The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC W EXP 12/24/201 00289Y115 11,966 1,259,636 SH   SOLE   1,259,636 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 14,180 998,162 SH   SOLE   998,162 0 0
ABIOMED INC COM 003654100 96,739 332,449 SH   SOLE   332,449 0 0
ABLYNX NV SPONSORED ADR 00372Y105 20,187 370,000 SH   SOLE   370,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 6,179 275,000 SH   SOLE   275,000 0 0
ACASTI PHARMA INC COM 00430K402 190 186,559 SH   SOLE   186,559 0 0
ACCELERON PHARMA INC COM 00434H108 59,286 1,516,259 SH   SOLE   1,516,259 0 0
ACHILLION PHARMACEUTICALS INC COM 00448Q201 3,710 1,000,000 SH   SOLE   1,000,000 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 15,057 630,000 SH   SOLE   630,000 0 0
ADMA BIOLOGICS INC COM 000899104 17,577 3,821,102 SH   SOLE   3,821,102 0 0
ADVAXIS INC COM NEW 007624208 2,535 1,500,000 SH   SOLE   1,500,000 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 469 80,845 SH   SOLE   80,845 0 0
AGILE THERAPEUTICS INC COM 00847L100 9,072 3,530,000 SH   SOLE   3,530,000 0 0
AGIO PHARMACEUTICALS INC COM 00847X104 20,445 250,000 SH   SOLE   250,000 0 0
AKCEA THERAPEUTICS INC COM 00972L107 2,488 97,144 SH   SOLE   97,144 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 23,467 2,462,400 SH   SOLE   2,462,400 0 0
ALBIREO PHARMA INC COM 01345P106 55,510 1,704,330 SH   SOLE   1,704,330 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 23,141 3,085,458 SH   SOLE   3,085,458 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 97,355 873,450 SH   SOLE   873,450 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 2,755 250,000 SH   SOLE   250,000 0 0
ALLIQUA BIOMEDICAL INC COM PAR 019621309 821 423,394 SH   SOLE   423,394 0 0
ALNYLAM PHARMACEUTICALS COM 02043Q107 152,543 1,280,802 SH   SOLE   1,280,802 0 0
AMICUS THERAPEUTICS INC COM 03152W109 301,167 20,024,424 SH   SOLE   20,024,424 0 0
ANAPTYSBIO INC COM 032724106 24,696 237,281 SH   SOLE   237,281 0 0
ANI PHARMACEUTICALS INC NOTE 3.000%12/0 00182CAA1 8,214 7,500,000 PRN   SOLE   7,500,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 6,793 171,978 SH   SOLE   171,978 0 0
ARGENX SE-ADR COM 04016X101 43,225 537,361 SH   SOLE   537,361 0 0
ARRAY BIOPHARMA INC COM 04269X105 655 40,133 SH   SOLE   40,133 0 0
ARROWHEAD PHARMACEUTICALS INC COM 04280A100 2,635 365,445 SH   SOLE   365,445 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 64,265 982,647 SH   SOLE   982,647 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 23,421 476,626 SH   SOLE   476,626 0 0
ATHENEX INC COM 04685N103 3,232 190,000 SH   SOLE   190,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 22,724 756,215 SH   SOLE   756,215 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 9,447 1,295,841 SH   SOLE   1,295,841 0 0
AVEO PHARMACEUTICALS INC COM 053588109 7,129 2,458,116 SH   SOLE   2,458,116 0 0
AVEXIS INC COM 05366U100 34,158 276,400 SH   SOLE   276,400 0 0
AZURRX BIOPHARMA INC COM 05502L105 714 227,272 SH   SOLE   227,272 0 0
BEIGENE LTD SPONSORED 07725L102 958 5,700 SH   SOLE   5,700 0 0
BIOGEN INC COM 09062X103 11 50,000 SH Call SOLE   50,000 0 0
BIOGEN INC COM 09062X103 5,476 20,000 SH   SOLE   20,000 0 0
BIOHAVEN PHARMACEUTICAL HLDG CO L COM G11196105 71,224 2,927,449 SH   SOLE   2,927,449 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 94,491 1,030,434 SH   SOLE   1,030,434 0 0
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201 1,260 400,000 SH   SOLE   400,000 0 0
CAPITAL SR LIVING CORP COM 140475104 1,077 100,173 SH   SOLE   100,173 0 0
CAPRICOR THERAPEUTICS INC COM 14070B101 5 4,000 SH   SOLE   4,000 0 0
