The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 2U INC COM USD0.001 | COM | 90214J101 | 183,816 | 2,849,417 | SH | DFND | 769,235 | 0 | 2,080,182 | ||
| ABIOMED INC | COM | 003654100 | 3,720 | 19,851 | SH | DFND | 5,145 | 0 | 14,706 | ||
| ABRAXAS PETE CORP | COM | 003830106 | 952 | 387,178 | SH | DFND | 48,374 | 0 | 338,804 | ||
| ACACIA COMMUNICATIONS INC COM | COM | 00401C108 | 44,664 | 1,232,791 | SH | DFND | 201,699 | 0 | 1,031,092 | ||
| ACADIA PHARMACEUTICALS INC COM | COM | 004225108 | 3,391 | 112,626 | SH | DFND | 19,952 | 0 | 92,674 | ||
| ACCELERATE DIAGNOSTICS INC COM USD0.001 | COM | 00430H102 | 1,609 | 61,420 | SH | DFND | 18,180 | 0 | 43,240 | ||
| ACM RESEARCH INC COM CL A | COM | 00108J109 | 515 | 98,033 | SH | DFND | 0 | 0 | 98,033 | ||
| ACTIVISION BLIZZARD INC COM | COM | 00507V109 | 54,299 | 857,539 | SH | DFND | 262,325 | 0 | 595,214 | ||
| ADESTO TECHNOLOGIES CORP COM | COM | 00687D101 | 10,586 | 1,641,221 | SH | DFND | 95,983 | 0 | 1,545,238 | ||
| ADOBE SYS INC | COM | 00724F101 | 89,687 | 511,796 | SH | DFND | 172,286 | 0 | 339,510 | ||
| ADVANCED MICRO DEVICES INC COM | COM | 007903107 | 268 | 26,111 | SH | DFND | 5,828 | 0 | 20,283 | ||
| ALASKA COMM SYS GRP INC | COM | 01167P101 | 6,259 | 2,335,308 | SH | DFND | 420,575 | 0 | 1,914,733 | ||
| ALIBABA GROUP HLDG LTD SPONSORED ADS | COM | 01609W102 | 84,988 | 492,886 | SH | DFND | 180,354 | 0 | 312,532 | ||
| ALIGN TECHNOLOGY INC COM | COM | 016255101 | 131,519 | 591,920 | SH | DFND | 76,663 | 0 | 515,257 | ||
| ALLEGIANT TRAVEL CO COM | COM | 01748X102 | 16,514 | 106,713 | SH | DFND | 8,077 | 0 | 98,636 | ||
| ALMOST FAMILY INC | COM | 020409108 | 12,702 | 229,483 | SH | DFND | 40,292 | 0 | 189,191 | ||
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 154,666 | 1,217,367 | SH | DFND | 315,945 | 0 | 901,422 | ||
| ALPHABET INC CAP STK CL A | COM | 02079K305 | 49,618 | 47,103 | SH | DFND | 4,059 | 0 | 43,044 | ||
| ALPHABET INC CAP STK CL C | COM | 02079K107 | 64,713 | 61,843 | SH | DFND | 7,352 | 0 | 54,491 | ||
| AMAZON.COM INC | COM | 023135106 | 388,948 | 332,585 | SH | DFND | 79,578 | 0 | 253,007 | ||
| AMBER ROAD INC COM USD0.001 | COM | 02318Y108 | 527 | 71,806 | SH | DFND | 5,416 | 0 | 66,390 | ||
| AMERICAN TOWER CORPORATION | COM | 03027X100 | 12,550 | 87,962 | SH | DFND | 8,397 | 0 | 79,565 | ||
| AMS AG NPV (BR) ISIN #AT0000A18XM4 SEDOL #BPF0548 | COM | A0400Q115 | 285 | 3,135 | SH | DFND | 359 | 0 | 2,776 | ||
| APACHE CORP | COM | 037411105 | 10,385 | 245,980 | SH | DFND | 27,365 | 0 | 218,615 | ||
| APPIAN CORP CL A | COM | 03782L101 | 9,668 | 307,117 | SH | DFND | 38,672 | 0 | 268,445 | ||
| APPLE INC | COM | 037833100 | 4,454 | 26,318 | SH | DFND | 6,455 | 0 | 19,863 | ||
| APPLIED MATERIALS INC | COM | 038222105 | 1,002 | 19,599 | SH | DFND | 7,416 | 0 | 12,183 | ||
| APPLIED OPTOELECTRONICS INC COM | COM | 03823U102 | 9,440 | 249,606 | SH | DFND | 28,932 | 0 | 220,674 | ||
| AQUANTIA CORP COM | COM | 03842Q108 | 18,790 | 1,658,451 | SH | DFND | 465,863 | 0 | 1,192,588 | ||
| ARISTA NETWORKS INC COM USD0.0001 | COM | 040413106 | 129,550 | 549,921 | SH | DFND | 28,478 | 0 | 521,443 | ||
| ASV HLDGS INC COM | COM | 00215L104 | 12,298 | 1,211,662 | SH | DFND | 98,905 | 0 | 1,112,757 | ||
| AT HOME GROUP INC COM | COM | 04650Y100 | 12,883 | 423,918 | SH | DFND | 50,488 | 0 | 373,430 | ||
| ATHENAHEALTH INC DELAWARE | COM | 04685W103 | 370 | 2,783 | SH | DFND | 281 | 0 | 2,502 | ||
| ATLASSIAN CORPORATION PLC COM USD0.1 CL A | COM | G06242104 | 22,203 | 487,761 | SH | DFND | 65,801 | 0 | 421,960 | ||
| AUTO TRADER GROUP PLC ORD GBP0.01 ISIN #GB00BVYVFW23 SEDOL #BVYV | COM | G06708104 | 5,009 | 1,049,638 | SH | DFND | 206,768 | 0 | 842,870 | ||
| AUTODESK INC COM | COM | 052769106 | 87,496 | 834,649 | SH | DFND | 134,121 | 0 | 700,528 | ||
| AXIS BANK GDR EACH REPR 1 INR10 REG S ISIN #US05462W1099 SEDOL # | COM | 05462W109 | 659 | 15,085 | SH | DFND | 15,000 | 0 | 85 | ||
