The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACHILLION PHARMACEUTICALS IN COM 00448Q201 1,347 300,000 SH   DFND 1,2 300,000 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 2,445 115,500 SH   DFND 1,2 115,500 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 2,083 21,000 SH Call DFND   0 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 266 2,686 SH   DFND   2,686 0 0
AILERON THERAPEUTICS INC COM 00887A105 1,673 125,000 SH   DFND 1,2 125,000 0 0
ALBIREO PHARMA INC COM 01345P106 2,274 108,526 SH   DFND 1,2 108,526 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 7,518 1,044,131 SH   DFND 1,2 1,044,131 0 0
ALLERGAN PLC SHS G0177J108 12,297 60,000 SH   DFND 1,2 60,000 0 0
ALPHABET INC CAP STK CL A 02079K305 5,615 5,767 SH   DFND   5,767 0 0
AMICUS THERAPEUTICS INC COM 03152W109 6,334 420,000 SH   DFND 1,2 420,000 0 0
ANAPTYSBIO INC COM 032724106 2,796 80,000 SH   DFND 1,2 80,000 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 1,072 75,535 SH   DFND 1,2 75,535 0 0
ARDELYX INC COM 039697107 1,932 345,000 SH   DFND 1,2 345,000 0 0
ARRAY BIOPHARMA INC COM 04269X105 4,982 405,000 SH   DFND 1,2 405,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 4,693 129,474 SH   DFND 1,2 129,474 0 0
ATHERSYS INC COM 04744L106 2 773 SH   DFND 1,2 773 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 2,661 95,000 SH   DFND 1,2 95,000 0 0
AVEO PHARMACEUTICALS INC COM 053588109 5,110 1,400,000 SH   DFND 1,2 1,400,000 0 0
AXOVANT SCIENCES LTD COM G0750W104 2,064 300,000 SH Put DFND 1,2 300,000 0 0
AXOVANT SCIENCES LTD COM G0750W104 1,238 180,000 SH Call DFND 1,2 0 0 0
AXSOME THERAPEUTICS INC COM 05464T104 2,781 501,000 SH   DFND 1,2 501,000 0 0
BIOGEN INC COM 09062X103 32,878 105,000 SH   DFND 1,2 105,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 7,911 85,000 SH   DFND 1,2 85,000 0 0
CAESARSTONE LTD ORD SHS M20598104 531 17,833 SH   DFND   17,833 0 0
CASCADIAN THERAPEUTICS INC COM NEW 14740B606 2,786 681,210 SH   DFND 1,2 681,210 0 0
CATABASIS PHARMACEUTICALS IN COM 14875P107 611 288,030 SH   DFND 1,2 288,030 0 0
CELGENE CORP COM 151020104 40,101 275,000 SH   DFND 1,2 275,000 0 0
CELLCOM ISRAEL LTD SHS M2196U109 14,301 1,535,988 SH   DFND   1,535,988 0 0
CELLECTIS S A SPONSORED ADS 15117K103 9,922 348,736 SH   DFND 1,2 348,736 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 4,856 13,362 SH   DFND   13,362 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 123 400 SH   DFND   400 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 2,622 300,000 SH   DFND 1,2 300,000 0 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 2,753 163,000 SH   DFND 1,2 163,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 13,019 158,000 SH   DFND 1,2 158,000 0 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 2,239 30,866 SH   DFND   30,866 0 0
COMCAST CORP NEW CL A 20030N101 2,554 66,360 SH   DFND   66,360 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 3,530 221,430 SH   DFND 1,2 221,430 0 0
CTI BIOPHARMA CORP COM NEW 12648L601 2,659 833,633 SH   DFND 1,2 833,633 0 0
CYTOKINETICS INC COM NEW 23282W605 1,450 100,000 SH Call DFND 1,2 0 0 0
CYTOKINETICS INC COM NEW 23282W605 3,306 227,990 SH   DFND 1,2 227,990 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 3,816 210,000 SH   DFND 1,2 210,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 1,424 75,000 SH   DFND 1,2 75,000 0 0
