The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AC IMMUNE SA SHS H00263105 6,400 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 13,100 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
ACCELERON PHARMA INC COM 00434H108 31,830 750,000 SH   DFND 1,2,3,4,5 750,000 0 0
ACHAOGEN INC COM 004449104 2,685 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 2,160 750,000 SH   DFND 1,2,3,4,5 750,000 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONSORED ADR 00653A107 4,676 700,000 SH   DFND 1,2,3,4,5 700,000 0 0
ADURO BIOTECH INC COM 00739L101 1,500 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
AGENUS INC COM NEW 00847G705 8,151 2,500,255 SH   DFND 1,2,3,4,5 2,500,255 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 28,585 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 5,717 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
ALBIREO PHARMA INC COM 01345P106 7,680 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 5,725 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 77,734 650,000 SH Call DFND 1,2,3,4,5 650,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 34,486 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
ALLERGAN PLC SHS G0177J108 32,716 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 57,173 450,000 SH   DFND 1,2,3,4,5 450,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 25,410 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
AMGEN INC COM 031162100 17,390 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 14,390 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 20,146 1,400,000 SH Call DFND 1,2,3,4,5 1,400,000 0 0
ANAPTYSBIO INC COM 032724106 15,108 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
ARGENX SE SPONSORED ADR 04016X101 12,628 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 19,200 1,500,000 SH   DFND 1,2,3,4,5 1,500,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 6,400 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 18,100 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
ATYR PHARMA INC COM 002120103 1,750 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 6,250 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
AVEXIS INC COM 05366U100 16,601 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
BANK AMER CORP COM 060505104 171,216 5,800,000 SH Call DFND 1,2,3,4,5 5,800,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 29,316 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 2,455 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 8,917 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
BIOTIME INC COM 09066L105 3,348 1,557,050 SH   DFND 1,2,3,4,5 1,557,050 0 0
BLUEBIRD BIO INC COM 09609G100 26,715 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
BLUEBIRD BIO INC COM 09609G100 8,905 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
BLUE BUFFALO PET PRODS INC COM 09531U102 2,867,842 87,460,875 SH   DFND 1,2,3,4 87,460,875 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 7,541 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
BRIGHTHOUSE FINL INC COM 10922N103 17,592 300,000 SH Call DFND 1,2,3,4,5 300,000 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 55,152 900,000 SH Call DFND 1,2,3,4,5 900,000 0 0
CALITHERA BIOSCIENCES INC COM 13089P101 835 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
CELGENE CORP COM 151020104 15,654 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
CELLDEX THERAPEUTICS INC NEW COM 15117B103 995 350,336 SH   DFND 1,2,3,4,5 350,336 0 0
CELLECTIS S A SPONSORED ADS 15117K103 2,915 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
CHEMOCENTRYX INC COM 16383L106 2,975 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
CHIMERIX INC COM 16934W106 2,315 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
CITIGROUP INC COM NEW 172967424 111,615 1,500,000 SH Call DFND 1,2,3,4,5 1,500,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 6,800 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 10,200 150,000 SH Call DFND 1,2,3,4,5 150,000 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 2,840 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 1,174 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 7,820 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 3,740 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
EDITAS MEDICINE INC COM 28106W103 1,537 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
FREEPORT-MCMORAN INC CL B 35671D857 4,740 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
GILEAD SCIENCES INC COM 375558103 89,550 1,250,000 SH Call DFND 1,2,3,4,5 1,250,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 13,773 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
GLYCOMIMETICS INC COM 38000Q102 4,198 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 50,952 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 3,039 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
HORIZON PHARMA PLC SHS G4617B105 7,300 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
