The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COM 00289Y107 3,329 210,000 SH   DFND 1,2 210,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 5,119 170,000 SH   DFND 1,2 170,000 0 0
ACORDA THERAPEUTICS INC COM 00484M106 1,073 50,000 SH   DFND 1,2 50,000 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 4,762 140,500 SH   DFND 1,2 140,500 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 2,093 21,000 SH Call DFND   0 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 831 8,336 SH   DFND   8,336 0 0
AILERON THERAPEUTICS INC COM 00887A105 1,318 125,000 SH   DFND 1,2 125,000 0 0
ALBIREO PHARMA INC COM 01345P106 907 35,431 SH   DFND 1,2 35,431 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 7,100 1,044,131 SH   DFND 1,2 1,044,131 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 14,351 120,000 SH   DFND 1,2 120,000 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 3,270 325,000 SH   DFND 1,2 325,000 0 0
ALLERGAN PLC SHS G0177J108 9,815 60,000 SH   DFND 1,2 60,000 0 0
ALPHABET INC CAP STK CL A 02079K305 6,075 5,767 SH   DFND   5,767 0 0
AMICUS THERAPEUTICS INC COM 03152W109 15,829 1,100,000 SH   DFND 1,2 1,100,000 0 0
ANAPTYSBIO INC COM 032724106 3,525 35,000 SH   DFND 1,2 35,000 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 888 75,535 SH   DFND 1,2 75,535 0 0
ARDELYX INC COM 039697107 2,277 345,000 SH   DFND 1,2 345,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 5,184 405,000 SH   DFND 1,2 405,000 0 0
ARSANIS INC COM 042873109 3,436 269,268 SH   DFND 1,2 269,268 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 5,187 129,474 SH   DFND 1,2 129,474 0 0
ATHERSYS INC COM 04744L106 1 773 SH   DFND 1,2 773 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 2,969 95,000 SH   DFND 1,2 95,000 0 0
AVEO PHARMACEUTICALS INC COM 053588109 3,627 1,300,000 SH   DFND 1,2 1,300,000 0 0
AXSOME THERAPEUTICS INC COM 05464T104 1,686 301,000 SH   DFND 1,2 301,000 0 0
BIOGEN INC COM 09062X103 23,638 74,200 SH   DFND 1,2 74,200 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 3,121 35,000 SH   DFND 1,2 35,000 0 0
CASCADIAN THERAPEUTICS INC COM NEW 14740B606 2,520 681,210 SH   DFND 1,2 681,210 0 0
CATABASIS PHARMACEUTICALS IN COM 14875P107 489 328,030 SH   DFND 1,2 328,030 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 2,255 576,825 SH   DFND 1,2 576,825 0 0
CELGENE CORP COM 151020104 32,247 309,000 SH   DFND 1,2 309,000 0 0
CELLCOM ISRAEL LTD SHS M2196U109 14,022 1,359,744 SH   DFND   1,359,744 0 0
CELLECTIS S A SPONSORED ADS 15117K103 9,893 339,367 SH   DFND 1,2 339,367 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 3,907 11,629 SH   DFND   11,629 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 116 400 SH   DFND   400 0 0
CIDARA THERAPEUTICS INC COM 171757107 5 800 SH   DFND 1,2 800 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 3,150 450,000 SH   DFND 1,2 450,000 0 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 3,094 163,000 SH   DFND 1,2 163,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 10,744 158,000 SH   DFND 1,2 158,000 0 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 3,912 55,086 SH   DFND   55,086 0 0
COMCAST CORP NEW CL A 20030N101 1,879 46,905 SH   DFND   46,905 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 2,663 375,000 SH   DFND 1,2 375,000 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 2,294 221,430 SH   DFND 1,2 221,430 0 0
CTI BIOPHARMA CORP COM NEW 12648L601 2,234 833,633 SH   DFND 1,2 833,633 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 2,208 240,000 SH   DFND 1,2 240,000 0 0
