609G100 7,848 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 44,436 700,000 SH   DFND 1,2,3,4,5 700,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 12,696 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 69,175 1,250,000 SH Call DFND 1,2,3,4,5 1,250,000 0 0
CELGENE CORP COM 151020104 158,840 2,000,000 SH Call DFND 1,2,3,4,5 2,000,000 0 0
CHIMERIX INC COM 16934W106 2,380 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 2,632 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 4,547 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 2,938 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 10,736 800,000 SH   DFND 1,2,3,4,5 800,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 7,625 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 5,206 425,000 SH   DFND 1,2,3,4,5 425,000 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 3,813 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
EXELIXIS INC COM 30161Q104 10,760 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
FATE THERAPEUTICS INC COM 31189P102 19,278 1,700,000 SH   DFND 1,2,3,4,5 1,700,000 0 0
FIBROGEN INC COM 31572Q808 15,650 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
FREEPORT-MCMORAN INC CL B 35671D857 17,260 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
GENERAL MTRS CO COM 37045V100 59,100 1,500,000 SH Call DFND 1,2,3,4,5 1,500,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 9,040 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
GLYCOMIMETICS INC COM 38000Q102 4,033 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 66,171 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
HOMOLOGY MEDICINES INC COM 438083107 2,040 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
IDERA PHARMACEUTICALS INC COM NEW 45168K306 3,630 2,750,000 SH   DFND 1,2,3,4,5 2,750,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 4,147 216,879 SH   DFND 1,2,3,4 216,879 0 0
INFLARX NV COM N44821101 16,125 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 2,462 90,000 SH   DFND 1,2,3,4,5 90,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 8,960 700,000 SH   DFND 1,2,3,4,5 700,000 0 0
ISHARES TR NASDAQ BIOTECH 464287556 49,419 450,000 SH Call DFND 1,2,3,4,5 450,000 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 1,735 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
KRYSTAL BIOTECH INC COM 501147102 2,231 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 7,293 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 42,195 3,516,214 SH   DFND 1,2,3,4,5 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 680,696 56,724,650 SH   DFND 1,2,3,4 56,724,650 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 13,985 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 2,700 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 3,535 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
MEDICINES CO COM 584688105 14,680 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
MEDICINES CO COM 584688105 25,690 700,000 SH Call DFND 1,2,3,4,5 700,000 0 0
MIRAGEN THERAPEUTICS INC COM 60463E103 3,205 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
MORGAN STANLEY COM NEW 617446448 71,100 1,500,000 SH Call DFND 1,2,3,4,5 1,500,000 0 0
NEKTAR THERAPEUTICS COM 640268108 43,947 900,000 SH   DFND 1,2,3,4,5 900,000 0 0
NEKTAR THERAPEUTICS COM 640268108 14,649 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
NOVAVAX INC COM 670002104 670 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
NOVELION THERAPEUTICS INC COM NEW 67001K202 944 256,400 SH   DFND 1,2,3,4,5 256,400 0 0
ONCOCYTE CORPORATION COM 68235C107 383 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 10,950 1,500,000 SH   DFND 1,2,3,4,5 1,500,000 0 0
REGENXBIO INC COM 75901B107 10,763 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
RESTORBIO INC COM 76133L103 5,033 550,000 SH   DFND 1,2,3,4,5 550,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 7,852 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 15,653 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
SANGAMO THERAPEUTICS INC COM 800677106 2,840 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 7,020 450,000 SH   DFND 1,2,3,4,5 450,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 30,358 1,946,040 SH   DFND 1,2,3,4 1,946,040 0 0
SELECTA BIOSCIENCES INC COM 816212104 6,625 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
SIENNA BIOPHARMACEUTICALS IN COM 82622H108 1,504 99,000 SH   DFND 1,2,3,4,5 99,000 0 0
SOLID BIOSCIENCES INC COM 83422E105 8,908 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 5,135 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 6,420 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 426 60,697 SH   DFND 1,2,3,4,5 60,697 0 0
SYNLOGIC INC COM 87166L100 3,932 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
TESARO INC COM 881569107 35,576 800,000 SH   DFND 1,2,3,4,5 800,000 0 0
TESARO INC COM 881569107 15,565 350,000 SH Call DFND 1,2,3,4,5 350,000 0 0
TG THERAPEUTICS INC COM 88322Q108 5,260 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
TOCAGEN INC COM 888846102 934 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
TRANSLATE BIO INC COM 89374L104 6,325 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
TRICIDA INC COM 89610F101 2,990 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 900 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
UNITY BIOTECHNOLOGY INC COM 91381U101 3,012 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
VITAL THERAPIES INC COM 92847R104 6,850 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 3,825 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
WEIGHT WATCHERS INTL INC NEW COM 948626106 2,104,730 20,818,300 SH   DFND 1,2,3,4 20,818,300 0 0
WELLS FARGO CO NEW COM 949746101 55,440 1,000,000 SH Call DFND 1,2,3,4,5 1,000,000 0 0
XENCOR INC COM 98401F105 14,804 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 1,380 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
ZAFGEN INC COM 98885E103 12,276 1,200,000 SH   DFND 1,2,3,4,5 1,200,000 0 0
ZOGENIX INC COM NEW 98978L204 22,100 500,000 SH   DFND 1,2,3,4,5 500,000 0 0