| AXOGEN INC COM | COM | 05463X106 | 15,121 | 534,311 | SH | DFND | 110,133 | 0 | 424,178 | ||
| AZUL SA SPON ADR EACH REP 3 PFD SHS | COM | 05501U106 | 124,667 | 5,231,502 | SH | DFND | 986,205 | 0 | 4,245,297 | ||
| BAIDU INC SPONS ADR REPR 0.10 ORD CLS A | COM | 056752108 | 4,591 | 19,603 | SH | DFND | 7,735 | 0 | 11,868 | ||
| BANCO MACRO S.A. ADR REP 10 CLS B SHS ARS1 | COM | 05961W105 | 37 | 315 | SH | DFND | 11 | 0 | 304 | ||
| BARCLAYS BK PLC IPATH S&P 500 VIX SHORT TERM FUTURES ETN NEW 201 | COM | 06746L422 | 13,735 | 491,935 | SH | DFND | 23,923 | 0 | 468,012 | ||
| BELLATRIX EXPLORATION LTD COM NPV ISIN #CA0783145075 SEDOL #BF23 | COM | 078314507 | 203 | 117,927 | SH | DFND | 21,794 | 0 | 96,133 | ||
| BERKLEY W R CORP | COM | 084423102 | 4,739 | 66,143 | SH | DFND | 17,940 | 0 | 48,203 | ||
| BERKSHIRE HATHAWAY INC DEL CL B NEW | COM | 084670702 | 43 | 218 | SH | DFND | 0 | 0 | 218 | ||
| BIOSCRIP INC | COM | 09069N108 | 45,469 | 15,625,055 | SH | DFND | 3,642,030 | 0 | 11,983,025 | ||
| BLUEBIRD BIO INC COM | COM | 09609G100 | 1,225 | 6,880 | SH | DFND | 2,542 | 0 | 4,338 | ||
| BMC STK HLDGS INC COM | COM | 05591B109 | 582 | 23,000 | SH | DFND | 23,000 | 0 | 0 | ||
| BOINGO WIRELESS INC COM USD0.0001 | COM | 09739C102 | 6,256 | 278,063 | SH | DFND | 43,656 | 0 | 234,407 | ||
| BOOHOO.COM PLC ORD GBP0.01 ISIN #JE00BG6L7297 SEDOL #BG6L729 | COM | G6153P109 | 20 | 8,005 | SH | DFND | 300 | 0 | 7,705 | ||
| BOSTON SCIENTIFIC CORP | COM | 101137107 | 1,099 | 44,340 | SH | DFND | 19,919 | 0 | 24,421 | ||
| BOX INC CL A | COM | 10316T104 | 8,091 | 383,106 | SH | DFND | 63,229 | 0 | 319,877 | ||
| BRIGHTCOVE INC COM USD0.001 | COM | 10921T101 | 213 | 30,007 | SH | DFND | 3,656 | 0 | 26,351 | ||
| BYD COMPANY LIMITED H CNY1 ISIN #CNE100000296 SEDOL #6536651 | COM | Y1023R104 | 36,485 | 4,188,180 | SH | DFND | 1,230,500 | 0 | 2,957,680 | ||
| C S X CORP | COM | 126408103 | 406 | 7,372 | SH | DFND | 157 | 0 | 7,215 | ||
| C&J ENERGY SVCS INC NEW COM | COM | 12674R100 | 234 | 6,997 | SH | DFND | 2,558 | 0 | 4,439 | ||
| CAESARS ENTMT CORP COM | COM | 127686103 | 1,275 | 100,789 | SH | DFND | 40,050 | 0 | 60,739 | ||
| CAMPING WORLD HLDGS INC CL A | COM | 13462K109 | 4,397 | 98,291 | SH | DFND | 30,986 | 0 | 67,305 | ||
| CANADA GOOSE HOLDINGS INC COM NPV SUB VTNG SHS ISIN #CA135086106 | COM | 135086106 | 606 | 19,189 | SH | DFND | 406 | 0 | 18,783 | ||
| CARL ZEISS MEDITEC AG NPV ISIN #DE0005313704 SEDOL #5922961 | COM | D14895102 | 1,071 | 17,214 | SH | DFND | 6,388 | 0 | 10,826 | ||
| CARROLS RESTAURANT GROUP INC COM | COM | 14574X104 | 9,321 | 767,136 | SH | DFND | 80,670 | 0 | 686,466 | ||
| CARVANA CO CL A | COM | 146869102 | 7,000 | 366,134 | SH | DFND | 59,978 | 0 | 306,156 | ||
| CASA SYS INC COM | COM | 14713L102 | 232 | 13,040 | SH | DFND | 1,362 | 0 | 11,678 | ||
| CATAPULT GROUP INTERNATIONAL ISIN #AU000000CAT9 SEDOL #BTL0Y76 | COM | Q2159P101 | 301 | 226,247 | SH | DFND | 17,428 | 0 | 208,819 | ||
| CBS CORP NEW CL B | COM | 124857202 | 1,080 | 18,306 | SH | DFND | 4,411 | 0 | 13,895 | ||
| CHARTER COMMUNICATIONS INC NEW CL A | COM | 16119P108 | 714 | 2,125 | SH | DFND | 46 | 0 | 2,079 | ||
| CHEGG INC COM USD0.001 | COM | 163092109 | 119,752 | 7,337,758 | SH | DFND | 1,558,858 | 0 | 5,778,900 | ||
| CISION LTD COM USD0.0001 | COM | G1992S109 | 1,831 | 154,225 | SH | DFND | 51,383 | 0 | 102,842 | ||
| CITIGROUP INC COM NEW | COM | 172967424 | 7,330 | 98,514 | SH | DFND | 21,114 | 0 | 77,400 | ||
| CLOUDERA INC COM | COM | 18914U100 | 1,885 | 114,127 | SH | DFND | 25,949 | 0 | 88,178 | ||
| COGNEX CORP COM | COM | 192422103 | 38,661 | 632,128 | SH | DFND | 226,185 | 0 | 405,943 | ||
| CONSTELLATION BRANDS INC CL A | COM | 21036P108 | 11,253 | 49,232 | SH | DFND | 4,603 | 0 | 44,629 | ||
| COSTAMARE INC COM USD0.0001 | COM | Y1771G102 | 1,715 | 297,272 | SH | DFND | 13,331 | 0 | 283,941 | ||
| COUPA SOFTWARE INC COM | COM | 22266L106 | 2,101 | 67,288 | SH | DFND | 11,215 | 0 | 56,073 | ||