CYTOKINETICS INC COM NEW 23282W605 1,712 210,000 SH   DFND 1,2 210,000 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 3,378 160,000 SH   DFND 1,2 160,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 5,008 224,154 SH   DFND 1,2 224,154 0 0
DENTSPLY SIRONA INC COM 24906P109 165 2,500 SH   DFND   2,500 0 0
ECOLAB INC COM 278865100 268 2,000 SH   DFND   2,000 0 0
EDGE THERAPEUTICS INC COM 279870109 3,127 333,737 SH   DFND 1,2 333,737 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 7,135 511,469 SH   DFND 1,2 511,469 0 0
ERYTECH PHARMA SPONSORED ADR 29604W108 2,642 120,000 SH   DFND 1,2 120,000 0 0
EVOKE PHARMA INC COM 30049G104 1,738 769,149 SH   DFND 1,2 769,149 0 0
EXPEDIA INC DEL COM NEW 30212P303 2,749 22,950 SH   DFND   22,950 0 0
FACEBOOK INC CL A 30303M102 6,011 34,067 SH   DFND   34,067 0 0
FIBROGEN INC COM 31572Q808 5,678 119,779 SH   DFND 1,2 119,779 0 0
FLEX PHARMA INC COM 33938A105 4,339 241,211 SH   DFND   241,211 0 0
GALMED PHARMACEUTICALS LTD SHS M47238106 2,164 238,095 SH   DFND 1,2 238,095 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 15,962 450,000 SH   DFND 1,2 450,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 3,935 100,000 SH   DFND 1,2 100,000 0 0
GLYCOMIMETICS INC COM 38000Q102 5,457 325,000 SH   DFND 1,2 325,000 0 0
HONEYWELL INTL INC COM 438516106 4,102 26,750 SH   DFND   26,750 0 0
IGNYTA INC COM 451731103 9,193 344,300 SH   DFND 1,2 344,300 0 0
IMMUNOGEN INC COM 45253H101 3,205 500,000 SH   DFND 1,2 500,000 0 0
IMMUNOMEDICS INC COM 452907108 3,717 230,000 SH   DFND 1,2 230,000 0 0
INCYTE CORP COM 45337C102 4,736 50,000 SH Put DFND 1,2 50,000 0 0
INCYTE CORP COM 45337C102 4,736 50,000 SH   DFND 1,2 50,000 0 0
INOTEK PHARMACEUTICALS CORP COM 45780V102 1,049 100,441 SH   DFND 1,2 100,441 0 0
ISHARES TR NASDAQ BIOTECH 464287556 53,385 500,000 SH Put DFND 1,2 500,000 0 0
KADMON HLDGS INC COM 48283N106 3,982 1,100,000 SH   DFND 1,2 1,100,000 0 0
KALA PHARMACEUTICALS INC COM 483119103 1,849 100,000 SH   DFND 1,2 100,000 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 7,241 225,000 SH   DFND 1,2 225,000 0 0
LAM RESEARCH CORP COM 512807108 3,052 16,580 SH   DFND   16,580 0 0
LIBERTY INTERACTIVE CORP LBT VEN COM A NE 53071M856 163 3,000 SH   DFND   3,000 0 0
LOWES COS INC COM 548661107 242 2,600 SH   DFND   2,600 0 0
MACROGENICS INC COM 556099109 2,635 138,700 SH   DFND 1,2 138,700 0 0
MASTERCARD INCORPORATED CL A 57636Q104 1,744 11,525 SH   DFND   11,525 0 0
MELINTA THERAPEUTICS INC COM 58549G100 3,160 200,000 SH   DFND 1,2 200,000 0 0
MELLANOX TECHNOLOGIES LTD SHS M51363113 4,752 73,446 SH   DFND   73,446 0 0
MERCK & CO INC COM 58933Y105 23,915 425,000 SH   DFND 1,2 425,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 4,689 775,000 SH   DFND 1,2 775,000 0 0
MOHAWK INDS INC COM 608190104 303 1,100 SH   DFND   1,100 0 0
MYLAN N V SHS EURO N59465109 2,116 50,000 SH Call DFND   0 0 0
MYLAN N V SHS EURO N59465109 3,446 81,449 SH   DFND   81,449 0 0
MYLAN N V SHS EURO N59465109 28,559 675,000 SH   DFND 1,2 675,000 0 0
NEOS THERAPEUTICS INC COM 64052L106 1,734 170,032 SH   DFND 1,2 170,032 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 2,871 37,000 SH   DFND 1,2 37,000 0 0
NICE LTD SPONSORED ADR 653656108 9,914 107,870 SH   DFND   107,870 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 5,752 340,162 SH   DFND   340,162 0 0
O REILLY AUTOMOTIVE INC NEW COM 67103H107 2,802 11,650 SH   DFND   11,650 0 0
