The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 105,267 1,756,796 SH   DFND   0 1,756,796 0
ACCURAY INC COM 004397105 32,120 6,424,070 SH   DFND   0 6,424,070 0
ACORDA THERAPEUTICS INC COM 00484M106 79,350 3,355,184 SH   DFND   0 3,355,184 0
ACORDA THERAPEUTICS INC NOTE 1.750% 6/1 00484MAA4 22,907 25,065,000 PRN   DFND   0 25,065,000 0
ACTIVISION BLIZZARD INC COM 00507V109 36,446 540,254 SH   DFND   0 540,254 0
AERIE PHARMACEUTICALS INC COM 00771V108 153,690 2,833,003 SH   DFND   0 2,833,003 0
AGILENT TECHNOLOGIES INC COM 00846U101 57,779 863,669 SH   DFND   0 863,669 0
AGIOS PHARMACEUTICALS INC COM 00847X104 55,373 677,091 SH   DFND   0 677,091 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 31,710 2,496,827 SH   DFND   0 2,496,827 0
ALDER BIOPHARMACEUTICALS INC NOTE 2.500% 2/0 014339AA3 16,430 17,776,000 PRN   DFND   0 17,776,000 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 51,300 279,501 SH   DFND   0 279,501 0
ALLENA PHARMACEUTICALS INC COM 018119107 7,454 676,362 SH   DFND   0 676,362 0
ALLENA PHARMACEUTICALS INC COM 018119107 7,787 787,532 SH   DFND   0 787,532 0
ALPHABET INC CAP STK CL A 02079K305 54,139 52,200 SH   DFND   0 52,200 0
AMAZON COM INC COM 023135106 44,636 30,840 SH   DFND   0 30,840 0
ANAPTYSBIO INC COM 032724106 7,322 70,354 SH   DFND   0 70,354 0
ANTHEM INC COM 036752103 145,193 660,870 SH   DFND   0 660,870 0
ARCUS BIOSCIENCES INC COM 03969F109 14,410 933,286 SH   DFND   0 933,286 0
BAIDU INC SPON ADR REP A 056752108 51,071 228,822 SH   DFND   0 228,822 0
BAXTER INTL INC COM 071813109 134,492 2,067,832 SH   DFND   0 2,067,832 0
BLUEBIRD BIO INC COM 09609G100 21,914 128,341 SH   DFND   0 128,341 0
BLUEPRINT MEDICINES CORP COM 09627Y109 84,180 917,990 SH   DFND   0 917,990 0
BOSTON SCIENTIFIC CORP COM 101137107 19,651 719,302 SH   DFND   0 719,302 0
BOX INC CL A 10316T104 41,691 2,028,739 SH   DFND   0 2,028,739 0
BRISTOL MYERS SQUIBB CO COM 110122908 92,187 1,457,500 SH Call DFND   0 1,457,500 0
BRISTOL MYERS SQUIBB CO COM 110122108 197,539 3,123,145 SH   DFND   0 3,123,145 0
CARDIOVASCULAR SYS INC DEL COM 141619106 18,008 821,154 SH   DFND   0 821,154 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 4,889 322,732 SH   DFND   0 322,732 0
CME GROUP INC COM CL A 12572Q105 56,621 350,074 SH   DFND   0 350,074 0
COUPA SOFTWARE INC COM 22266L106 25,017 548,371 SH   DFND   0 548,371 0
CUTERA INC COM 232109108 20,136 400,726 SH   DFND   0 400,726 0
DAVITA INC COM 23918K108 41,213 625,003 SH   DFND   0 625,003 0
DEXCOM INC COM 252131107 38,130 514,164 SH   DFND   0 514,164 0
DROPBOX INC CL A 26210C104 21,291 681,302 SH   DFND   0 681,302 0
EDWARDS LIFESCIENCES CORP COM 28176E108 78,131 559,995 SH   DFND   0 559,995 0
ENDOCYTE INC COM 29269A102 39,444 4,339,244 SH   DFND   0 4,339,244 0
ENDOLOGIX INC COM 29266S106 32,753 7,742,929 SH   DFND   0 7,742,929 0
ENDOLOGIX INC NOTE 3.250%11/0 29266SAB2 41,210 47,642,000 PRN   DFND   0 47,642,000 0
ESPERION THERAPEUTICS INC NE COM 29664W105 81,733 1,129,998 SH   DFND   0 1,129,998 0
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 1,632 1,911,400 PRN   DFND   0 1,911,400 0
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAD0 27,059 29,243,000 PRN   DFND   0 29,243,000 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 3,235 66,967 SH   DFND   0 66,967 0
GODADDY INC CL A 380237107 79,788 1,299,060 SH   DFND   0 1,299,060 0
HCA HEALTHCARE INC COM 40412C101 56,789 585,451 SH   DFND   0 585,451 0
HOLOGIC INC COM 436440101 58,762 1,572,857 SH   DFND   0 1,572,857 0