DENTSPLY SIRONA INC COM 24906P109 150 2,500 SH   DFND   2,500 0 0
DOVA PHARMACEUTICALS INC COM 25985T102 1,901 78,284 SH   DFND 1,2 78,284 0 0
ECOLAB INC COM 278865100 257 2,000 SH   DFND   2,000 0 0
EDGE THERAPEUTICS INC COM 279870109 3,581 333,737 SH   DFND 1,2 333,737 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 5,723 520,269 SH   DFND 1,2 520,269 0 0
EVOKE PHARMA INC COM 30049G104 1,907 571,022 SH   DFND 1,2 571,022 0 0
FACEBOOK INC CL A 30303M102 5,496 32,167 SH   DFND   32,167 0 0
FIBROGEN INC COM 31572Q808 6,982 129,779 SH   DFND 1,2 129,779 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 1,636 40,000 SH   DFND 1,2 40,000 0 0
FLEX PHARMA INC COM 33938A105 2,341 141,300 SH   DFND   141,300 0 0
GENOCEA BIOSCIENCES INC COM 372427104 715 490,000 SH   DFND 1,2 490,000 0 0
GILEAD SCIENCES INC COM 375558103 18,635 230,000 SH   DFND 1,2 230,000 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 18,270 450,000 SH   DFND 1,2 450,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 3,943 127,000 SH   DFND 1,2 127,000 0 0
IGNYTA INC COM 451731103 5,672 459,300 SH   DFND 1,2 459,300 0 0
IMMUNOMEDICS INC COM 452907108 6,291 450,000 SH   DFND 1,2 450,000 0 0
INOTEK PHARMACEUTICALS CORP COM 45780V102 715 401,764 SH   DFND 1,2 401,764 0 0
INSMED INC COM PAR $.01 457669307 4,213 135,000 SH   DFND 1,2 135,000 0 0
ITURAN LOCATION AND CONTROL SHS M6158M104 8,266 229,283 SH   DFND   229,283 0 0
KADMON HLDGS INC COM 48283N106 3,685 1,100,000 SH   DFND 1,2 1,100,000 0 0
KORNIT DIGITAL LTD SHS M6372Q113 1,025 67,006 SH   DFND   67,006 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 5,217 150,000 SH   DFND 1,2 150,000 0 0
LIBERTY INTERACTIVE CORP LBT VEN COM A NE 53071M856 173 3,000 SH   DFND   3,000 0 0
LOWES COS INC COM 548661107 208 2,600 SH   DFND   2,600 0 0
MACROGENICS INC COM 556099109 3,857 208,700 SH   DFND 1,2 208,700 0 0
MASTERCARD INCORPORATED CL A 57636Q104 1,627 11,525 SH   DFND   11,525 0 0
MERCK & CO INC COM 58933Y105 27,213 425,000 SH   DFND 1,2 425,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 4,750 625,000 SH   DFND 1,2 625,000 0 0
MOHAWK INDS INC COM 608190104 272 1,100 SH   DFND   1,100 0 0
MYLAN N V SHS EURO N59465109 4,706 150,000 SH Call DFND   0 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 5,331 87,000 SH   DFND 1,2 87,000 0 0
NICE LTD SPONSORED ADR 653656108 8,876 109,159 SH   DFND   109,159 0 0
NIGHTSTAR THERAPEUTICS PLC ADR 65413A101 1,728 90,000 SH   DFND 1,2 90,000 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 2,428 166,662 SH   DFND   166,662 0 0
NUCANA PLC SPONSORED ADR 67022C106 919 50,000 SH   DFND 1,2 50,000 0 0
O REILLY AUTOMOTIVE INC NEW COM 67103H107 2,154 10,000 SH Call DFND   0 0 0
O REILLY AUTOMOTIVE INC NEW COM 67103H107 366 1,700 SH   DFND   1,700 0 0
OBSEVA SA COM H5861P103 2,118 260,197 SH   DFND 1,2 260,197 0 0
ORACLE CORP COM 68389X105 2,285 47,250 SH   DFND   47,250 0 0
ORBOTECH LTD ORD M75253100 7,397 175,243 SH   DFND   175,243 0 0
OVID THERAPEUTICS INC COM 690469101 2,620 305,674 SH   DFND 1,2 305,674 0 0
PALO ALTO NETWORKS INC COM 697435105 2,998 20,805 SH   DFND   20,805 0 0
PFIZER INC COM 717081103 13,923 390,000 SH   DFND 1,2 390,000 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 5,760 1,000,000 SH   DFND 1,2 1,000,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 7,834 145,000 SH   DFND 1,2 145,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 2,571 530,000 SH   DFND 1,2 530,000 0 0