| COVANTA HLDG CORP COM | COM | 22282E102 | 8,953 | 529,749 | SH | DFND | 87,181 | 0 | 442,568 | ||
| CREDICORP LTD COM | COM | G2519Y108 | 251 | 1,208 | SH | DFND | 447 | 0 | 761 | ||
| CRIMSON WINE GROUP COM USD0.01 | COM | 22662X100 | 219 | 20,524 | SH | DFND | 372 | 0 | 20,152 | ||
| DEERE & COMPANY | COM | 244199105 | 16 | 100 | SH | DFND | 0 | 0 | 100 | ||
| DELIVERY HERO AG NPV 144A ISIN #DE000A2E4K43 SEDOL #BZCNB42 | COM | D1T0KZ103 | 268 | 6,760 | SH | DFND | 3,022 | 0 | 3,738 | ||
| DELTA AIR LINES INC DEL COM NEW | COM | 247361702 | 4,288 | 76,570 | SH | DFND | 1,037 | 0 | 75,533 | ||
| DENALI THERAPEUTICS INC COM | COM | 24823R105 | 237 | 15,130 | SH | DFND | 27 | 0 | 15,103 | ||
| DEXCOM INC | COM | 252131107 | 7,680 | 133,814 | SH | DFND | 10,620 | 0 | 123,194 | ||
| DIRTT ENVIRONMENTAL SOLUT LTD COM ISIN #CA25490H1064 SEDOL #BH13 | COM | 25490H106 | 2,392 | 444,610 | SH | DFND | 70,304 | 0 | 374,306 | ||
| DOMINO S PIZZA ENTERPRISES L ISIN #AU000000DMP0 SEDOL #B07SFG7 | COM | Q32503106 | 9,978 | 273,182 | SH | DFND | 30,620 | 0 | 242,562 | ||
| ECO STIM ENERGY SOLUTIONS INC COM | COM | 27888D101 | 893 | 708,486 | SH | DFND | 61,513 | 0 | 646,973 | ||
| ECOSYNTHETIX INC COM ISIN #CA27923D1087 SEDOL #B4XBZ35 | COM | 27923D108 | 111 | 63,092 | SH | DFND | 7,325 | 0 | 55,767 | ||
| ELBIT SYSTEMS LTD ISIN #IL0010811243 SEDOL #6308913 | COM | M3760D101 | 51,070 | 383,153 | SH | DFND | 153,754 | 0 | 229,399 | ||
| ELECTRONIC ARTS | COM | 285512109 | 4,624 | 44,014 | SH | DFND | 897 | 0 | 43,117 | ||
| ENPHASE ENERGY INC COM USD0.00001 | COM | 29355A107 | 4,540 | 1,883,791 | SH | DFND | 301,672 | 0 | 1,582,119 | ||
| ENTERCOM COMMUNICATIONS CORP CL A | COM | 293639100 | 460 | 42,630 | SH | DFND | 6,104 | 0 | 36,526 | ||
| ENZO BIOCHEM INC | COM | 294100102 | 8,772 | 1,076,312 | SH | DFND | 234,691 | 0 | 841,621 | ||
| EPAM SYS INC COM USD0.001 | COM | 29414B104 | 66,840 | 622,170 | SH | DFND | 34,966 | 0 | 587,204 | ||
| EROS INTERNATIONAL COM GBP0.30 | COM | G3788M114 | 36,466 | 3,778,852 | SH | DFND | 1,070,707 | 0 | 2,708,145 | ||
| ESPERION THERAPEUTICS INC COM USD0.001 | COM | 29664W105 | 111 | 1,689 | SH | DFND | 204 | 0 | 1,485 | ||
| ETSY INC COM | COM | 29786A106 | 29,847 | 1,459,522 | SH | DFND | 102,938 | 0 | 1,356,584 | ||
| EVERBRIDGE INC COM | COM | 29978A104 | 20,215 | 680,186 | SH | DFND | 109,367 | 0 | 570,819 | ||
| EVOQUA WATER TECHNOLOGIES CORP COM | COM | 30057T105 | 1,859 | 78,424 | SH | DFND | 7,266 | 0 | 71,158 | ||
| EXACT SCIENCES CORP | COM | 30063P105 | 110,082 | 2,095,198 | SH | DFND | 423,148 | 0 | 1,672,050 | ||
| EXTRACTION OIL AND GAS INC COM | COM | 30227M105 | 10,900 | 761,715 | SH | DFND | 120,038 | 0 | 641,677 | ||
| FACEBOOK INC COM USD0.000006 CL A | COM | 30303M102 | 302,595 | 1,714,806 | SH | DFND | 493,862 | 0 | 1,220,944 | ||
| FAIRFAX INDIA HOLDINGS CORPORATION COM SUB VTG SHS ISIN #CA30389 | COM | 303897102 | 300 | 20,000 | SH | DFND | 20,000 | 0 | 0 | ||
| FARMER BROS CO COM | COM | 307675108 | 2,291 | 71,258 | SH | DFND | 17,679 | 0 | 53,579 | ||
| FB FINL CORP COM | COM | 30257X104 | 4,150 | 98,842 | SH | DFND | 20,618 | 0 | 78,224 | ||
| FEVERTREE DRINKS PLC ORD GBP0.0025 ISIN #GB00BRJ9BJ26 SEDOL #BRJ | COM | G33929103 | 562 | 18,260 | SH | DFND | 9,020 | 0 | 9,240 | ||
| FIRST REP BK SAN FRANCISCO CAL COM | COM | 33616C100 | 10,592 | 122,255 | SH | DFND | 9,136 | 0 | 113,119 | ||
| FIVE BELOW INC COM | COM | 33829M101 | 69,990 | 1,055,345 | SH | DFND | 69,935 | 0 | 985,410 | ||
| FLEXION THERAPEUTICS INC COM | COM | 33938J106 | 93,889 | 3,749,572 | SH | DFND | 793,230 | 0 | 2,956,342 | ||
| FLOOR &DECOR HLDGS INC CL A | COM | 339750101 | 127,782 | 2,624,941 | SH | DFND | 462,625 | 0 | 2,162,316 | ||
| FORESCOUT TECHNOLOGIES INC COM | COM | 34553D101 | 20,081 | 629,685 | SH | DFND | 157,320 | 0 | 472,365 | ||
| FOUNDATION MEDICINE INC USD0.0001 | COM | 350465100 | 102,612 | 1,504,572 | SH | DFND | 493,491 | 0 | 1,011,081 | ||
