The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abbott Laboratories COM 002824100 12,104 202,000 SH   SOLE   0 0 202,000
AbbVie Inc COM 00287Y109 19,564 206,700 SH   SOLE   0 0 206,700
Abiomed Inc COM 003654100 22,258 76,490 SH   SOLE   0 0 76,490
Acadia Pharmaceuticals Inc COM 004225108 6,067 270,000 SH   SOLE   0 0 270,000
Achillion Pharmaceuticals Inc COM 00448Q201 2,478 667,800 SH   SOLE   0 0 667,800
Adamas Pharmaceuticals Inc COM 00548A106 5,010 209,644 SH   SOLE   0 0 209,644
Adverum Biotechnologies Inc COM 00773U108 737 127,006 SH   SOLE   0 0 127,006
Aerie Pharmaceuticals Inc COM 00771V108 2,170 40,000 SH   SOLE   0 0 40,000
Agios Pharmaceuticals Inc COM 00847X104 7,769 95,000 SH   SOLE   0 0 95,000
Alexion Pharmaceuticals Inc COM 015351109 24,729 221,863 SH   SOLE   0 0 221,863
Alkermes Plc SHS G01767105 5,263 90,800 SH   SOLE   0 0 90,800
Allergan Plc SHS G0177J108 10,097 60,000 SH   SOLE   0 0 60,000
Alnylam Pharmaceuticals Inc COM 02043Q107 10,000 83,967 SH   SOLE   0 0 83,967
AmerisourceBergen Corp COM 03073E105 8,988 104,261 SH   SOLE   0 0 104,261
Anheuser-Busch InBev SA ADR spons repr 1 Share SPONSORED ADR 03524A108 463 4,209 SH   SOLE   0 0 4,209
Anthem Inc COM 036752103 13,402 61,000 SH   SOLE   0 0 61,000
Arena Pharmaceuticals Inc Reg COM NEW 040047607 11,283 285,642 SH   SOLE   0 0 285,642
Array BioPharma Inc COM 04269X105 11,448 701,470 SH   SOLE   0 0 701,470
Becton Dickinson & Co COM 075887109 16,253 75,000 SH   SOLE   0 0 75,000
Biogen Inc COM 09062X103 11,583 42,300 SH   SOLE   0 0 42,300
BioMarin Pharmaceutical Inc COM 09061G101 16,607 204,849 SH   SOLE   0 0 204,849
Boston Scientific Corp COM 101137107 9,506 347,968 SH   SOLE   0 0 347,968
Bristol Myers Squibb Co COM 110122108 22,138 350,000 SH   SOLE   0 0 350,000
Celgene Corp COM 151020104 26,443 296,412 SH   SOLE   0 0 296,412
Centene Corp COM 15135B101 6,947 65,000 SH   SOLE   0 0 65,000
Chevron Corp COM 166764100 473 4,148 SH   SOLE   0 0 4,148
Chimerix Inc COM 16934W106 1,778 342,000 SH   SOLE   0 0 342,000
Cigna Corp COM 125509109 18,518 110,400 SH   SOLE   0 0 110,400
Coherus BioSciences Inc COM 19249H103 3,868 350,000 SH   SOLE   0 0 350,000
CVS Health Corp COM 126650100 15,793 253,868 SH   SOLE   0 0 253,868
Dermira Inc Reg COM 24983L104 759 95,000 SH   SOLE   0 0 95,000
Edwards Lifesciences Corp COM 28176E108 11,631 83,364 SH   SOLE   0 0 83,364
Eli Lilly & Co COM 532457108 17,243 222,859 SH   SOLE   0 0 222,859
Endologix Inc COM 29266S106 3,832 906,002 SH   SOLE   0 0 906,002
Epizyme Inc COM 29428V104 3,218 181,291 SH   SOLE   0 0 181,291
Esperion Therapeutics Inc COM 29664W105 17,688 244,540 SH   SOLE   0 0 244,540
Exelixis Inc COM 30161Q104 21,845 986,214 SH   SOLE   0 0 986,214
Express Scripts Hg Co COM 30219G108 14,852 215,000 SH   SOLE   0 0 215,000
Exxon Mobil Corp COM 30231G102 636 8,526 SH   SOLE   0 0 8,526
FibroGen Inc COM 31572Q808 7,833 169,547 SH   SOLE   0 0 169,547
Flexion Therapeutics Inc COM 33938J106 5,304 236,686 SH   SOLE   0 0 236,686
Ford Motor Co COM 345370860 472 42,606 SH   SOLE   0 0 42,606
Gilead Sciences Inc COM 375558103 17,869 237,027 SH   SOLE   0 0 237,027
Glaukos Corp COM 377322102 15,520 503,400 SH   SOLE   0 0 503,400
Halliburton Co (Hg Co) COM 406216101 688 14,659 SH   SOLE   0 0 14,659
Horizon Pharma Plc SHS G4617B105 28,502 2,007,212 SH   SOLE   0 0 2,007,212