HUMANA INC COM 444859102 86,147 320,450 SH   DFND   0 320,450 0
ICON PLC SHS G4705A100 31,703 268,353 SH   DFND   0 268,353 0
INOGEN INC COM 45780L104 204 1,657 SH   DFND   0 1,657 0
INTUIT COM 461202103 41,405 238,851 SH   DFND   0 238,851 0
INVUITY INC COM NEW 46187J205 5,237 1,360,334 SH   DFND   0 1,360,334 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 171,453 1,135,527 SH   DFND   0 1,135,527 0
JOUNCE THERAPEUTICS INC COM 481116101 42,994 1,923,651 SH   DFND   0 1,923,651 0
KURA ONCOLOGY INC COM 50127T109 25,113 1,339,362 SH   DFND   0 1,339,362 0
LENDINGTREE INC NEW COM 52603B107 16,804 51,208 SH   DFND   0 51,208 0
MEDICINES CO COM 584688105 72,578 2,203,331 SH   DFND   0 2,203,331 0
MEDICINES CO NOTE 2.750% 7/1 584688AG0 34,109 35,342,000 PRN   DFND   0 35,342,000 0
MERIT MED SYS INC COM 589889104 38,856 856,794 SH   DFND   0 856,794 0
MICROSOFT CORP COM 594918104 96,461 1,056,879 SH   DFND   0 1,056,879 0
MOLINA HEALTHCARE INC COM 60855R100 104,430 1,286,398 SH   DFND   0 1,286,398 0
MYLAN N V COM N59465909 56,687 1,376,900 SH Call DFND   0 1,376,900 0
MYLAN N V SHS EURO N59465109 190,373 4,624,079 SH   DFND   0 4,624,079 0
MYOKARDIA INC COM 62857M105 46,356 949,911 SH   DFND   0 949,911 0
NETFLIX INC COM 64110L106 23,507 79,591 SH   DFND   0 79,591 0
NIGHTSTAR THERAPEUTICS PLC ADR 65413A101 14,453 1,009,973 SH   DFND   0 1,009,973 0
NUCANA PLC SPONSORED ADR 67022C106 8,463 447,324 SH   DFND   0 447,324 0
NVIDIA CORP COM 67066G104 15,424 66,602 SH   DFND   0 66,602 0
OPTINOSE INC COM 68404V100 6,693 334,297 SH   DFND   0 334,297 0
PACIRA PHARMACEUTICALS INC COM 695127100 53,099 1,704,608 SH   DFND   0 1,704,608 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 7,527 196,418 SH   DFND   0 196,418 0
PAYPAL HLDGS INC COM 70450Y103 67,733 892,756 SH   DFND   0 892,756 0
PENUMBRA INC COM 70975L107 74,824 646,986 SH   DFND   0 646,986 0
PERKINELMER INC COM 714046109 81,892 1,081,507 SH   DFND   0 1,081,507 0
PORTOLA PHARMACEUTICALS INC COM 737010908 17,418 533,300 SH Call DFND   0 533,300 0
PORTOLA PHARMACEUTICALS INC COM 737010108 173,969 5,326,671 SH   DFND   0 5,326,671 0
PUMA BIOTECHNOLOGY INC COM 74587V107 138,320 2,032,619 SH   DFND   0 2,032,619 0
QUALITY SYS INC COM 747582104 6,050 443,210 SH   DFND   0 443,210 0
RED HAT INC COM 756577102 38,672 258,660 SH   DFND   0 258,660 0
REGENXBIO INC COM 75901B107 23,699 793,951 SH   DFND   0 793,951 0
SALESFORCE COM INC COM 79466L302 64,640 555,808 SH   DFND   0 555,808 0
SERVICENOW INC COM 81762P102 789 4,767 SH   DFND   0 4,767 0
SIENNA BIOPHARMACEUTICALS IN COM 82622H108 29,131 1,551,176 SH   DFND   0 1,551,176 0
SPARK THERAPEUTICS INC COM 84652J103 42,460 637,636 SH   DFND   0 637,636 0
SPDR SERIES TRUST S&P BIOTECH 78464A950 103,416 1,178,800 SH Put DFND   0 1,178,800 0
SQUARE INC CL A 852234103 44,053 895,391 SH   DFND   0 895,391 0
SQUARE INC NOTE 0.375% 3/0 852234AB9 38,492 17,557,000 PRN   DFND   0 17,557,000 0
SYNEOS HEALTH INC CL A 87166B102 19,205 540,984 SH   DFND   0 540,984 0
TABLEAU SOFTWARE INC CL A 87336U105 64,363 796,373 SH   DFND   0 796,373 0
TELEFLEX INC COM 879369106 42,773 167,751 SH   DFND   0 167,751 0
TENET HEALTHCARE CORP COM NEW 88033G407 86,091 3,550,161 SH   DFND   0 3,550,161 0
TESLA INC COM 88160R101 19,304 72,537 SH   DFND   0 72,537 0
TWITTER INC COM 90184L102 54,390 1,874,859 SH   DFND   0 1,874,859 0
UNITEDHEALTH GROUP INC COM 91324P102 109,412 511,271 SH   DFND   0 511,271 0
ZIMMER BIOMET HLDGS INC COM 98956P102 97,201 891,421 SH   DFND   0 891,421 0
ZSCALER INC COM 98980G102 1,368 48,726 SH   DFND   0 48,726 0