| FRANCO NEVADA CORP COM ISIN #CA3518581051 SEDOL #B29NF31 | COM | 351858105 | 6,870 | 85,927 | SH | DFND | 2,715 | 0 | 83,212 | ||
| FRESHPET INC COM | COM | 358039105 | 50,830 | 2,682,342 | SH | DFND | 240,928 | 0 | 2,441,414 | ||
| FRONTIER DEVELOPMENTS PLC GBP0.005 ISIN #GB00BBT32N39 SEDOL #BBT | COM | G36793100 | 980 | 54,691 | SH | DFND | 31,635 | 0 | 23,056 | ||
| FUSION TELECOMMUNICATIONS INTL INC COM NEW | COM | 36113B400 | 659 | 175,621 | SH | DFND | 22,034 | 0 | 153,587 | ||
| GALAPAGOS NV NPV ISIN #BE0003818359 SEDOL #B07Q2V5 | COM | B44170106 | 1,182 | 12,459 | SH | DFND | 4,896 | 0 | 7,563 | ||
| GASLOG LTD COM USD0.01 | COM | G37585109 | 6,248 | 280,795 | SH | DFND | 53,672 | 0 | 227,123 | ||
| GEOPARK LIMITED COM USD0.001 | COM | G38327105 | 2,245 | 226,541 | SH | DFND | 458 | 0 | 226,083 | ||
| GILDAN ACTIVEWEAR INC COM ISIN #CA3759161035 SEDOL #2254645 | COM | 375916103 | 9,695 | 300,142 | SH | DFND | 38,124 | 0 | 262,018 | ||
| GLAUKOS CORP COM | COM | 377322102 | 34,824 | 1,357,647 | SH | DFND | 338,067 | 0 | 1,019,580 | ||
| GLOBAL BLOOD THERAPEUTICS INC COM | COM | 37890U108 | 348 | 8,854 | SH | DFND | 3,384 | 0 | 5,470 | ||
| GLOBANT SA USD1.20 | COM | L44385109 | 19,372 | 416,953 | SH | DFND | 186,950 | 0 | 230,003 | ||
| GOLAR LNG LIMITED COM STK USD1.00 | COM | G9456A100 | 15,919 | 533,999 | SH | DFND | 96,647 | 0 | 437,352 | ||
| GOLD STD VENTURES CORP COM ISIN #CA3807381049 SEDOL #B05J9S2 | COM | 380738104 | 1,705 | 974,525 | SH | DFND | 104,700 | 0 | 869,825 | ||
| GRACE W R & CO DEL NEW | COM | 38388F108 | 17,538 | 250,074 | SH | DFND | 49,168 | 0 | 200,906 | ||
| GRUPO FINANCIERO GALICIA SA ADR EACH REPR 10 CLASS B ARS1 LVL11 | COM | 399909100 | 27,708 | 420,774 | SH | DFND | 72,264 | 0 | 348,510 | ||
| GRUPO SUPERVIELLE S.A. SPON ADS EACH REP 5 ORD SHS CL B | COM | 40054A108 | 4,900 | 167,138 | SH | DFND | 29,520 | 0 | 137,618 | ||
| GTT COMMUNICATIONS INC COM USD0.0001 | COM | 362393100 | 87,451 | 1,862,646 | SH | DFND | 354,765 | 0 | 1,507,881 | ||
| GUIDEWIRE SOFTWARE INC COM USD0.0001 | COM | 40171V100 | 213 | 2,864 | SH | DFND | 2,060 | 0 | 804 | ||
| H &E EQUIPMENT SERVICES INC COM | COM | 404030108 | 3,561 | 87,605 | SH | DFND | 13,467 | 0 | 74,138 | ||
| HDFC BANK LTD ADS EACH REPR 3 INR10(MGT) | COM | 40415F101 | 56,649 | 557,185 | SH | DFND | 167,205 | 0 | 389,980 | ||
| HEALTHEQUITY INC COM | COM | 42226A107 | 3,745 | 80,261 | SH | DFND | 6,121 | 0 | 74,140 | ||
| HEARTLAND EXPRESS INC COM | COM | 422347104 | 8,249 | 353,418 | SH | DFND | 56,605 | 0 | 296,813 | ||
| HERC HLDGS INC COM | COM | 42704L104 | 94 | 1,507 | SH | DFND | 928 | 0 | 579 | ||
| HUBSPOT INC COM | COM | 443573100 | 93,556 | 1,058,324 | SH | DFND | 114,051 | 0 | 944,273 | ||
| IDORSIA LTD CHF0.05 ISIN #CH0363463438 SEDOL #BF0YK62 | COM | H3879B109 | 4,613 | 176,653 | SH | DFND | 31,295 | 0 | 145,358 | ||
| ILLUMINA INC COM | COM | 452327109 | 317 | 1,452 | SH | DFND | 227 | 0 | 1,225 | ||
| IMPINJ INC COM | COM | 453204109 | 46,265 | 2,053,490 | SH | DFND | 472,745 | 0 | 1,580,745 | ||
| INCYTE CORP COM | COM | 45337C102 | 35,269 | 372,385 | SH | DFND | 147,186 | 0 | 225,199 | ||
| INPHI CORPORATION COM USD0.001 | COM | 45772F107 | 7,404 | 202,293 | SH | DFND | 31,705 | 0 | 170,588 | ||
| INSULET CORP COM | COM | 45784P101 | 913 | 13,226 | SH | DFND | 5,794 | 0 | 7,432 | ||
| INTUITIVE SURGICAL INC COM NEW | COM | 46120E602 | 80,194 | 219,747 | SH | DFND | 16,290 | 0 | 203,457 | ||
| IRHYTHM TECHNOLOGIES INC COM | COM | 450056106 | 5,879 | 104,887 | SH | DFND | 14,565 | 0 | 90,322 | ||
| JD COM INC SPONSORED ADR REPSTG COM CL A | COM | 47215P106 | 57,357 | 1,384,764 | SH | DFND | 478,079 | 0 | 906,685 | ||
| KANSAS CITY SOUTHERN COM | COM | 485170302 | 8,049 | 76,496 | SH | DFND | 7,815 | 0 | 68,681 | ||
| KORNIT DIGITAL LTD ORD ILS0.01 | COM | M6372Q113 | 28,478 | 1,763,373 | SH | DFND | 561,734 | 0 | 1,201,639 | ||
| LARSEN AND TOUBRO LTD GDR RP 1SH REG S ISIN #USY5217N1183 SEDOL | COM | ZZZ9952A4 | 444 | 22,925 | SH | DFND | 0 | 0 | 22,925 | ||