INCYTE CORP COM 45337C102 47,355 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
INCYTE CORP COM 45337C102 23,678 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 4,805 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 122,736 800,000 SH Call DFND 1,2,3,4,5 800,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 3,251 216,879 SH   DFND 1,2,3,4 216,879 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 4,497 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
JOUNCE THERAPEUTICS INC COM 481116101 1,913 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 4,571 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 15,999 350,000 SH Call DFND 1,2,3,4,5 350,000 0 0
KRYSTAL BIOTECH INC COM 501147102 1,578 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
KURA ONCOLOGY INC COM 50127T109 1,530 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 560,440 56,724,650 SH   DFND 1,2,3,4 56,724,650 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 15,314 1,550,000 SH   DFND 1,2,3,4,5 1,550,000 0 0
MACROGENICS INC COM 556099109 1,900 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 1,632 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
MEDICINES CO COM 584688105 5,468 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
MEDICINES CO COM 584688105 19,138 700,000 SH Call DFND 1,2,3,4,5 700,000 0 0
METLIFE INC COM 59156R108 12,640 250,000 SH Call DFND 1,2,3,4,5 250,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 1,520 251,300 SH   DFND 1,2,3,4,5 251,300 0 0
MIRAGEN THERAPEUTICS INC COM 60463E103 1,043 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 1,825 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
MORGAN STANLEY COM NEW 617446448 26,235 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
NANTKWEST INC COM 63016Q102 1,010 225,000 SH   DFND 1,2,3,4,5 225,000 0 0
NEKTAR THERAPEUTICS COM 640268108 23,888 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
NEKTAR THERAPEUTICS COM 640268108 65,692 1,100,000 SH Call DFND 1,2,3,4,5 1,100,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 19,398 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
NEWLINK GENETICS CORP COM 651511107 1,622 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
NOVAVAX INC COM 670002104 620 500,000 SH   DFND 1,2,3,4,5 500,000 0 0
NOVELION THERAPEUTICS INC COM NEW 67001K202 800 256,400 SH   DFND 1,2,3,4,5 256,400 0 0
ONCOCYTE CORPORATION COM 68235C107 698 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 7,302 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 6,128 1,900,000 SH   DFND 1,2,3,4,5 1,900,000 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 4,943 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
RADIUS HEALTH INC COM NEW 750469207 12,708 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
RADIUS HEALTH INC COM NEW 750469207 3,177 100,000 SH Call DFND 1,2,3,4,5 100,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107 18,798 50,000 SH Call DFND 1,2,3,4,5 50,000 0 0
REGENXBIO INC COM 75901B107 8,313 250,000 SH   DFND 1,2,3,4,5 250,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 1,453 50,000 SH   DFND 1,2,3,4,5 50,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 12,353 75,000 SH   DFND 1,2,3,4,5 75,000 0 0
SERES THERAPEUTICS INC COM 81750R102 3,042 300,000 SH   DFND 1,2,3,4,5 300,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 33,948 400,000 SH Call DFND 1,2,3,4,5 400,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 4,113 350,000 SH   DFND 1,2,3,4,5 350,000 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 3,120 200,000 SH   DFND 1,2,3,4,5 200,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 1,314 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
SYNLOGIC INC COM 87166L100 5,335 550,000 SH   DFND 1,2,3,4,5 550,000 0 0
TESARO INC COM 881569107 8,287 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
TESARO INC COM 881569107 2,072 25,000 SH Call DFND 1,2,3,4,5 25,000 0 0
TG THERAPEUTICS INC COM 88322Q108 3,280 400,000 SH   DFND 1,2,3,4,5 400,000 0 0
TOCAGEN INC COM 888846102 1,025 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 1,088 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
VALE S A ADR 91912E105 6,115 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0
VERASTEM INC COM 92337C104 3,070 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 29,972 200,000 SH Call DFND 1,2,3,4,5 200,000 0 0
VITAL THERAPIES INC COM 92847R104 5,206 875,000 SH   DFND 1,2,3,4,5 875,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 3,232 92,078 SH   DFND 1,2,3,4,5 92,078 0 0
WEIGHT WATCHERS INTL INC NEW COM 948626106 1,303,749 29,443,300 SH   DFND 1,2,3,4 29,443,300 0 0
WELLS FARGO CO NEW COM 949746101 91,005 1,500,000 SH Call DFND 1,2,3,4,5 1,500,000 0 0
XENCOR INC COM 98401F105 2,192 100,000 SH   DFND 1,2,3,4,5 100,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 424 150,000 SH   DFND 1,2,3,4,5 150,000 0 0
ZAFGEN INC COM 98885E103 4,620 1,000,000 SH   DFND 1,2,3,4,5 1,000,000 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 7,925 500,000 SH Call DFND 1,2,3,4,5 500,000 0 0