The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
58 COM INC SPON ADR REP A 31680Q104 74,550 933,520 SH   SOLE 933,520 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 725 32,300 SH   SOLE 32,300 0 0
ACCELERON PHARMA INC COM 00434H108 2,287 58,500 SH   SOLE 58,500 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 2,039 37,600 SH   SOLE 37,600 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 2,469 30,200 SH   SOLE 30,200 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 421,595 2,297,025 SH   SOLE 2,143,725 0 153,300
ALLY FINL INC COM 02005N100 107,978 3,977,100 SH   SOLE 3,517,800 0 459,300
ALPHABET INC CAP STK CL A 02079K305 167,500 161,502 SH   SOLE 147,212 0 14,290
ALPHABET INC CAP STK CL C 02079K107 203,500 197,231 SH   SOLE 182,145 0 15,086
ANALOG DEVICES INC COM 032654105 464 5,100 SH   SOLE 5,100 0 0
APPLE INC COM 037833100 2,130 12,700 SH   SOLE 12,700 0 0
ARCUS BIOSCIENCES INC COM 03969F109 154 10,000 SH   SOLE 10,000 0 0
ARMO BIOSCIENCES INC COM 04225U104 748 20,000 SH   SOLE 20,000 0 0
BAIDU INC SPON ADR REP A 056752108 18,237 81,714 SH   SOLE 81,714 0 0
BARRICK GOLD CORP COM 067901108 7,303 586,595 SH   SOLE 586,595 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 1,120 13,820 SH   SOLE 13,820 0 0
BITAUTO HLDGS LTD SPONSORED ADS 091727107 50,004 2,364,248 SH   SOLE 2,274,848 0 89,400
CALLAWAY GOLF CO COM 131193104 18,259 1,116,100 SH   SOLE 1,116,100 0 0
CARNIVAL CORP UNIT 99/99/9999 143658300 1,918 29,260 SH   SOLE 29,260 0 0
CENTURYLINK INC COM 156700106 6,771 412,151 SH   SOLE 412,151 0 0
CF INDS HLDGS INC COM 125269100 94,005 2,491,533 SH   SOLE 2,097,133 0 394,400
CISCO SYS INC COM 17275R102 1,531 35,700 SH   SOLE 35,700 0 0
COCA COLA CO COM 191216100 18,918 435,600 SH   SOLE 435,600 0 0
COHERUS BIOSCIENCES INC COM 19249H103 1,513 137,000 SH   SOLE 137,000 0 0
CONFORMIS INC COM 20717E101 865 596,656 SH   SOLE 596,656 0 0
DERMIRA INC COM 24983L104 502 62,900 SH   SOLE 62,900 0 0
EBAY INC COM 278642103 1,235 30,700 SH   SOLE 30,700 0 0
EQUIFAX INC COM 294429105 82,196 697,703 SH   SOLE 622,703 0 75,000
FACEBOOK INC CL A 30303M102 160,643 1,005,340 SH   SOLE 912,440 0 92,900
FIVE PRIME THERAPEUTICS INC COM 33830X104 1,618 94,200 SH   SOLE 94,200 0 0
FOUNDATION MEDICINE INC COM 350465100 2,118 26,900 SH   SOLE 26,900 0 0
GILDAN ACTIVEWEAR INC COM 375916103 13,659 472,800 SH   SOLE 472,800 0 0
GILEAD SCIENCES INC COM 375558103 229,557 3,044,930 SH   SOLE 2,672,830 0 372,100
HANESBRANDS INC COM 410345102 44,904 2,437,800 SH   SOLE 2,148,500 0 289,300
ICON PLC SHS G4705A100 2,303 19,500 SH   SOLE 19,500 0 0
IHS MARKIT LTD SHS G47567105 24,385 505,500 SH   SOLE 505,500 0 0
INCYTE CORP COM 45337C102 805 9,664 SH   SOLE 9,664 0 0
INFINERA CORPORATION COM 45667G103 1,268 116,800 SH   SOLE 116,800 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 2,728 1,299,232 SH   SOLE 1,299,232 0 0
INTEL CORP COM 458140100 245,423 4,712,431 SH   SOLE 4,712,431 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 1,159 55,000 SH   SOLE 55,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,612 104,500 SH   SOLE 104,500 0 0