| LENDINGCLUB CORP COM | COM | 52603A109 | 425 | 102,975 | SH | DFND | 44,366 | 0 | 58,609 | ||
| LGI HOMES INC COM | COM | 50187T106 | 127,700 | 1,701,981 | SH | DFND | 299,452 | 0 | 1,402,529 | ||
| LHC GROUP INC COM | COM | 50187A107 | 1,903 | 31,072 | SH | DFND | 9,050 | 0 | 22,022 | ||
| LIBERTY MEDIA CORP DELAWARE COM A BRAVES GRP | COM | 531229706 | 5,989 | 271,631 | SH | DFND | 2,084 | 0 | 269,547 | ||
| LIBERTY MEDIA CORP DELAWARE COM C BRAVES GRP | COM | 531229888 | 15,769 | 709,680 | SH | DFND | 110,570 | 0 | 599,110 | ||
| LIBERTY MEDIA CORP DELAWARE COM C SIRIUSXM | COM | 531229607 | 284 | 7,154 | SH | DFND | 130 | 0 | 7,024 | ||
| LIBERTY MEDIA CORP DELAWARE COM SER C FRMLA | COM | 531229854 | 612 | 17,915 | SH | DFND | 383 | 0 | 17,532 | ||
| LILIS ENERGY INC COM NEW | COM | 532403201 | 6,413 | 1,254,910 | SH | DFND | 313,421 | 0 | 941,489 | ||
| LIVEPERSON INC | COM | 538146101 | 35,794 | 3,112,529 | SH | DFND | 212,213 | 0 | 2,900,316 | ||
| LULULEMON ATHLETICA INC COM | COM | 550021109 | 171 | 2,170 | SH | DFND | 476 | 0 | 1,694 | ||
| LUMBER LIQUIDATORS HLDGS INC COM | COM | 55003T107 | 48,538 | 1,546,304 | SH | DFND | 609,332 | 0 | 936,972 | ||
| LUMENTUM HLDGS INC COM | COM | 55024U109 | 92,037 | 1,882,140 | SH | DFND | 349,263 | 0 | 1,532,877 | ||
| MADISON SQUARE GARDEN CO NEW CL A | COM | 55825T103 | 5,955 | 28,242 | SH | DFND | 5,649 | 0 | 22,593 | ||
| MAKEMYTRIP LTD USD0.0005 | COM | V5633W109 | 3,279 | 109,847 | SH | DFND | 25,194 | 0 | 84,653 | ||
| MARTIN MARIETTA MATLS INC | COM | 573284106 | 91,386 | 413,437 | SH | DFND | 42,152 | 0 | 371,285 | ||
| MASONITE INTERNATIONAL CORP COM NPV | COM | 575385109 | 1,038 | 14,000 | SH | DFND | 14,000 | 0 | 0 | ||
| MASTERCARD INCORPORATED CL A | COM | 57636Q104 | 15,587 | 102,982 | SH | DFND | 20,957 | 0 | 82,025 | ||
| MATCH GROUP INC COM | COM | 57665R106 | 8,657 | 276,485 | SH | DFND | 44,326 | 0 | 232,159 | ||
| MATERIALISE NV SPON ADS EA REPSTG 1 ORD | COM | 57667T100 | 319 | 25,069 | SH | DFND | 2,000 | 0 | 23,069 | ||
| MAZOR ROBOTICS LTD SPON ADS EA REPR 2 ORD ILS0.00 | COM | 57886P103 | 11,826 | 229,183 | SH | DFND | 40,751 | 0 | 188,432 | ||
| MCDONALDS CORP | COM | 580135101 | 64,324 | 373,717 | SH | DFND | 26,060 | 0 | 347,657 | ||
| MEG ENERGY CORP COM ISIN #CA5527041084 SEDOL #B4XF9J1 | COM | 552704108 | 54 | 13,105 | SH | DFND | 3,600 | 0 | 9,505 | ||
| MERCADOLIBRE INC | COM | 58733R102 | 41,499 | 131,884 | SH | DFND | 44,013 | 0 | 87,871 | ||
| MERCURY SYS INC COM | COM | 589378108 | 41,157 | 801,507 | SH | DFND | 268,285 | 0 | 533,222 | ||
| METRO BANK PLC ORD GBP0.000001 ISIN #GB00BZ6STL67 SEDOL #BZ6STL6 | COM | G60640102 | 172,928 | 3,566,804 | SH | DFND | 807,612 | 0 | 2,759,192 | ||
| MICRON TECHNOLOGY | COM | 595112103 | 1,589 | 38,642 | SH | DFND | 14,304 | 0 | 24,338 | ||
| MICROSOFT CORP | COM | 594918104 | 50,081 | 585,464 | SH | DFND | 148,673 | 0 | 436,791 | ||
| MIMECAST LIMITED COM USD0.012 | COM | G14838109 | 965 | 33,650 | SH | DFND | 3,086 | 0 | 30,564 | ||
| MONGODB INC CL A | COM | 60937P106 | 37,571 | 1,265,857 | SH | DFND | 128,884 | 0 | 1,136,973 | ||
| MONOLITHIC PWR SYS INC COM | COM | 609839105 | 12,113 | 107,801 | SH | DFND | 10,780 | 0 | 97,021 | ||
| MULESOFT INC CL A | COM | 625207105 | 225 | 9,682 | SH | DFND | 9,682 | 0 | 0 | ||
| NEOPHOTONICS CORP COM | COM | 64051T100 | 59 | 8,963 | SH | DFND | 2,658 | 0 | 6,305 | ||
| NETFLIX COM INC COM | COM | 64110L106 | 429,940 | 2,239,735 | SH | DFND | 489,713 | 0 | 1,750,022 | ||
| NETGEAR INC | COM | 64111Q104 | 1,922 | 32,719 | SH | DFND | 5,966 | 0 | 26,753 | ||
| NETSHOES CAYMAN LTD COM USD0.0033 | COM | G6455X107 | 7,709 | 975,776 | SH | DFND | 344,201 | 0 | 631,575 | ||
| NEW HOME CO INC COM | COM | 645370107 | 388 | 30,942 | SH | DFND | 1,273 | 0 | 29,669 | ||
| NEW RELIC INC COM | COM | 64829B100 | 7,799 | 135,000 | SH | DFND | 24,356 | 0 | 110,644 | ||