Humana Inc COM 444859102 18,280 68,000 SH   SOLE   0 0 68,000
IBM Corp COM 459200101 579 3,773 SH   SOLE   0 0 3,773
Immunomedics Inc COM 452907108 6,068 415,330 SH   SOLE   0 0 415,330
Incyte Corp Ltd COM 45337C102 13,246 158,963 SH   SOLE   0 0 158,963
Intra-Cellular Therapies Inc COM 46116X101 16,687 792,730 SH   SOLE   0 0 792,730
Iovance Biotherapeutics Inc Reg COM 462260100 15,957 944,185 SH   SOLE   0 0 944,185
Janus Henderson Group Plc Reg ORD SHS G4474Y904 591 17,859 SH   SOLE   0 0 17,859
Jazz Pharmaceuticals Plc SHS USD G50871105 22,412 148,436 SH   SOLE   0 0 148,436
JPMorgan Chase & Co COM 46625H100 593 5,391 SH   SOLE   0 0 5,391
Keryx Biopharmaceuticals Inc COM 492515101 1,236 302,157 SH   SOLE   0 0 302,157
Livanova Plc SHS G5509L901 4,425 50,000 SH   SOLE   0 0 50,000
Loxo Oncology Inc COM 548862101 8,653 75,000 SH   SOLE   0 0 75,000
Macrogenics Inc COM 556099109 7,548 300,000 SH   SOLE   0 0 300,000
Medicines Co COM 584688105 3,294 100,000 SH   SOLE   0 0 100,000
Medtronic Plc Reg SHS G5960L103 16,949 211,283 SH   SOLE   0 0 211,283
Microsoft Corp COM 594918104 499 5,465 SH   SOLE   0 0 5,465
MyoKardia Inc Reg COM 62857M105 8,212 168,272 SH   SOLE   0 0 168,272
Nektar Therapeutics COM 640268108 22,044 207,458 SH   SOLE   0 0 207,458
Neurocrine Biosciences Inc COM 64125C109 9,122 110,000 SH   SOLE   0 0 110,000
NewLink Genetics Corp COM 651511107 1,313 181,047 SH   SOLE   0 0 181,047
NovoCure Ltd Reg ORD SHS G6674U108 9,483 435,000 SH   SOLE   0 0 435,000
Omnicell Inc COM 68213N109 2,537 58,445 SH   SOLE   0 0 58,445
Pfizer Inc COM 717081103 311 8,754 SH   SOLE   0 0 8,754
Pieris Pharmaceuticals Inc Reg COM 720795103 2,046 300,000 SH   SOLE   0 0 300,000
Portola Pharmaceuticals Inc COM 737010108 8,826 270,248 SH   SOLE   0 0 270,248
Qualcomm Inc COM 747525103 446 8,052 SH   SOLE   0 0 8,052
Ra Pharmaceuticals Inc Reg COM 74933V108 208 39,115 SH   SOLE   0 0 39,115
Regeneron Pharmaceuticals Inc COM 75886F107 11,708 34,000 SH   SOLE   0 0 34,000
Regulus Therapeutic Inc COM 75915K101 354 492,878 SH   SOLE   0 0 492,878
Revance Therapeutics Inc COM 761330109 6,258 203,181 SH   SOLE   0 0 203,181
Rigel Pharmaceuticals Inc COM NEW 766559603 5,727 1,617,769 SH   SOLE   0 0 1,617,769
Sage Therapeutics Inc COM 78667J108 15,302 95,000 SH   SOLE   0 0 95,000
Sangamo Therapeutics Inc Reg COM 800677106 4,860 255,793 SH   SOLE   0 0 255,793
Seattle Genetics Inc Reg COM 812578102 6,804 130,000 SH   SOLE   0 0 130,000
Spark Therapeutics Inc COM 84652J103 4,501 67,600 SH   SOLE   0 0 67,600
Staar Surgical Co COM PAR $0.01 852312305 365 24,658 SH   SOLE   0 0 24,658
Sunesis Pharmaceuticals Inc Reg COM PAR 867328700 1,224 450,100 SH   SOLE   0 0 450,100
Symantec Corp COM 871503108 363 14,039 SH   SOLE   0 0 14,039
United Health Group Inc COM 91324P102 17,334 81,000 SH   SOLE   0 0 81,000
Walgreens Boots Alliance Inc COM 931427108 4,910 75,000 SH   SOLE   0 0 75,000
Walt Disney Co (The) COM DISNEY 254687106 463 4,613 SH   SOLE   0 0 4,613
Wells Fargo & Co COM 949746101 307 5,858 SH   SOLE   0 0 5,858
Vertex Pharmaceuticals Inc COM 92532F100 24,447 150,000 SH   SOLE   0 0 150,000
ViewRay Inc Reg COM 92672L107 2,137 332,385 SH   SOLE   0 0 332,385
Xencor Inc COM 98401F105 8,994 300,000 SH   SOLE   0 0 300,000
Zogenix Inc Reg COM NEW 98978L204 2,003 50,000 SH   SOLE   0 0 50,000