The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q201 | 4,632 | 1,608,433 | SH | DFND | 1 | 0 | 1,608,433 | 0 | |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 7,569 | 675,759 | SH | DFND | 1 | 0 | 675,759 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 59,868 | 594,397 | SH | DFND | 1 | 0 | 594,397 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U300 | 2,007 | 1,216,403 | SH | DFND | 1 | 0 | 1,216,403 | 0 | |
| ARQULE INC | COM | 04269E107 | 27,121 | 16,436,912 | SH | DFND | 1 | 0 | 16,436,912 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 111,187 | 8,686,498 | SH | DFND | 1 | 0 | 8,686,498 | 0 | |
| BIOLINERX LTD | SPONSORED ADR | 09071M106 | 28,335 | 25,995,575 | SH | DFND | 1 | 0 | 25,995,575 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 57,866 | 767,354 | SH | DFND | 1 | 0 | 767,354 | 0 | |
| CASCADIAN THERAPEUTICS INC | COM NEW | 14740B606 | 11,593 | 3,133,224 | SH | DFND | 1 | 0 | 3,133,224 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 45,145 | 7,587,416 | SH | DFND | 1 | 0 | 7,587,416 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 50,958 | 1,969,789 | SH | DFND | 1 | 0 | 1,969,789 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 3,535 | 3,500,000 | SH | DFND | 1 | 0 | 3,500,000 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 4,759 | 459,396 | SH | DFND | 1 | 0 | 459,396 | 0 | |
| CTI BIOPHARMA CORP | COM NEW | 12648L601 | 23,038 | 8,596,357 | SH | DFND | 1 | 0 | 8,596,357 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 46,633 | 5,721,888 | SH | DFND | 1 | 0 | 5,721,888 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 23,738 | 1,124,483 | SH | DFND | 1 | 0 | 1,124,483 | 0 | |
| ERYTECH PHARMA | SPONSORED ADR | 29604W108 | 13,763 | 625,000 | SH | DFND | 1 | 0 | 625,000 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 12,646 | 3,455,117 | SH | DFND | 1 | 0 | 3,455,117 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 8,353 | 497,474 | SH | DFND | 1 | 0 | 497,474 | 0 | |
| GTX INC DEL | COM NEW | 40052B207 | 14,075 | 1,107,433 | SH | DFND | 1 | 0 | 1,107,433 | 0 | |
| IMMUNE DESIGN CORP | COM | 45252L103 | 5,732 | 1,469,800 | SH | DFND | 1 | 0 | 1,469,800 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 19,826 | 9,766,508 | SH | DFND | 1 | 0 | 9,766,508 | 0 | |
| INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 3,958 | 273,350 | SH | DFND | 1 | 0 | 273,350 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 20,714 | 1,353,846 | SH | DFND | 1 | 0 | 1,353,846 | 0 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 369 | 4,386 | SH | DFND | 1 | 0 | 4,386 | 0 | |
| MOLECULAR TEMPLATES INC | COM | 608550109 | 7,256 | 724,132 | SH | DFND | 1 | 0 | 724,132 | 0 | |
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 17,512 | 4,271,289 | SH | DFND | 1 | 0 | 4,271,289 | 0 | |
| OREXIGEN THERAPEUTICS INC | COM NEW | 686164302 | 948 | 734,976 | SH | DFND | 1 | 0 | 734,976 | 0 | |
| OREXIGEN THERAPEUTICS INC | NOTE 2.750%12/0 | 686164AB0 | 3,550 | 10,000,000 | PRN | DFND | 1 | 0 | 10,000,000 | 0 | |
| PAIN THERAPEUTICS INC | COM NEW | 69562K506 | 1,302 | 325,509 | SH | DFND | 1 | 0 | 325,509 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 19,808 | 2,623,562 | SH | DFND | 1 | 0 | 2,623,562 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 6,118 | 294,117 | SH | DFND | 1 | 0 | 294,117 | 0 | |
| REGULUS THERAPEUTICS INC | COM | 75915K101 | 14,533 | 13,974,249 | SH | DFND | 1 | 0 | 13,974,249 | 0 | |
| SPERO THERAPEUTICS INC | COM | 84833T103 | 12,093 | 1,029,185 | SH | DFND | 1 | 0 | 1,029,185 | 0 | |
| SPRING BK PHARMACEUTICALS INC | COM | 849431101 | 11,076 | 823,474 | SH | DFND | 1 | 0 | 823,474 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 7,539 | 2,043,196 | SH | DFND | 1 | 0 | 2,043,196 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 28,326 | 3,233,618 | SH | DFND | 1 | 0 | 3,233,618 | 0 | |
| TOCAGEN INC | COM | 888846102 | 5,706 | 556,683 | SH | DFND | 1 | 0 | 556,683 | 0 | |
| VBI VACCINES INC | COM NEW | 91822J103 | 13,237 | 3,100,000 | SH | DFND | 1 | 0 | 3,100,000 | 0 | |
| VERASTEM INC | COM | 92337C104 | 6,908 | 2,250,000 | SH | DFND | 1 | 0 | 2,250,000 | 0 | |
| VICAL INC | COM NEW | 925602203 | 2,579 | 1,409,444 | SH | DFND | 1 | 0 | 1,409,444 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 10,138 | 3,588,830 | SH | DFND | 1 | 0 | 3,588,830 | 0 | |
| XOMA CORP DEL | COM NEW | 98419J206 | 53,500 | 1,502,800 | SH | DFND | 1 | 0 | 1,502,800 | 0 | |