| NINTENDO CO LTD ADR(8 CNV INTO 1 ORD)NPV | COM | 654445303 | 4,542 | 99,375 | SH | DFND | 25,959 | 0 | 73,416 | ||
| NINTENDO CO LTD NPV ISIN #JP3756600007 SEDOL #6639550 | COM | J51699106 | 557 | 1,523 | SH | DFND | 376 | 0 | 1,147 | ||
| NOBLE MIDSTREAM PARTNERS LP COM UNIT REPST | COM | 65506L105 | 60 | 1,207 | SH | DFND | 0 | 0 | 1,207 | ||
| NORTHERN DYNASTY MINS COM NPV ISIN #CA66510M2040 SEDOL #2637848 | COM | 66510M204 | 807 | 456,023 | SH | DFND | 25,639 | 0 | 430,384 | ||
| NRG ENERGY INC COM NEW | COM | 629377508 | 251 | 8,810 | SH | DFND | 158 | 0 | 8,652 | ||
| NUTANIX INC CL A | COM | 67059N108 | 282 | 7,989 | SH | DFND | 975 | 0 | 7,014 | ||
| NUTRI SYS INC NEW COM | COM | 67069D108 | 9,458 | 179,814 | SH | DFND | 33,762 | 0 | 146,052 | ||
| NUVECTRA CORP COM | COM | 67075N108 | 6,977 | 899,132 | SH | DFND | 155,114 | 0 | 744,018 | ||
| NV5 GLOBAL INC COM | COM | 62945V109 | 9,644 | 178,105 | SH | DFND | 8,738 | 0 | 169,367 | ||
| NVIDIA CORP | COM | 67066G104 | 46,348 | 239,522 | SH | DFND | 92,863 | 0 | 146,659 | ||
| NXSTAGE MED INC COM | COM | 67072V103 | 3,115 | 128,550 | SH | DFND | 13,101 | 0 | 115,449 | ||
| OCADO GROUP PLC ORD GBP0.02 ISIN #GB00B3MBS747 SEDOL #B3MBS74 | COM | G6718L106 | 93,261 | 17,361,333 | SH | DFND | 2,989,052 | 0 | 14,372,281 | ||
| OKTA INC CL A | COM | 679295105 | 19,508 | 761,725 | SH | DFND | 119,518 | 0 | 642,207 | ||
| ORASURE TECHNOLOGIES INC COM | COM | 68554V108 | 499 | 26,463 | SH | DFND | 2,783 | 0 | 23,680 | ||
| OVERSTOCK COM INC DEL COM | COM | 690370101 | 410 | 6,422 | SH | DFND | 4,147 | 0 | 2,275 | ||
| PACIFIC BIOSCIENCES CALIFORNIA INC COM USD0.0001 | COM | 69404D108 | 23 | 8,659 | SH | DFND | 2,782 | 0 | 5,877 | ||
| PALO ALTO NETWORKS INC COM USD0.0001 | COM | 697435105 | 1,381 | 9,529 | SH | DFND | 2,139 | 0 | 7,390 | ||
| PARAMOUNT RESOURCES LIMITED COM NPV CLASS A ISIN #CA6993202069 S | COM | 699320206 | 12,792 | 825,306 | SH | DFND | 88,581 | 0 | 736,725 | ||
| PAYPAL HLDGS INC COM | COM | 70450Y103 | 49,060 | 666,389 | SH | DFND | 205,724 | 0 | 460,665 | ||
| PDF SOLUTIONS INC | COM | 693282105 | 18,564 | 1,182,428 | SH | DFND | 78,998 | 0 | 1,103,430 | ||
| PENSKE AUTOMOTIVE GROUP INC | COM | 70959W103 | 3,675 | 76,800 | SH | DFND | 18,492 | 0 | 58,308 | ||
| POLARITYTE INC COM | COM | 731094108 | 1,507 | 64,949 | SH | DFND | 19,367 | 0 | 45,582 | ||
| POOL CORP COM | COM | 73278L105 | 54,443 | 419,924 | SH | DFND | 66,087 | 0 | 353,837 | ||
| PRICELINE GROUP INC COM USD0.008 | COM | 741503403 | 200 | 115 | SH | DFND | 2 | 0 | 113 | ||
| PROOFPOINT INC COM USD0.0001 | COM | 743424103 | 4,590 | 51,686 | SH | DFND | 3,757 | 0 | 47,929 | ||
| Q2 HLDGS INC COM | COM | 74736L109 | 23,550 | 639,078 | SH | DFND | 189,935 | 0 | 449,143 | ||
| R1 RCM INC COM | COM | 749397105 | 1,692 | 383,785 | SH | DFND | 112,245 | 0 | 271,540 | ||
| REPUBLIC FIRST BANCORP INC COM | COM | 760416107 | 14,779 | 1,748,965 | SH | DFND | 723,762 | 0 | 1,025,203 | ||
| RIGHTMOVE PLC WINTERHILL SHS ISIN #GB00B2987V85 SEDOL #B2987V8 | COM | G75657109 | 21,810 | 358,276 | SH | DFND | 50,681 | 0 | 307,595 | ||
| RINGCENTRAL INC-CLASS A | COM | 76680R206 | 155,848 | 3,220,001 | SH | DFND | 589,778 | 0 | 2,630,223 | ||
| ROKU INC COM CL A | COM | 77543R102 | 27,004 | 521,507 | SH | DFND | 26,422 | 0 | 495,085 | ||
| SAFETY INS GROUP INC | COM | 78648T100 | 455 | 5,663 | SH | DFND | 1,075 | 0 | 4,588 | ||
| SAILPOINT TECHNLGIES HLDGS INC COM | COM | 78781P105 | 22,033 | 1,519,531 | SH | DFND | 191,708 | 0 | 1,327,823 | ||
| SALESFORCE COM INC | COM | 79466L302 | 59,623 | 583,223 | SH | DFND | 181,582 | 0 | 401,641 | ||
| SANGAMO THERAPEUTICS INC COM | COM | 800677106 | 459 | 27,992 | SH | DFND | 7,213 | 0 | 20,779 | ||
| SAREPTA THERAPEUTICS INC COM | COM | 803607100 | 48,564 | 872,824 | SH | DFND | 284,530 | 0 | 588,294 | ||
| SCHNEIDER NATIONAL INC CL B | COM | 80689H102 | 2,517 | 88,118 | SH | DFND | 21,034 | 0 | 67,084 | ||
| SCIENTIFIC GAMES CRP CL A | COM | 80874P109 | 3,744 | 72,977 | SH | DFND | 20,063 | 0 | 52,914 | ||
