The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
IRONWOOD PHARMACEUTICALS INC COM 46333X908 7,885 500,000 SH Call SOLE   500,000 0 0
IRONWOOD PHARMACEUTICALS INC COM 46333X908 1,892 120,000 SH Call SOLE   120,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F900 10,278 67,600 SH Call SOLE   67,600 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 76,401 2,107,600 SH   SOLE   2,107,600 0 0
BEIGENE LTD SPONSORED ADR SPONSORED ADR 07725L102 1,009 9,800 SH   SOLE   9,800 0 0
GALAPAGOS NV SPON ADR SPONSORED ADR 36315X101 24,499 240,776 SH   SOLE   240,776 0 0
ZAI LAB LIMITED SPONSORED ADR 98887Q104 4,307 159,535 SH   SOLE   159,535 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 1,549 60,000 SH   SOLE   60,000 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 2,785 762,947 SH   SOLE   762,947 0 0
ARRAY BIOPHARMA INC COM 04269X105 15,375 1,250,000 SH   SOLE   1,250,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 102,775 2,943,164 SH   SOLE   2,943,164 0 0
ATYR PHARMA INC COM 002120103 19,871 3,934,849 SH   SOLE   3,934,849 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 1,087 17,060 SH   SOLE   17,060 0 0
CASCADIAN THERAPEUTICS INC COM 14740B606 12,270 3,000,000 SH   SOLE   3,000,000 0 0
CLEMENTIA PHARMACEUTICALS INC COM 185575107 3,279 194,166 SH   SOLE   194,166 0 0
CLOVIS ONCOLOGY INC COM 189464100 2,123 25,765 SH   SOLE   25,765 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 14,482 908,525 SH   SOLE   908,525 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 15,077 829,771 SH   SOLE   829,771 0 0
DECIPHERA PHARMACEUTICALS INC COM 24344T101 855 45,000 SH   SOLE   45,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 5,508 957,992 SH   SOLE   957,992 0 0
FATE THERAPEUTICS INC COM 31189P102 8,960 2,262,678 SH   SOLE   2,262,678 0 0
FIBROGEN INC COM 31572Q808 93,379 1,735,677 SH   SOLE   1,735,677 0 0
IMMUNOMEDICS INC COM 452907108 39,983 2,860,019 SH   SOLE   2,860,019 0 0
INSMED INC COM 457669307 12,653 405,400 SH   SOLE   405,400 0 0
INTEC PHARMA LTD JERUSALEM COM M53644106 13,425 1,500,000 SH   SOLE   1,500,000 0 0
IRONWOOD PHARMACEUTICALS INC COM 46333X108 86,098 5,459,583 SH   SOLE   5,459,583 0 0
KINDRED BIOSCIENCES INC COM 494577109 4,277 544,880 SH   SOLE   544,880 0 0
KURA ONCOLOGY INC COM COM 50127T109 56,314 3,766,852 SH   SOLE   3,766,852 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 21,263 3,622,271 SH   SOLE   3,622,271 0 0
MYOKARDIA INC COM 62857M105 29,566 689,986 SH   SOLE   689,986 0 0
OMEROS CORP COM 682143102 9,729 450,000 SH   SOLE   450,000 0 0
OVASCIENCE INC COM 69014Q101 4,988 3,512,332 SH   SOLE   3,512,332 0 0
REGULUS THERAPEUTICS INC COM 75915K101 6,549 5,239,225 SH   SOLE   5,239,225 0 0
SANGAMO BIOSCIENCES INC COM 800677106 3,336 222,388 SH   SOLE   222,388 0 0
SEATTLE GENETICS INC COM 812578102 1,632 30,000 SH   SOLE   30,000 0 0
SPRING BK PHARMACEUTICALS INC COM 849431101 269 16,000 SH   SOLE   16,000 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 1,531 104,000 SH   SOLE   104,000 0 0
TOCAGEN INC COM 888846102 18,720 1,502,373 SH   SOLE   1,502,373 0 0
WAVE LIFE SCIENCES LTD COM Y95308105 12,272 564,248 SH   SOLE   564,248 0 0
XENCOR INC COM 98401F105 2,065 90,114 SH   SOLE   90,114 0 0