CAREDX INC COM 14167L103 8,294 1,040,676 SH   SOLE   1,040,676 0 0
CASI PHARMACEUTICALS INC COM 14757U109 182 43,682 SH   SOLE   43,682 0 0
CATALYST BIOSCIENCES IINC COM NEW 14888D208 1,419 55,000 SH   SOLE   55,000 0 0
CELLECTIS S A SPONSORED ADS 15117K103 9,453 300,000 SH   SOLE   300,000 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307 1,335 366,973 SH   SOLE   366,973 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 7,681 715,181 SH   SOLE   715,181 0 0
CORIUM INTERNATIONAL INC COM 21887L107 72,916 6,357,133 SH   SOLE   6,357,133 0 0
CUTERA INC COM 232109108 602 11,981 SH   SOLE   11,981 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 33,745 2,802,821 SH   SOLE   2,802,821 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 62,841 2,208,812 SH   SOLE   2,208,812 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 48,296 2,093,498 SH   SOLE   2,093,498 0 0
DOVA PHARMACEUTICALS INC COM 25985T102 75,420 2,780,977 SH   SOLE   2,780,977 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 1,106 55,713 SH   SOLE   55,713 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,553 157,679 SH   SOLE   157,679 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 739 9,132 SH   SOLE   9,132 0 0
ENDOCYTE INC COM 29269A102 20,013 2,201,700 SH   SOLE   2,201,700 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 779 10,769 SH   SOLE   10,769 0 0
FERRARI N V COM N3167Y103 747 6,200 SH   SOLE   6,200 0 0
FIAT CHRYSLER AUTOMOBILES N SHS N31738102 1,272 62,000 SH   SOLE   62,000 0 0
FLEXION THERAPEUTICS INC COM 33938J106 6,902 307,989 SH   SOLE   307,989 0 0
FOAMIX PHARMACEUTICALS LTD COM M46135105 5,732 1,117,324 SH   SOLE   1,117,324 0 0
GALAPAGOS N V SPON ADR 36315X101 20,581 206,305 SH   SOLE   206,305 0 0
GERON CORP COM 374163103 600 600,000 SH Put SOLE   600,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 240,971 4,989,066 SH   SOLE   4,989,066 0 0
HISTOGENICS CORP COM 43358V109 6,059 2,203,277 SH   SOLE   2,203,277 0 0
HUMANA INC COM 444859102 16,323 60,718 SH   SOLE   60,718 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 296 10,000 SH   SOLE   10,000 0 0
INCYTE CORP COM 45337C102 6,946 1,510,000 SH Call SOLE   1,510,000 0 0
INCYTE CORP COM 45337C102 2,230 100,000 SH Put SOLE   100,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 1,474 70,000 SH   SOLE   70,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 4,128 10,000 SH   SOLE   10,000 0 0
INVACARE CORP COM 461203101 3,480 200,000 SH   SOLE   200,000 0 0
INVITAE CORP COM 46185L103 8,700 1,851,100 SH   SOLE   1,851,100 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 104,141 6,162,202 SH   SOLE   6,162,202 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 26,420 419,706 SH   SOLE   419,706 0 0
KADMON HLDGS INC COM 48283N106 21,954 5,165,746 SH   SOLE   5,165,746 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 128,459 4,313,611 SH   SOLE   4,313,611 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 16,645 142,522 SH   SOLE   142,522 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 3,467 907,732 SH   SOLE   907,732 0 0
MCKESSON CORP COM 58155Q103 2,113 15,000 SH   SOLE   15,000 0 0
MENLO THERAPEUTICS INC COM 586858102 60,089 1,598,958 SH   SOLE   1,598,958 0 0
MERIT MED SYS INC COM 589889104 47,391 1,045,013 SH   SOLE   1,045,013 0 0
MIRATI THERAPEUTICS INC COM 60468T105 893 29,091 SH   SOLE   29,091 0 0
MOLECULAR TEMPLATES INC COM 608550109 5,793 724,133 SH   SOLE   724,133 0 0
MOTUS GI HLDGS INC COM 62014P108 12,591 2,810,542 SH   SOLE   2,810,542 0 0