| SEA LIMITED ADS EACH REP ONE CLASS A ORD SHS | COM | 81141R100 | 9,804 | 735,468 | SH | DFND | 1,588 | 0 | 733,880 | ||
| SEASPAN CORPORATION COM STK USD0.01 | COM | Y75638109 | 2,759 | 408,777 | SH | DFND | 68,298 | 0 | 340,479 | ||
| SEASPINE HLDGS CORP COM | COM | 81255T108 | 3,484 | 344,267 | SH | DFND | 60,592 | 0 | 283,675 | ||
| SENESTECH INC COM | COM | 81720R109 | 1,025 | 1,424,173 | SH | DFND | 199,988 | 0 | 1,224,185 | ||
| SEQUANS COMMUNICATIONS SPON ADR EA REPR 1 ORD SHS | COM | 817323108 | 149 | 78,270 | SH | DFND | 11,651 | 0 | 66,619 | ||
| SERVICENOW INC COM USD0.001 | COM | 81762P102 | 20,223 | 155,093 | SH | DFND | 29,089 | 0 | 126,004 | ||
| SHAKE SHACK INC CL A | COM | 819047101 | 67,195 | 1,555,450 | SH | DFND | 242,154 | 0 | 1,313,296 | ||
| SHERWIN WILLIAMS CO | COM | 824348106 | 1,098 | 2,679 | SH | DFND | 55 | 0 | 2,624 | ||
| SHOPIFY INC COM NPV CL A ISIN #CA82509L1076 SEDOL #BX865C7 | COM | 82509L107 | 3,774 | 37,362 | SH | DFND | 11,755 | 0 | 25,607 | ||
| SHOTSPOTTER INC COM | COM | 82536T107 | 24,642 | 1,753,848 | SH | DFND | 489,221 | 0 | 1,264,627 | ||
| SIENTRA INC COM USD0.01 | COM | 82621J105 | 15,006 | 1,067,310 | SH | DFND | 154,118 | 0 | 913,192 | ||
| SIGNATURE BK NEW YORK N Y COM | COM | 82669G104 | 3,148 | 22,935 | SH | DFND | 4,150 | 0 | 18,785 | ||
| SILVERCREST METALS INC COM NPV ISIN #CA8283631015 SEDOL #BYVY3D2 | COM | 828363101 | 2,551 | 1,785,449 | SH | DFND | 178,788 | 0 | 1,606,661 | ||
| SIMPLY GOOD FOODS CO COM | COM | 82900L102 | 351 | 24,592 | SH | DFND | 529 | 0 | 24,063 | ||
| SIRIUS XM HLDGS INC COM | COM | 82968B103 | 101 | 18,826 | SH | DFND | 3,564 | 0 | 15,262 | ||
| SITEONE LANDSCAPE SUPPLY INC COM | COM | 82982L103 | 28,435 | 370,728 | SH | DFND | 48,868 | 0 | 321,860 | ||
| SIX FLAGS ENTMT CORP NEW COM | COM | 83001A102 | 4,749 | 71,345 | SH | DFND | 38,646 | 0 | 32,699 | ||
| SNAP INC CL A | COM | 83304A106 | 24,487 | 1,676,025 | SH | DFND | 389,006 | 0 | 1,287,019 | ||
| SOCIAL CAP HEDOSOPHIA HLDGS CORP UNIT 1 CL A & 1/3 WT EXP ISIN # | COM | G8250R111 | 2,052 | 193,619 | SH | DFND | 33,657 | 0 | 159,962 | ||
| SOLARIS OILFIELD INFRSTR INC COM CL A | COM | 83418M103 | 36,521 | 1,705,799 | SH | DFND | 208,690 | 0 | 1,497,109 | ||
| SONY CORP SPON ADR EACH REPR 1 ORD | COM | 835699307 | 88,068 | 1,959,246 | SH | DFND | 465,202 | 0 | 1,494,044 | ||
| SPARK THERAPEUTICS INC COM | COM | 84652J103 | 28,188 | 548,189 | SH | DFND | 232,909 | 0 | 315,280 | ||
| SPIRIT AIRLS INC COM | COM | 848577102 | 15,481 | 345,173 | SH | DFND | 36,093 | 0 | 309,080 | ||
| SPLUNK INC COM USD0.001 | COM | 848637104 | 4,431 | 53,491 | SH | DFND | 5,284 | 0 | 48,207 | ||
| SQUARE INC CL A | COM | 852234103 | 11,909 | 343,501 | SH | DFND | 53,351 | 0 | 290,150 | ||
| SS&C TECHNOLOGIES HLDGS INC COM | COM | 78467J100 | 30,028 | 741,803 | SH | DFND | 128,987 | 0 | 612,816 | ||
| STAMPS COM INC COM NEW | COM | 852857200 | 212 | 1,127 | SH | DFND | 224 | 0 | 903 | ||
| STAR BULK CARRIERS CORP COM USD0.01(POST REV SPLIT) | COM | Y8162K204 | 4,176 | 370,868 | SH | DFND | 72,446 | 0 | 298,422 | ||
| STEADYMED LTD ILS0.01 | COM | M84920103 | 31 | 8,512 | SH | DFND | 387 | 0 | 8,125 | ||
| STITCH FIX INC COM CL A | COM | 860897107 | 25,974 | 1,005,564 | SH | DFND | 955 | 0 | 1,004,609 | ||
| STRAIGHT PATH COMMUNICATIONS INC COM USD0.01 CL B | COM | 862578101 | 11,261 | 61,944 | SH | DFND | 45,169 | 0 | 16,775 | ||
| SUMMIT MATLS INC CL A | COM | 86614U100 | 14,018 | 445,864 | SH | DFND | 31,926 | 0 | 413,938 | ||
| SUNOPTA INC COM ISIN #CA8676EP1086 SEDOL #2817510 | COM | 8676EP108 | 6,860 | 885,149 | SH | DFND | 150,836 | 0 | 734,313 | ||
| SUNRUN INC COM | COM | 86771W105 | 267 | 45,194 | SH | DFND | 4,882 | 0 | 40,312 | ||
| SVB FINL GROUP | COM | 78486Q101 | 6,292 | 26,914 | SH | DFND | 4,997 | 0 | 21,917 | ||
| T MOBILE US INC COM | COM | 872590104 | 51,949 | 817,961 | SH | DFND | 60,920 | 0 | 757,041 | ||
