The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADURO BIOTECH INC | COM | 00739L101 | 7,501 | 806,534 | SH | DFND | 1 | 0 | 806,534 | 0 | |
| ALBIREO PHARMA INC | COM | 01345P106 | 7,328 | 225,000 | SH | DFND | 1 | 0 | 225,000 | 0 | |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 5,406 | 675,759 | SH | DFND | 1 | 0 | 675,759 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 40,182 | 386,065 | SH | DFND | 1 | 0 | 386,065 | 0 | |
| ARCUS BIOSCIENCES INC | COM | 03969F109 | 19,606 | 1,269,788 | SH | DFND | 1 | 0 | 1,269,788 | 0 | |
| ARQULE INC | COM | 04269E107 | 47,338 | 16,436,912 | SH | DFND | 1 | 0 | 16,436,912 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 82,624 | 5,062,768 | SH | DFND | 1 | 0 | 5,062,768 | 0 | |
| BIOLINERX LTD | SPONSORED ADR | 09071M106 | 22,616 | 25,995,575 | SH | DFND | 1 | 0 | 25,995,575 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 60,120 | 655,611 | SH | DFND | 1 | 0 | 655,611 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 97,938 | 7,201,316 | SH | DFND | 1 | 0 | 7,201,316 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 44,246 | 1,932,123 | SH | DFND | 1 | 0 | 1,932,123 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 5,565 | 3,500,000 | SH | DFND | 1 | 0 | 3,500,000 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 22,533 | 1,954,254 | SH | DFND | 1 | 0 | 1,954,254 | 0 | |
| CTI BIOPHARMA CORP | COM NEW | 12648L601 | 27,026 | 6,929,690 | SH | DFND | 1 | 0 | 6,929,690 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 41,198 | 5,721,888 | SH | DFND | 1 | 0 | 5,721,888 | 0 | |
| ERYTECH PHARMA | SPONSORED ADR | 29604W108 | 13,125 | 625,000 | SH | DFND | 1 | 0 | 625,000 | 0 | |
| ESSA PHARMA INC | COM | 29668H104 | 1,935 | 10,183,646 | SH | DFND | 1 | 0 | 10,183,646 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 10,319 | 4,755,117 | SH | DFND | 1 | 0 | 4,755,117 | 0 | |
| GENOCEA BIOSCIENCES INC | COM | 372427104 | 5,250 | 5,000,000 | SH | DFND | 1 | 0 | 5,000,000 | 0 | |
| GTX INC DEL | COM NEW | 40052B207 | 10,823 | 609,748 | SH | DFND | 1 | 0 | 609,748 | 0 | |
| IMMUNE DESIGN CORP | COM | 45252L103 | 13,550 | 4,106,200 | SH | DFND | 1 | 0 | 4,106,200 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 20,510 | 9,766,508 | SH | DFND | 1 | 0 | 9,766,508 | 0 | |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 85,519 | 5,542,400 | SH | DFND | 1 | 0 | 5,542,400 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 25,385 | 1,353,846 | SH | DFND | 1 | 0 | 1,353,846 | 0 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 506 | 4,386 | SH | DFND | 1 | 0 | 4,386 | 0 | |
| MERUS N V | COM | N5749R100 | 44,832 | 2,419,443 | SH | DFND | 1 | 0 | 2,419,443 | 0 | |
| MOLECULAR TEMPLATES INC | COM | 608550109 | 5,509 | 688,629 | SH | DFND | 1 | 0 | 688,629 | 0 | |
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 13,525 | 4,253,189 | SH | DFND | 1 | 0 | 4,253,189 | 0 | |
| OREXIGEN THERAPEUTICS INC | COM NEW | 686164302 | 108 | 534,900 | SH | DFND | 1 | 0 | 534,900 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 24,501 | 3,592,549 | SH | DFND | 1 | 0 | 3,592,549 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 3,484 | 405,600 | SH | DFND | 1 | 0 | 405,600 | 0 | |
| REGULUS THERAPEUTICS INC | COM | 75915K101 | 10,027 | 13,974,249 | SH | DFND | 1 | 0 | 13,974,249 | 0 | |
| SPERO THERAPEUTICS INC | COM | 84833T103 | 14,948 | 1,048,958 | SH | DFND | 1 | 0 | 1,048,958 | 0 | |
| SPRING BK PHARMACEUTICALS INC | COM | 849431101 | 12,800 | 832,247 | SH | DFND | 1 | 0 | 832,247 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 4,582 | 1,684,636 | SH | DFND | 1 | 0 | 1,684,636 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 46,014 | 3,233,618 | SH | DFND | 1 | 0 | 3,233,618 | 0 | |
| TOCAGEN INC | COM | 888846102 | 5,978 | 504,483 | SH | DFND | 1 | 0 | 504,483 | 0 | |
| VBI VACCINES INC | COM NEW | 91822J103 | 10,850 | 3,100,000 | SH | DFND | 1 | 0 | 3,100,000 | 0 | |
| VERASTEM INC | COM | 92337C104 | 8,156 | 2,737,000 | SH | DFND | 1 | 0 | 2,737,000 | 0 | |
| VICAL INC | COM NEW | 925602203 | 2,044 | 1,409,444 | SH | DFND | 1 | 0 | 1,409,444 | 0 | |
| XENCOR INC | COM | 98401F105 | 27,042 | 902,000 | SH | DFND | 1 | 0 | 902,000 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 3,532 | 720,830 | SH | DFND | 1 | 0 | 720,830 | 0 | |
| XOMA CORP DEL | COM NEW | 98419J206 | 30,402 | 1,502,800 | SH | DFND | 1 | 0 | 1,502,800 | 0 | |