The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COM 00289Y107 4,233 295,000 SH   DFND 1,2 295,000 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 8,018 335,500 SH   DFND 1,2 335,500 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 633 5,336 SH   DFND   5,336 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 7,568 1,009,131 SH   DFND 1,2 1,009,131 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 9,140 82,000 SH   DFND 1,2 82,000 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 4,520 410,199 SH   DFND 1,2 410,199 0 0
ALLERGAN PLC SHS G0177J108 10,097 60,000 SH   DFND 1,2 60,000 0 0
ALPHABET INC CAP STK CL A 02079K305 4,970 4,792 SH   DFND   4,792 0 0
AMICUS THERAPEUTICS INC COM 03152W109 27,759 1,845,704 SH   DFND 1,2 1,845,704 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 1,064 75,535 SH   DFND 1,2 75,535 0 0
ARQULE INC COM 04269E107 5,075 1,762,000 SH   DFND 1,2 1,762,000 0 0
ARQULE INC COM 04269E107 1,446 502,136 SH   DFND 1,2 502,136 0 0
ARRAY BIOPHARMA INC COM 04269X105 6,610 405,000 SH   DFND 1,2 405,000 0 0
ARSANIS INC COM 042873109 2,632 114,972 SH   DFND 1,2 114,972 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 6,244 95,474 SH   DFND 1,2 95,474 0 0
ATHERSYS INC COM 04744L106 1 773 SH   DFND 1,2 773 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 2,855 95,000 SH   DFND 1,2 95,000 0 0
BIOGEN INC COM 09062X103 17,798 65,000 SH   DFND 1,2 65,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 3,377 131,100 SH   DFND 1,2 131,100 0 0
CAESARSTONE LTD ORD SHS M20598104 240 12,195 SH   DFND   12,195 0 0
CELGENE CORP COM 151020104 28,458 319,000 SH   DFND 1,2 319,000 0 0
CELLECTIS S A SPONSORED ADS 15117K103 10,693 339,367 SH   DFND 1,2 339,367 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 1,036 3,329 SH   DFND   3,329 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 11,052 1,030,000 SH   DFND 1,2 1,030,000 0 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 3,030 200,000 SH   DFND 1,2 200,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 8,870 168,000 SH   DFND 1,2 168,000 0 0
COHERUS BIOSCIENCES INC COM 19249H103 2,984 270,000 SH   DFND 1,2 270,000 0 0
COMCAST CORP NEW CL A 20030N101 342 10,000 SH   DFND   10,000 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 3,706 321,430 SH   DFND 1,2 321,430 0 0
CTI BIOPHARMA CORP COM NEW 12648L601 3,251 833,633 SH   DFND 1,2 833,633 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 5,121 180,000 SH   DFND 1,2 180,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 819 40,846 SH   DFND 1,2 40,846 0 0
DELEK US HLDGS INC NEW COM 24665A103 4,977 122,284 SH   DFND   122,284 0 0
DENTSPLY SIRONA INC COM 24906P109 126 2,500 SH   DFND   2,500 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 4,679 475,000 SH   DFND 1,2 475,000 0 0
ENDO INTL PLC SHS G30401106 3,267 550,000 SH   DFND 1,2 550,000 0 0
ERYTECH PHARMA SPONSORED ADR 29604W108 2,520 120,000 SH   DFND 1,2 120,000 0 0
EVOKE PHARMA INC COM 30049G104 819 393,852 SH   DFND 1,2 393,852 0 0
EXPEDIA GROUP INC COM NEW 30212P303 2,087 18,900 SH   DFND   18,900 0 0
FACEBOOK INC CL A 30303M102 974 6,097 SH   DFND   6,097 0 0
FIBROGEN INC COM 31572Q808 1,838 39,779 SH   DFND 1,2 39,779 0 0
FLEX LTD ORD Y2573F102 5,027 307,839 SH   DFND   307,839 0 0
GCI LIBERTY INC COM CLASS A 36164V305 159 3,000 SH   DFND   3,000 0 0
GEMPHIRE THERAPEUTICS INC COM 36870A108 3,132 481,046 SH   DFND 1,2 481,046 0 0
GILAT SATELLITE NETWORKS LTD SHS NEW M51474118 985 111,646 SH   DFND   111,646 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 19,535 500,000 SH   DFND 1,2 500,000 0 0
GLYCOMIMETICS INC COM 38000Q102 2,435 150,000 SH   DFND 1,2 150,000 0 0
HOMOLOGY MEDICINES INC COM 438083107 2,487 133,000 SH   DFND 1,2 133,000 0 0
IMMUNOMEDICS INC COM 452907108 7,013 480,000 SH   DFND 1,2 480,000 0 0
INNOVATE BIOPHARMACEUTICLS I COM PAR 45782F105 12,256 980,502 SH   DFND 1,2 980,502 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 3,374 160,000 SH   DFND 1,2 160,000 0 0
KADMON HLDGS INC COM 48283N106 6,333 1,490,000 SH   DFND 1,2 1,490,000 0 0