| TACTILE SYS TECHNOLOGY INC COM | COM | 87357P100 | 8,046 | 277,651 | SH | DFND | 47,272 | 0 | 230,379 | ||
| TAKE-TWO INTERACTIVE SOFTWARE COM | COM | 874054109 | 45,875 | 417,885 | SH | DFND | 133,356 | 0 | 284,529 | ||
| TAL EDUCATION GROUP SPON ADS EACH REP 0.3333 CL A ORD SHS | COM | 874080104 | 74,764 | 2,516,452 | SH | DFND | 556,522 | 0 | 1,959,930 | ||
| TALEND SA ADR EACH REP 1 ORD SHS | COM | 874224207 | 1,466 | 39,107 | SH | DFND | 8,021 | 0 | 31,086 | ||
| TELADOC INC COM | COM | 87918A105 | 47,237 | 1,355,425 | SH | DFND | 548,358 | 0 | 807,067 | ||
| TELARIA INC COM | COM | 879181105 | 4,494 | 1,115,180 | SH | DFND | 170,527 | 0 | 944,653 | ||
| TELESITES SAB DE CV COM NPV SER B-1 ISIN #MX01SI080038 SEDOL #BD | COM | P90355135 | 153 | 199,189 | SH | DFND | 23,883 | 0 | 175,306 | ||
| TENCENT HOLDINGS LIMITED HKD0.00002 ISIN #KYG875721634 SEDOL #BM | COM | G87572163 | 90,251 | 1,737,731 | SH | DFND | 562,406 | 0 | 1,175,325 | ||
| TESLA INC COM | COM | 88160R101 | 215,136 | 690,978 | SH | DFND | 242,443 | 0 | 448,535 | ||
| THERAPEUTICSMD INC COM USD0.001 | COM | 88338N107 | 1,492 | 246,969 | SH | DFND | 246,969 | 0 | 0 | ||
| TIME INC NEW COM TENDER FROM CUSIP 887228104 | COM | 887991578 | 32 | 1,736 | SH | DFND | 0 | 0 | 1,736 | ||
| TRANSDIGM GROUP INC COM | COM | 893641100 | 4,842 | 17,631 | SH | DFND | 153 | 0 | 17,478 | ||
| TRIPADVISOR INC COM | COM | 896945201 | 392 | 11,385 | SH | DFND | 1,668 | 0 | 9,717 | ||
| TSO3 INC COM ISIN #CA8730151013 SEDOL #2798518 | COM | 873015101 | 11,148 | 5,351,875 | SH | DFND | 488,666 | 0 | 4,863,209 | ||
| TWITTER INC COM USD0.000005 | COM | 90184L102 | 1,422 | 59,211 | SH | DFND | 23,825 | 0 | 35,386 | ||
| UBIQUITI NETWORKS INC COM USD0.001 | COM | 90347A100 | 112 | 1,582 | SH | DFND | 206 | 0 | 1,376 | ||
| ULTIMATE SOFTWARE GROUP INC | COM | 90385D107 | 2,635 | 12,075 | SH | DFND | 2,418 | 0 | 9,657 | ||
| UNITEDHEALTH GROUP | COM | 91324P102 | 87 | 396 | SH | DFND | 57 | 0 | 339 | ||
| UNIVERSAL DISPLAY CORP | COM | 91347P105 | 666 | 3,856 | SH | DFND | 2,645 | 0 | 1,211 | ||
| USA TECHNOLOGIES INC COM NO PAR | COM | 90328S500 | 618 | 63,354 | SH | DFND | 0 | 0 | 63,354 | ||
| VALIDUS HOLDING LTD COM STK USD0.175 | COM | G9319H102 | 7,400 | 157,723 | SH | DFND | 33,326 | 0 | 124,397 | ||
| VANECK VECTORS ETF TR GOLD MINERS ETF | COM | 92189F106 | 11,382 | 489,750 | SH | DFND | 17,175 | 0 | 472,575 | ||
| VEEVA SYS INC CL A COM | COM | 922475108 | 19,471 | 352,224 | SH | DFND | 47,405 | 0 | 304,819 | ||
| VIVENDI SA EUR5.50 ISIN #FR0000127771 SEDOL #4834777 | COM | F97982106 | 81,285 | 3,019,295 | SH | DFND | 539,355 | 0 | 2,479,940 | ||
| VOCERA COMMUNICATIONS INC COM | COM | 92857F107 | 8,987 | 297,383 | SH | DFND | 49,812 | 0 | 247,571 | ||
| VOYAGER THERAPEUTICS INC COM | COM | 92915B106 | 15 | 877 | SH | DFND | 45 | 0 | 832 | ||
| WAL-MART STORES INC COM | COM | 931142103 | 121,781 | 1,233,222 | SH | DFND | 226,574 | 0 | 1,006,648 | ||
| WHEATON PRECIOUS METALS CORP COM NPV ISIN #CA9628791027 SEDOL #B | COM | 962879102 | 1,963 | 88,714 | SH | DFND | 635 | 0 | 88,079 | ||
| WORKDAY INC COM USD0.001 CL A | COM | 98138H101 | 13,869 | 136,322 | SH | DFND | 27,954 | 0 | 108,368 | ||
| XILINX INC | COM | 983919101 | 548 | 8,122 | SH | DFND | 1,772 | 0 | 6,350 | ||
| ZAI LAB LTD-ADR | COM | 98887Q104 | 19,471 | 917,123 | SH | DFND | 339,560 | 0 | 577,563 | ||
| ZAYO GROUP HLDGS INC COM | COM | 98919V105 | 276 | 7,504 | SH | DFND | 965 | 0 | 6,539 | ||
| ZENDESK INC COM USD0.01 | COM | 98936J101 | 4,257 | 125,800 | SH | DFND | 23,586 | 0 | 102,214 | ||
| ZILLOW GROUP INC CL A | COM | 98954M101 | 17,162 | 421,266 | SH | DFND | 28,774 | 0 | 392,492 | ||
| ZILLOW GROUP INC CL C CAP STK | COM | 98954M200 | 39,046 | 954,204 | SH | DFND | 76,327 | 0 | 877,877 | ||
| ZOETIS INC COM USD0.01 CL A | COM | 98978V103 | 276 | 3,826 | SH | DFND | 0 | 0 | 3,826 | ||
| ZYNGA INC COM USD0.00000625 CLASS A | COM | 98986T108 | 7,754 | 1,938,457 | SH | DFND | 286,690 | 0 | 1,651,767 | ||