The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABEONA THERAPEUTICS INC | COM | 00289Y107 | 9,114 | 575,000 | SH | DFND | 1 | 575,000 | 0 | 0 | |
| ACCELERON PHARMA INC | COM | 00434H108 | 3,183 | 75,000 | SH | DFND | 1 | 75,000 | 0 | 0 | |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 13,563 | 550,000 | SH | DFND | 1 | 550,000 | 0 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 126,050 | 1,251,485 | SH | DFND | 1 | 1,251,485 | 0 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 13,597 | 135,000 | SH | Call | DFND | 1 | 135,000 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 81,782 | 3,768,757 | SH | DFND | 1 | 3,768,757 | 0 | 0 | |
| ARDELYX INC | COM | 039697107 | 3,780 | 572,738 | SH | DFND | 1 | 572,738 | 0 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 18,311 | 290,000 | SH | DFND | 1 | 290,000 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 8,960 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 12,018 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| AUDENTES THERAPEUTICS INC | COM | 05070R104 | 10,559 | 337,876 | SH | DFND | 1 | 337,876 | 0 | 0 | |
| AVEXIS INC | COM | 05366U100 | 22,134 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 8,035 | 297,803 | SH | DFND | 1 | 297,803 | 0 | 0 | |
| BLUEBIRD BIO INC | COM | 09609G100 | 14,248 | 80,000 | SH | DFND | 1 | 80,000 | 0 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 33,935 | 450,000 | SH | DFND | 1 | 450,000 | 0 | 0 | |
| CELLECTAR BIOSCIENCES INC | *W EXP 08/20/201 | 15117F120 | 5 | 52,999 | SH | DFND | 1 | 52,999 | 0 | 0 | |
| CLEARSIDE BIOMEDICAL INC | COM | 185063104 | 13,586 | 1,940,880 | SH | DFND | 1 | 1,940,880 | 0 | 0 | |
| COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 | 5,538 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 3,586 | 3,550,000 | SH | DFND | 1 | 3,550,000 | 0 | 0 | |
| DICERNA PHARMACEUTICALS INC | COM | 253031108 | 33,020 | 3,656,669 | SH | DFND | 1 | 3,656,669 | 0 | 0 | |
| G1 THERAPEUTICS INC | COM | 3621LQ109 | 17,806 | 897,505 | SH | DFND | 1 | 897,505 | 0 | 0 | |
| GEMPHIRE THERAPEUTICS INC | COM | 36870A108 | 6,360 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 3,620 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| INFLARX NV | COM | N44821101 | 30,130 | 1,438,207 | SH | DFND | 1 | 1,438,207 | 0 | 0 | |
| INTEC PHARMA LTD JERUSALEM | SHS | M53644106 | 4,170 | 809,804 | SH | DFND | 1 | 809,804 | 0 | 0 | |
| JOUNCE THERAPEUTICS INC | COM | 481116101 | 4,682 | 367,223 | SH | DFND | 1 | 367,223 | 0 | 0 | |
| JUNO THERAPEUTICS INC | COM | 48205A109 | 25,141 | 550,000 | SH | DFND | 1 | 550,000 | 0 | 0 | |
| MARINUS PHARMACEUTICALS INC | COM | 56854Q101 | 4,080 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| MERSANA THERAPEUTICS INC | COM | 59045L106 | 4,856 | 295,548 | SH | DFND | 1 | 295,548 | 0 | 0 | |
| MINERVA NEUROSCIENCES INC | COM | 603380106 | 3,678 | 607,903 | SH | DFND | 1 | 607,903 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 22,475 | 1,231,522 | SH | DFND | 1 | 1,231,522 | 0 | 0 | |
| MYOKARDIA INC | COM | 62857M105 | 33,680 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| NEKTAR THERAPEUTICS | COM | 640268108 | 119,303 | 1,997,700 | SH | DFND | 1 | 1,997,700 | 0 | 0 | |
| NEKTAR THERAPEUTICS | COM | 640268108 | 44,790 | 750,000 | SH | Call | DFND | 1 | 250,000 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 15,518 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| OMEROS CORP | COM | 682143102 | 17,001 | 875,000 | SH | DFND | 1 | 875,000 | 0 | 0 | |
| OMEROS CORP | COM | 682143102 | 34,004 | 1,750,000 | SH | Call | DFND | 1 | 750,000 | 0 | 0 |
| ONCOBIOLOGICS INC | COM | 68235M105 | 40 | 30,536 | SH | DFND | 1 | 30,536 | 0 | 0 | |
| ONCOBIOLOGICS INC | *W EXP 02/18/201 | 68235M113 | 13 | 416,666 | SH | DFND | 1 | 416,666 | 0 | 0 | |
| ONCOBIOLOGICS INC | *W EXP 05/18/201 | 68235M121 | 9 | 416,666 | SH | DFND | 1 | 416,666 | 0 | 0 | |
| OVID THERAPEUTICS INC | COM | 690469101 | 2,211 | 223,972 | SH | DFND | 1 | 223,972 | 0 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 8,320 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| PROTEOSTASIS THERAPEUTICS IN | COM | 74373B109 | 19,239 | 3,300,000 | SH | DFND | 1 | 3,300,000 | 0 | 0 | |
| QUANTERIX CORP | COM | 74766Q101 | 18,202 | 847,789 | SH | DFND | 1 | 847,789 | 0 | 0 | |
| QUOTIENT LTD | SHS | G73268107 | 22,216 | 4,488,121 | SH | DFND | 1 | 4,488,121 | 0 | 0 | |
| REATA PHARMACEUTICALS INC | CL A | 75615P103 | 5,664 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| SANGAMO THERAPEUTICS INC | COM | 800677106 | 6,560 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| SYROS PHARMACEUTICALS INC | COM | 87184Q107 | 2,883 | 296,296 | SH | DFND | 1 | 296,296 | 0 | 0 | |
| THERAVANCE BIOPHARMA INC | COM | G8807B106 | 25,101 | 900,000 | SH | DFND | 1 | 900,000 | 0 | 0 | |
| TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 4,380 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 7,093 | 202,079 | SH | DFND | 1 | 202,079 | 0 | 0 | |
| ZAI LAB LTD | ADR | 98887Q104 | 7,073 | 333,166 | SH | DFND | 1 | 333,166 | 0 | 0 | |