JD COM INC SPON ADR CL A 47215P106 30,462 752,342 SH   SOLE 752,342 0 0
JOHNSON & JOHNSON COM 478160104 4,203 32,800 SH   SOLE 32,800 0 0
LAM RESEARCH CORP COM 512807108 1,361 6,700 SH   SOLE 6,700 0 0
LIBERTY GLOBAL PLC SHS CL A G5480U104 463 14,800 SH   SOLE 14,800 0 0
LIVANOVA PLC SHS G5509L101 2,184 24,682 SH   SOLE 24,682 0 0
MELCO RESORT ENTERTAINMENT L ADR 585464100 72,651 2,506,967 SH   SOLE 2,506,967 0 0
MERCK & CO INC COM 58933Y105 1,024 18,800 SH   SOLE 18,800 0 0
MERUS N V COM N5749R100 1,894 102,219 SH   SOLE 102,219 0 0
MICROCHIP TECHNOLOGY INC COM 595017104 59,493 651,200 SH   SOLE 651,200 0 0
MICRON TECHNOLOGY INC COM 595112103 1,251 24,000 SH   SOLE 24,000 0 0
MICROSOFT CORP COM 594918104 2,117 23,200 SH   SOLE 23,200 0 0
MYOVANT SCIENCES LTD COM G637AM102 1,152 54,200 SH   SOLE 54,200 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 1,508 200,800 SH   SOLE 200,800 0 0
NEWMONT MINING CORP COM 651639106 3,946 101,000 SH   SOLE 101,000 0 0
NIELSEN HLDGS PLC SHS EUR G6518L108 43,688 1,374,272 SH   SOLE 1,025,757 0 348,515
ORACLE CORP COM 68389X105 2,310 50,500 SH   SOLE 50,500 0 0
PAYPAL HLDGS INC COM 70450Y103 137,390 1,810,868 SH   SOLE 1,709,951 0 100,917
PEABODY ENERGY CORP NEW COM 704551100 123,910 3,394,799 SH   SOLE 2,954,799 0 440,000
PERKINELMER INC COM 714046109 2,922 38,600 SH   SOLE 38,600 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 847 124,200 SH   SOLE 124,200 0 0
PROTHENA CORP PLC SHS G72800108 2,870 78,200 SH   SOLE 78,200 0 0
QIAGEN NV SHS NEW N72482123 19,513 603,941 SH   SOLE 603,941 0 0
QIWI PLC SPON ADR REP B 74735M108 43,729 2,288,321 SH   SOLE 1,952,781 0 335,540
QUANTERIX CORP COM 74766Q101 2,982 175,000 SH   SOLE 175,000 0 0
SCHLUMBERGER LTD COM 806857108 117,692 1,816,800 SH   SOLE 1,457,400 0 359,400
SEATTLE GENETICS INC COM 812578102 2,119 40,500 SH   SOLE 40,500 0 0
SINA CORP ORD 82922RAD5 331,684 3,181,016 SH   SOLE 3,054,529 0 126,487
SKYWORKS SOLUTIONS INC COM 83088M102 111,665 1,113,760 SH   SOLE 989,460 0 124,300
SUNCOR ENERGY INC NEW COM 867224107 358 10,360 SH   SOLE 10,360 0 0
TECHNIPFMC PLC COM G87110105 259,910 8,825,500 SH   SOLE 7,672,200 0 1,153,300
TIME WARNER INC COM NEW 887317303 701 7,421 SH   SOLE 7,421 0 0
TRANSOCEAN INC REG SHS H8817H100 47,837 4,832,100 SH   SOLE 4,832,100 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 1,255 175,339 SH   SOLE 175,339 0 0
UNITED TECHNOLOGIES CORP COM 913017109 1,006 8,000 SH   SOLE 8,000 0 0
UNUM THERAPEUTICS INC COM 903214104 2,499 225,000 SH   SOLE 225,000 0 0
VERISIGN INC COM 92343E102 663 5,600 SH   SOLE 5,600 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 1,291 32,200 SH   SOLE 32,200 0 0
WEIBO CORP SPONSORED ADR 948596101 9,312 77,900 SH   SOLE 77,900 0 0
WYNN RESORTS LTD COM 983134107 9,482 52,000 SH   SOLE 52,000 0 0
XILINX INC COM 983919101 809 11,200 SH   SOLE 11,200 0 0
YANDEX NV SHS CLASS A N97284108 4,734 120,000 SH   SOLE 120,000 0 0
ZAI LAB LTD ADR 98887Q104 427 20,000 SH   SOLE 20,000 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 98,817 6,592,241 SH   SOLE 5,632,076 0 960,165