The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 98,876 1,732,542 SH   DFND   0 1,732,542 0
ACCURAY INC COM 004397105 18,819 4,376,578 SH   DFND   0 4,376,578 0
ACORDA THERAPEUTICS INC COM 00484M106 74,036 3,451,553 SH   DFND   0 3,451,553 0
ACORDA THERAPEUTICS INC NOTE 1.750% 6/1 00484MAA4 20,885 24,516,000 PRN   DFND   0 24,516,000 0
ACTIVISION BLIZZARD INC COM 00507V109 44,080 696,151 SH   DFND   0 696,151 0
AERIE PHARMACEUTICALS INC COM 00771V108 155,781 2,607,211 SH   DFND   0 2,607,211 0
AKORN INC COM 009728106 3,352 104,000 SH Put DFND   0 104,000 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 62,147 360,420 SH   DFND   0 360,420 0
ALLENA PHARMACEUTICALS INC COM 018119107 6,807 676,672 SH   DFND   0 676,672 0
ALLENA PHARMACEUTICALS INC COM 018119107 6,448 787,532 SH   DFND   0 787,532 0
ALPHABET INC CAP STK CL A 02079K305 45,000 42,719 SH   DFND   0 42,719 0
AMAZON COM INC COM 023135106 36,214 30,966 SH   DFND   0 30,966 0
AMERICAN TOWER CORP NEW COM 03027X100 17,617 123,478 SH   DFND   0 123,478 0
ANAPTYSBIO INC COM 032724106 42,896 425,896 SH   DFND   0 425,896 0
ANTHEM INC COM 036752103 60,259 267,805 SH   DFND   0 267,805 0
BAIDU INC SPON ADR REP A 056752108 90,650 387,046 SH   DFND   0 387,046 0
BAXTER INTL INC COM 071813109 82,352 1,274,017 SH   DFND   0 1,274,017 0
BLUEBIRD BIO INC COM 09609G100 24,897 139,791 SH   DFND   0 139,791 0
BLUEPRINT MEDICINES CORP COM 09627Y109 65,361 866,740 SH   DFND   0 866,740 0
BOX INC CL A 10316T104 60,136 2,847,325 SH   DFND   0 2,847,325 0
CARDIOVASCULAR SYS INC DEL COM 141619106 13,021 549,657 SH   DFND   0 549,657 0
CIGNA CORPORATION COM 125509109 60,325 297,035 SH   DFND   0 297,035 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 5,917 311,755 SH   DFND   0 311,755 0
CME GROUP INC COM CL A 12572Q105 57,267 392,106 SH   DFND   0 392,106 0
COUPA SOFTWARE INC COM 22266L106 10,700 342,725 SH   DFND   0 342,725 0
CUTERA INC COM 232109108 18,812 414,815 SH   DFND   0 414,815 0
DAVITA INC COM 23918K108 87,443 1,210,282 SH   DFND   0 1,210,282 0
DISH NETWORK CORP NOTE 3.375% 8/1 25470MAB5 91,403 83,808,000 PRN   DFND   0 83,808,000 0
DXC TECHNOLOGY CO COM 23355L106 44,324 467,064 SH   DFND   0 467,064 0
EDWARDS LIFESCIENCES CORP COM 28176E108 100,682 893,283 SH   DFND   0 893,283 0
ENDOCYTE INC COM 29269A102 14,730 3,441,594 SH   DFND   0 3,441,594 0
ENDOLOGIX INC COM 29266S106 40,178 7,509,909 SH   DFND   0 7,509,909 0
ENDOLOGIX INC NOTE 3.250%11/0 29266SAB2 39,584 43,409,000 PRN   DFND   0 43,409,000 0
ESPERION THERAPEUTICS INC NE COM 29664W105 57,288 870,102 SH   DFND   0 870,102 0
FACEBOOK INC CL A 30303M102 648 3,670 SH   DFND   0 3,670 0
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 25,127 30,114,500 PRN   DFND   0 30,114,500 0
GODADDY INC CL A 380237107 97,721 1,943,528 SH   DFND   0 1,943,528 0
HCA HEALTHCARE INC COM 40412C101 64,299 732,007 SH   DFND   0 732,007 0
HILL ROM HLDGS INC COM 431475102 40,238 477,370 SH   DFND   0 477,370 0
HOLOGIC INC COM 436440101 73,974 1,730,384 SH   DFND   0 1,730,384 0
