The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
21VIANET GROUP INC SPONSORED ADR 90138A103 86,008 10,778,004 SH   DFND 5,18 10,778,004 0 0
AC IMMUNE SA SHS H00263105 17,120 1,337,500 SH   DFND 8,17,20 1,337,500 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 180,022 1,505,325 SH   DFND 1,2,8,11,14,16 1,505,325 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 6,120,453 35,495,289 SH   DFND 1,4,14,15,16 35,495,289 0 0
AMAZON COM INC COM 023135106 154,060 131,735 SH   DFND 1,14,16 131,735 0 0
AMGEN INC COM 031162100 32,785 188,527 SH   DFND 1,14,16 188,527 0 0
AMYRIS INC COM NEW 03236M200 12,385 3,302,585 SH   DFND 2,8,11 3,302,585 0 0
AMYRIS INC NOTE 6.500% 5/1 03236MAC5 5,686 10,000,000 PRN   DFND 2,8,11 10,000,000 0 0
ANTERO RES CORP COM 03674X106 185,357 9,755,618 SH   DFND 6,16 9,755,618 0 0
BANK AMER CORP COM 060505104 15,707 532,082 SH   DFND 1,14,16 532,082 0 0
BEIGENE LTD SPONSORED ADR 07725L102 125,082 1,280,000 SH   DFND 8,17,20 1,280,000 0 0
BIOGEN INC COM 09062X103 37,796 118,644 SH   DFND 1,14,16 118,644 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 309,662 3,472,712 SH   DFND 2,8,11,17,20 3,472,712 0 0
BOEING CO COM 097023105 155,015 525,636 SH   DFND 6,16 525,636 0 0
BROADCOM LTD SHS Y09827109 96,607 376,050 SH   DFND 1,14,16 376,050 0 0
CELGENE CORP COM 151020104 26,654 255,406 SH   DFND 1,14,16 255,406 0 0
CENTURYLINK INC COM 156700106 1,549,643 92,904,239 SH   DFND   92,904,239 0 0
CHINA BIOLOGIC PRODS HLDGS I COM G21515104 77,982 990,000 SH   DFND 8,17,20 990,000 0 0
COGNEX CORP COM 192422103 8,513 139,192 SH   DFND 1,14,16 139,192 0 0
COHERUS BIOSCIENCES INC COM 19249H103 57,694 6,556,116 SH   DFND 8,17,20 6,556,116 0 0
CTRIP COM INTL LTD AMERICAN DEP SHS 22943F100 329,203 7,464,928 SH   DFND 1,4,6,14,16 7,464,928 0 0
DENALI THERAPEUTICS INC COM 24823R105 68,980 4,410,457 SH   DFND 8,17,20 4,410,457 0 0
DOWDUPONT INC COM 26078J100 400,263 5,620,090 SH   DFND 6,16 5,620,090 0 0
EMERSON ELEC CO COM 291011104 8,635 123,908 SH   DFND 1,14,16 123,908 0 0
EROS INTL PLC SHS NEW G3788M114 26,589 2,755,310 SH   DFND 4,13,14,16 2,755,310 0 0
EVOQUA WATER TECHNOLOGIES CO COM 30057T105 191,750 8,087,290 SH   DFND 7,9 8,087,290 0 0
GILEAD SCIENCES INC COM 375558103 797,053 11,125,816 SH   DFND 1,8,14,16,17,20 11,125,816 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 3,454 13,558 SH   DFND 1,14,16 13,558 0 0
GRACE W R & CO DEL NEW COM 38388F108 153,409 2,187,501 SH   DFND 6,16 2,187,501 0 0
ICICI BK LTD ADR 45104G104 27,331 2,808,987 SH   DFND 2,8 2,808,987 0 0
IHS MARKIT LTD SHS G47567105 782,747 17,336,588 SH   DFND 5,18 17,336,588 0 0
ILLUMINA INC COM 452327109 60,579 277,261 SH   DFND 1,14,16 277,261 0 0
INCYTE CORP COM 45337C102 23,882 252,160 SH   DFND 1,14,16 252,160 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 15,194 790,527 SH   DFND 6,8,16,17 790,527 0 0
JD COM INC SPON ADR CL A 47215P106 302,638 7,306,572 SH   DFND 6,16 7,306,572 0 0
JPMORGAN CHASE & CO COM 46625H100 18,846 176,225 SH   DFND 1,14,16 176,225 0 0
JUNO THERAPEUTICS INC COM 48205A109 41,859 915,750 SH   DFND 8,17,20 915,750 0 0
KKR REAL ESTATE FIN TR INC COM 48251K100 48,805 2,439,024 SH   DFND 1,14,16 2,439,024 0 0
MASTERCARD INCORPORATED CL A 57636Q104 139,716 923,068 SH   DFND 1,14,16 923,068 0 0
MEDTRONIC PLC SHS G5960L103 5,087 63,000 SH   DFND 1,14,16 63,000 0 0
MONSANTO CO NEW COM 61166W101 50,120 429,184 SH   DFND 1,14,16 429,184 0 0
MORGAN STANLEY COM NEW 617446448 3,787 72,173 SH   DFND 1,14,16 72,173 0 0
NETSHOES CAYMAN LTD COM G6455X107 16,362 2,071,127 SH   DFND 7 2,071,127 0 0
NEWFIELD EXPL CO COM 651290108 199,460 6,326,046 SH   DFND 1,14,16 6,326,046 0 0
PAYPAL HLDGS INC COM 70450Y103 396,662 5,387,963 SH   DFND 4,8,10,14,16 5,387,963 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 237,732 4,883,568 SH   DFND 2,8,11,17,20 4,883,568 0 0
PPG INDS INC COM 693506107 201,823 1,727,645 SH   DFND 1,14,16 1,727,645 0 0
RADIUS HEALTH INC COM NEW 750469207 615 19,344 SH   DFND 7 19,344 0 0
REGENERON PHARMACEUTICALS COM 75886F107 71,666 190,621 SH   DFND 1,8,14,16,17,20 190,621 0 0
ROCKWELL AUTOMATION INC COM 773903109 8,720 44,409 SH   DFND 1,14,16 44,409 0 0
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 195,915 2,868,867 SH   DFND 6,16 2,868,867 0 0
SENSEONICS HLDGS INC COM 81727U105 752 282,582 SH   DFND 7 282,582 0 0
SPDR SERIES TRUST S&P REGL BKG 78464A698 20,233 343,800 SH   DFND 1,14,16 343,800 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 285,406 1,503,087 SH   DFND 2,8,11 1,503,087 0 0
TUNIU CORP SPONSORED ADS CL 89977P106 62,851 8,194,444 SH   DFND 5,18 8,194,444 0 0
TURQUOISE HILL RES LTD COM 900435108 251,124 73,213,884 SH   DFND 3,18,19 73,213,884 0 0
UNIVAR INC COM 91336L107 438,753 14,171,599 SH   DFND 3,18,19 14,171,599 0 0
VANTIV INC CL A 92210H105 97,605 1,327,057 SH   DFND 1,14,16 1,327,057 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 36,653 244,582 SH   DFND 1,14,16 244,582 0 0
VIRTU FINL INC CL A 928254101 372,048 20,330,503 SH   DFND 1,7,9,14,16 20,330,503 0 0
VISA INC COM CL A 92826C839 417,367 3,660,475 SH   DFND 1,14,16 3,660,475 0 0
WELLS FARGO CO NEW COM 949746101 10,531 173,576 SH   DFND 1,14,16 173,576 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 193,001 12,176,750 SH   DFND 1,14,16 12,176,750 0 0