OBSEVA SA COM H5861P103 5,346 547,697 SH   DFND 1,2 547,697 0 0
ORBOTECH LTD ORD M75253100 2,185 43,488 SH   DFND   43,488 0 0
OVID THERAPEUTICS INC COM 690469101 1,783 180,674 SH   DFND 1,2 180,674 0 0
PALO ALTO NETWORKS INC COM 697435105 2,327 16,055 SH   DFND   16,055 0 0
PFIZER INC COM 717081103 14,126 390,000 SH   DFND 1,2 390,000 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 6,040 800,000 SH   DFND 1,2 800,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 10,223 210,000 SH   DFND 1,2 210,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 1,709 530,000 SH   DFND 1,2 530,000 0 0
PROTHENA CORP PLC SHS G72800108 7,685 205,000 SH   DFND 1,2 205,000 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 3,460 35,000 SH   DFND 1,2 35,000 0 0
RADCOM LTD SHS NEW M81865111 1,305 65,760 SH   DFND   65,760 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 6,372 225,000 SH   DFND 1,2 225,000 0 0
REGENXBIO INC COM 75901B107 735 22,107 SH   DFND 1,2 22,107 0 0
SAGE THERAPEUTICS INC COM 78667J108 395 2,400 SH Put DFND 1,2 2,400 0 0
SAGE THERAPEUTICS INC COM 78667J108 4,941 30,000 SH   DFND 1,2 30,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 21,421 384,997 SH   DFND 1,2 384,997 0 0
SAVARA INC COM 805111101 2,968 200,000 SH   DFND 1,2 200,000 0 0
SEALED AIR CORP NEW COM 81211K100 222 4,500 SH   DFND   4,500 0 0
SELECT SECTOR SPDR TR SBI INT-FINL 81369Y605 4,326 155,000 SH   DFND   155,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 2,242 228,534 SH   DFND 1,2 228,534 0 0
SERVICEMASTER GLOBAL HLDGS I COM 81761R109 410 8,000 SH   DFND   8,000 0 0
SHIRE PLC SPONSORED ADR 82481R106 13,418 86,500 SH   DFND 1,2 86,500 0 0
SIERRA ONCOLOGY INC COM 82640U107 2,052 550,000 SH   DFND 1,2 550,000 0 0
SNAP ON INC COM 833034101 1,271 7,292 SH   DFND   7,292 0 0
SPARK THERAPEUTICS INC COM 84652J103 5,142 100,000 SH   DFND 1,2 100,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 165,497 1,950,000 SH Put DFND 1,2 1,950,000 0 0
SPRING BK PHARMACEUTICALS IN COM 849431101 999 74,309 SH   DFND 1,2 74,309 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 4,680 300,000 SH   DFND 1,2 300,000 0 0
SUMMIT THERAPEUTICS PLC SPONS ADS 86627R102 2,349 212,018 SH   DFND 1,2 212,018 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 2,177 248,472 SH   DFND 1,2 248,472 0 0
TESARO INC COM 881569107 7,873 95,000 SH   DFND 1,2 95,000 0 0
TEVA PHARMACEUTICAL FIN LLC DBCV 0.250% 2/0 88163VAE9 758 2,135 SH   DFND   2,135 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 2,250 118,750 SH   DFND   118,750 0 0
THERAPEUTICSMD INC COM 88338N107 2,899 479,980 SH   DFND 1,2 479,980 0 0
TJX COS INC NEW COM 872540109 443 5,800 SH   DFND   5,800 0 0
TRIPADVISOR INC COM 896945201 138 4,000 SH   DFND   4,000 0 0
ULTIMATE SOFTWARE GROUP INC COM 90385D107 175 800 SH   DFND   800 0 0
UNITEDHEALTH GROUP INC COM 91324P102 441 2,000 SH   DFND   2,000 0 0
VBI VACCINES INC COM NEW 91822J103 3,416 800,000 SH   DFND 1,2 800,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 12,861 85,823 SH   DFND 1,2 85,823 0 0
VIKING THERAPEUTICS INC COM 92686J106 8,710 2,145,300 SH   DFND 1,2 2,145,300 0 0
VISA INC COM CL A 92826C839 6,887 60,401 SH   DFND   60,401 0 0
VISTA OUTDOOR INC COM 928377100 87 6,000 SH   DFND   6,000 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 1,384 1,247,251 SH   DFND 1,2 1,247,251 0 0
VTV THERAPEUTICS INC CL A 918385105 1,693 281,679 SH   DFND 1,2 281,679 0 0
WATSCO INC COM 942622200 357 2,100 SH   DFND   2,100 0 0
WIX COM LTD SHS M98068105 4,499 78,180 SH   DFND   78,180 0 0