HUMANA INC COM 444859102 20,391 82,200 SH Call DFND   0 82,200 0
HUMANA INC COM 444859102 73,052 294,480 SH   DFND   0 294,480 0
ICON PLC SHS G4705A100 37,119 330,979 SH   DFND   0 330,979 0
INC RESH HLDGS INC CL A 45329R109 13,658 313,257 SH   DFND   0 313,257 0
INOGEN INC COM 45780L104 10,935 91,829 SH   DFND   0 91,829 0
INVUITY INC COM NEW 46187J205 6,776 1,092,979 SH   DFND   0 1,092,979 0
JOUNCE THERAPEUTICS INC COM 481116101 26,612 2,087,224 SH   DFND   0 2,087,224 0
JUNO THERAPEUTICS INC COM 48205A109 84,601 1,850,820 SH   DFND   0 1,850,820 0
KURA ONCOLOGY INC COM 50127T109 26,807 1,752,124 SH   DFND   0 1,752,124 0
LANNET INC COM 516012101 12,083 520,800 SH Put DFND   0 520,800 0
LENDINGTREE INC NEW COM 52603B107 22,245 65,340 SH   DFND   0 65,340 0
MALLINCKRODT PUB LTD CO COM G5785G107 36,956 1,638,100 SH Put DFND   0 1,638,100 0
MEDICINES CO COM 584688105 50,444 1,845,052 SH   DFND   0 1,845,052 0
MEDICINES CO NOTE 2.750% 7/1 584688AG0 31,692 34,471,000 PRN   DFND   0 34,471,000 0
MERIT MED SYS INC COM 589889104 51,800 1,199,081 SH   DFND   0 1,199,081 0
MICROSOFT CORP COM 594918104 27,111 316,941 SH   DFND   0 316,941 0
MOLINA HEALTHCARE INC COM 60855R100 90,082 1,174,777 SH   DFND   0 1,174,777 0
MYOKARDIA INC COM 62857M105 54,450 1,293,360 SH   DFND   0 1,293,360 0
NETFLIX INC COM 64110L106 28,249 147,162 SH   DFND   0 147,162 0
NIGHTSTAR THERAPEUTICS PLC ADR 65413A101 12,850 979,393 SH   DFND   0 979,393 0
NVIDIA CORP COM 67066G104 27,967 144,533 SH   DFND   0 144,533 0
OPTINOSE INC COM 68404V100 6,103 322,927 SH   DFND   0 322,927 0
PAYPAL HLDGS INC COM 70450Y103 50,917 691,622 SH   DFND   0 691,622 0
PENUMBRA INC COM 70975L107 77,681 825,512 SH   DFND   0 825,512 0
PERKINELMER INC COM 714046109 65,673 898,160 SH   DFND   0 898,160 0
PORTOLA PHARMACEUTICALS INC COM 737010108 289,211 5,941,055 SH   DFND   0 5,941,055 0
POWERSHARES QQQ TRUST UNIT SERIES 1 73935A104 109,203 701,100 SH Put DFND   0 701,100 0
PUMA BIOTECHNOLOGY INC COM 74587V107 180,085 1,821,800 SH   DFND   0 1,821,800 0
REGENERON PHARMACEUTICALS COM 75886F107 73,730 196,112 SH   DFND   0 196,112 0
REGENXBIO INC COM 75901B107 25,596 769,795 SH   DFND   0 769,795 0
SALESFORCE COM INC COM 79466L302 84,041 822,080 SH   DFND   0 822,080 0
SERVICENOW INC COM 81762P102 68,760 527,341 SH   DFND   0 527,341 0
SIENNA BIOPHARMACEUTICALS IN COM 82622H108 27,962 1,628,142 SH   DFND   0 1,628,142 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 95,665 1,127,200 SH Put DFND   0 1,127,200 0
SQUARE INC CL A 852234103 25,596 738,276 SH   DFND   0 738,276 0
TESLA INC COM 88160R101 25,749 82,700 SH   DFND   0 82,700 0
UNITEDHEALTH GROUP INC COM 91324P102 82,101 372,408 SH   DFND   0 372,408 0
UNIVERSAL HLTH SVCS INC CL B 913903100 46,890 413,671 SH   DFND   0 413,671 0
ZAYO GROUP HLDGS INC COM 98919V105 48,535 1,318,879 SH   DFND   0 1,318,879 0
ZENDESK INC COM 98936J101 45,236 1,336,763 SH   DFND   0 1,336,763 0
ZIMMER BIOMET HLDGS INC COM 98956P102 81,429 674,808 SH   DFND   0 674,808 0