PROTHENA CORP PLC SHS G72800108 3,886 60,000 SH   DFND 1,2 60,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 6,376 205,000 SH   DFND 1,2 205,000 0 0
RETROPHIN INC COM 761299106 4,334 174,131 SH   DFND 1,2 174,131 0 0
SAGE THERAPEUTICS INC COM 78667J108 150 2,400 SH Put DFND 1,2 2,400 0 0
SAGE THERAPEUTICS INC COM 78667J108 381 6,118 SH   DFND 1,2 6,118 0 0
SAPIENS INTL CORP N V SHS NEW N7716A151 4,650 354,866 SH   DFND   354,866 0 0
SAREPTA THERAPEUTICS INC COM 803607100 6,804 150,000 SH Call DFND 1,2 0 0 0
SAREPTA THERAPEUTICS INC COM 803607100 17,463 384,997 SH   DFND 1,2 384,997 0 0
SAVARA INC COM 805111101 4,921 526,315 SH   DFND 1,2 526,315 0 0
SEALED AIR CORP NEW COM 81211K100 192 4,500 SH   DFND   4,500 0 0
SELECTA BIOSCIENCES INC COM 816212104 4,171 228,534 SH   DFND 1,2 228,534 0 0
SERVICEMASTER GLOBAL HLDGS I COM 81761R109 374 8,000 SH   DFND   8,000 0 0
SHIRE PLC SPONSORED ADR 82481R106 13,247 86,500 SH   DFND 1,2 86,500 0 0
SNAP ON INC COM 833034101 1,087 7,292 SH   DFND   7,292 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 2,912 102,003 SH   DFND   102,003 0 0
SPDR GOLD TRUST GOLD SHS 78463V107 4,035 33,190 SH   DFND   33,190 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 121,198 1,400,000 SH Put DFND 1,2 1,400,000 0 0
SPRING BK PHARMACEUTICALS IN COM 849431101 2,685 159,417 SH   DFND 1,2 159,417 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 3,330 300,000 SH   DFND 1,2 300,000 0 0
SUMMIT THERAPEUTICS PLC SPONS ADS 86627R102 2,654 212,018 SH   DFND 1,2 212,018 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 217 111,762 SH   DFND 1,2 111,762 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 2,907 248,472 SH   DFND 1,2 248,472 0 0
TESARO INC COM 881569107 10,328 80,000 SH   DFND 1,2 80,000 0 0
TEVA PHARMACEUTICAL FIN LLC DBCV 0.250% 2/0 88163VAE9 4,096 11,885 SH   DFND   11,885 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 7,040 400,000 SH   DFND 1,2 400,000 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 1,267 72,000 SH Put DFND   72,000 0 0
THERAPEUTICSMD INC COM 88338N107 2,010 380,000 SH   DFND 1,2 380,000 0 0
TJX COS INC NEW COM 872540109 428 5,800 SH   DFND   5,800 0 0
TRIPADVISOR INC COM 896945201 162 4,000 SH   DFND   4,000 0 0
ULTIMATE SOFTWARE GROUP INC COM 90385D107 152 800 SH   DFND   800 0 0
UNION PAC CORP COM 907818108 3,149 27,156 SH   DFND   27,156 0 0
UNITEDHEALTH GROUP INC COM 91324P102 392 2,000 SH   DFND   2,000 0 0
VERISK ANALYTICS INC COM 92345Y106 782 9,400 SH   DFND   9,400 0 0
VERSARTIS INC COM 92529L102 802 327,524 SH   DFND 1,2 327,524 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 3,166 20,823 SH   DFND 1,2 20,823 0 0
VIKING THERAPEUTICS INC COM 92686J106 554 290,000 SH   DFND 1,2 290,000 0 0
VISA INC COM CL A 92826C839 5,573 52,951 SH   DFND   52,951 0 0
VISTA OUTDOOR INC COM 928377100 138 6,000 SH   DFND   6,000 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 1,693 1,058,386 SH   DFND 1,2 1,058,386 0 0
VTV THERAPEUTICS INC CL A 918385105 1,794 300,000 SH   DFND 1,2 300,000 0 0
WATSCO INC COM 942622200 338 2,100 SH   DFND   2,100 0 0
XENON PHARMACEUTICALS INC COM 98420N105 673 228,029 SH   DFND 1,2 228,029 0 0
ZOGENIX INC COM NEW 98978L204 5,082 145,000 SH   DFND 1,2 145,000 0 0