MYOKARDIA INC COM 62857M105 40,732 834,679 SH   SOLE   834,679 0 0
NEKTAR THERAPEUTICS COM 640268108 644 6,057 SH   SOLE   6,057 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 24,092 8,574,015 SH   SOLE   8,574,015 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 394,912 4,761,989 SH   SOLE   4,761,989 0 0
NUVECTRA CORP COM 67075N108 5,007 384,600 SH   SOLE   384,600 0 0
ODONATE THERAPEUTICS INC COM 676079106 3,177 150,000 SH   SOLE   150,000 0 0
ONCOMED PHARMACEUTICALS INC COM 68234X102 8,334 2,620,897 SH   SOLE   2,620,897 0 0
ONCOSEC MED INC COM NEW 68234L207 94 50,000 SH   SOLE   50,000 0 0
PERNIX THERAPEUTICS HLDGS IN DBVC 4.250% 4/0 71426VAK4 462 1,000,000 PRN   SOLE   1,000,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 14,370 440,000 SH   SOLE   440,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 158 100,000 SH Put SOLE   100,000 0 0
PROGENICS PHARMACEUTICALS IN COM 743187106 1,212 162,500 SH   SOLE   162,500 0 0
PROTEON THERAPEUTICS INC COM 74371L109 835 334,116 SH   SOLE   334,116 0 0
PTC THERAPEUTICS INC COM 69366J200 8,118 300,000 SH   SOLE   300,000 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 1,610 200,000 SH Call SOLE   200,000 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 30,090 442,179 SH   SOLE   442,179 0 0
QUOTIENT LTD COM G73268107 28,415 6,033,020 SH   SOLE   6,033,020 0 0
REGENERON PHARMACEUTICALS COM 75886F107 335 50,000 SH Call SOLE   50,000 0 0
REGENXBIO INC COM 75901B107 26,301 881,106 SH   SOLE   881,106 0 0
RETROPHIN INC COM 761299106 71,839 3,212,871 SH   SOLE   3,212,871 0 0
REVANCE THERAPEUTICS INC COM 761330109 19,064 618,957 SH   SOLE   618,957 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 11,786 592,286 SH   SOLE   592,286 0 0
SANGAMO THERAPEUTICS INC COM 800677106 475 25,000 SH   SOLE   25,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 6,050 593,750 SH   SOLE   593,750 0 0
SENSEONICS HLDGS INC COM 81727U105 345 115,000 SH   SOLE   115,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 10,350 5,000,000 SH   SOLE   5,000,000 0 0
SOLID BIOSCIENCES INC COM 3422E1055 29,454 3,927,222 SH   SOLE   3,927,222 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 1,548 900,000 SH Put SOLE   900,000 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 2,434 275,000 SH   SOLE   275,000 0 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 183 100,000 SH   SOLE   100,000 0 0
SYNLOGIC INC COM 87166L100 8,844 942,852 SH   SOLE   942,852 0 0
TABULA RASA HEALTHCARE INC COM 873379101 569 14,663 SH   SOLE   14,663 0 0
TELADOC INC COM 87918A105 20,956 520,000 SH   SOLE   520,000 0 0
TELEFLEX INC COM 879369106 10,429 40,900 SH   SOLE   40,900 0 0
UNIQURE NV COM N90064101 32,774 1,394,628 SH   SOLE   1,394,628 0 0
VBI VACCINES INC COM NEW 91822J103 33,830 9,665,843 SH   SOLE   9,665,843 0 0
VERICEL CORP COM 92346J108 271 27,211 SH   SOLE   27,211 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 1,123 56,168 SH   SOLE   56,168 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 24,756 151,898 SH   SOLE   151,898 0 0
VICAL INC COM 925602203 1,657 1,142,858 SH   SOLE   1,142,858 0 0
VIEWRAY INC COM 92672L107 643 100,000 SH   SOLE   100,000 0 0
VITAL THERAPIES INC COM 92847R104 454 150,000 SH Put SOLE   150,000 0 0
VIVEVE MED INC COM NEW 92852W204 1,226 334,894 SH   SOLE   334,894 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 18,558 462,798 SH   SOLE   462,798 0 0
XENCOR INC COM 98401F105 39,516 1,318,095 SH   SOLE   1,318,095 0 0
ZOGENIX INC COM NEW 98978L204 159,012 3,970,357 SH   SOLE   3,970,357 0 0
ZYMEWORKS INC COM 98985W102 7,779 693,890 SH   SOLE   693,890 0 0