KURA ONCOLOGY INC COM 50127T109 6,188 330,000 SH   DFND 1,2 330,000 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 7,743 260,000 SH   DFND 1,2 260,000 0 0
LAM RESEARCH CORP COM 512807108 2,713 13,356 SH   DFND   13,356 0 0
LEAP THERAPEUTICS INC COM 52187K101 3,545 427,086 SH   DFND 1,2 427,086 0 0
LIVEPERSON INC COM 538146101 2 136 SH   DFND   136 0 0
MACROGENICS INC COM 556099109 3,397 135,000 SH   DFND 1,2 135,000 0 0
MASTERCARD INCORPORATED CL A 57636Q104 2,895 16,525 SH   DFND   16,525 0 0
MEDICINOVA INC COM NEW 58468P206 6,447 630,838 SH   DFND 1,2 630,838 0 0
MELINTA THERAPEUTICS INC COM 58549G100 1,805 243,896 SH   DFND 1,2 243,896 0 0
MELLANOX TECHNOLOGIES LTD SHS M51363113 7,305 100,279 SH   DFND   100,279 0 0
MERCK & CO INC COM 58933Y105 31,593 580,000 SH   DFND 1,2 580,000 0 0
MICROSOFT CORP COM 594918104 6,101 66,850 SH   DFND   66,850 0 0
MINERVA NEUROSCIENCES INC COM 603380106 4,844 775,000 SH   DFND 1,2 775,000 0 0
MOHAWK INDS INC COM 608190104 255 1,100 SH   DFND   1,100 0 0
MYLAN N V SHS EURO N59465109 23,632 574,000 SH   DFND 1,2 574,000 0 0
NEOS THERAPEUTICS INC COM 64052L106 2,662 320,692 SH   DFND 1,2 320,692 0 0
NICE LTD SPONSORED ADR 653656108 6,365 67,758 SH   DFND   67,758 0 0
O REILLY AUTOMOTIVE INC NEW COM 67103H107 2,683 10,844 SH   DFND   10,844 0 0
OBSEVA SA COM H5861P103 10,053 745,197 SH   DFND 1,2 745,197 0 0
PERRIGO CO PLC SHS G97822103 1,600 19,221 SH   DFND   19,221 0 0
PFIZER INC COM 717081103 20,939 590,000 SH   DFND 1,2 590,000 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 5,456 800,000 SH   DFND 1,2 800,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 6,532 200,000 SH Call DFND 1,2 0 0 0
POWERSHARES QQQ TRUST UNIT SER 1 73935A104 12,810 80,000 SH Put DFND   80,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 2,025 658,500 SH   DFND 1,2 658,500 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 4,083 60,000 SH   DFND 1,2 60,000 0 0
RADCOM LTD SHS NEW M81865111 1,207 65,760 SH   DFND   65,760 0 0
RADWARE LTD ORD M81873107 389 18,230 SH   DFND   18,230 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 4,615 225,000 SH   DFND 1,2 225,000 0 0
RECRO PHARMA INC COM 75629F109 4,010 364,197 SH   DFND 1,2 364,197 0 0
REGENERON PHARMACEUTICALS COM 75886F107 14,291 41,500 SH   DFND 1,2 41,500 0 0
REGENXBIO INC COM 75901B107 2,985 100,000 SH   DFND 1,2 100,000 0 0
RETROPHIN INC COM 761299106 4,919 220,000 SH   DFND 1,2 220,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 5,668 302,275 SH   DFND 1,2 302,275 0 0
SAREPTA THERAPEUTICS INC COM 803607100 18,448 248,997 SH   DFND 1,2 248,997 0 0
SEALED AIR CORP NEW COM 81211K100 193 4,500 SH   DFND   4,500 0 0
SERVICEMASTER GLOBAL HLDGS I COM 81761R109 483 9,500 SH   DFND   9,500 0 0
SHIRE PLC SPONSORED ADR 82481R106 29,355 196,500 SH   DFND 1,2 196,500 0 0
SIERRA ONCOLOGY INC COM 82640U107 2,070 1,000,000 SH   DFND 1,2 1,000,000 0 0
SITEONE LANDSCAPE SUPPLY INC COM 82982L103 231 3,000 SH   DFND   3,000 0 0
SNAP ON INC COM 833034101 202 1,366 SH   DFND   1,366 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 904 17,190 SH   DFND   17,190 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 65,798 750,000 SH Put DFND 1,2 750,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 4,247 298,472 SH   DFND 1,2 298,472 0 0
TESARO INC COM 881569107 6,067 106,175 SH   DFND 1,2 106,175 0 0
TEVA PHARMACEUTICAL FIN LLC DBCV 0.250% 2/0 88163VAE9 703 2,135 SH   DFND   2,135 0 0
ULTIMATE SOFTWARE GROUP INC COM 90385D107 195 800 SH   DFND   800 0 0
UNIQURE NV SHS N90064101 2,999 127,600 SH   DFND 1,2 127,600 0 0
UNITEDHEALTH GROUP INC COM 91324P102 428 2,000 SH   DFND   2,000 0 0
VBI VACCINES INC COM NEW 91822J103 2,332 666,284 SH   DFND 1,2 666,284 0 0
VIKING THERAPEUTICS INC COM 92686J106 6,959 1,592,416 SH   DFND 1,2 1,592,416 0 0
VISA INC COM CL A 92826C839 4,833 40,401 SH   DFND   40,401 0 0
VISTA OUTDOOR INC COM 928377100 98 6,000 SH   DFND   6,000 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 1,157 1,247,251 SH   DFND 1,2 1,247,251 0 0
VTV THERAPEUTICS INC CL A 918385105 1,146 281,679 SH   DFND 1,2 281,679 0 0
WATSCO INC COM 942622200 380 2,100 SH   DFND   2,100 0 0